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WO2011016712A1 - Estimation du risque vasculaire par le biais de l'utilisation d'une technologie optique non invasive - Google Patents

Estimation du risque vasculaire par le biais de l'utilisation d'une technologie optique non invasive Download PDF

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Publication number
WO2011016712A1
WO2011016712A1 PCT/MY2010/000135 MY2010000135W WO2011016712A1 WO 2011016712 A1 WO2011016712 A1 WO 2011016712A1 MY 2010000135 W MY2010000135 W MY 2010000135W WO 2011016712 A1 WO2011016712 A1 WO 2011016712A1
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WO
WIPO (PCT)
Prior art keywords
ppg
pulse
risk
data
red
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/MY2010/000135
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English (en)
Inventor
Mohd Alauddin Mohd Ali
Edmond Zahedi
Oteh Maskon
Kalaivani Chellappan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNIVERSITI KEBANGSAAN MALAYSIA (UKM)
Original Assignee
UNIVERSITI KEBANGSAAN MALAYSIA (UKM)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNIVERSITI KEBANGSAAN MALAYSIA (UKM) filed Critical UNIVERSITI KEBANGSAAN MALAYSIA (UKM)
Publication of WO2011016712A1 publication Critical patent/WO2011016712A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate
    • A61B5/02416—Measuring pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

Definitions

  • the present invention relates to vascular risk prediction using non-invasive optical technology.
  • a method for vascular risk prediction utilizes photoplethysmogram (PPG) within the micro-vasculature using a non-invasive optical technology characterized in that the method includes the steps of placing a finger probe on subject, recording PPG pulse signal, transmitting pulse signal from to a PPG recording means , converting PPG data pulse into computer readable format, transmitting computer readable format to a computer system, , identifying start and end of each data pulse, normalising amplitude, analyzing pulses variability and duration of each PPG data pulse, calculating a morphological fitness index, comparing value of index to reference model for each recorded pulse, identifying the typical pulse according to fitness index, calculating risk based on model output, calculating estimated vascular age and displaying result.
  • PPG photoplethysmogram
  • a system for a vascular risk prediction using non-invasive optical sensor characterized in that the system includes a PPG recording systems, a finger probe, a computer and a processing program wherein the finger probe further include two infra-red/red LEDs and a photodetector the computer process pulse data and the processing program converts pulse data to computer readable format.
  • an apparatus for a finger probe using two light emitting diode (LED) and two photo detector characterized in that the finger probe is a reusable optical sensor and the finger probe utilizes two infra-red or red LED and two photodiode for SpO 2 .
  • FIG. 1 is a diagram depicting the layout of the system
  • FIG. 2 is an example showing a subject risk free
  • FIG. 3 is an example showing a subject at risk
  • FIG. 4 is a graph chart showing the fitness levels against age
  • FIG. 5 is a graph chart showing the residual plot of risk
  • FIG. 6 is a graph chart showing the Exponential regression for exact matched subjects with and without risk
  • FIG.7 is a graph chart showing the categorical risk prediction for data set (a) 5L (b) 5U;
  • FIG.8 is block diagram showing a connection of Dolphin system and a synchronization circuit.
  • the present invention relates to vascular risk prediction using non-invasive optical technology.
  • this specification will describe the present invention according to the preferred embodiments of the present invention.
  • limiting the description to the preferred embodiments of the invention is merely to facilitate discussion of the present invention and it is envisioned that those skilled in the art may devise various modifications and equivalents without departing from the scope of the appended claims.
  • the present invention employs a photoplethysmogram (PPG) recording systems (16) to record the PPG from a finger of a subject.
  • PPG photoplethysmogram
  • the present invention utilizes Dolphin OEM 601 for the PPG recording system.
  • a finger sensor (18) i.e. Dolphin
  • ONETM 210 Adult Finger Clip is a reusable optical sensor designed for adults and children heavier than 30 kg.
  • the finger sensor (18) utilizes two photo detectors at 660 nm and 905 nm wavelengths for SpO 2 monitoring by using a photodiode which senses the light transmitted through the finger and converting it into a digital signal.
  • the PPG recording systems (16) is built based on the following three main modules.
  • the board PPG recording systems is designed to substantially eliminate the problems of motion artifact, low peripheral perfusion and most weak signal-to-noise situations, greatly extending the utility of pulse oximetry into high motion, low signal and noise intensive environment. It uses an advanced digital signal-processing (DSP) engine capable of discerning pulsatile waveforms in the presence of motion, making the module ideal for use in demanding clinical environments. Additionally, the module is capable of receiving the return digital information from the finger probes (18) instead of the more traditional low-level analog signals, wherein eliminating corruption of the sensor waveform by external electrical noise sources.
  • DSP digital signal-processing
  • the computer (13) is installed with a software module for the PPG recording systems (16) i.e. Dolphin OneTM Software communicates with the board through a single, asynchronous serial channel at TTL voltage levels.
  • the application is capable of recording and storing the following information SpO 2 %, pulse rate, bar graph intensity proportional to AC/DC ratio, graphical display of PPG waveform, sensor Status Information.
  • commands protocols do not require any commands protocols from the computers (13). However, commands protocols can be used to suit the needs of a practitioner. These commands can enable special features and gives the computers (13) additional control over a board operation.
  • FIG.2 is a photoplethysmogram waveform corresponding to Table 1
  • FIG.3 is a photoplethysmogram waveform corresponding to Table 2.
  • the present invention is a non-linear regression model (exponent) to predict degrees of vascular health based on a fitness index defined by using a PPG waveform.
  • the PPG is a non-invasively derived signal using a low-cost optical instrumentation which is known to depend on arterial stiffness.
  • PPG signals from right index fingers of 72 male subjects which has age range of 47 with the youngest subject is 19 years old and the oldest is 66 years old followed by a mean age of 45.3 ⁇ 10.69, free from any cardiovascular risk factors are recorded.
  • An amplitude and duration of each single pulse are normalized and their fitness is calculated based on the square of residuals from a single PPG pulse of a 19-years old subject chosen as the reference.
  • the potential application of this technique is the assessment of vascular problems in subjects with risk factors such as hypertension and diabetes
  • FIG. 4 shows an exponential regression line of the both male and female for subjects without risk.
  • the R square is very promising.
  • FIG. 5 is a residual plot of the both risk and without risk for male and female samples. It is very clear that the risk and without risk subjects are well separated in this figure. This further increases the reliability of the technique in predicting the vascular risk.
  • the overall accuracy of this model to predict subjects having RISK is 92.4%.
  • FIG. 7 shows the selection of the cut-off values from the graph for data set. Refer to FIG. 7 (a) and (b).
  • Table 3 shows the risk index quantification from the residual values devised in Figure 7 (a) and (b).
  • Moderate Risk 16.0 ⁇ R ⁇ 22.0
  • Moderate Risk 12.0 ⁇ R ⁇ 20.0

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

La présente invention concerne un nouveau procédé d'évaluation de la santé vasculaire se basant sur l'âge et un signal biologique optique non invasif destiné à estimer le risque vasculaire. La présente invention utilise des systèmes d'enregistrement de photopléthysmogrammes (PPG) destinés à enregistrer des PPG à partir d'un doigt d'un sujet, en utilisant un capteur digital, un ordinateur étant utilisé pour la visualisation et l'enregistrement des signaux provenant du PPG connecté par le biais de ports série.
PCT/MY2010/000135 2009-08-04 2010-08-03 Estimation du risque vasculaire par le biais de l'utilisation d'une technologie optique non invasive Ceased WO2011016712A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MYPI20097012 2009-08-04
MYPI20097012 2009-08-04

Publications (1)

Publication Number Publication Date
WO2011016712A1 true WO2011016712A1 (fr) 2011-02-10

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PCT/MY2010/000135 Ceased WO2011016712A1 (fr) 2009-08-04 2010-08-03 Estimation du risque vasculaire par le biais de l'utilisation d'une technologie optique non invasive

Country Status (1)

Country Link
WO (1) WO2011016712A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258366A (zh) * 2011-08-17 2011-11-30 天津大学 一种正交方波调制光电容积脉搏波测量装置和测量方法
GB2505890A (en) * 2012-09-12 2014-03-19 To Health Ltd Screening to determine a cardiac arrhythmia risk parameter using photoplethysmograph measurements

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030036685A1 (en) * 2000-04-27 2003-02-20 Vitalsines International, Inc. Physiological signal monitoring system
WO2005069740A2 (fr) * 2004-01-27 2005-08-04 Cardiometer Ltd. Procede et systeme de diagnostic du systeme cardio-vasculaire
US20060229519A1 (en) * 2005-04-06 2006-10-12 Konica Minolta Sensing, Inc. Biological information processing apparatus and operation program product for the same
US20070112259A1 (en) * 2005-11-14 2007-05-17 Konica Minolta Sensing Inc. Vital information measuring device
WO2008092215A1 (fr) * 2007-01-31 2008-08-07 Atcor Medical Pty Limited Caractérisation de l'effet du vieillissement et du risque cardio-vasculaire
WO2008132751A2 (fr) * 2007-05-01 2008-11-06 Spirocor Ltd. Procédé, appareil et système de détection de la rigidité artérielle et du tonus artériel par analyse de sphygmogramme

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030036685A1 (en) * 2000-04-27 2003-02-20 Vitalsines International, Inc. Physiological signal monitoring system
WO2005069740A2 (fr) * 2004-01-27 2005-08-04 Cardiometer Ltd. Procede et systeme de diagnostic du systeme cardio-vasculaire
US20060229519A1 (en) * 2005-04-06 2006-10-12 Konica Minolta Sensing, Inc. Biological information processing apparatus and operation program product for the same
US20070112259A1 (en) * 2005-11-14 2007-05-17 Konica Minolta Sensing Inc. Vital information measuring device
WO2008092215A1 (fr) * 2007-01-31 2008-08-07 Atcor Medical Pty Limited Caractérisation de l'effet du vieillissement et du risque cardio-vasculaire
WO2008132751A2 (fr) * 2007-05-01 2008-11-06 Spirocor Ltd. Procédé, appareil et système de détection de la rigidité artérielle et du tonus artériel par analyse de sphygmogramme

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102258366A (zh) * 2011-08-17 2011-11-30 天津大学 一种正交方波调制光电容积脉搏波测量装置和测量方法
CN102258366B (zh) * 2011-08-17 2014-04-09 天津大学 一种正交方波调制光电容积脉搏波测量装置和测量方法
GB2505890A (en) * 2012-09-12 2014-03-19 To Health Ltd Screening to determine a cardiac arrhythmia risk parameter using photoplethysmograph measurements

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