[go: up one dir, main page]

WO2011080050A3 - Ccl21 binding molecules - Google Patents

Ccl21 binding molecules Download PDF

Info

Publication number
WO2011080050A3
WO2011080050A3 PCT/EP2010/069430 EP2010069430W WO2011080050A3 WO 2011080050 A3 WO2011080050 A3 WO 2011080050A3 EP 2010069430 W EP2010069430 W EP 2010069430W WO 2011080050 A3 WO2011080050 A3 WO 2011080050A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding molecules
ccl21
treatment
methods
ccl21 binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/069430
Other languages
French (fr)
Other versions
WO2011080050A2 (en
Inventor
Michael Bardroff
Stefan Ewert
Ute Jaeger
Gabor Jarai
Christian Carsten Silvester Kunz
Katja Wiesehan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of WO2011080050A2 publication Critical patent/WO2011080050A2/en
Publication of WO2011080050A3 publication Critical patent/WO2011080050A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to binding molecules, in particular antibodies and immunoglobulins to human CCL21 (hCCL21) and their use in the treatment and/or prevention of human diseases and disorders, particularly those of a fibrotic nature. Pharmaceutical compositions, methods of manufacture and methods of treatment are also disclosed.
PCT/EP2010/069430 2009-12-11 2010-12-10 Binding molecules Ceased WO2011080050A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US28563409P 2009-12-11 2009-12-11
US28563209P 2009-12-11 2009-12-11
US61/285,634 2009-12-11
US61/285,632 2009-12-11

Publications (2)

Publication Number Publication Date
WO2011080050A2 WO2011080050A2 (en) 2011-07-07
WO2011080050A3 true WO2011080050A3 (en) 2011-08-25

Family

ID=44121666

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/069430 Ceased WO2011080050A2 (en) 2009-12-11 2010-12-10 Binding molecules

Country Status (1)

Country Link
WO (1) WO2011080050A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2950527A1 (en) 2014-06-03 2015-12-10 Novartis Ag Pulmonary hypertension biomarker
US20240018228A1 (en) * 2020-08-28 2024-01-18 Board Of Regents, The University Of Texas System Antibodies specific to ccl21 and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075592A2 (en) * 2005-12-23 2007-07-05 The Regents Of The University Of Michigan Materials and methods for treating chronic fibrotic disease

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD266710A3 (en) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Process for the biotechnical production of alkaline phosphatase
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
FR2646437B1 (en) 1989-04-28 1991-08-30 Transgene Sa NOVEL DNA SEQUENCES, THEIR APPLICATION AS A SEQUENCE ENCODING A SIGNAL PEPTIDE FOR THE SECRETION OF MATURE PROTEINS BY RECOMBINANT YEASTS, EXPRESSION CASSETTES, PROCESSED YEASTS AND PROCESS FOR PREPARING THE SAME
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE69229477T2 (en) 1991-09-23 1999-12-09 Cambridge Antibody Technology Ltd., Melbourn Methods for the production of humanized antibodies
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
GB9203459D0 (en) 1992-02-19 1992-04-08 Scotgen Ltd Antibodies with germ-line variable regions
DE69308573T2 (en) 1992-08-17 1997-08-07 Genentech Inc SPECIFIC IMMUNOADHESINE
ATE183513T1 (en) 1993-06-03 1999-09-15 Therapeutic Antibodies Inc PREPARATION OF ANTIBODY FRAGMENTS
SE9400088D0 (en) 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
DE19742706B4 (en) 1997-09-26 2013-07-25 Pieris Proteolab Ag lipocalin muteins
GB9806530D0 (en) 1998-03-26 1998-05-27 Glaxo Group Ltd Inflammatory mediator
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
US6818418B1 (en) 1998-12-10 2004-11-16 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
DE19932688B4 (en) 1999-07-13 2009-10-08 Scil Proteins Gmbh Design of beta-sheet proteins of gamma-II-crystalline antibody-like
US20050048512A1 (en) 2001-04-26 2005-03-03 Avidia Research Institute Combinatorial libraries of monomer domains
US20050053973A1 (en) 2001-04-26 2005-03-10 Avidia Research Institute Novel proteins with targeted binding
US20040175756A1 (en) 2001-04-26 2004-09-09 Avidia Research Institute Methods for using combinatorial libraries of monomer domains
GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
DE10324447A1 (en) 2003-05-28 2004-12-30 Scil Proteins Gmbh Generation of artificial binding proteins based on ubiquitin
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007075592A2 (en) * 2005-12-23 2007-07-05 The Regents Of The University Of Michigan Materials and methods for treating chronic fibrotic disease

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
LITTLE M ET AL: "Of mice and men: hybridoma and recombinant antibodies", IMMUNOLOGY TODAY, ELSEVIER PUBLICATIONS, CAMBRIDGE, GB, vol. 21, no. 8, 1 August 2000 (2000-08-01), pages 364 - 370, XP004215163, ISSN: 0167-5699, DOI: DOI:10.1016/S0167-5699(00)01668-6 *
MOXLEY R ET AL: "Cloning and pharmacological characterization of CCR7, CCL21 and CCL19 from Macaca fascicularis", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER, AMSTERDAM, NL, vol. 37, no. 3-4, 28 June 2009 (2009-06-28), pages 264 - 271, XP026160252, ISSN: 0928-0987, [retrieved on 20090306], DOI: DOI:10.1016/J.EJPS.2009.02.013 *
NAGIRA M ET AL: "MOLECULAR CLONING OF A NOVEL HUMAN CC CHEMOKINE SECONDARY LYMPHOID-TISSUE CHEMOKINE THAT IS A POTENT CHEMOATTRACTANT FOR LYMPHOCYTES AND MAPPED TO CHROMOSOME 9P13", JOURNAL OF BIOLOGICAL CHEMISTRY, THE AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, INC., BALTIMORE, MD, US, vol. 272, no. 31, 1 August 1997 (1997-08-01), pages 19518 - 19524, XP002937425, ISSN: 0021-9258, DOI: DOI:10.1074/JBC.272.31.19518 *
SAEKI H ET AL: "Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 MAR 1999 LNKD- PUBMED:10072485, vol. 162, no. 5, 1 March 1999 (1999-03-01), pages 2472 - 2475, XP009149791, ISSN: 0022-1767 *
SHIELDS J D ET AL: "Chemokine-mediated migration of melanoma cells towards lymphatics--a mechanism contributing to metastasis.", ONCOGENE 10 MAY 2007 LNKD- PUBMED:17130836, vol. 26, no. 21, 10 May 2007 (2007-05-10), pages 2997 - 3005, XP009149792, ISSN: 0950-9232 *
SKERRA ET AL: "Alternative non-antibody scaffolds for molecular recognition", CURRENT OPINION IN BIOTECHNOLOGY, LONDON, GB, vol. 18, no. 4, 14 September 2007 (2007-09-14), pages 295 - 304, XP022244962, ISSN: 0958-1669, DOI: DOI:10.1016/J.COPBIO.2007.04.010 *
WADA T ET AL: "Fibrocytes: a new insight into kidney fibrosis", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 72, no. 3, 1 August 2007 (2007-08-01), pages 269 - 273, XP009149767, ISSN: 0085-2538 *
WILEY HENRY E ET AL: "Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma", JOURNAL OF THE NATIONAL CANCER INSTITUTE, OXFORD UNIVERSITY PRESS, GB, vol. 93, no. 21, 1 January 2000 (2000-01-01), pages 1638 - 1643, XP009149768, ISSN: 0027-8874 *

Also Published As

Publication number Publication date
WO2011080050A2 (en) 2011-07-07

Similar Documents

Publication Publication Date Title
WO2011050262A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2011059755A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2011047262A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2011014659A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2010127284A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2011028811A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2011163478A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2010127294A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2009149189A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2009134776A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2009149185A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2009126688A3 (en) Novel compositions and methods for the treatment of immune related diseases
WO2010006060A3 (en) Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
EP2373692A4 (en) Dual variable domain immunoglobulins and uses thereof
WO2012018790A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2012061558A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2012027570A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2012061374A3 (en) Dual variable domain immunoglobulins and uses thereof
EP2921177A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2013101972A3 (en) Dual variable domain immunoglobulins and uses thereof
WO2012088290A3 (en) Tri-variable domain binding proteins and uses thereof
WO2010032059A3 (en) Antibodies directed to cd105 and uses thereof
WO2013102042A3 (en) Dual variable domain immunoglobulins against il-13 and/or il-17
WO2012007880A3 (en) Modified single domain antigen binding molecules and uses thereof
WO2010135521A3 (en) Compositions and methods for the therapy and diagnosis of influenza

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10818130

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10818130

Country of ref document: EP

Kind code of ref document: A2