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WO2011018800A3 - In-situ gel forming solution for ocular drug delivery - Google Patents

In-situ gel forming solution for ocular drug delivery Download PDF

Info

Publication number
WO2011018800A3
WO2011018800A3 PCT/IN2010/000536 IN2010000536W WO2011018800A3 WO 2011018800 A3 WO2011018800 A3 WO 2011018800A3 IN 2010000536 W IN2010000536 W IN 2010000536W WO 2011018800 A3 WO2011018800 A3 WO 2011018800A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
gel forming
situ gel
ocular drug
forming solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2010/000536
Other languages
French (fr)
Other versions
WO2011018800A2 (en
Inventor
Nandan Mohan Chandavarkar
Kour Chand Jindal
Rajkumar Malayandi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FDC Ltd
Original Assignee
FDC Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FDC Ltd filed Critical FDC Ltd
Publication of WO2011018800A2 publication Critical patent/WO2011018800A2/en
Publication of WO2011018800A3 publication Critical patent/WO2011018800A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed herein is a novel in-situ gel forming system for ocular drug delivery comprises a combination of natural polysaccharide having thixotropic behavior, thermoreversible polymer and a vehicle alongwith one or more optional components selected from active pharmaceutical ingredient(s), buffer, preservative with or without stabilizer, pH modifier(s) and tonicity modifiers.
PCT/IN2010/000536 2009-08-13 2010-08-13 A novel in-situ gel forming solution for ocular drug delivery Ceased WO2011018800A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1874MU2009 2009-08-13
IN1874/MUM/2009 2009-08-13

Publications (2)

Publication Number Publication Date
WO2011018800A2 WO2011018800A2 (en) 2011-02-17
WO2011018800A3 true WO2011018800A3 (en) 2011-07-21

Family

ID=43428604

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000536 Ceased WO2011018800A2 (en) 2009-08-13 2010-08-13 A novel in-situ gel forming solution for ocular drug delivery

Country Status (1)

Country Link
WO (1) WO2011018800A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8859525B2 (en) * 2011-07-19 2014-10-14 Bausch & Lomb Incorporated Pharmaceutical compositions comprising mushroom-based polysaccharides and uses thereof
EP2836200B1 (en) * 2012-04-08 2020-07-15 Urogen Pharma Ltd. Reverse thermal hydrogel preparations for use in the treatment of disorders of the urothelium
CN103977008B (en) * 2013-02-07 2017-03-08 沈阳兴齐眼药股份有限公司 Gel for eye containing Dorzolamide and timolol and preparation method thereof
MX364440B (en) 2013-03-15 2019-04-26 Warner Chilcott Co Llc Pharmaceutical soft gelatin capsule dosage form with modified guar gum.
US9757330B2 (en) 2013-10-18 2017-09-12 Industrial Technology Research Institute Recipe for in-situ gel, and implant, drug delivery system formed thereby
CN103550819A (en) * 2013-10-31 2014-02-05 天津市中科健新材料技术有限公司 Absorbable product
CA3002384C (en) * 2015-10-25 2021-02-16 Iview Therapeutics, Inc. Pharmaceutical formulations that form gel in situ
EP3512522B1 (en) * 2017-09-02 2025-11-12 IVIEW Therapeutics, Inc. In situ gel-forming pharmaceutical compositions and uses thereof for sinus diseases
CN110200904B (en) * 2019-05-27 2021-07-23 上海昊海生物科技股份有限公司 A kind of ocular hypotensive sustained-release eye drop composition and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300295A (en) * 1990-05-01 1994-04-05 Mediventures, Inc. Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH
US6174524B1 (en) * 1999-03-26 2001-01-16 Alcon Laboratories, Inc. Gelling ophthalmic compositions containing xanthan gum
WO2004112836A2 (en) * 2003-06-13 2004-12-29 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
EP1911447A1 (en) * 2005-07-11 2008-04-16 Senju Pharmaceutical Co., Ltd. Eye drop preparation comprising xanthan gum and terpenoid
WO2009001899A1 (en) * 2007-06-26 2008-12-31 Wakamoto Pharmaceutical Co., Ltd. Aqueous composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3700451A (en) 1970-04-06 1972-10-24 Itek Corp Gelable and gelled compositions
US4131677A (en) 1975-05-02 1978-12-26 Merck & Co., Inc. Anti-inflammatory oxazolo [5,4-b]pyridines
US4136173A (en) 1977-01-31 1979-01-23 American Home Products Corp. Mixed xanthan gum and locust beam gum therapeutic compositions
FR2653021A1 (en) 1989-10-17 1991-04-19 Merck Sharp & Dohme AQUEOUS LIQUID OPHTHALMIC COMPOSITION WITH LIQUID-GEL PHASE TRANSITION.
FR2678832B1 (en) 1991-07-10 1995-03-17 Europhta Sa Laboratoire NOVEL OPHTHALMIC COMPOSITIONS WITH IMPROVED RESORPTION AND METHODS OF PREPARING THE SAME.
US5422116A (en) 1994-02-18 1995-06-06 Ciba-Geigy Corporation Liquid ophthalmic sustained release delivery system

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300295A (en) * 1990-05-01 1994-04-05 Mediventures, Inc. Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH
US6174524B1 (en) * 1999-03-26 2001-01-16 Alcon Laboratories, Inc. Gelling ophthalmic compositions containing xanthan gum
WO2004112836A2 (en) * 2003-06-13 2004-12-29 Alcon, Inc. Ophthalmic compositions containing a synergistic combination of two polymers
EP1911447A1 (en) * 2005-07-11 2008-04-16 Senju Pharmaceutical Co., Ltd. Eye drop preparation comprising xanthan gum and terpenoid
WO2009001899A1 (en) * 2007-06-26 2008-12-31 Wakamoto Pharmaceutical Co., Ltd. Aqueous composition
EP2172224A1 (en) * 2007-06-26 2010-04-07 Wakamoto Pharmaceutical Co., Ltd. Aqueous composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
COVIELLO ET AL: "Polysaccharide hydrogels for modified release formulations", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 119, no. 1, 16 April 2007 (2007-04-16), pages 5 - 24, XP022031535, ISSN: 0168-3659, DOI: DOI:10.1016/J.JCONREL.2007.01.004 *

Also Published As

Publication number Publication date
WO2011018800A2 (en) 2011-02-17

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