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WO2011027365A2 - Compositions ophtalmiques contenant du dorzolamide, du timolol et de la brimonidine - Google Patents

Compositions ophtalmiques contenant du dorzolamide, du timolol et de la brimonidine Download PDF

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Publication number
WO2011027365A2
WO2011027365A2 PCT/IN2010/000591 IN2010000591W WO2011027365A2 WO 2011027365 A2 WO2011027365 A2 WO 2011027365A2 IN 2010000591 W IN2010000591 W IN 2010000591W WO 2011027365 A2 WO2011027365 A2 WO 2011027365A2
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WO
WIPO (PCT)
Prior art keywords
rotor
cone
wind
composition
blades
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2010/000591
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English (en)
Other versions
WO2011027365A3 (fr
WO2011027365A9 (fr
Inventor
Rajesh Kshirsagar
Chandrashekar Kadam
Ajay Mhaske
Sm Mudda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micro Labs Ltd
Original Assignee
Micro Labs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micro Labs Ltd filed Critical Micro Labs Ltd
Priority to RU2012113380/15A priority Critical patent/RU2012113380A/ru
Publication of WO2011027365A2 publication Critical patent/WO2011027365A2/fr
Publication of WO2011027365A9 publication Critical patent/WO2011027365A9/fr
Publication of WO2011027365A3 publication Critical patent/WO2011027365A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Definitions

  • the present invention relates to the fields of rotor control system of a wind turbine.
  • The-present invention specifically relates to a system for controlling cone and pitch angle of a rotor blade assembly and rotor blade of the wind turbine.
  • wind turbines are used to extract energy from wind, which includes both horizontal-axis and vertical-axis turbine systems.
  • rotor systems include one or more blades attached to a rotor hub, which turns a generator through an operating connection.
  • the nacelle bearing the rotor systems, typically pivots about the vertical tower to take advantage of wind from any direction.
  • Horizontal-axis turbines include upwind turbines and downwind turbines. In downwind turbines, the rotor blades are contacted by wind after the wind travels past the tower and nacelle whereas in upwind turbines, the rotor blades are contacted by wind before the wind passes the tower and nacelle.
  • the blade cross-section is often aerodynamic and may be based upon any airfoil configuration that enhances the efficiency of the blade. As wind moves past the blades with enough speed to generate sufficient lift to overcome inertia! and drag forces, the rotor system rotates and the wind turbine converts the wind energy into electrical or mechanical energy for performing useful work.
  • US7071578 discloses a wind turbine provided with a controller for adjusting active annular plane area and the operating method thereof uses elbows, links and hinges to adjust the cone and pitch angle, which are less reliable and results in cantilever forces on the elbow and the hub. Hence, it is necessary to have a coning turbine with parts that can handle and withstand loads experienced in the operating environment.
  • An object of the present invention is to provide a system for controlling cone and pitch angle of a rotor blade assembly of a wind turbine, which is capable of improving a productivity and efficiency of the wind turbine by adjusting the rotor diameter of the wind turbine.
  • Another object of the present invention is to provide a system for controlling cone and pitch angle of a rotor blade assembly of a wind turbine, which effectively reduces the loads and stresses acting on the parts of the wind turbine and foundation due to variations in wind speeds.
  • Yet another object of the present invention is to provide a system for controlling cone and pitch angle of a rotor blade assembly of a wind turbine, which is capable of improving the fatigue life of all parts of the wind turbine.
  • Yet another object of the present invention is to provide a system for controlling cone and pitch angle of a rotor blade assembly of a wihd turbine, which is capable of increasing survival wind speed of the wind turbine.
  • Yet another object of the present invention is to provide a system for controlling cone and pitch angle of a rotor blade assembly of a wind turbine, which improves the capacity factor and operating range of the wind turbine with range of 2 m/s up to 30 or 35 m/s.
  • Yet another object of the present invention is to provide a system for controlling cone and pitch angle of a rotor blade assembly of a wind turbine, which is capable of controlling rotor thrust, blade root stress, centrifugal force, blade deflection, tangential force on the blade, diameter, tip speed, RPM, pitch angle, cone angle and torque of the rotor and coefficient of lift and drag to generate energy at its maximum output level.
  • Yet another object of the present invention is to provide a system for controlling cone and pitch angle of a rotor blade assembly of a wind turbine, which attains its rated capacity even at the lowest possible wind speed.
  • the present invention which achieves the objectives, relates to a system for controlling cone and pitch angle of a rotor blade assembly of a wind turbine comprising a rotor mounted to a tower of the wind turbine positioned on a platform/foundation/ground surface.
  • the rotor is incorporated with a hub and one or more rotor blades.
  • a control mechanism is associated between the hub and the rotor blades in such a way that the rotor blades are connected to the hub in an inclined and swiveled manner.
  • the control mechanism is configured with a drive for coupling the hub to the rotor blades through a bearing in an inclined and swiveled manner.
  • the control mechanism is configured for operating the drive to drive the bearing, such that cone and pitch angles of the rotor blades are independently or simultaneously controlled to adjust rotor diameter along with changing the cone and pitch angles of the rotor blades, in accordance with variations in wind speeds.
  • Such system improves a productivity and efficiency of the wind turbine, and effectively reduces the loads and stresses acting on the parts of the wind turbine due to the variations in wind speeds.
  • the drive is configured as a cone drive and a pitch drive, if the intermediate parts are employed in the control mechanism.
  • the bearing is configured as a cone bearing and a pitch bearing, if the intermediate parts are employed in the control mechanism.
  • the intermediate parts connect the cone bearing and the pitch bearing for coupling the hub to the rotor blades at an inclined angle, in a swiveled connection manner.
  • the control mechanism is configured for operating the pitch drive alone to adjust the pitch angle or stall or aerodynamic stall for further optimization.
  • the control mechanism is configured for combined coning and pitching adjustment of the rotor blades.
  • the rotor blades are assembled in an operating connection with the hub.
  • the rotor blades are swivel connected with the hub at an inclined angle, such that the rotor blades rotate about axis to move in a direction defining the cone angle.
  • the cone angle of the rotor blades is adjusted with accompanied motion of the pitch of the rotor blades, where the rotor blades can be vanes.
  • the cone and pitch drives exhibit a freedom of rotation ranging from 0° to 360° for adjusting the cone angle up to 90° towards and away from the tower and pitch angles of the rotor blades ranging from 0° to 360°.
  • the cone and pitch drives are operated independently or intermittently or synchronized in accordance with the variations in wind speeds.
  • the cone and pitch angles of the rotor blades are determined based on an angle of inclination defined by the cone and pitch drives and also by angle of the axis of the blade in relation to the intermediate part, incase, the blades are swivel connected with the hub directly, the inclination of the axis of the blades will determine pitch and cone angle.
  • the cone and pitch angles of the rotor blades are adjusted towards, beyond or away from the tower of the wind turbine.
  • the cone bearing is designed in such a way that it is capable of withstanding radial, axial and bending loads.
  • two or more cone drives can be operated independently or intermittently or synchronized in accordance with the variations in wind speeds.
  • the cone and pitch drives are assembled externally or internally and made into a compact drive.
  • the cone angles of the rotor blades ranging from 0° to 90° and the pitch angles of the rotor blades ranging from 0° to 360° are adjusted for each rotor blade separately depending on wind forces and expected wind forces.
  • the pitch drive is placed as first drive whereas the cone drive is placed as second drive or vice-versa.
  • the pitch drive is configured for both pitching and stalling. In the parking position, each rotor blade is operated individually to place the rotor blades in either sides of the tower to balance the weight.
  • each rotor blade exhibits a main axis on its surface, which makes swiveled connection between the rotor blades and the hub at an inclined angle.
  • the main axis of the rotor blades is created by an operating area of the rotor blades for energy capture.
  • the rotor is in operating connection with a generator.
  • the cone drive is operated with full brakes or partial brakes for controlling the speed of coning.
  • the cone drive has a higher angle of rotation than resulting coning angle of the rotor blades, so as to reduce the force/torque required for drive operation.
  • the cone and pitch angles of said rotor blades are determined based on an angle of inclination for swiveling as defined by the intermediate parts.
  • the cone drive is operated, which results in axial and radial movement of the rotor blades, where the cone drive is an inclined and swivel drive.
  • FIG. 1 shows a schematic view of a horizontal-axis wind turbine with a system for controlling cone and pitch angle of a rotor blade assembly, in accordance with an exemplary embodiment of the present invention
  • FIG. 2 illustrates a detailed view of a control mechanism for controlling cone and pitch angle of the rotor blade assembly of the wind turbine, in accordance with an exemplary embodiment of the present invention
  • FIG. 3a illustrates a perspective view of the horizontal-axis wind turbine with a rotor diameter before combined cone and pitch angle adjustment of the rotor blade assembly, in accordance with an exemplary embodiment of the present invention
  • FIG. 3b illustrates a perspective view of the horizontal-axis wind turbine with a rotor diameter after combined cone and pitch angle adjustment away from a tower in an upwind turbine, in accordance with an exemplary embodiment of the present invention
  • FIG. 4a illustrates a perspective view of the horizontal-axis wind turbine without blade pitch adjustment, in accordance with an exemplary embodiment of the present invention
  • FIG. 4b illustrates a perspective view of the horizontal-axis wind turbine with blade pitch adjustment, in accordance with an exemplary embodiment of the present invention
  • FIG. 5 illustrates combined cone and pitch angle adjustment away from the tower in a downwind turbine, in accordance with an exemplary embodiment of the present invention
  • FIG. 6a illustrates combined cone and pitch angle adjustment towards the tower in the upwind turbine, in accordance.with an exemplary embodiment of the present invention
  • FIG. 6b illustrates combined cone and pitch angle adjustment towards the tower in the downwind turbine, in accordance with an exemplary embodiment of the present invention.
  • FIG. 7 illustrates combined cone and pitch angle adjustment beyond the tower in the upwind turbine, in accordance with an exemplary embodiment of the present invention.
  • FIG. 1 a schematic view of a horizontal-axis wind turbine with a system for controlling cone and pitch angle of a rotor blade assembly is illustrated, in accordance with an exemplary embodiment of the present invention.
  • the system for controlling the cone and pitch angle of the rotor blade assembly can specifically be designed, but not limited to the horizontal-axis wind turbine.
  • the wind turbine is being referred as horizontal-axis wind turbine only for the purpose of clarity and specificity; however, they should not be interpreted in any limiting way.
  • the wind turbine can be upwind or downwind type and installed on shore or off shore.
  • a generator (not shown), a rotor hub (2) and blades or blade assemblies (3) are positioned at a distance above the surface of the ground by a tower (1) mounted on the ground.
  • the rotor can be made of single or multi blades (3), where the blades (3) can be segmented blades and vanes.
  • the rotor blades (3) are configured in an operating connection with the rotor hub (2) and the generator for converting rotor motion into mechanical or electrical energy.
  • the blades (3) are swivel connected to the rotor hub (2) at an inclined angle.
  • the system comprises a control mechanism (4) that couples the blades (3) to the rotor hub (2).
  • the control mechanism (4) is an arrangement for combined coning and pitching adjustment of the rotor blades (3).
  • the control mechanism (4) is mounted between the rotor hub (2) and the blades (3) in an inclined angle.
  • a cone drive (6) drives the control mechanism (4) so as to permit the rotor blades (3) to move to a cone angle, which decreases the amount of energy absorbed by the blades (3), and to limit peak pitching and moment loads. Since it is mounted in an inclined angle, the control mechanism (4) makes different cone and pitch angles simultaneously when the drive (6) is operated up to 180°, but exhibits the freedom up to 360°.
  • the control mechanism (4) includes a cone bearing (4b), a pitch bearing (5) and an intermediate part (4a) that is connected with the hub (2) through the cone bearing (4b). Similarly, the intermediate part (4a) is connected with the blades (3) through the pitch bearing (5).
  • the cone bearing (4b) is driven by the cone drive (6) whereas the pitch bearing is driven by a pitch drive (7), where the cone drive (6) and the pitch drive (7) through the intermediate part (4a) are connected with the control mechanism (4).
  • the control mechanism (4) controls cone and pitch simultaneously for each rotor blade (3), to the front or back, in order to adjust the rotor diameter along with changing cone and pitch angles of the blades (3).
  • the control mechanism (4) adjusts the cone angle with accompanied motion of the pitch of the blades (3).
  • the cone angles are formed relative to a reference plane of blade rotation, which is perpendicular to the axis of blade rotation.
  • the inclination angle with the hub is preferably fixed, but the blades (3) can be swivel connected to the rotor hub (2) in a manner that permits free coning. With free coning, the cone angles change during operation in response to fluctuations in wind speeds, rotor thrust and centrifugal forces.
  • the control mechanism (4) adjusts the pitch angle or stall or aerodynamic stall alone for further optimization to reduce the loads and fatigue.
  • the rotor diameter, cone angle and pitch angle can be adjusted depending upon the wind speed and forces, in response to changes in wind speeds and gust.
  • the pitch angle can be adjusted by means of the pitch drive (7), which exhibits a freedom of 360° of rotation.
  • the cone angles range from 0° to 90° and pitch angles range from 0° to 360°.
  • blades are typically somewhat flexible and the term “fixed coning angle” must be read to account for the flexing of blades during operation in response to centrifugal and wind forces.
  • horizontal-axis wind turbines includes wind turbines whose axis of rotation forms a slight angle of tilt relative to the horizontal.
  • Such control mechanism (4) adjusts the cone angle to more effectively to reduce thrust forces of the wind.
  • the control mechanism (4) is arranged in such a way that the hub (2) is connected to the blades (3) directly or indirectly through an inclined angle, swivel connection.
  • the cone drive (6) from the hub (2) rotates the connection, the cone angle of the rotor blades (3) can be changed along with pitch angle due to the inclined angle, which achieves up to 90° coning of the rotor blades (3).
  • the combined cone and pitch angle ratios can be determined based on the inclination of the swiveling angle defined in the wind turbine design.
  • FIG. 3a a perspective view of the horizontal-axis wind turbine with a rotor diameter before combined cone and pitch angle adjustment of the rotor blade assembly is illustrated, in accordance with an exemplary embodiment of the present invention.
  • the rotor diameter is at / closer to maximum level of its range. In this position, the wind turbine can generate more energy in low and medium wind speeds, as shown in FIG. 3a, which improves the efficiency of the wind turbine in the low and medium wind speeds.
  • the cone angle can be increased to reduce the rotor diameter by means of combined cone and pitch angle adjustment away from the tower (1) in an upwind turbine, as shown in FIG.
  • FIG. 3b which illustrates a perspective view of the horizontal-axis wind turbine with a rotor diameter after combined cone and pitch angle adjustment away from a tower in an upwind turbine.
  • the wind is directed towards the front side of the blades (3), which is away from the tower (1).
  • the wind is directed towards the side of the blades (3) closer to the tower (1).
  • FIGS. 4a and 4b respectively illustrate perspective views of the horizontal- axis wind turbine without and with blade pitch adjustment, in accordance with an exemplary embodiment of the present invention.
  • the cone angle can be adjusted to reduce the wind forces.
  • the pitch angle can be changed for maximum energy generation.
  • the blade pitch is changed to enhance the wind forces directed to the blades (3), as shown in FIG. 4a.
  • the blade pitch is changed to suppress the forces directed to the blades (3), as shown in FIG. 4b.
  • the cone and pitch drives (6, 7) are arranged in such a way that it is flexible to use each drive independently or intermittently or synchronized depending on wind forces and expected wind forces.
  • FIGS. 6a and 6b illustrate combined cone and pitch angle adjustment towards the tower in the upwind turbine and in the downwind turbine, in accordance with an exemplary embodiment of the present invention.
  • both the upwind and downwind turbines are normally working below its capacity due to lesser forces available in the lower wind speeds.
  • the combined cone and pitch angle adjustment makes the blades (3) to maximize the rotor diameter to allow the wind turbine to attain its rated capacity in the lower wind speeds. Further adjustment reduces the diameter to reduce forces and control output.
  • generation of energy is controlled to achieve more efficient machine with higher capacity factor.
  • Such capacity factor improvement leads to better utilization of the grid.
  • combined cone and pitch angle adjustment beyond the tower in the upwind turbine is illustrated, in accordance with an exemplary embodiment of the present invention.
  • This is a parking position in the upwind turbine.
  • the combined cone and pitch angle adjustment makes the blades (3) to angle beyond the tower (1), which improves the fatigue life of all parts of the wind turbine.
  • Such design allows the use of larger rotor to capture more energy, but it reduces stress of higher and excessive wind forces by the combined coning and pitching adjustment in parked position. In this position, rotor lock is suitably provided, to safeguard the turbine.
  • survival wind speeds are also increased by optimizing the pitching or stall or aerodynamic stall along with the combined coning and pitching adjustment. So, the loads acting on the rotor and the turbine are greatly reduced, which reduces the loads, fatigue and stresses on the turbine parts to achieve optimization of the turbine parts.
  • Such system can cone up to 90 degrees, which makes the blades (3) horizontal to the ground to improve survival wind speeds. _ ,
  • the further optimization on the blade pitch can make the major surface area of the blades (3) to become parallel to the ground, which increases the survival wind speed even further.
  • Two or more control mechanisms for combined coning and pitching adjustment can be mounted and work together with identical or different angles for each mechanisms. These control mechanisms can be work independently or synchronized as the situation demands.
  • the expansion and contraction of the rotor blades (3) to increase or decrease rotor diameter, respectively, is based on wind conditions and blade cone and pitch angles. For example, in low wind speeds, the rotor can be fully expanded. As the winds increase in speed, the blades start to pitch and if required the rotor blades can be contracted. Thus, the diameter of the rotor can be increased to increase energy capture in frequently occurring moderate wind speeds (e.g., wind speed operating turbine below rated capacity) where most of the wind resources is available. At the same time, the rotor diameter can be reduced in the higher wind speeds. Further diameter reduction can be done in excessive wind speeds.
  • the cone drive can also be fitted with brakes (not shown) to control coning. The wind force can be utilized for supporting the cone drive to improve the coning speed by applying partial brake. The cone drive can be utilized to increase rpm of the rotor for adapting it to the generator requirements.
  • a number of variations and modifications of the present invention can also be used. Although a three-blade turbine has been illustrated, at least the cone angle adjustment and pitch adjustment aspects of the invention, and can be used in connection with turbines having one or more blades.
  • the present invention can be used in connection with a . variety of sizes and output capacities of wind turbines.
  • additional types of controls and devices can be used, including mechanical, electro-mechanical, pneumatic, computer controlled devices, and the like.
  • pitch angle or stall or aerodynamic stall can be controlled as a function of cone angle at the same time that cone angle is controlled as a function of pitch angle or stall or aerodynamic stall.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Wind Motors (AREA)

Abstract

La présente invention concerne une composition ophtalmique comprenant du timolol, du dorzolamide et de la brimonidine. Plus spécifiquement, la présente invention concerne une composition ophtalmique stable comprenant du timolol, du dorzolamide et de la brimonidine, y compris de l'hydroxyéthyl cellulose.
PCT/IN2010/000591 2009-09-07 2010-09-03 Compositions ophtalmiques contenant du dorzolamide, du timolol et de la brimonidine Ceased WO2011027365A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2012113380/15A RU2012113380A (ru) 2009-09-07 2010-09-03 Офтальмологические композиции, содержащие дорзоламид, тимолол и бримонидин

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2151/CHE/2009 2009-09-07
IN2151CH2009 2009-09-07

Publications (3)

Publication Number Publication Date
WO2011027365A2 true WO2011027365A2 (fr) 2011-03-10
WO2011027365A9 WO2011027365A9 (fr) 2011-04-14
WO2011027365A3 WO2011027365A3 (fr) 2011-06-23

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PCT/IN2010/000591 Ceased WO2011027365A2 (fr) 2009-09-07 2010-09-03 Compositions ophtalmiques contenant du dorzolamide, du timolol et de la brimonidine

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RU (1) RU2012113380A (fr)
WO (1) WO2011027365A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015097600A3 (fr) * 2013-12-24 2015-10-29 Sentiss Pharma Private Limited Solution ophthalmique topique de tartrate de brimonidine

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017146036A1 (fr) * 2016-02-22 2017-08-31 参天製薬株式会社 Composition pharmaceutique comprenant du dorzolamide et de la brimonidine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048261A1 (en) 2007-08-17 2009-02-19 Arturo Jimenez Bayardo Pharmaceutical Composition for Treatment of Ocular Hypertension
US20090069345A1 (en) 2007-09-12 2009-03-12 Arturo Jimenez Bayardo Pharmaceutically Stable Compound Consisting of Timolol, Dorzolamide and Brimonidine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008027340A2 (fr) * 2006-08-30 2008-03-06 Merck & Co., Inc. Formulations ophtalmiques locales

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048261A1 (en) 2007-08-17 2009-02-19 Arturo Jimenez Bayardo Pharmaceutical Composition for Treatment of Ocular Hypertension
US20090069345A1 (en) 2007-09-12 2009-03-12 Arturo Jimenez Bayardo Pharmaceutically Stable Compound Consisting of Timolol, Dorzolamide and Brimonidine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015097600A3 (fr) * 2013-12-24 2015-10-29 Sentiss Pharma Private Limited Solution ophthalmique topique de tartrate de brimonidine
EA030615B1 (ru) * 2013-12-24 2018-08-31 Сентисс Фарма Прайвет Лимитед Офтальмологический раствор бримонидина для местного применения
US10517869B2 (en) 2013-12-24 2019-12-31 Sentiss Pharma Private Limited Topical brimonidine tartrate ophthalmic solution

Also Published As

Publication number Publication date
WO2011027365A3 (fr) 2011-06-23
WO2011027365A9 (fr) 2011-04-14
RU2012113380A (ru) 2013-10-20

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