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WO2011071799A3 - Purification de la bivalirudine - Google Patents

Purification de la bivalirudine Download PDF

Info

Publication number
WO2011071799A3
WO2011071799A3 PCT/US2010/059045 US2010059045W WO2011071799A3 WO 2011071799 A3 WO2011071799 A3 WO 2011071799A3 US 2010059045 W US2010059045 W US 2010059045W WO 2011071799 A3 WO2011071799 A3 WO 2011071799A3
Authority
WO
WIPO (PCT)
Prior art keywords
bivalirudin
purification
processes
substantially pure
pure bivalirudin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/059045
Other languages
English (en)
Other versions
WO2011071799A2 (fr
Inventor
Pratap Reddy Padi
Santhana Krishnan Srinivasan
Venugopal Rao Dama
Basanthi Devi
Chakravarthula Kalyan Narasimham Nalla
Ramesh Bochha
Parameswara Reddy Koche
Yagna Kiran Kumar Komaravolu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Dr Reddys Laboratories Inc
Original Assignee
Dr Reddys Laboratories Ltd
Dr Reddys Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd, Dr Reddys Laboratories Inc filed Critical Dr Reddys Laboratories Ltd
Publication of WO2011071799A2 publication Critical patent/WO2011071799A2/fr
Publication of WO2011071799A3 publication Critical patent/WO2011071799A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des procédés de purification de la bivalirudine. L'invention concerne également la bivalirudine essentiellement pure.
PCT/US2010/059045 2009-12-11 2010-12-06 Purification de la bivalirudine Ceased WO2011071799A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN3077CH2009 2009-12-11
IN3077/CHE/2009 2009-12-11
US31286510P 2010-03-11 2010-03-11
US61/312,865 2010-03-11

Publications (2)

Publication Number Publication Date
WO2011071799A2 WO2011071799A2 (fr) 2011-06-16
WO2011071799A3 true WO2011071799A3 (fr) 2011-10-27

Family

ID=44146122

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/059045 Ceased WO2011071799A2 (fr) 2009-12-11 2010-12-06 Purification de la bivalirudine

Country Status (1)

Country Link
WO (1) WO2011071799A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1737889B1 (fr) 2004-10-19 2010-09-08 Lonza AG Procede de synthese de peptides en phase solide
CN104877024B (zh) * 2015-06-29 2018-09-18 海南中和药业股份有限公司 一种比伐芦定原料药的纯化工艺
CN114965458B (zh) * 2022-06-09 2024-12-31 昆明龙津药业股份有限公司 一种比伐芦定原料药及其制剂的质量检测方法
CN116087389B (zh) * 2022-12-28 2023-11-10 江苏诺泰澳赛诺生物制药股份有限公司 一种注射用比伐芦定有关物质的hplc测定方法
CN117088966A (zh) * 2022-12-29 2023-11-21 江苏诺泰澳赛诺生物制药股份有限公司 一种比伐芦定杂质的合成方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070093423A1 (en) * 2005-09-14 2007-04-26 Avi Tovi Process for production of Bivalirudin
US20080051558A1 (en) * 2006-03-10 2008-02-28 Yiming Zhou Method of preparing bivalirudin
US20080287650A1 (en) * 2007-03-01 2008-11-20 Avi Tovi High purity peptides
US20090062511A1 (en) * 2007-09-05 2009-03-05 Raghavendracharyulu Venkata Palle Process for the preparation of bivalirudin and its pharmaceutical compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070093423A1 (en) * 2005-09-14 2007-04-26 Avi Tovi Process for production of Bivalirudin
US20080051558A1 (en) * 2006-03-10 2008-02-28 Yiming Zhou Method of preparing bivalirudin
US20080287650A1 (en) * 2007-03-01 2008-11-20 Avi Tovi High purity peptides
US20090062511A1 (en) * 2007-09-05 2009-03-05 Raghavendracharyulu Venkata Palle Process for the preparation of bivalirudin and its pharmaceutical compositions

Also Published As

Publication number Publication date
WO2011071799A2 (fr) 2011-06-16

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