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WO2011087995A3 - Nitro - imidazo - oxazine derivatives and their use in the treatment of mycobacterial infections - Google Patents

Nitro - imidazo - oxazine derivatives and their use in the treatment of mycobacterial infections Download PDF

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Publication number
WO2011087995A3
WO2011087995A3 PCT/US2011/020724 US2011020724W WO2011087995A3 WO 2011087995 A3 WO2011087995 A3 WO 2011087995A3 US 2011020724 W US2011020724 W US 2011020724W WO 2011087995 A3 WO2011087995 A3 WO 2011087995A3
Authority
WO
WIPO (PCT)
Prior art keywords
mycobacterium
treatment
mycobacterial infections
imidazo
trypanosoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/020724
Other languages
French (fr)
Other versions
WO2011087995A2 (en
Inventor
Clifton Barry
Joseph Cherian
Inhee Choi
Thomas Keller
Ujjini Manjunatha
Amit Nayyar
Hwan Ha Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2011087995A2 publication Critical patent/WO2011087995A2/en
Anticipated expiration legal-status Critical
Publication of WO2011087995A3 publication Critical patent/WO2011087995A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention provides 6,7-dihydro-imidazo-oxazine derivatives which are useful in the treatment of mycobacterial infections, pharmaceutical compositions containing the compounds, processes for their preparation, and uses of the compounds in various medicinal applications, such as the treatment or prevention of mycobacterial infections, such as those caused by Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium leprae, Mycobacterium africanum, Mycobacterium avium, Mycobacterium microti, or any mycobacterium that causes multi-drug resistant (MDR) TB or extensively resistant (XDR) TB, or any other mycobacterial species known to cause disease in humans; or the treatment or prevention of parasitic diseases, such as those caused by a parasite of the genus Trypanosoma, e.g. Trypanosoma cruzi or Trypanosoma brucei or a parasite of the genus Leishmania which causes visceral leishmaniasis or kala-azar, e.g., Leishmania donovani.
PCT/US2011/020724 2010-01-13 2011-01-11 Organic compounds Ceased WO2011087995A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29463410P 2010-01-13 2010-01-13
US61/294,634 2010-01-13

Publications (2)

Publication Number Publication Date
WO2011087995A2 WO2011087995A2 (en) 2011-07-21
WO2011087995A3 true WO2011087995A3 (en) 2013-03-21

Family

ID=44304922

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/020724 Ceased WO2011087995A2 (en) 2010-01-13 2011-01-11 Organic compounds

Country Status (1)

Country Link
WO (1) WO2011087995A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10227362B2 (en) 2015-01-29 2019-03-12 Medshine Discovery Inc. Anti-pulmonary tuberculosis nitroimidazole derivative

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104059082B (en) * 2013-03-21 2016-08-03 苏州迈泰生物技术有限公司 Nitroimidazole heterocycle compound and the application in preparation treatment tubercular drugs thereof
KR101682356B1 (en) * 2014-11-04 2016-12-06 한국화학연구원 Imidazo oxazine derivatives, pharmaceutically acceptable salts thereof or optical isomer thereof and pharmaceutical composition containing the same as an active ingredient
CN105732659B (en) * 2014-12-12 2019-07-16 上海阳帆医药科技有限公司 Nitro glyoxaline compound and preparation method thereof and the purposes in pharmacy

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087358A (en) * 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
WO2007075872A2 (en) * 2005-12-23 2007-07-05 Novartis Ag Nitroimidazole compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087358A (en) * 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
WO2007075872A2 (en) * 2005-12-23 2007-07-05 Novartis Ag Nitroimidazole compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LI ET AL: "Synthesis and antitubercular activity of 7-(R)- and 7-(S)-methyl-2-nitro-6-(S)-(4-(trifluoromethoxy)benzyloxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazines, analogues of PA-824", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 18, no. 7, 7 March 2008 (2008-03-07), pages 2256 - 2262, XP022574941, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2008.03.011 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10227362B2 (en) 2015-01-29 2019-03-12 Medshine Discovery Inc. Anti-pulmonary tuberculosis nitroimidazole derivative

Also Published As

Publication number Publication date
WO2011087995A2 (en) 2011-07-21

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