[go: up one dir, main page]

WO2011156410A8 - Conjugated polymeric material and uses thereof - Google Patents

Conjugated polymeric material and uses thereof Download PDF

Info

Publication number
WO2011156410A8
WO2011156410A8 PCT/US2011/039497 US2011039497W WO2011156410A8 WO 2011156410 A8 WO2011156410 A8 WO 2011156410A8 US 2011039497 W US2011039497 W US 2011039497W WO 2011156410 A8 WO2011156410 A8 WO 2011156410A8
Authority
WO
WIPO (PCT)
Prior art keywords
particles
polymeric material
conjugated polymeric
compositions
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/039497
Other languages
French (fr)
Other versions
WO2011156410A1 (en
Inventor
Anthony Harris
Jonathan Thompson
Rebecca Rone
Sheila Grant
David Grant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Missouri Columbia
University of Missouri St Louis
Original Assignee
University of Missouri Columbia
University of Missouri St Louis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2011264946A priority Critical patent/AU2011264946B2/en
Priority to DK11730136.6T priority patent/DK2575908T3/en
Priority to CN201180028726.0A priority patent/CN103124568B/en
Priority to PL11730136T priority patent/PL2575908T3/en
Priority to CA2801716A priority patent/CA2801716A1/en
Priority to SI201130749T priority patent/SI2575908T1/en
Priority to HRP20160275TT priority patent/HRP20160275T1/en
Priority to EP11730136.6A priority patent/EP2575908B8/en
Priority to HK13111350.6A priority patent/HK1183829B/en
Priority to MX2012014302A priority patent/MX2012014302A/en
Priority to RS20160162A priority patent/RS54601B1/en
Priority to ES11730136.6T priority patent/ES2565059T3/en
Application filed by University of Missouri Columbia, University of Missouri St Louis filed Critical University of Missouri Columbia
Priority to BR112012031311A priority patent/BR112012031311A2/en
Priority to JP2013514313A priority patent/JP2013528108A/en
Publication of WO2011156410A1 publication Critical patent/WO2011156410A1/en
Priority to IL223499A priority patent/IL223499A/en
Anticipated expiration legal-status Critical
Publication of WO2011156410A8 publication Critical patent/WO2011156410A8/en
Priority to SM201600095T priority patent/SMT201600095B/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1866—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle the nanoparticle having a (super)(para)magnetic core coated or functionalised with a peptide, e.g. protein, polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/60—Particulates further characterized by their structure or composition
    • A61K2800/61—Surface treated
    • A61K2800/62—Coated
    • A61K2800/624—Coated by macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/16—Materials with shape-memory or superelastic properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Inorganic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers & Plastics (AREA)

Abstract

Disclosed are compositions comprising collagen covalently bound to particles, wherein covalent bonds are formed between reactive groups of the collagen and reactive groups of the particles, and wherein the particles have an average particle diameter ranging from 20 to 1000 nanometers. Also disclosed are various methods that utilize the compositions.
PCT/US2011/039497 2010-06-07 2011-06-07 Conjugated polymeric material and uses thereof Ceased WO2011156410A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
RS20160162A RS54601B1 (en) 2010-06-07 2011-06-07 CONJUGATED POLYMER MATERIAL AND ITS USE
CN201180028726.0A CN103124568B (en) 2010-06-07 2011-06-07 Bonded polymeric materials and uses thereof
PL11730136T PL2575908T3 (en) 2010-06-07 2011-06-07 Conjugated polymeric material and uses thereof
CA2801716A CA2801716A1 (en) 2010-06-07 2011-06-07 Conjugated polymeric material and uses thereof
SI201130749T SI2575908T1 (en) 2010-06-07 2011-06-07 Conjugated polymeric material and uses thereof
HRP20160275TT HRP20160275T1 (en) 2010-06-07 2011-06-07 Conjugated polymeric material and uses thereof
EP11730136.6A EP2575908B8 (en) 2010-06-07 2011-06-07 Conjugated polymeric material and uses thereof
HK13111350.6A HK1183829B (en) 2010-06-07 2011-06-07 Conjugated polymeric material and uses thereof
MX2012014302A MX2012014302A (en) 2010-06-07 2011-06-07 Conjugated polymeric material and uses thereof.
AU2011264946A AU2011264946B2 (en) 2010-06-07 2011-06-07 Conjugated polymeric material and uses thereof
DK11730136.6T DK2575908T3 (en) 2010-06-07 2011-06-07 Conjugated polymer material and uses thereof
ES11730136.6T ES2565059T3 (en) 2010-06-07 2011-06-07 Conjugated polymeric material and its uses
BR112012031311A BR112012031311A2 (en) 2010-06-07 2011-06-07 "conjugated polymeric material and its uses"
JP2013514313A JP2013528108A (en) 2010-06-07 2011-06-07 COMPOSITE POLYMER MATERIAL AND USE THEREOF
IL223499A IL223499A (en) 2010-06-07 2012-12-06 Conjugated polymeric material and uses thereof
SM201600095T SMT201600095B (en) 2010-06-07 2016-04-05 POLYMERIC MATERIAL CONJUGATED AND ITS USES

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39710010P 2010-06-07 2010-06-07
US61/397,100 2010-06-07

Publications (2)

Publication Number Publication Date
WO2011156410A1 WO2011156410A1 (en) 2011-12-15
WO2011156410A8 true WO2011156410A8 (en) 2016-03-17

Family

ID=44483792

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/039497 Ceased WO2011156410A1 (en) 2010-06-07 2011-06-07 Conjugated polymeric material and uses thereof

Country Status (18)

Country Link
US (2) US9827323B2 (en)
EP (1) EP2575908B8 (en)
JP (2) JP2013528108A (en)
CN (1) CN103124568B (en)
AU (1) AU2011264946B2 (en)
BR (1) BR112012031311A2 (en)
CA (1) CA2801716A1 (en)
DK (1) DK2575908T3 (en)
ES (1) ES2565059T3 (en)
HR (1) HRP20160275T1 (en)
HU (1) HUE027146T2 (en)
IL (1) IL223499A (en)
MX (1) MX2012014302A (en)
PL (1) PL2575908T3 (en)
RS (1) RS54601B1 (en)
SI (1) SI2575908T1 (en)
SM (1) SMT201600095B (en)
WO (1) WO2011156410A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014013081A2 (en) 2011-11-30 2020-10-20 Chugai Seiyaku Kabushiki Kaisha drug-containing cell vehicle for formation of an immune complex
US20150289967A1 (en) * 2012-03-22 2015-10-15 The Curators Of The University Of Missouri Nanocomposites for soft tissue repair and replacement
HUE044160T2 (en) * 2012-03-22 2019-10-28 Trb Chemedica Int S A Method for repair of ligament or tendon
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US11160906B2 (en) 2016-02-18 2021-11-02 The Curators Of The University Of Missouri Injectable nanomaterial-extracellular matrix constructs
US20220168463A1 (en) * 2020-11-30 2022-06-02 The Curators Of The University Of Missouri Enhanced performance solution for tissue grafts

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US20020128722A1 (en) * 1987-07-30 2002-09-12 Steven R. Jefferies Bone repair material and delayed drug delivery system
US6311690B1 (en) 1986-03-27 2001-11-06 Gensci Orthobiologics, Inc. Bone repair material and delayed drug delivery system
FR2790475B1 (en) 1999-03-02 2003-01-24 Flamel Tech Sa COLLAGENIC PEPTIDES MODIFIED BY GRAFTING OF MERCAPTO FUNCTIONS, ONE OF THEIR PROCESSES AND THEIR APPLICATIONS AS BIOMATERIALS
US8283414B2 (en) 2004-11-23 2012-10-09 The Johns Hopkins University Compositions comprising modified collagen and uses therefor
US8728463B2 (en) * 2005-03-11 2014-05-20 Wake Forest University Health Science Production of tissue engineered digits and limbs
AU2007249488B2 (en) * 2006-05-15 2011-11-10 Immunonomedics, Inc. Methods and compositions for treatment of human immunodeficiency virus infection with conjugated antibodies or antibody fragments
CA2737542C (en) * 2008-09-18 2019-01-29 The Curators Of The University Of Missouri Bionanocomposite for tissue regeneration and soft tissue repair
US9333163B2 (en) * 2008-10-06 2016-05-10 Massachusetts Institute Of Technology Particles with multiple functionalized surface domains

Also Published As

Publication number Publication date
CN103124568B (en) 2015-02-11
WO2011156410A1 (en) 2011-12-15
US9827323B2 (en) 2017-11-28
EP2575908B8 (en) 2016-05-18
DK2575908T3 (en) 2016-03-14
MX2012014302A (en) 2013-05-01
SMT201600095B (en) 2016-04-29
AU2011264946B2 (en) 2014-03-06
HK1183829A1 (en) 2014-01-10
SI2575908T1 (en) 2016-04-29
HRP20160275T1 (en) 2016-04-08
EP2575908B1 (en) 2015-12-16
JP2016073671A (en) 2016-05-12
IL223499A (en) 2016-02-29
US20120070466A1 (en) 2012-03-22
ES2565059T3 (en) 2016-03-31
US20140302104A1 (en) 2014-10-09
CA2801716A1 (en) 2011-12-15
EP2575908A1 (en) 2013-04-10
BR112012031311A2 (en) 2016-10-25
JP2013528108A (en) 2013-07-08
PL2575908T3 (en) 2016-07-29
CN103124568A (en) 2013-05-29
RS54601B1 (en) 2016-08-31
HUE027146T2 (en) 2016-10-28

Similar Documents

Publication Publication Date Title
WO2011156410A8 (en) Conjugated polymeric material and uses thereof
WO2011063217A3 (en) Compositions comprising conductive particles with surface-modified nanoparticles covalently attached thereto, and methods of making
WO2008127299A3 (en) Antimicrobial polymeric articles, processes to prepare them and methods of their use
WO2010006194A3 (en) Non-covalent modification of microparticles and process of preparing same
WO2012040623A3 (en) Nanostructured gels capable of controlled release of encapsulated agents
EP4467630A3 (en) Chromophoric polymer dots
WO2015156870A3 (en) Biopolymer-mediated assembly of nanoparticles using genetically encoded proteins
WO2010132879A3 (en) Multicomponent degradable cationic polymers
EP4218718A3 (en) Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
WO2012066308A3 (en) Compositions
MX2012006515A (en) Polymeric hybrid organometalloglass.
WO2011013130A3 (en) Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof
WO2012118930A3 (en) Stable colloidal gold nanoparticles with controllable surface modification and functionalization
WO2008152450A3 (en) Coated aluminum hydroxide particles produced by mill drying
WO2009097508A3 (en) Methods and compositions for wound healing
HK1201212A1 (en) Hemostatic compositions
WO2011139817A3 (en) Photochemical cross-linkable polymers, methods of marking photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers
WO2011034765A3 (en) Freshening compositions comprising malodor binding polymers
MY161272A (en) Compositions comprising metallated malodor control polymers
WO2009000650A3 (en) Particulate polymers comprising biocidal active substance
WO2010096444A3 (en) Photochemical cross-linkable polymers, methods of making photochemical cross-linkable polymers, and methods of using photochemical cross-linkable polymers
WO2012126600A3 (en) Microstructured composite particles
WO2011137329A3 (en) Chewing gum with pretreated polyols
WO2012035283A8 (en) Pharmaceutical composition
WO2010041834A3 (en) Pigment consisting of photonic crystals for a paint composition, and method for producing same

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201180028726.0

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11730136

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
ENP Entry into the national phase

Ref document number: 2801716

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2013514313

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 223499

Country of ref document: IL

Ref document number: MX/A/2012/014302

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2011730136

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2011264946

Country of ref document: AU

Date of ref document: 20110607

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112012031311

Country of ref document: BR

WWE Wipo information: entry into national phase

Ref document number: P-2016/0162

Country of ref document: RS

ENP Entry into the national phase

Ref document number: 112012031311

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20121207