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WO2011093355A1 - Lentille pour observation intraoculaire et son procédé de production - Google Patents

Lentille pour observation intraoculaire et son procédé de production Download PDF

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Publication number
WO2011093355A1
WO2011093355A1 PCT/JP2011/051547 JP2011051547W WO2011093355A1 WO 2011093355 A1 WO2011093355 A1 WO 2011093355A1 JP 2011051547 W JP2011051547 W JP 2011051547W WO 2011093355 A1 WO2011093355 A1 WO 2011093355A1
Authority
WO
WIPO (PCT)
Prior art keywords
lens
mold
intraocular observation
intraocular
resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2011/051547
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English (en)
Japanese (ja)
Inventor
栄 中塚
雨宮　勲
和丈 谷口
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoya Corp
Original Assignee
Hoya Corp
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Filing date
Publication date
Application filed by Hoya Corp filed Critical Hoya Corp
Publication of WO2011093355A1 publication Critical patent/WO2011093355A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/17—Component parts, details or accessories; Auxiliary operations
    • B29C45/26—Moulds
    • B29C45/37—Mould cavity walls, i.e. the inner surface forming the mould cavity, e.g. linings
    • B29C45/372—Mould cavity walls, i.e. the inner surface forming the mould cavity, e.g. linings provided with means for marking or patterning, e.g. numbering articles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A61B3/125—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes with contact lenses
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B3/00—Simple or compound lenses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2033/00—Use of polymers of unsaturated acids or derivatives thereof as moulding material
    • B29K2033/04—Polymers of esters
    • B29K2033/12—Polymers of methacrylic acid esters, e.g. PMMA, i.e. polymethylmethacrylate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2907/00—Use of elements other than metals as mould material
    • B29K2907/04—Carbon
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2011/00—Optical elements, e.g. lenses, prisms
    • B29L2011/0016—Lenses

Definitions

  • the present invention relates to an intraocular observation lens for observing the inside of the eye while being held on the cornea, and a method for manufacturing the same.
  • a contact lens for vitreous surgery or an intraocular observation lens (hereinafter, both are collectively referred to as an intraocular observation lens) is placed on the cornea via an ophthalmic viscoelastic substance.
  • an intraocular instrument such as a vitreous cutter or a vertical scissors
  • an intraocular illumination guide connected to the light source device by an optical fiber in the hand opposite to the dominant hand.
  • only one hand can be used for the intraocular treatment (hereinafter referred to as one method), and thus skill is required and the treatment takes a long time.
  • the operator needs to maintain extremely high concentration for a long time. is there. Further, when the treatment from the peripheral fundus of the eye to the most peripheral fundus is performed, the iris is in the way and the treatment part cannot be seen through the pupil. Therefore, it is necessary for the surgical assistant to press the treatment part from the outside of the eyeball into the eyeball using the presser, and when it cannot be compressed as desired by the surgeon, both the surgeon and the assistant are stressed. turn into.
  • an illumination device (extraocular illumination) attached to a surgical microscope is used instead of fiber illumination inserted into the eye.
  • a method for illuminating the inside of the eye from outside the eye through the intraocular observation lens and cornea has been studied. However, a part of the illumination light is reflected on the lens surface and the operator feels dazzled, and the quality of the fundus image is degraded by the reflected light.
  • lenses having a multilayer film such as an antireflection film on the surface thereof have been used (for example, see Patent Document 1).
  • a technique in which a fine projection is formed on a windshield of a car after performing a hydrophilic treatment with a material different from that of the windshield to exhibit a low reflection function and anti-fogging property. (For example, see Patent Document 4).
  • the conventional intraocular observation lens as described above has been repeatedly used, and it has been cleaned and sterilized each time it is used. Therefore, from the viewpoint of eliminating the hassle of sterilization, an intraocular observation lens that can be disposable has been demanded.
  • a transparent resin As a material for the above-mentioned disposable intraocular observation lens, a transparent resin can be mentioned.
  • the transparent resins there are hydrophilic or hydrophobic polymers, and hydrophobic surgical lenses are preferred. This is because in vitreous surgery performed using surgical surgical lenses, it is usual to perform surgery while putting raw water in the surgical position, and we want to quickly remove water from the lens surface for intraocular observation from the lens surface. is there.
  • An object of the present invention is made in consideration of the above-described circumstances, and provides an intraocular observation lens imparted not only with a reduced reflectance but also with an excellent antifogging property and a method for producing the same. It is in.
  • the first aspect of the present invention is an intraocular observation having a lens main body, a lens lower surface held on the cornea, and a lens upper surface for observing the inside of the eye via the lens lower surface and the lens main body.
  • the lens for intraocular observation is made of a polymer material containing a hydrophobic polymer, and the upper surface of the lens is hydrophobic and has fine protrusions with a pitch of 180 nm or less.
  • the hydrophobic polymer is PMMA
  • the intraocular observation lens is composed of only PMMA.
  • the upper surface of the lens has fine protrusions having a pitch of 180 nm or less.
  • the maximum outer diameter of the fine protrusion is 100 nm or more and less than 130 nm, and the height of the fine protrusion is 50 nm or more.
  • the aspect ratio is 0.3 or more and 20 or less.
  • the fifth aspect of the present invention provides an intraocular observation having a lens main body, a lens lower surface held on the cornea, and a lens upper surface for observing the inside of the eye via the lens lower surface and the lens main body.
  • a master mold by forming a pattern for fine protrusions having a pitch of 180 nm or less on a substrate in a method for producing a lens for a substrate, a step of producing a resin mold from the master mold by thermal imprinting or optical imprinting, A step of producing a metal mold by performing metal plating on the resin mold, a step of attaching the metal mold to an injection mold, and the metal mold attached to the injection mold.
  • the intraocular region is made of a polymer material containing a hydrophobic polymer. And performing injection molding of observation lens, it is a method for producing intraocular observation lens having.
  • an intraocular observation having a lens main body, a lens lower surface held on the cornea, and a lens upper surface for observing the inside of the eye via the lens lower surface and the lens main body.
  • Forming a master mold by forming a pattern for fine protrusions having a pitch of 180 nm or less on a substrate in a method for producing a lens for a substrate, a step of producing a resin mold from the master mold by thermal imprinting or optical imprinting, Providing an injection molding mold with an amorphous carbon layer and applying a pattern for fine projection to the amorphous carbon layer by the resin mold; and the injection molding mold so that the amorphous carbon layer corresponds to the upper surface of the intraocular observation lens By placing the mold, injection molding of an intraocular observation lens made of a resin containing a hydrophobic polymer is performed. And extent, a method for producing intraocular observation lens having.
  • the reflectance can be reduced, but also an intraocular observation lens provided with excellent antifogging properties and a method for producing the same can be provided.
  • the intraocular observation lens is made of a hydrophobic substance from the viewpoint of preventing water droplets from adhering and preventing unnecessary light scattering.
  • the intraocular observation lens it is necessary to prevent fogging that normally occurs with a hydrophobic substance.
  • the present inventor has found the following.
  • a hydrophobic polymer used for the intraocular observation lens
  • the area where water droplets come into contact with the observation surface is increased by providing nano-order fine protrusions on the observation surface of the intraocular observation lens (hereinafter also referred to as the lens upper surface).
  • the lens upper surface the observation surface of the intraocular observation lens
  • the hydrophobicity with respect to the surface of the water droplet is further improved.
  • innumerable water droplets having a finer diameter are formed on the upper surface of the lens. Therefore, it has been generally considered that there is a demerit that the upper surface of the lens is clouded to the extent that it exceeds the merit of preventing reflection by fine protrusions.
  • the present inventor dares to use a hydrophobic polymer on the observation surface of the intraocular observation lens and provide fine protrusions on the hydrophobic polymer to improve the antifogging property of the intraocular observation lens. We found that it can be improved dramatically.
  • the lens body 10 of the intraocular observation lens 1 includes a protective surface (hereinafter also referred to as a lens lower surface 12) having a concave curved surface matched to the curvature of the cornea 20, a lens upper surface 11 forming a prism lens, and a cylindrical shape. It is comprised with the lens main-body part 10 which is.
  • nano-order fine protrusions are formed on the entire upper surface of the lens body 10.
  • fine protrusions may be formed only in regions used for intraocular observation.
  • the lens main-body part 10 was cylindrical shape was described, if the function of the lens 1 for intraocular observation can be exhibited, even if it is a cube shape, a rectangular parallelepiped shape, a taper-shaped cylinder shape, and a rectangular parallelepiped shape,
  • the upper and lower surfaces may be polygonal.
  • the lens upper surface 11 may be parallel to the tangent plane of the lens lower surface 12 to the cornea 20 or may be inclined at a predetermined angle. This inclination angle becomes the prism angle.
  • This prism angle is determined depending on the part desired to be observed. When the part is in the range from the intermediate peripheral fundus to the peripheral fundus, 5 to 70 degrees, preferably 10 to 60 degrees is appropriate. It becomes a range. If it is 5 degrees or more, the effect of the prism can be sufficiently obtained. When the angle is 70 degrees or less, the effective optical portion of the lens can be kept wide and distortion of the observation image can be suppressed.
  • the lens upper surface 11 is parallel to the tangent plane of the lens lower surface 12 to the cornea 20, a part of the lens upper surface 11 may be inclined at a predetermined angle.
  • a prism may be added to the intraocular observation lens 1 in advance.
  • the lens upper surface 11 may be concave so that the lens upper surface 11 works negatively with respect to the cornea 20 that works positively. Further, when the lens upper surface 11 is parallel to the tangential plane of the lens lower surface 12 to the cornea 20, the inclined surface may be concave while inclining a part of the lens upper surface 11 at a predetermined angle. Conversely, the lens upper surface 11 may be convex, while the lens lower surface 12 may be a concave shape having a steeper curve than the lens upper surface 11, and a lens having a minus power may be produced as the entire lens.
  • the outer diameter of the lens body 10 needs to be larger than the mydriatic diameter, and is preferably about 10 to 14 mm.
  • the diameter of the mydriasis is about 9 mm at the maximum.
  • the intraocular observation lens 1 is placed on the cornea 20 via an ophthalmic viscoelastic substance (hyaluronic acid or the like).
  • ophthalmic viscoelastic substance hyaluronic acid or the like.
  • the curvature of the lens lower surface 12 needs to follow the curvature of the cornea 20.
  • the concave radius of curvature of the lens lower surface 12 of the lens body 10 is preferably around 8 mm. However, for children, make it smaller.
  • the material of the intraocular observation lens 1 here, in the present embodiment, in order to manufacture the disposable intraocular observation lens 1, and further during the surgical operation, antifogging and low reflection properties are provided.
  • a resin containing a hydrophobic polymer is used as a lens material.
  • the “hydrophobic substance” refers to a substance that is not easily compatible with water molecules, and preferably has a contact angle equal to or greater than a contact angle when the water droplet contacts polymethyl methacrylate (hereinafter also referred to as PMMA). Refers to the substance that contacts.
  • thermoplastic and amorphous polymer substance is preferable in order to achieve low reflectance and high transmittance.
  • PMMA polymethyl methacrylate
  • polyolefins such as polyethylene, polystyrene, polypropylene, polysulfone (Union Carbite), polyphenylsulfone (Radel), polyether polyetheretherketone, polycarbonate, modified polyphenylsulfone ( Acudel), styrene acrylonitrile, CR-39 (diethylene glycol bisallyl carbonate), polyhydroxyethyl methacrylate, soft acrylic resin, silicone resin, and transparent materials such as fluoroplastics can be used.
  • PMMA is more preferable from the viewpoint of transparency and cost.
  • a resin containing the hydrophobic polymer may be blended with the above polymer, or any one of the above polymer alone May be used.
  • a hydrophilic polymer may be further added to the hydrophobic polymer. Examples of this hydrophilic polymer include (meth) acrylate hydrophilic monomers, acrylamide hydrophilic monomers, sulfone hydrophilic monomers, and the like.
  • the refractive index of the material of the lens body 10 is preferably 1.35 or more, preferably 1.45 or more.
  • a fine protrusion structure having a periodic structure of 180 nm or less is provided on the upper surface 11 of the intraocular observation lens.
  • the period in this periodic structure is also referred to as a pitch, and indicates the distance between the fine protrusion vertices.
  • the fine protrusion structure is composed of a plurality of fine irregularities provided with a period equal to or shorter than the used light wavelength.
  • the size of the convex portion is fine below the wavelength used, and examples of its cross-sectional shape include a triangle, a trapezoid, and a square in the case of a one-dimensional periodic structure.
  • the shape of the fine protrusions is not only an accurate cone (the bus line is a straight line) and a pyramid (the ridge line is a straight line), but as long as the taper is tapered, the shape of the bus bar and the ridge line is curved and the side surface It may be a curved surface bulging outward.
  • Specific examples include a bell, a cone, a truncated cone, and a cylinder. With such a structure, it is possible to incline the refractive index difference between the lens and the living tissue and suppress reflection that occurs between the lens and the living tissue. Furthermore, the tip portion may be flattened or rounded in consideration of moldability and breakage resistance. Furthermore, this fine protrusion may produce a continuous fine protrusion with respect to one direction.
  • the fine protrusion is provided on the lens upper surface 11 which originally has hydrophobicity
  • the contact between the water droplet and the fine protrusion which causes clouding occurs.
  • the area will increase. Therefore, the water repellency due to hydrophobicity is too exerted on the upper surface 11 of the lens, and the contact angle ( ⁇ in FIG. 8) between the droplet and the upper surface 11 of the lens increases up to 180 °.
  • the droplets cannot withstand their own weight and cannot maintain a substantially spherical shape, and are deformed into a flat shape.
  • the periodic structure of the fine protrusions is 130 nm or less, which is finer than 180 nm or less, a more remarkable antifogging effect can be exhibited.
  • the maximum outer diameter (pattern size) of the fine protrusions is not necessarily constant, as shown in FIGS. 2A and 2B, which are explanatory diagrams regarding the surface reflectance of the quartz master mold according to the present embodiment. , Preferably in the range of 100 nm or more and less than 130 nm. Particularly, as shown in FIG. 2B, when the maximum outer diameter of the fine protrusion is within this range, the reflectance is further reduced.
  • the height of the fine protrusions in the vertical direction (hereinafter also referred to as the depth of the fine protrusions) is 50 nm or more, and the aspect ratio (height of the fine protrusions in the vertical direction / maximum outer diameter of the fine protrusions) is 0.3-20. Is preferred.
  • the distance between adjacent fine protrusions is a flat portion, the distance between the fine protrusions is preferably 20 nm or less. This is because light reflection is reduced if the flat portion that prevents the refractive index from being inclined becomes small.
  • the fine protrusions may be arranged so as to be closely packed when the intraocular observation lens 1 is viewed from a plane, or may be arranged in the vertical and horizontal directions, and the fine protrusions are constant. Although it may be arranged so as to have the undulations, it is preferably arranged so as to be closely packed. This is because when the fine protrusions are closely packed, it is possible to achieve a gentle gradient in the refractive index, which contributes most to the reduction in reflectance.
  • the intraocular observation lens 1 of the present embodiment is manufactured by injection molding described later, it is only necessary that the fine protrusions protrude in a direction parallel to the drawing direction after the injection molding.
  • the intraocular observation lens 1 is cylindrical and the lens upper surface 11 and the lens lower surface 12 are parallel, the intraocular observation lens 1 is parallel to the longitudinal direction of the cylindrical lens body 10 and simultaneously with the lens upper surface 11.
  • the protruding direction of the fine protrusions can be inclined by applying shear in the manufacturing process.
  • the intraocular observation lens 1 of the present embodiment has conventionally had a problem of light scattering due to cloudiness due to water droplet adhesion as well as the reflectance of the lens itself.
  • a method in which fogging is further increased with respect to the hydrophobic polymer that is, an area where the lens upper surface 11 is in contact with water droplets.
  • the intraocular observation lens 1 can be imparted (see FIGS. 8A and 9 described later).
  • the entire lens is formed by integral molding of a thermoplastic resin, it can be easily mass-produced at low cost. Therefore, it can be used disposable, and sterilization is not required, and a large amount of usage requirements can be met.
  • the same effect can be obtained with a hydrophilic lens.
  • the upper surface of the intraocular observation lens 1 in which the fine protrusions have a periodic structure of 130 nm is made of a hydrophilic polymer, the contact angle of the water droplet on the lens upper surface 11 is dramatically reduced, and as a result The change in refractive index can be moderated, and the reflectance can be reduced.
  • FIG. 3 is a diagram schematically showing a manufacturing process of the intraocular observation lens 1 in the present embodiment.
  • FIG. 3A shows a master mold 100 provided with a reverse pattern with respect to a desired transfer pattern.
  • FIG. 3B shows a state in which a resin mold 102 having a transfer pattern is produced from the master mold 100.
  • FIG. 3C shows the produced resin mold 102.
  • FIG. 3D shows a state in which the Ni mold 103 provided with a pattern reversed with respect to the transfer pattern is produced from the resin mold 102
  • FIG. 3E shows an adhesive on the injection mold 105.
  • FIG. 3A shows a master mold 100 provided with a reverse pattern with respect to a desired transfer pattern.
  • FIG. 3B shows a state in which a resin mold 102 having a transfer pattern is produced from the master mold 100.
  • FIG. 3C shows the produced resin mold 102.
  • FIG. 3D shows a state in which the Ni mold 103 provided with a pattern reversed with respect to the transfer
  • FIG. 3 (f) shows the state in which the layer 104 is provided and the Ni mold 103 and the resin mold 102 are mounted thereon, and the resin mold 102 is removed from the layer 104.
  • FIG. It shows how it was done.
  • FIG. 3G shows a state in which the intraocular observation lens 1 is manufactured by the injection molding method using the injection mold 105 with the Ni mold 103.
  • FIG. 1 shows an intraocular observation lens 1 according to this embodiment manufactured as described above.
  • a material that transmits light may be used.
  • a glass substrate, particularly a quartz substrate can be preferably used. In this embodiment, a case where a quartz substrate is used will be described.
  • a master mold 100 is manufactured by providing a resist on a quartz substrate and drawing a fine pattern on the resist.
  • a resist for blue semiconductor laser exposure is applied on a quartz substrate.
  • the resist for the blue semiconductor laser may be any heat-sensitive material that changes its state due to thermal change and is suitable for the subsequent etching process.
  • the characteristics of the resist having a function of improving the resolution of the resist may be continuously changed in the resist depth direction.
  • resist characteristics such as thermal conductivity, refractive index, and light absorption coefficient may be continuously changed in the depth direction. This is because when the resist is locally irradiated with a laser, the anisotropy of the region reaching a certain temperature is increased and the resolution performance is improved.
  • the resist material is Ti, V, Cr, Mn, Cu, Zn, Ge, Se, Y, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Sb, Te, Hf, Ir, Pt, W. , Au, Bi, and preferably a combination of oxygen and nitrogen.
  • a functionally graded inorganic resist can be obtained by continuously changing the composition ratio of each element described above with respect to the depth direction of the resist. As a result, the characteristics of the resist can be continuously inclined in the vertical direction (depth direction) of the resist, and the resolution of the resist can be improved.
  • a photosensitive resin composition resist may be used other than the functionally gradient type inorganic resist.
  • This photosensitive resin composition contains a polymer compound, a photopolymerizable compound, and a photopolymerization initiator, and as a specific polymer compound, patterning by exposure or before exposure failed.
  • a monomer having a carboxyl group in the side chain and acrylic It is preferable to copolymerize with a monomer.
  • the monomer having a carboxyl group in the side chain include acrylic acid, fumaric acid, cinnamic acid, crotonic acid, itaconic acid, citraconic acid, maleic anhydride, and maleic acid half ester.
  • a method for producing a functionally gradient inorganic resist using tungsten (W) and oxygen (O) will be described.
  • a quartz substrate is used as a base material, and a tungsten oxide film is formed on the quartz substrate by a reactive sputtering method using a general tungsten target, sputtering gas, and oxygen gas.
  • the oxygen concentration in the resist film that is, the composition ratio of tungsten (W) and oxygen (O) is continuously changed.
  • the oxygen partial pressure during film formation increases, the oxygen ratio in the film increases and the tungsten ratio in the film decreases.
  • the composition ratio (W: O) of the W / O-based inorganic resist is in the range of (4: 1) to (1: 2.5). This is because the functionally gradient inorganic resist can be formed on the quartz substrate while adjusting the film forming conditions so as to have an appropriate composition.
  • a quartz substrate (hereinafter also referred to as a resist substrate) on which a functionally gradient inorganic resist is formed is set on a stage of a blue laser drawing apparatus and drawing is performed.
  • drawing it is preferable to perform drawing while adjusting the focus on the resist by always controlling the height of the objective lens during laser irradiation of the resist. This is because the dimensional stability of the drawing pattern is excellent.
  • Drawing may be performed in accordance with the shape of the fine protrusions. For example, when drawing a straight line or a dot pattern on a flat substrate, a drawing apparatus including an XY stage is used.
  • a high-resolution resist substrate is set with high positional accuracy on a rotating stage, and drawing is performed in a rotated state to form a concentric pattern.
  • the resist drawing can be performed.
  • a resist substrate having a desired fine pattern (that is, a pattern reverse to the finally obtained fine protrusion structure) is obtained by exposing and developing the drawn resist substrate. After the development is completed, a pattern is formed on the resist as described above, and a fine pattern can be formed on the quartz substrate by performing etching using the resist as an etching mask. Thereafter, by performing resist removal, washing, and vapor drying with isopropyl alcohol, the master mold 100 in which a desired fine pattern is transferred to the quartz substrate can be produced.
  • a secondary mold and a tertiary mold are produced through a transfer molding process such as an optical nanoimprint method or a hot press method for the master mold 100 produced as described above. be able to.
  • the resin is cured by performing an exposure process after pressing the photocurable resin 101 against the master mold 100 described above. After this curing process, the resin is peeled off from the master mold 100 to produce a secondary mold (hereinafter also referred to as a resin mold 102).
  • the shape of the secondary mold is an inverted version of the master mold 100, that is, the shape of the upper surface of the intraocular observation lens 1 finally provided with fine protrusions.
  • Examples of the photo-curable resin 101 include a UV curable resin sheet.
  • a radical polymerizable fluororesin, a photopolymerization initiator having an absorption peak at a predetermined wavelength, and a resin containing a photocatalyst having photocatalytic activity can be used.
  • the resin is cured by performing a cooling process after heating and filling the thermoplastic resin 101 such as silicone or acrylic into the master mold 100 described above. After this curing process, the resin is peeled off from the master mold 100 to produce the resin mold 102.
  • the resin mold 102 produced by the above procedure may be similarly heated and filled with the thermoplastic resin 101, followed by a cooling treatment and curing to produce a tertiary mold.
  • This tertiary mold is an inverted version of the secondary mold, that is, has the same surface shape as the master mold 100, and has a plurality of recesses.
  • the material constituting the tertiary mold is preferably a material that can be transferred from the secondary mold without deterioration and damage of the shape, and that fine projections to be finally formed can be appropriately formed.
  • Ni mold manufacturing process As shown in FIG. 3D, the Ni mold 103 used as a part of the injection mold 105 is subjected to a nickel plating process on the resin mold 102 or the tertiary mold produced as described above. Can be produced.
  • the metal mold material include gold, silver, copper, palladium, platinum, rhodium, tin, and chromium.
  • Ni electroless plating is directly performed on the resin mold 102.
  • a Ni coating can be provided on the resin mold 102, and any of those usually used in Ni plating may be used. Examples thereof include nickel sulfate and sodium hypophosphite. In this way, the Ni mold 103 is formed on the resin mold 102 by electroless plating.
  • a release agent for releasing the Ni mold 103 may be applied on the resin mold 102, a release agent layer may be provided, and electroless Ni plating may be applied to the release agent layer.
  • the release agent preferably contains at least one compound selected from the group consisting of silicone resins and fluorine-containing compounds from the viewpoint of transferability.
  • Fluorine-containing compounds include amorphous fluororesins, copolymer oligomers containing perfluoroalkyl group-containing acrylates or methacrylates, fluorine-based coating agents, fluorine-based surface treatment agents containing electron beam or UV-curing components, and thermosetting components Preferred are fluorine-based surface treatment agents, fluorine-based surfactants, and the like.
  • the release agent is applied to the above-mentioned organic polymer film by using a known application method such as Mayer coating, gravure coating, doctor coating, or air knife coating, and then heat treatment or Examples thereof include a method of drying or curing by a known method suitable for a release agent such as ultraviolet irradiation.
  • the protruding direction of the fine protrusions of the intraocular observation lens 1 can be finally inclined as desired by the method described in the resin mold manufacturing process.
  • the fine pattern since the fine pattern is inclined, it may be difficult to release the Ni mold 103 from the resin mold 102. Therefore, in the Ni mold 103 sticking step described later, it is preferable to remove the resin mold 102 by dissolving the resin mold 102 with a chemical instead of releasing the resin mold 102.
  • the Ni mold may be produced by electrolytic plating using a Ni seed layer.
  • a Ni seed layer is formed on the resin mold 102 by vapor deposition / sputtering or the like.
  • the Ni mold 103 may be formed on the resin mold 102 by performing electrolytic Ni plating using the Ni seed layer as a plating electrode and forming a Ni layer so as to fill the resin mold 102.
  • the adhesive layer 104 is provided on the surface of the Ni mold 103 with the resin mold 102 on the Ni mold 103 side.
  • a resin mold 102 provided with the adhesive layer 104 is provided between a silicone pad 106 having a convex shape on the upper surface (hereinafter also simply referred to as a pad 106) and a cylindrical injection mold 105.
  • the Ni mold 103 is disposed (FIG. 3E).
  • the adhesive layer 104 side is disposed so as to face the injection mold 105 and the resin mold 102 side is opposed to the pad 106.
  • the injection mold 105 is made of, for example, a cylindrical copper alloy.
  • the injection molds 105 may be provided in a plurality of rows, and in that case, a plurality of pads 106 are preferably provided.
  • foil pressing can be performed simultaneously on the injection mold 105 in a plurality of rows or a plurality of columns per press of the pad 106, and the productivity of the foil stamping product is improved.
  • the pad 106 is specifically driven by an induction motor, but can be driven by another motor such as a servo motor or a pulse motor. The rotation of the induction motor is controlled by the control unit.
  • a heater (not shown) is incorporated in the pad 106, and the pad 106 is heated by this heater.
  • the heater may be disposed outside the pad 106 so as to follow the peripheral surface of the pad 106.
  • the pad 106 melts the adhesive layer 104 of the Ni mold 103 with the resin mold 102, and the heating temperature is about 200 ° C., for example. Note that the Ni mold 103 with the resin mold 102 may be preheated before the heating.
  • the preheating means is specifically a heating halogen lamp, heating wire, hot air, etc., and the preheating means is preferably arranged on each supply path of the injection mold 105 and the Ni mold 103 with the resin mold 102,
  • the preheating means may be opposed to the Ni mold 103 with the resin mold 102 or may be opposed to the adhesive layer 104 side.
  • the adhesive layer 104 of the Ni mold 103 with the resin mold 102 is softened to the extent that it can be transferred by heating by the preheating means on the Ni mold 103 side with the resin mold 102, and for injection molding by heating with a halogen lamp on the injection mold side.
  • the mold is also heated to the same temperature as the Ni mold 103 with the resin mold 102.
  • the heat-fusible adhesive of the Ni mold 103 with the resin mold 102 is melted in advance by preheating, and the injection mold is heated to be convenient for fusing the heat-fusible adhesive. It is preferable that it is attached to the upper surface of the injection mold.
  • the adhesive layer 104 may be any material that melts when heated and adheres to the injection mold 105 together with the Ni mold 103, but is preferably an inorganic adhesive made of an epoxy resin or an alloy.
  • an inorganic fusion agent in which a gold layer is provided on an alloy layer of tin and gold is preferable. When heat is applied to this inorganic fusing agent, the gold in the gold layer diffuses into the alloy layer, the composition ratio of Sn: Au changes, the melting point after bonding increases, and the mold heat resistance during injection molding improves. it can. This is particularly effective when the disposable intraocular observation lens 1 is mass-produced.
  • the pad 106 is heated, and the Ni mold 103 with the resin mold 102 is pressurized by the pad 106 in a heated state.
  • the pad 106 is separated from the pressurizing portion, the injection mold 105 and the Ni mold 103 with the resin mold 102 are separated from each other.
  • only the Ni mold 103 is transferred from the Ni mold 103 with the resin mold 102 to the upper surface of the injection mold 105 in the same shape as the pad 106 as shown in FIG.
  • the case where the upper surface of the injection mold 105 is a horizontal surface has been described, but it may be a concave surface or a convex surface. Furthermore, an inclined surface may be sufficient. In the case of the concave surface, the fine structure may not be oriented in a certain direction, but even in this case, sufficient antifogging properties and low reflection can be realized. In order to reduce the thickness of the Ni mold 103 and reduce the internal stress as much as possible, it is preferable to accurately place the Ni mold 103 on the injection mold 105.
  • the adhesive layer 104 may be provided on the injection mold 105. Further, the Ni mold 103 from which the resin mold 102 is removed may be attached on the adhesive layer 104 after the adhesive layer 104 is provided on the injection mold 105.
  • the injection mold 105 with the Ni mold 103 provided with the concave portions for fine projections and the lens body mold 108 (hereinafter simply referred to as the mold).
  • the molds 105 and 108 are attached to an injection molding machine, and a thermoplastic resin (PMMA in this embodiment) having fluidity at high temperature is injected into the gap.
  • the mold 108 is provided with a portion for injecting a resin, that is, a mold resin injection portion. The thermoplastic resin is injected from this portion, and then cooled.
  • the pre-finishing intraocular observation lens 1 which is a molded product is taken out from the mold, and the gate part is cut and removed with a heated nipper to produce the intraocular observation lens 1.
  • the following effects are obtained.
  • the intraocular observation having excellent antifogging properties despite having hydrophobicity since the fine projections are provided on the upper surface 11 of the lens.
  • Lens 1 can be obtained. Therefore, the scattering on the lens surface is reduced, and the surgeon can clearly observe the fundus image without being bothered by scattered light with strong extraocular irradiation such as slit light attached to the surgical microscope. This eliminates the need for the operator to have intraocular illumination in one hand during vitreous surgery, so that intraocular treatment can be performed with both hands, and surgery with less stress can be performed.
  • the condensing lens or the quartz substrate is moved, the laser is irradiated with the laser focused on the quartz substrate surface, and a non-through hole for fine projections on the lens surface is used. A certain recess is processed. Thereby, finally, a concave portion that becomes a fine protrusion on the surface of the intraocular observation lens 1 can be produced.
  • the position of the condenser lens and the surface of the quartz substrate are relatively moved so that the focal position of the laser coincides with the bottom of the recess, or Processing may be performed by irradiating the laser again using a condensing lens having a different focal length, fixed to the bottom of the recess.
  • Processing may be performed by irradiating the laser again using a condensing lens having a different focal length, fixed to the bottom of the recess.
  • Embodiment 3 apart from the method of Embodiment 1 in which the lens upper surface 11 is parallel to the tangent plane of the lens lower surface 12 to the cornea 20, the lens upper surface 11 is concave or convex.
  • a method for manufacturing the intraocular observation lens 1 in the case of having the above will be described.
  • the process from the master mold 100 manufacturing process to the Ni mold 103 manufacturing process is performed in the same manner as in the first embodiment.
  • the Ni mold 103 attaching step when the lens upper surface 11 has a concave surface, a convex injection mold 105 is prepared. Then, by performing the same operation as the Ni mold 103 attaching step of Embodiment 1, the convex injection mold 105 with the Ni mold 103 is produced.
  • the injection mold 105 is a convex mold, when the Ni mold 103 is pasted, there is a possibility that the fine projections spread radially along the convex surface. However, even if the fine protrusions do not face in one direction, low light reflectivity and antifogging properties can be obtained.
  • a concave injection mold 105 is prepared and the same Ni mold 103 attaching step is performed. Also in the intraocular observation lens 1 obtained in this way, the low light reflectivity equivalent to the case where the lens upper surface 11 is concave and the lens upper surface 11 is parallel to the tangential plane of the lens lower surface 12 to the cornea 20. And anti-fogging property can be obtained.
  • the mold is arranged so that the extraction direction of the intraocular observation lens 1 is parallel to the protruding direction of the fine protrusions after injection molding. That's fine.
  • a resin for transferring the fine pattern of the resin mold 102 is applied on the amorphous carbon 107 (FIG. 4B).
  • This resin is preferably the photocurable resin 101 as described above when using the optical nanoimprint, and is preferably the thermoplastic resin 101 as described above when using the thermal nanoimprint.
  • the fine pattern of the resin mold 102 is transferred to this resin, and light irradiation or heat treatment is performed (FIG. 4C). Thereafter, the resin mold 102 is removed, and a fine pattern made of resin is provided on the amorphous carbon 107 (FIG. 4D).
  • the amorphous carbon 107 is dry-etched to form a fine pattern on the amorphous carbon 107 (FIG. 4E). Finally, the resin is removed to produce an injection mold 105 (FIG. 4 (f)).
  • the method for producing the planar master mold 100 has been described. However, separately from the method, the master mold 100 has a cylindrical shape in which a fine pattern is provided on the outer side surface or a hollow cylindrical shape inside. A method of manufacturing the will be described. In the present embodiment, a cylindrical master mold 100 having a hollow inside will be described.
  • a cylindrical aluminum (Al) base material is prepared, and a concave portion having a fine pattern is formed on the cylindrical base material by the method of the first or third embodiment.
  • the fine pattern may be formed by using an anodic oxidation method, whereby a fine oxide film may be formed on the Al surface, and the oxide film may be partially dissolved by an electrolytic solution to form a fine pattern.
  • the cylindrical master mold 100 is provided with not only one intraocular observation lens 1 but also a plurality of fine patterns.
  • a cylindrical or columnar quartz base material may be prepared, and a concave portion that becomes a fine pattern may be formed on the cylindrical quartz base material by the method of the first or third embodiment.
  • the photocurable resin 101 is conveyed between the pressing roller adjacent to the cylindrical master mold 100 and the cylindrical master mold 100. To do. Then, the photocurable resin 101 is directly pressed onto the cylindrical master mold 100 by this pressing roller to transfer the fine pattern onto the photocurable resin 101.
  • the resin molds 102 for a plurality of intraocular observation lenses 1 can be preferably produced. Thereafter, the Ni-plating is performed on the resin mold 102 for a plurality of intraocular observation lenses as they are, and then affixed to the upper surface of the injection mold 105 for each minute pattern of the intraocular observation lens 1. May be performed.
  • the resin mold 102 is cut out for each one of the intraocular observation lenses 1, Ni plating may be performed on each resin mold 102.
  • the intraocular observation lens 1 is produced by the same method as in the first to fourth embodiments. By this method, the resin mold 102 can be produced in a larger amount at a time than the step and repeat method, and the Ni mold 103 and the intraocular observation lens 1 can be efficiently produced.
  • the present invention is applied to the intraocular observation lens.
  • the present invention may be applied.
  • it may be applied to a contact lens, a spectacle lens, an intraocular lens, or the like, or may be a substance other than a lens.
  • the present invention can be applied to cases where irregular reflection due to water droplets occurs when an operator looks at the lens from the outside, such as an intraocular observation lens, and the reverse case, that is, a spectacle lens or contact from the wearer side. It can also be applied to cases where irregular reflection due to water droplets occurs when looking at a lens or the like.
  • the configuration is as follows.
  • the lens is made of a polymer material containing a hydrophobic polymer, and the lens upper surface or lower surface is hydrophobic.
  • An example thereof is a lens having a fine protrusion having a pitch of 180 nm or less.
  • the inorganic resist was formed by ion beam sputtering, and the oxygen concentration in the inorganic resist was inclined by continuously changing the oxygen concentration during film formation. Further, Rutherford Back Scattering Spectroscopy (RBS) was used for composition analysis in the inorganic resist.
  • a fine pattern was drawn on this inorganic resist using a blue laser drawing apparatus (wavelength 405 nm, output 12 mW). After drawing, an etching process and a cleaning process were performed to produce a master mold 100 provided with a pattern opposite to the desired transfer pattern.
  • a resin mold 102 having a transfer pattern was produced.
  • Optical imprinting was adopted for the production of the resin mold 102.
  • a 50 ⁇ m PET film coated with a photopolymerization agent and a photocatalyst was pressed against the master mold 100 and exposed to ultraviolet rays.
  • the conditions were a UV irradiation output of 1500 mJ and a transfer pressure of 0.3 MPa.
  • the composition of the plating solution used for non-electrolytic Ni plating is nickel sulfate 20 g / L, sodium hypophosphite 25 g / L, the temperature of the solution is 80 ° C., the pH value of the solution is 4.5, and the catalyst Palladium was used for.
  • an adhesive layer 104 made of an epoxy resin was provided on an injection mold 105 (diameter 13 mm, height 20 mm) made of a cylindrical copper alloy.
  • a pad 106 heated to 200 ° C. is placed above the injection mold 105 with the adhesive layer 104, and the Ni mold 103 and the resin mold 102 are integrated between the injection mold 105 and the pad 106. Arranged what became.
  • the injection mold 105 and the pad 106 were pressed together with the Ni mold 103 and the resin mold 102, and only the Ni mold 103 was pressed onto the upper surface of the injection mold 105.
  • the injection mold 105 is arranged so that the curved surface of the injection mold 105 to which the Ni mold 103 is attached corresponds to the upper surface of the intraocular observation lens 1, and for the lens body 10 portion.
  • the gap for the intraocular observation lens 1 was produced by installing the above mold. Then, PMMA was injected into the gap and then cooled.
  • the intraocular observation lens 1 according to this example was produced by such an injection molding method.
  • the surface reflectance of the master mold 100 used in this example was measured. The result is shown in FIG. In this measurement, Olympus USPM-RU was used, and the measurement was performed at an incident angle of 90 ° and a spot diameter of 40 ⁇ m. As shown in FIG. 5, when the pitch of the fine protrusions is 130 nm and the depth of the fine protrusions is 270 nm, a reflectance of 0.3% or less can be achieved.
  • FIGS. 6A to 6D show the state of light diffraction when a fine projection pattern (concave pattern on a quartz substrate) having a pitch of 130 to 180 nm is provided on a disk-shaped quartz substrate.
  • E shows the state of light diffraction in the case where a pattern for fine projections (concave) having a pitch of 300 nm is provided on a disk-shaped quartz substrate.
  • FIG. 6 shows that light reflection hardly occurs in FIG. 6A in which a pattern for fine protrusions with a pitch of 130 nm is provided, whereas a pattern for fine protrusion with a pitch of 300 nm is provided. In (e), light reflection occurred clearly.

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  • Biomedical Technology (AREA)
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  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Surface Treatment Of Optical Elements (AREA)
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  • Moulds For Moulding Plastics Or The Like (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne une lentille pour observation intraoculaire (1) comportant un corps principal de lentille (10), une surface inférieure de lentille (12) qui est maintenue sur une cornée (20), et une surface supérieure de lentille (11) pour l'observation intraoculaire à travers la surface inférieure de lentille (12) et le corps principal de lentille (10). La lentille pour observation intraoculaire (1) est formée à partir d'un matériau de poids moléculaire élevé contenant un polymère hydrophobe, et la surface supérieure de lentille (11) est hydrophobe et dotée de fines protubérances avec un pas égal ou inférieur à 180 nm.
PCT/JP2011/051547 2010-01-29 2011-01-27 Lentille pour observation intraoculaire et son procédé de production Ceased WO2011093355A1 (fr)

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JP2010-019660 2010-08-11

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JP2016502920A (ja) * 2013-01-15 2016-02-01 ノバルティス アーゲー 微細構造化遠位面を有するマルチスポットレーザプローブ
JP2016503691A (ja) * 2013-01-08 2016-02-08 ノバルティス アーゲー 微細構造化ファセット近位面を有するマルチスポットレーザプローブ

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JP6732372B2 (ja) * 2016-03-28 2020-07-29 株式会社吉野工業所 樹脂製射出成形品及びその製造方法
JP6799932B2 (ja) * 2016-03-28 2020-12-16 株式会社トプコン 手術顕微鏡用光学素子および医療用光学機器
JP6932341B2 (ja) * 2017-04-27 2021-09-08 トヨタ車体株式会社 車両部品、及びその製造方法
CN110945388A (zh) * 2017-07-26 2020-03-31 太平洋灯光全息图公司 防眩光的阳极氧化铝表面
JPWO2020045668A1 (ja) * 2018-08-31 2021-04-30 株式会社 東北テクノアーチ 成形型及びレンズ
JP7724249B2 (ja) * 2023-03-24 2025-08-15 コネクテックジャパン株式会社 インプリント用マスターモールドの作製方法

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JP2009519149A (ja) * 2005-12-15 2009-05-14 エシロール アテルナジオナール カンパニー ジェネラーレ デ オプティック 超高疎水性膜で被覆された物品およびその取得方法

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JP2003275230A (ja) * 2002-03-22 2003-09-30 Mitsubishi Chemicals Corp 眼内レンズ及びその製造方法
WO2006038501A1 (fr) * 2004-10-01 2006-04-13 Hoya Corporation Lentille pour observation intraoculaire et lentille de contact pour opération vitreuse
JP2009519149A (ja) * 2005-12-15 2009-05-14 エシロール アテルナジオナール カンパニー ジェネラーレ デ オプティック 超高疎水性膜で被覆された物品およびその取得方法
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JP2016503691A (ja) * 2013-01-08 2016-02-08 ノバルティス アーゲー 微細構造化ファセット近位面を有するマルチスポットレーザプローブ
JP2016502920A (ja) * 2013-01-15 2016-02-01 ノバルティス アーゲー 微細構造化遠位面を有するマルチスポットレーザプローブ
JP2015530298A (ja) * 2013-03-14 2015-10-15 エスデイシー テクノロジーズ、インコーポレイテッド 防曇性のナノ織目加工された表面及び同表面を含有する物品
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