[go: up one dir, main page]

WO2011014850A3 - Formulations à usage topique à base d'un eutectique - Google Patents

Formulations à usage topique à base d'un eutectique Download PDF

Info

Publication number
WO2011014850A3
WO2011014850A3 PCT/US2010/044036 US2010044036W WO2011014850A3 WO 2011014850 A3 WO2011014850 A3 WO 2011014850A3 US 2010044036 W US2010044036 W US 2010044036W WO 2011014850 A3 WO2011014850 A3 WO 2011014850A3
Authority
WO
WIPO (PCT)
Prior art keywords
eutectic
methods
based formulations
topical
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/044036
Other languages
English (en)
Other versions
WO2011014850A2 (fr
Inventor
Servet Buyuktimkin
Nadir Buyuktimkin
Jagat Singh
John M. Newsam
Dominic King-Smith
Edward Kisak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuvo Research Inc
Original Assignee
Nuvo Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuvo Research Inc filed Critical Nuvo Research Inc
Publication of WO2011014850A2 publication Critical patent/WO2011014850A2/fr
Publication of WO2011014850A3 publication Critical patent/WO2011014850A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cette invention concerne des compositions à usage topique, des procédés de préparation, et des méthodes de traitement impliquant l'incorporation d'un eutectique à l'état fondu dans une formulation. La formulation améliorée peut accroître la perméabilité et la biodisponibilité. Dans certains modes de réalisation spécifiques, cette invention concerne une composition pharmaceutique antifongique à usage topique comprenant un agent antifongique, au moins un agent eutectique, et un solvant à bas point d'ébullition pharmaceutiquement acceptable.
PCT/US2010/044036 2009-07-31 2010-07-30 Formulations à usage topique à base d'un eutectique Ceased WO2011014850A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23047309P 2009-07-31 2009-07-31
US61/230,473 2009-07-31

Publications (2)

Publication Number Publication Date
WO2011014850A2 WO2011014850A2 (fr) 2011-02-03
WO2011014850A3 true WO2011014850A3 (fr) 2011-11-17

Family

ID=42634505

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/044036 Ceased WO2011014850A2 (fr) 2009-07-31 2010-07-30 Formulations à usage topique à base d'un eutectique

Country Status (1)

Country Link
WO (1) WO2011014850A2 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011079234A2 (fr) 2009-12-23 2011-06-30 Nuvo Research Inc. Formulation de terbinafine à grande perméation
EP2664327A1 (fr) * 2012-05-14 2013-11-20 Almirall S.A. Compositions pharmaceutiques topiques comprenant du terbinafide et de l'urée
MX2015008021A (es) 2012-12-21 2016-03-04 Teikoku Pharma Usa Inc Composiciones y metodos para administracion transdermica de hormonas y otros agentes medicos.
US9452173B2 (en) 2013-01-31 2016-09-27 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9446131B2 (en) 2013-01-31 2016-09-20 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9433680B2 (en) 2013-01-31 2016-09-06 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US11241520B2 (en) * 2014-08-07 2022-02-08 Cook Medical Technologies Llc Compositions and devices incorporating water-insoluble therapeutic agents and methods of the use thereof
WO2017062761A1 (fr) 2015-10-07 2017-04-13 Exodos Life Sciences Lp Compositions antifongiques topiques
BR112018075998A2 (pt) * 2016-06-13 2019-04-02 Vyome Therapeutics Limited. composições antifúngicas sinérgicas e métodos das mesmas
WO2017216722A2 (fr) * 2016-06-13 2017-12-21 Vyome Biosciences Pvt. Ltd. Compositions antifongiques synergiques et leurs procédés
FR3058905B1 (fr) * 2016-11-18 2020-02-28 Universite Du Littoral Cote D'opale Procede d'epuration d'un effluent gazeux
WO2019214838A1 (fr) * 2018-05-09 2019-11-14 Eviderm Institute Ab Utilisation d'une composition contenant de l'alcool pour améliorer la fonction barrière de la peau
CN112839633A (zh) * 2018-08-01 2021-05-25 诺维拉制药有限公司 包含药剂的低共熔溶剂及其制造方法和用途
JP2022509479A (ja) * 2018-10-24 2022-01-20 セラノヴォ・ベー・フェー 経口医薬製剤のための深共晶溶媒プラットフォーム
CA3138194A1 (fr) * 2019-04-30 2020-11-05 Bayer Healthcare Llc Compositions de gel analgesique topique
WO2020223097A1 (fr) * 2019-04-30 2020-11-05 Bayer Healthcare Llc Compositions analgésiques topiques
NL2023661B1 (en) 2019-08-19 2021-04-21 Seranovo Holding B V Pharmaceutical Eutectic Salt Formulation
EP4041839A4 (fr) * 2019-10-08 2023-10-11 Hallux, Inc. Compositions et procédés de traitement de l'onychomycose
EP4178701A4 (fr) * 2020-07-10 2024-07-10 Aquafortus Technologies Limited Solution de séchage par solvant et processus s'y rapportant
CN113024362B (zh) * 2021-03-10 2022-02-15 中国科学院上海药物研究所 一种辅酶qh与烟酰胺的共晶及其制备方法和用途
CN114949324B (zh) * 2022-06-15 2024-02-02 浙江工业大学 一种生物相容性抗菌凝胶膜的制备方法
EP4543465A1 (fr) * 2022-06-24 2025-04-30 Royal Melbourne Institute of Technology Gels antimicrobiens
GB202302434D0 (en) 2023-02-21 2023-04-05 Univ Of Reading Compositions and method for the treatment of onychomycosis
CN118831062B (zh) * 2024-06-21 2025-04-08 江苏知原药业股份有限公司 一种稳定性好且溶出度高的阿普米司特片及其制备方法
CN119707642B (zh) * 2025-02-28 2025-08-08 深圳杉海创新技术有限公司 一种苯乙基间苯二酚甜菜碱共晶及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0197076A1 (fr) * 1984-10-08 1986-10-15 Durst Phototechnik Gmbh Agrandisseur ou machine a copier photographique pour tirage couleur.
EP0503988A1 (fr) * 1991-03-08 1992-09-16 Sandoz Ltd. Compositions pour le traitement des onychomycoses
WO2004084826A2 (fr) * 2003-03-21 2004-10-07 Nexmed Holdings, Inc. Enduit a ongles antifongique et procede d'utilisation
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration
US20060078599A1 (en) * 2004-10-12 2006-04-13 Mathew Ebmeier Pharmaceutical composition applicable to body tissue

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7713618L (sv) 1977-12-01 1979-06-02 Astra Laekemedel Ab Lokalanestetisk blandning
US6368618B1 (en) 1999-07-01 2002-04-09 The University Of Georgia Research Foundation, Inc. Composition and method for enhanced transdermal absorption of nonsteroidal anti-inflammatory drugs
US20070224261A1 (en) 2006-03-22 2007-09-27 Peter Draper Eutectic liquid drug formulation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0197076A1 (fr) * 1984-10-08 1986-10-15 Durst Phototechnik Gmbh Agrandisseur ou machine a copier photographique pour tirage couleur.
EP0503988A1 (fr) * 1991-03-08 1992-09-16 Sandoz Ltd. Compositions pour le traitement des onychomycoses
WO2004084826A2 (fr) * 2003-03-21 2004-10-07 Nexmed Holdings, Inc. Enduit a ongles antifongique et procede d'utilisation
WO2005018530A2 (fr) * 2003-08-25 2005-03-03 Foamix Ltd. Mousse pharmaceutique de penetration
US20060078599A1 (en) * 2004-10-12 2006-04-13 Mathew Ebmeier Pharmaceutical composition applicable to body tissue

Also Published As

Publication number Publication date
WO2011014850A2 (fr) 2011-02-03

Similar Documents

Publication Publication Date Title
WO2011014850A3 (fr) Formulations à usage topique à base d'un eutectique
BR112014031773A2 (pt) entrega de drogas biodegradável para composições hidrofóbicas
WO2012021715A3 (fr) Formulations stables de linaclotide
WO2010021607A3 (fr) Préparation pharmaceutique
WO2008132229A3 (fr) Solutions et compositions hautement concentrées en insuline
PT2344198T (pt) Preparações farmacêuticas à base de lípidos para aplicação tópica
WO2006099169A3 (fr) Nouvelles compositions de liposomes
ZA200809864B (en) Pharmaceutical formulations for the sustained release of active ingredients(s), as well as their applications, especially therapeutic
WO2011141685A3 (fr) Compositions nasales a visee systemique a base de cocoyl proline ou d'au moins un de ses constituants
WO2011017502A3 (fr) Formulations comprenant du linaclotide
WO2007133751A3 (fr) Formulations de polyorthoester à base stabilisée
WO2012053009A3 (fr) Compositions pharmaceutiques comprenant des agents de décoloration de la peau
WO2006138735A3 (fr) Compositions de gel pour administration topique
WO2011002422A3 (fr) Formulation pharmaceutique améliorant la solubilité
WO2010049449A3 (fr) Nouveaux sels de sunitinib
WO2008129501A3 (fr) Compositions pharmaceutiques de duloxetine
WO2012085284A3 (fr) Formulations pharmaceutiques à charge médicamenteuse élevée comprenant de la dronédarone et des sels pharmaceutiquement acceptables de celles-ci
WO2011076209A3 (fr) Composition pharmaceutique comprenant un mélange de solvants et un dérivé de la vitamine d ou analogue
WO2009094457A3 (fr) Benzhydryléthers substitués
WO2011064558A3 (fr) Composition pharmaceutique
WO2014064652A3 (fr) Composition pharmaceutique stable d'interféron pégylé alpha-2b
IL210975A (en) Annapomapungin History, Pharmaceuticals Containing Them and Their Use in Preparing Medicines to Treat Fungal Infections
WO2009084036A3 (fr) Composition utilisée pour traiter les infections virales
WO2009074853A3 (fr) Composition ophtalmique comprenant de la phényléphrine
WO2011014003A3 (fr) Dérivés de (+)-3-(+)-3-hydroxymorphinan utilisés comme neuroprotecteurs

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10740814

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10740814

Country of ref document: EP

Kind code of ref document: A2