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WO2011021717A3 - Method for producing hydroxylated amino acids - Google Patents

Method for producing hydroxylated amino acids Download PDF

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Publication number
WO2011021717A3
WO2011021717A3 PCT/JP2010/064323 JP2010064323W WO2011021717A3 WO 2011021717 A3 WO2011021717 A3 WO 2011021717A3 JP 2010064323 W JP2010064323 W JP 2010064323W WO 2011021717 A3 WO2011021717 A3 WO 2011021717A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxylated
amino acids
hydroxylated amino
producing hydroxylated
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2010/064323
Other languages
French (fr)
Other versions
WO2011021717A2 (en
Inventor
Sergey Vasilievich Smirnov
Natalia Nikolaevna Samsonova
Veronika Aleksandrovna Kotliarova
Natalia Yurievna Rushkevich
Ekaterina Aleksandrovna Fedorina
Pavel Mikhailovich Sokolov
Aleksandra Viktorovna Kolokolova
Jun Ogawa
Makoto Hibi
Sakayu Shimizu
Yuki Imabayashi
Shunichi Suzuki
Masakazu Sugiyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2010107900/10A external-priority patent/RU2460779C2/en
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of WO2011021717A2 publication Critical patent/WO2011021717A2/en
Publication of WO2011021717A3 publication Critical patent/WO2011021717A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A method for manufacturing hydroxylated amino acid, particularily hydroxylated isoleucine, hydroxylated methionine, hydroxylated threonine, hydroxylated leucine or hydroxylated valine, by enzymatic conversion using a dioxygenase.
PCT/JP2010/064323 2009-08-21 2010-08-18 Method for producing hydroxylated amino acids Ceased WO2011021717A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
RU2009131660 2009-08-21
RU2009131660 2009-08-21
RU2010107900/10A RU2460779C2 (en) 2010-03-04 2010-03-04 Method for producing hydroxylated amino acid (versions) and microorganism transformed by dna coding dioxygenase
RU2010107900 2010-03-04

Publications (2)

Publication Number Publication Date
WO2011021717A2 WO2011021717A2 (en) 2011-02-24
WO2011021717A3 true WO2011021717A3 (en) 2011-05-26

Family

ID=43466496

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2010/064323 Ceased WO2011021717A2 (en) 2009-08-21 2010-08-18 Method for producing hydroxylated amino acids

Country Status (1)

Country Link
WO (1) WO2011021717A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105543128A (en) * 2015-12-24 2016-05-04 山东大学 Polar cold-adapted salt-tolerant alginate lyase and coding gene c3 and application thereof
CN113355371A (en) * 2021-05-27 2021-09-07 无锡晶海氨基酸股份有限公司 Method for preparing 4-hydroxyisoleucine through whole-cell catalysis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008013262A1 (en) * 2006-07-28 2008-01-31 Meiji Seika Kaisha, Ltd. L-leucine hydroxylase and dna encoding the enzyme
WO2008044614A1 (en) * 2006-09-28 2008-04-17 Ajinomoto Co., Inc. Method for producing 4-hydroxy-l-isoleucine
WO2009082028A2 (en) * 2007-12-21 2009-07-02 Ajinomoto Co., Inc. Process for producing (2s,3r,4s)-4-hydroxy-l-isoleucine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2695317B1 (en) 1992-09-07 1995-03-10 Monal Lab Composition capable of stimulating the secretion of insulin intended for the treatment of non-insulin-dependent diabetes.
AU756507B2 (en) 1998-03-18 2003-01-16 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
US6513470B1 (en) 2000-10-20 2003-02-04 Delphi Technologies, Inc. Deactivation hydraulic valve lifter
JP4665451B2 (en) 2003-07-29 2011-04-06 味の素株式会社 Process for producing L-lysine or L-threonine
KR100565732B1 (en) 2004-02-26 2006-03-28 씨제이 주식회사 Gammabutylopetine hydroxylase of Neurospora Krasa origin
RU2006131211A (en) 2006-08-30 2008-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING 4-HYDROXY-L-ISOLEUCIN OR ITS SALTS
RU2418069C2 (en) 2006-09-29 2011-05-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Method of constructing recombinant bacteria belonging to genus pantoea and method of l-amino acids production with application of bacteria belonging to genus pantoea
RU2007147436A (en) 2007-12-21 2009-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) BACTERIA-PRODUCER (2S, 3R, 4S) -4-HYDROXY-L-ISOLEUCIN AND METHOD FOR PRODUCTION (2S, 3R, 4S) -4-HYDROXY-L-ISOLEUCIN

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008013262A1 (en) * 2006-07-28 2008-01-31 Meiji Seika Kaisha, Ltd. L-leucine hydroxylase and dna encoding the enzyme
WO2008044614A1 (en) * 2006-09-28 2008-04-17 Ajinomoto Co., Inc. Method for producing 4-hydroxy-l-isoleucine
WO2009082028A2 (en) * 2007-12-21 2009-07-02 Ajinomoto Co., Inc. Process for producing (2s,3r,4s)-4-hydroxy-l-isoleucine

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE UniProt [online] 13 September 2005 (2005-09-13), "SubName: Full=Conserved domain protein;", XP002618316, retrieved from EBI accession no. UNIPROT:Q48ER7 Database accession no. Q48ER7 *
HAEFELE C ET AL: "Characterization of a dioxygenase from trigonella foenum-graecum involved in 4-hydroxyisoleucine biosynthesis", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 44, no. 4, 1 February 1997 (1997-02-01), pages 563 - 566, XP004292840, ISSN: 0031-9422, DOI: DOI:10.1016/S0031-9422(96)00620-6 *
JOARDAR VINITA ET AL: "Whole-genome sequence analysis of Pseudomonas syringae pv. phaseolicola 1448A reveals divergence among pathovars in genes involved in virulence and transposition", JOURNAL OF BACTERIOLOGY, vol. 187, no. 18, September 2005 (2005-09-01), pages 6488 - 6498, XP002618322, ISSN: 0021-9193 *
NARENDER T ET AL: "4-Hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 16, no. 2, 15 January 2006 (2006-01-15), pages 293 - 296, XP025106517, ISSN: 0960-894X, [retrieved on 20060115], DOI: DOI:10.1016/J.BMCL.2005.10.003 *

Also Published As

Publication number Publication date
WO2011021717A2 (en) 2011-02-24

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