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WO2011027359A3 - Process for the preparation of 4 -hydroxy atomoxetine and intermediates in the manufacture thereof - Google Patents

Process for the preparation of 4 -hydroxy atomoxetine and intermediates in the manufacture thereof Download PDF

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Publication number
WO2011027359A3
WO2011027359A3 PCT/IN2010/000505 IN2010000505W WO2011027359A3 WO 2011027359 A3 WO2011027359 A3 WO 2011027359A3 IN 2010000505 W IN2010000505 W IN 2010000505W WO 2011027359 A3 WO2011027359 A3 WO 2011027359A3
Authority
WO
WIPO (PCT)
Prior art keywords
atomoxetine
hydroxy
preparation
intermediates
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2010/000505
Other languages
French (fr)
Other versions
WO2011027359A2 (en
Inventor
Siva Rama Prasad Vellanki
Arabinda Sahu
Aravind Kumar Katukuri
Ramakrishna Pilli
Satish Babu Kothari
Debashish Datta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Matrix Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Ltd filed Critical Matrix Laboratories Ltd
Publication of WO2011027359A2 publication Critical patent/WO2011027359A2/en
Publication of WO2011027359A3 publication Critical patent/WO2011027359A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to novel process for the preparation of 4-hydroxy Atomoxetine or its pharmaceutically acceptable salts thereof. The present invention also relates to novel intermediates used in the preparation of 4-hydroxy Atomoxetine.
PCT/IN2010/000505 2009-07-30 2010-07-30 Novel process for the preparation of 4-hydroxy atomoxetine Ceased WO2011027359A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1800CH2009 2009-07-30
IN1800/CHE/2009 2009-07-30

Publications (2)

Publication Number Publication Date
WO2011027359A2 WO2011027359A2 (en) 2011-03-10
WO2011027359A3 true WO2011027359A3 (en) 2011-07-14

Family

ID=43384445

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000505 Ceased WO2011027359A2 (en) 2009-07-30 2010-07-30 Novel process for the preparation of 4-hydroxy atomoxetine

Country Status (1)

Country Link
WO (1) WO2011027359A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012020418A1 (en) * 2010-08-12 2012-02-16 Matrix Laboratories Ltd Novel polymorphs of 4-hydroxy atomoxetine hydrochloride
EP3034500A1 (en) 2014-12-17 2016-06-22 Genkyotex Sa Amido thiazole derivatives as NADPH oxidase inhibitors
CN112708641A (en) * 2019-10-24 2021-04-27 上海医药工业研究院 Chemical-enzymatic synthesis method of tomoxetine
CN114702510B (en) * 2022-05-05 2023-06-30 重庆华邦胜凯制药有限公司 Preparation method of rifabutin oxidation impurity
KR20250038193A (en) * 2023-09-11 2025-03-19 주식회사 아스트로젠 Prodrug of Norepinephrine Reuptake Inhibitor and Method for Preparing the Same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040082666A1 (en) * 2001-03-06 2004-04-29 Mattiuz Edward Louis Inhibitor of monoamine uptake
WO2008062473A1 (en) * 2006-10-31 2008-05-29 Cadila Healthcare Limited Process for preparing atomoxetine hydrochloride

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4314081A (en) 1974-01-10 1982-02-02 Eli Lilly And Company Arloxyphenylpropylamines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040082666A1 (en) * 2001-03-06 2004-04-29 Mattiuz Edward Louis Inhibitor of monoamine uptake
WO2008062473A1 (en) * 2006-10-31 2008-05-29 Cadila Healthcare Limited Process for preparing atomoxetine hydrochloride

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHRISTOPHER J CREIGHTON ET AL: "Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial j-opioid agonist effect", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 14, 2 August 2004 (2004-08-02), pages 4083 - 4085, XP007918336, ISSN: 0968-0896, [retrieved on 20040624], DOI: DOI:10.1016/J.BMCL.2004.05.018 *
JOHN-MICHAEL SAUER ET AL: "Atomoxetine Hydrochloride: Clinical Drug-Drug Interaction Prediction and Outcome", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 308, no. 2, 1 February 2004 (2004-02-01), pages 410 - 418, XP007918348, ISSN: 0022-3565, [retrieved on 20031110], DOI: DOI:10.1124/JPET.103.058727 *

Also Published As

Publication number Publication date
WO2011027359A2 (en) 2011-03-10

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