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WO2011027146A3 - Ultrasound & magnetic method - Google Patents

Ultrasound & magnetic method Download PDF

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Publication number
WO2011027146A3
WO2011027146A3 PCT/GB2010/051434 GB2010051434W WO2011027146A3 WO 2011027146 A3 WO2011027146 A3 WO 2011027146A3 GB 2010051434 W GB2010051434 W GB 2010051434W WO 2011027146 A3 WO2011027146 A3 WO 2011027146A3
Authority
WO
WIPO (PCT)
Prior art keywords
paramagnetic particles
chamber
paramagnetic
ultrasound
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2010/051434
Other languages
French (fr)
Other versions
WO2011027146A2 (en
Inventor
Paul Birch
Damian Joseph Peter Bond
Christopher John Stanley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PROKYMA TECHNOLOGIES Ltd
Original Assignee
PROKYMA TECHNOLOGIES Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PROKYMA TECHNOLOGIES Ltd filed Critical PROKYMA TECHNOLOGIES Ltd
Publication of WO2011027146A2 publication Critical patent/WO2011027146A2/en
Publication of WO2011027146A3 publication Critical patent/WO2011027146A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/0009—Settling tanks making use of electricity or magnetism
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283—Settling tanks provided with vibrators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/02—Magnetic separation acting directly on the substance being separated
    • B03C1/28—Magnetic plugs and dipsticks
    • B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

A method of processing of a sample mixed with paramagnetic particles comprises exposing the sample mixed with paramagnetic particles to a magnetic field to draw the paramagnetic particles, and then forming an ultrasound standing wave to drive the paramagnetic particles into one or more pressure nodes. Apparatus is also described for the analysis of biological samples which comprises a chamber, an acoustic transducer capable of creating at least one pressure node in a fluid contained in the chamber, and one or more magnets associated with the chamber to attract paramagnetic materials contained in a sample.
PCT/GB2010/051434 2009-09-01 2010-09-01 Ultrasound & magnetic method Ceased WO2011027146A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0915072A GB0915072D0 (en) 2009-09-01 2009-09-01 Ultrasound & magnetic method
GB0915072.3 2009-09-01

Publications (2)

Publication Number Publication Date
WO2011027146A2 WO2011027146A2 (en) 2011-03-10
WO2011027146A3 true WO2011027146A3 (en) 2011-04-28

Family

ID=41172093

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2010/051434 Ceased WO2011027146A2 (en) 2009-09-01 2010-09-01 Ultrasound & magnetic method

Country Status (2)

Country Link
GB (1) GB0915072D0 (en)
WO (1) WO2011027146A2 (en)

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US8956538B2 (en) 2010-06-16 2015-02-17 Flodesign Sonics, Inc. Phononic crystal desalination system and methods of use
US8679338B2 (en) 2010-08-23 2014-03-25 Flodesign Sonics, Inc. Combined acoustic micro filtration and phononic crystal membrane particle separation
US9421553B2 (en) 2010-08-23 2016-08-23 Flodesign Sonics, Inc. High-volume fast separation of multi-phase components in fluid suspensions
US9783775B2 (en) 2012-03-15 2017-10-10 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US10322949B2 (en) 2012-03-15 2019-06-18 Flodesign Sonics, Inc. Transducer and reflector configurations for an acoustophoretic device
US9688958B2 (en) 2012-03-15 2017-06-27 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9567559B2 (en) 2012-03-15 2017-02-14 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9822333B2 (en) 2012-03-15 2017-11-21 Flodesign Sonics, Inc. Acoustic perfusion devices
US10040011B2 (en) 2012-03-15 2018-08-07 Flodesign Sonics, Inc. Acoustophoretic multi-component separation technology platform
US9752113B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc. Acoustic perfusion devices
US9416344B2 (en) 2012-03-15 2016-08-16 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US10953436B2 (en) 2012-03-15 2021-03-23 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US9272234B2 (en) 2012-03-15 2016-03-01 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US9422328B2 (en) 2012-03-15 2016-08-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9796956B2 (en) 2013-11-06 2017-10-24 Flodesign Sonics, Inc. Multi-stage acoustophoresis device
US9340435B2 (en) 2012-03-15 2016-05-17 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US10689609B2 (en) 2012-03-15 2020-06-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9752114B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc Bioreactor using acoustic standing waves
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9623348B2 (en) 2012-03-15 2017-04-18 Flodesign Sonics, Inc. Reflector for an acoustophoretic device
US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10370635B2 (en) 2012-03-15 2019-08-06 Flodesign Sonics, Inc. Acoustic separation of T cells
CN104334206B (en) 2012-04-20 2017-05-17 弗洛设计声能学公司 Acoustophoretic separation of lipid particles from red blood cells
US11324873B2 (en) 2012-04-20 2022-05-10 Flodesign Sonics, Inc. Acoustic blood separation processes and devices
US10737953B2 (en) 2012-04-20 2020-08-11 Flodesign Sonics, Inc. Acoustophoretic method for use in bioreactors
EP2893335A1 (en) 2012-09-04 2015-07-15 Koninklijke Philips N.V. A sensor device and a method of sampling
WO2014210046A1 (en) 2013-06-24 2014-12-31 Flodesign Sonics, Inc. Fluid dynamic sonic separator
US9745569B2 (en) 2013-09-13 2017-08-29 Flodesign Sonics, Inc. System for generating high concentration factors for low cell density suspensions
CN105939767B (en) 2014-01-08 2018-04-06 弗洛设计声能学公司 Sound electrophoretic apparatus with alliteration electrophoresis chamber
CN106470748A (en) 2014-05-08 2017-03-01 弗洛设计声能学公司 There is the sound field device of piezoelectric transducer array
US9744483B2 (en) 2014-07-02 2017-08-29 Flodesign Sonics, Inc. Large scale acoustic separation device
US9827511B2 (en) 2014-07-02 2017-11-28 Flodesign Sonics, Inc. Acoustophoretic device with uniform fluid flow
SG11201702489PA (en) 2014-09-30 2017-04-27 Flodesign Sonics Inc Acoustophoretic clarification of particle-laden non-flowing fluids
US10106770B2 (en) 2015-03-24 2018-10-23 Flodesign Sonics, Inc. Methods and apparatus for particle aggregation using acoustic standing waves
US10640760B2 (en) 2016-05-03 2020-05-05 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
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US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
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WO2016187596A1 (en) 2015-05-20 2016-11-24 Flodesign Sonics, Inc. Acoustic manipulation of particles in standing wave fields
US10161926B2 (en) 2015-06-11 2018-12-25 Flodesign Sonics, Inc. Acoustic methods for separation of cells and pathogens
EP3319739B1 (en) 2015-07-09 2021-03-31 Flodesign Sonics Inc. Non-planar and non-symmetrical piezolectric crystals and reflectors
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
EP3352882B1 (en) * 2015-09-23 2019-05-22 Aenitis Technologies Multi-use acoustic levitation trap
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Non-Patent Citations (2)

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Also Published As

Publication number Publication date
GB0915072D0 (en) 2009-09-30
WO2011027146A2 (en) 2011-03-10

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