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WO2011095615A1 - Dispositif d'application pour pulvériser un liquide - Google Patents

Dispositif d'application pour pulvériser un liquide Download PDF

Info

Publication number
WO2011095615A1
WO2011095615A1 PCT/EP2011/051697 EP2011051697W WO2011095615A1 WO 2011095615 A1 WO2011095615 A1 WO 2011095615A1 EP 2011051697 W EP2011051697 W EP 2011051697W WO 2011095615 A1 WO2011095615 A1 WO 2011095615A1
Authority
WO
WIPO (PCT)
Prior art keywords
cuvette
valve unit
application device
holder
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2011/051697
Other languages
German (de)
English (en)
Inventor
Dieter Gulik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meddrop Tech AG
Original Assignee
Meddrop Tech AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meddrop Tech AG filed Critical Meddrop Tech AG
Priority to EP11703434A priority Critical patent/EP2531246A1/fr
Publication of WO2011095615A1 publication Critical patent/WO2011095615A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/14—Detection of the presence or absence of a tube, a connector or a container in an apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use

Definitions

  • the invention relates to an application device for atomizing a liquid by means of a gas stream according to the preamble of claim 1.
  • Another possibility is to disperse drugs in microemulsions that are easier for the skin to penetrate.
  • the penetration effect can be significantly increased if the microemulsion is applied under high pressure to the skin and if this is effected with simultaneous supply of gases, in particular oxygen.
  • This method allows the incorporation of an active substance in areas of the body that are not just under the skin, such as bone joints, etc.
  • a microemulsion takes place in particular by means of an application device by atomizing a liquid by means of a gas flow, in which the liquid is taken up in a liquid container and is atomized via a nozzle head.
  • the atomization is carried out in the manner of a paint spray gun, in which exploiting the Ventu effect, a gas stream, especially oxygen, liquid, ie the active substance, finely atomized and the active ingredient is thus applied to the skin surface to be treated.
  • a corresponding method and the basic principle of a corresponding application device are known from WO 2006/0401 19 A2. It describes in detail how and which medicaments can be administered in this way.
  • the application system specified there contains a drug reservoir which is atomized via a venturi nozzle with a surrounding gas jet at the nozzle leading end.
  • the drug is delivered to the application system via a tubing connection from an external source.
  • the invention is therefore based on the object to provide an application system for atomizing a liquid by means of a gas stream, which is particularly suitable for the percutaneous administration of drugs that allows easy and flexible handling in almost any spatial position and that a rapid interchangeability with administering drug allows.
  • the invention is based on an application system for atomizing a liquid which can be atomized by means of a gas flow with a nozzle head contained in a nozzle needle.
  • the application device contains a valve unit with at least one gas barrier valve for controlling the gas supply to the application device.
  • a valve unit can be attached to the first end of a cuvette holder for receiving a cuvette containing the liquid, the valve unit containing at least one release valve which is opened by attaching the cuvette with inserted cuvette to the valve unit and thus a gas flow from the valve unit via the cuvette holder releases to the nozzle head. This is attached to a second end of the cuvette holder.
  • the at least one release valve in the valve unit is operable by a side wing of the cuvette.
  • the application device therefore consists essentially of three parts, namely a valve unit for controlling the gas supply, a cuvette holder for receiving a cuvette containing the liquid to be administered and a nozzle head which can be fastened to the front end of the cuvette holder.
  • the cuvette holder may be fitted with a syringe-like cuvette configured at the rear end to actuate one or more release valves in the valve unit such that the valve unit releases a gas flow only if a cuvette is actually present in the cuvette holder.
  • the valve unit of the application device preferably has a central pressure channel for the supply of compressed gas to the rear end of a cuvette inserted into the cuvette holder.
  • at least two release valves arranged diagonally opposite one another in respective side channels of the valve unit are preferably provided, which can be actuated by at least two side wings attached to the cuvette when the cuvette is inserted into the cuvette holder.
  • the valve unit thus branches a gas flow supplied via a connection of the valve unit into a central gas flow, which is applied to the rear end of the cuvette, and in particular two side flows, which flow via the release valves, which can be actuated by a cuvette inserted into the cuvette holder.
  • the sidestreams are led via the cuvette holder to the nozzle head where they form the gas jet, which causes atomization of the liquid contained in the cuvette at the nozzle leading end by means of the venturi effect.
  • the located on the cuvette wings ensure that only one properly designed cuvette actuates the release valves.
  • the gas flow guided through the release valves can be controlled as a function of the actuation depth of the release valves.
  • the thickness of the side wings is therefore designed differently, so that the volume flow of guided through the side channels gas flow can be adjusted.
  • cuvettes can be used for different active substance fluids whose side wings have different strengths, so that an automatic adjustment of the volume flow of the gas flows guided via the side channels can be achieved by selecting the thickness of the side wings and thus the setting of the operating depth of the release valves.
  • the release valves are preloaded by spring force, so that opening of the release valves takes place only when a suitable cuvette with a suitable thickness of side wings is inserted into the cuvette holder.
  • the application device further preferably comprises at the front end of the valve unit a centering mandrel provided with a central passage which forms an annular gap at the front end of the valve unit into which an annular axially directed projection of a cuvette inserted into the cuvette holder can be inserted.
  • the cuvette's approach prevents overflow of the gas streams of the side channels and the central gas stream directed towards the rear end of the cuvette.
  • the approach of the cuvette can also act on an additional central valve in the valve unit, which can then additionally shut off the central gas flow.
  • Valve unit and cuvette holder are preferably connectable to each other by means of a screw ring, wherein during screwing the side wings of a cuvette inserted in the cuvette holder actuate the head ends of the release valves to open and a passage of the gas flow from the valve unit to the front end of the cuvette holder and the nozzle head of the application device to enable.
  • Cell holder and valve unit can thus be very easily assembled and separated, so that a simple and quick exchange of a cuvette against another cuvette or after emptying a first cuvette against a filled cuvette is possible.
  • a cuvette which can be inserted into the application device according to the invention is in particular formed as a hollow cylinder with a nozzle-like end provided at the outlet opening and a rear end with at least one radially projecting side wing.
  • a cuvette is designed in the manner of a syringe barrel, but neither a hand-operated piston nor a needle unit are present.
  • the rear end of the cuvette has an axial cylindrical projection which is sealingly inserted into the valve unit.
  • this contains a pressure piston, which can be moved forward by the gas flow centrally applied via the valve unit.
  • the plunger may also include means for preventing retraction or back-up in the cuvette to prevent an empty cuvette from being refilled improperly. This type provides security against incorrect use of the application device according to the invention.
  • usable means for preventing the retraction of the pressure piston is known for example from DE 40 34 673 A1.
  • the application device according to the invention can be used both in the field of human medicine and veterinary medicine. There is a high level of protection against incorrect use, the application is simple and the cuvette system used allows a flexible use, with manipulation possibilities are essentially excluded.
  • Fig. 1 is a side view of a disassembled application device, partially in
  • valve unit 3 shows the transition region between valve unit and cuvette holder in a second axial sectional view
  • Fig. 4 is a cuvette in sectional view
  • Fig. 5 is a cuvette in supervision.
  • the application device essentially contains three functional units, namely a valve unit 3, a cuvette holder 2 and a nozzle head 31.
  • the valve unit includes at its rear side a gas port 30, via the gas, in particular oxygen, under a pressure of z. B. 2 bar can be supplied.
  • the gas supply can shut off and control.
  • the oxygen stream supplied to the gas connection 30 is divided via the valve unit 3 into two side streams and one central stream.
  • the central stream leads over a centering mandrel 4 on the back of the cuvette 6 inserted into the cuvette holder 2.
  • the side streams are also introduced via the release valves 5 and 7 in the cuvette holder 2, but on the outside of the cuvette 6 along to the front end of the cuvette holder 2.
  • the actuation of the valves 5 and 7 takes place via the side wings 32 and 33 of the cuvette 6 by the side wings acting on the head ends of the valves 5 and 7.
  • the nozzle head 31 can be screwed into the screwed-in nozzle head 31, a needle 36 projects, which is anchored in the cuvette holder 2, wherein the tip of the needle 36 together with the nozzle head 31 forms a spray nozzle.
  • the needle 36 is mounted in the cuvette holder 2 such that the rotational position of the nozzle head 31 relative to the cuvette holder 2 influences the position of the needle tip in the cuvette holder 2 and thus both the spray pattern and the spray strength are adjustable in a conventional manner.
  • the cuvette holder is designed such that the side streams fed from the back of the cuvette holder 2 from the valve unit are guided along the outside of a cuvette inserted or along separate side channels into the nozzle head 31.
  • the cuvette 6 has a front spout which is sealed against the side channels so that the liquid exiting the cuvette only contacts the side channel streams at the tip of the needle 36.
  • the sealing of the cuvette holder with respect to the spray head 31 is accomplished by means of an O-ring 38.
  • the nozzle head further includes a filter 37 inserted into a window of the nozzle head to reduce the spray pressure and to collect excess spray that would otherwise be distributed in the environment ,
  • Fig. 2 shows a sectional view of the connecting portion between the valve unit 3 and the cuvette holder 2.
  • the lower half of the figure shows a view in which the screw ring 29 firmly connects the valve unit and the cuvette holder, while the upper half of the view shows a state in the valve unit and Cuvette holders are not yet connected.
  • the valve unit 3 has two diagonally opposite side channels 19 and 20, in which a first release valve 5 and a second release valve 7 are held axially.
  • the first valve spring 9 and the second valve spring 8 hold the release valves 5 and 7 in the unloaded state in the closed position, wherein the closure of the valves is ensured by the O-rings 13 and 14.
  • the release valves 5 and 7 have at the front end valve tappets 15 and 16 which are actuated by the side wings 32 and 33 of the cuvette 6.
  • a state is shown in which the second release valve 7 via the second valve spring 8 and the O-ring 14 is held in the closed position, wherein the second valve stem 15 and the second release valve head 22 from the valve unit. 3 sticking out a bit.
  • the release valve 5 is already held in the open position by the first release valve head 21 of the release valve 5 was pressed by the side wing 33 in the cuvette 6 to the rear.
  • the cuvette holder 2 contains a central receiving space for receiving a cuvette 6.
  • the cuvette holder is designed similar to a syringe body with a cylindrical receiving space for receiving active liquid.
  • the two side wings 32 and 33 which act on the release valves 5 and 7.
  • a cuvette attachment 17 which is cylindrical and surrounds the centering mandrel 4 of the valve unit 3 with sealing on the O-ring 1 1.
  • the gas pressure supplied to the central pressure channel 18 in the valve unit 3 can therefore act centrally directly on the rear side of the cuvette 6.
  • the side channels 19 and 20, which receive the release valves 5 and 7, supplied gas flow flows with open release valves via an annular channel 23 through the side channels 25 and 26 of the cuvette holder 2 (see Fig. 3) head to the nozzle.
  • the O-ring 10 is used to seal the cuvette in the cuvette holder 2 and to ensure inadvertent falling out of a cuvette from the cuvette holder 2 in the separated state of the application device.
  • the O-ring 12 serves to seal the centering mandrel 4.
  • Fig. 3 shows a rotated by 90 ° view of an application device with composite valve unit and cuvette holder.
  • cuvette holder 2 and valve unit 3 are firmly connected to each other, at the same time the annular channel 23 is formed, in which the side channels 19 and 20 open.
  • the gas guided via the side channels 19 and 20 flows into the diagonally opposite side channels 25 and 26 of the cuvette holder 2 and thus within the cuvette holder 2 to the front end of the application device.
  • At the outer front end of the cuvette holder 2 is an external thread 27, on which the nozzle head 31 can be screwed.
  • FIG. 4 shows a sectional view of a cuvette 6 which can be inserted into the cuvette holder 2.
  • This cuvette is of integral design and has a hollow cylindrical shape and has at the front end a spout 35, which is sealingly formed with respect to the injection head.
  • At the rear end of the cuvette 6 are laterally two side wings 32 and 33.
  • a sleeve-shaped cuvette shoulder 17 is provided axially.
  • a displaceable piston 34 Inside the cuvette is a displaceable piston 34 which is pressurized by the central pressure channel 18 of the valve unit 3 and thus pushes the liquid located in front of the piston 34 forwards from the nozzle 5 into the spray head.
  • Fig. 5 shows a rear view of a cuvette with the two side wings 32 and 33 and the annular cuvette extension 17.
  • the strength of the two side wings 32 and 33 is selected so that a cuvette inserted into the cuvette holder 2 releases the release valves 5 and 7.
  • the thickness of the side wings 32 and 33 control the size of the pressure gas flowing through the release valves, so that there is a Kodier réellekeit a cuvette by depending on the strength of the side wings, the amount of gas flowing through the release valves can be adjusted ,

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un dispositif d'application pour pulvériser un liquide au moyen d'un flux gazeux, le liquide étant contenu dans un réservoir à liquide (6) et pouvant être pulvérisé au moyen d'un flux gazeux sur une tête de buse (31) du dispositif d'application comportant une aiguille de buse (36). Le dispositif d'application comporte une unité soupape arrière (3) pourvue d'au moins une soupape d'arrêt de gaz pour commander l'alimentation en gaz vers le dispositif d'application. Selon l'invention, l'unité soupape (3) peut être logée sur la première extrémité d'un support de cuvette (2) pour recevoir une cuvette (6) contenant le liquide. L'unité soupape (3) comporte au moins une soupape de libération (5, 7) qui est ouverte par logement du support de cuvette (2) comprenant la cuvette insérée (6), sur l'unité soupape (3), et libère ainsi un flux gazeux de l'unité soupape (3) vers la tête de buse (31), à travers le support de cuvette (2), la tête de buse pouvant être fixée à la deuxième extrémité du support de cuvette (2). La ou les soupapes de libération peuvent être actionnées par la cuvette (6).
PCT/EP2011/051697 2010-02-06 2011-02-05 Dispositif d'application pour pulvériser un liquide Ceased WO2011095615A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11703434A EP2531246A1 (fr) 2010-02-06 2011-02-05 Dispositif d'application pour pulvériser un liquide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102010007063.7 2010-02-06
DE201010007063 DE102010007063B4 (de) 2010-02-06 2010-02-06 Applikationseinrichtung zum Zerstäuben einer Flüssigkeit

Publications (1)

Publication Number Publication Date
WO2011095615A1 true WO2011095615A1 (fr) 2011-08-11

Family

ID=43971158

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2011/051697 Ceased WO2011095615A1 (fr) 2010-02-06 2011-02-05 Dispositif d'application pour pulvériser un liquide

Country Status (3)

Country Link
EP (1) EP2531246A1 (fr)
DE (1) DE102010007063B4 (fr)
WO (1) WO2011095615A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016142527A1 (fr) * 2015-03-11 2016-09-15 Linde Aktiengesellschaft Dispositif pour pulvériser un liquide

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB662943A (en) * 1948-01-30 1951-12-12 Becton Dickinson Co Injection device
US3292621A (en) * 1963-07-19 1966-12-20 Oscar H Banker Jet type protable inoculator
US4790824A (en) * 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
DE4034673A1 (de) 1990-09-27 1992-04-02 Bader & Partner Medizintechnik Spritze, insbesondere fuer den medizinischen gebrauch
US20020188251A1 (en) * 2001-06-08 2002-12-12 Bioject, Inc. Jet injector apparatus and method
US20050267403A1 (en) * 2004-05-28 2005-12-01 Sergio Landau Needle-free injection system
WO2006040119A2 (fr) 2004-10-12 2006-04-20 Meddrop Technology Ag Medicament et systeme d'administration percutanee de substances pharmaceutiques

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3844247A1 (de) * 1988-12-29 1990-07-12 Minnesota Mining & Mfg Vorrichtung, insbesondere pflaster zum transdermalen verabreichen eines medikaments

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB662943A (en) * 1948-01-30 1951-12-12 Becton Dickinson Co Injection device
US3292621A (en) * 1963-07-19 1966-12-20 Oscar H Banker Jet type protable inoculator
US4790824A (en) * 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
DE4034673A1 (de) 1990-09-27 1992-04-02 Bader & Partner Medizintechnik Spritze, insbesondere fuer den medizinischen gebrauch
US20020188251A1 (en) * 2001-06-08 2002-12-12 Bioject, Inc. Jet injector apparatus and method
US20050267403A1 (en) * 2004-05-28 2005-12-01 Sergio Landau Needle-free injection system
WO2006040119A2 (fr) 2004-10-12 2006-04-20 Meddrop Technology Ag Medicament et systeme d'administration percutanee de substances pharmaceutiques

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016142527A1 (fr) * 2015-03-11 2016-09-15 Linde Aktiengesellschaft Dispositif pour pulvériser un liquide

Also Published As

Publication number Publication date
DE102010007063B4 (de) 2012-11-22
DE102010007063A1 (de) 2011-08-11
EP2531246A1 (fr) 2012-12-12

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