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WO2011027365A3 - Ophthalmic compositions containing dorzolamide, timolol and brimonidine - Google Patents

Ophthalmic compositions containing dorzolamide, timolol and brimonidine Download PDF

Info

Publication number
WO2011027365A3
WO2011027365A3 PCT/IN2010/000591 IN2010000591W WO2011027365A3 WO 2011027365 A3 WO2011027365 A3 WO 2011027365A3 IN 2010000591 W IN2010000591 W IN 2010000591W WO 2011027365 A3 WO2011027365 A3 WO 2011027365A3
Authority
WO
WIPO (PCT)
Prior art keywords
brimonidine
timolol
compositions containing
ophthalmic compositions
dorzolamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2010/000591
Other languages
French (fr)
Other versions
WO2011027365A9 (en
WO2011027365A2 (en
Inventor
Rajesh Kshirsagar
Chandrashekar Kadam
Ajay Mhaske
Sm Mudda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micro Labs Ltd
Original Assignee
Micro Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micro Labs Ltd filed Critical Micro Labs Ltd
Priority to RU2012113380/15A priority Critical patent/RU2012113380A/en
Publication of WO2011027365A2 publication Critical patent/WO2011027365A2/en
Publication of WO2011027365A9 publication Critical patent/WO2011027365A9/en
Publication of WO2011027365A3 publication Critical patent/WO2011027365A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Wind Motors (AREA)

Abstract

The present invention is related to ophthalmic composition comprising Timolol, Dorzolamide and Brimonidine. More specifically, the present invention is related to a stable ophthalmic composition comprising Timolol, Dorzolamide and Brimonidine and hydroxyethyl cellulose.
PCT/IN2010/000591 2009-09-07 2010-09-03 Ophthalmic compositions containing dorzolamide, timolol and brimonidine Ceased WO2011027365A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2012113380/15A RU2012113380A (en) 2009-09-07 2010-09-03 OPHTHALMIC COMPOSITIONS CONTAINING DORZOLAMIDE, THYMOL AND BRIMONIDINE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2151/CHE/2009 2009-09-07
IN2151CH2009 2009-09-07

Publications (3)

Publication Number Publication Date
WO2011027365A2 WO2011027365A2 (en) 2011-03-10
WO2011027365A9 WO2011027365A9 (en) 2011-04-14
WO2011027365A3 true WO2011027365A3 (en) 2011-06-23

Family

ID=43429374

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000591 Ceased WO2011027365A2 (en) 2009-09-07 2010-09-03 Ophthalmic compositions containing dorzolamide, timolol and brimonidine

Country Status (2)

Country Link
RU (1) RU2012113380A (en)
WO (1) WO2011027365A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3086776B1 (en) * 2013-12-24 2020-06-17 Sentiss Pharma Private Limited Topical brimonidine tartrate ophthalmic solution
JP6903448B2 (en) * 2016-02-22 2021-07-14 参天製薬株式会社 Pharmaceutical composition containing dorzolamide and brimonidine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008027340A2 (en) * 2006-08-30 2008-03-06 Merck & Co., Inc. Topical ophthalmic formulations
US20090048261A1 (en) * 2007-08-17 2009-02-19 Arturo Jimenez Bayardo Pharmaceutical Composition for Treatment of Ocular Hypertension
US20090069345A1 (en) * 2007-09-12 2009-03-12 Arturo Jimenez Bayardo Pharmaceutically Stable Compound Consisting of Timolol, Dorzolamide and Brimonidine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008027340A2 (en) * 2006-08-30 2008-03-06 Merck & Co., Inc. Topical ophthalmic formulations
US20090048261A1 (en) * 2007-08-17 2009-02-19 Arturo Jimenez Bayardo Pharmaceutical Composition for Treatment of Ocular Hypertension
US20090069345A1 (en) * 2007-09-12 2009-03-12 Arturo Jimenez Bayardo Pharmaceutically Stable Compound Consisting of Timolol, Dorzolamide and Brimonidine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YEH ET AL.: "Rational use of the fixed combination of dorzolamide-timolol in the management of raised intraocular pressure and glaucoma", CLINICAL OPHTHALMOLOGY, vol. 2, no. 2, 1 January 2008 (2008-01-01), pages 389 - 399, XP002633634 *

Also Published As

Publication number Publication date
WO2011027365A9 (en) 2011-04-14
WO2011027365A2 (en) 2011-03-10
RU2012113380A (en) 2013-10-20

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