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WO2011071280A3 - Liant peptidique bipode à ciblage intracellulaire - Google Patents

Liant peptidique bipode à ciblage intracellulaire Download PDF

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Publication number
WO2011071280A3
WO2011071280A3 PCT/KR2010/008646 KR2010008646W WO2011071280A3 WO 2011071280 A3 WO2011071280 A3 WO 2011071280A3 KR 2010008646 W KR2010008646 W KR 2010008646W WO 2011071280 A3 WO2011071280 A3 WO 2011071280A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptide binder
bipodal peptide
bonded
target
region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2010/008646
Other languages
English (en)
Korean (ko)
Other versions
WO2011071280A9 (fr
WO2011071280A2 (fr
Inventor
전상용
김성현
김대진
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gwangju Institute of Science and Technology
Original Assignee
Gwangju Institute of Science and Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gwangju Institute of Science and Technology filed Critical Gwangju Institute of Science and Technology
Priority to KR1020127015777A priority Critical patent/KR20120125455A/ko
Priority to JP2012543021A priority patent/JP5677454B2/ja
Priority to US13/515,026 priority patent/US20120309934A1/en
Publication of WO2011071280A2 publication Critical patent/WO2011071280A2/fr
Publication of WO2011071280A9 publication Critical patent/WO2011071280A9/fr
Publication of WO2011071280A3 publication Critical patent/WO2011071280A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un liant peptidique bipode pouvant se lier spécifiquement avec une molécule cible intracellulaire, et un procédé d'élaboration de ce liant qui comprend: (a) une zone de stabilisation de structure à brins d'acides aminés parallèles, antiparallèles ou parallèles et antiparallèles dans lesquels sont formées des liaisons inter-brin non covalentes; (b) une zone de liaison de cible I et une zone de liaison de cible II liées aux deux terminaisons de la zone de stabilisation de structure et comprenant n et m acides aminés sélectionnés de façon aléatoire, respectivement; et (c) un peptide de pénétration cellulaire lié à ladite zone de stabilisation de structure ou à la zone de liaison de cible. Le liant selon l'invention peut se lier spécifiquement à une molécule cible intracellulaire pour des applications médicales, d'imagerie moléculaire in vivo, d'imagerie cellulaire in vitro, et de ciblage d'administration de médicament, et il peut être très utile comme molécule escorte.
PCT/KR2010/008646 2009-12-11 2010-12-03 Liant peptidique bipode à ciblage intracellulaire Ceased WO2011071280A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR1020127015777A KR20120125455A (ko) 2009-12-11 2010-12-03 세포내 타겟 결합용 바이포달 펩타이드 바인더
JP2012543021A JP5677454B2 (ja) 2009-12-11 2010-12-03 細胞内ターゲット結合用二座ペプチドバインダー
US13/515,026 US20120309934A1 (en) 2009-12-11 2010-12-03 Intracelluar targeting bipodal peptide binder

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090123134 2009-12-11
KR10-2009-0123134 2009-12-11

Publications (3)

Publication Number Publication Date
WO2011071280A2 WO2011071280A2 (fr) 2011-06-16
WO2011071280A9 WO2011071280A9 (fr) 2011-08-25
WO2011071280A3 true WO2011071280A3 (fr) 2011-11-10

Family

ID=44146029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/008646 Ceased WO2011071280A2 (fr) 2009-12-11 2010-12-03 Liant peptidique bipode à ciblage intracellulaire

Country Status (4)

Country Link
US (1) US20120309934A1 (fr)
JP (1) JP5677454B2 (fr)
KR (1) KR20120125455A (fr)
WO (1) WO2011071280A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009307249B2 (en) 2008-10-20 2012-11-01 Gwangju Institute Of Science And Technology Bipodal peptide binder
KR101323846B1 (ko) * 2011-04-08 2013-10-31 광주과학기술원 타겟 친화도가 유지되고 안정성이 개선된 ｄ－앱타이드
WO2013061818A1 (fr) * 2011-10-25 2013-05-02 国立大学法人岡山大学 Nouveau complexe peptidique et complexe hybride de celui-ci, et utilisation dudit complexe hybride
KR102092345B1 (ko) 2013-09-30 2020-03-24 삼성전자주식회사 류신 지퍼 변이체 및 이의 용도
KR101531944B1 (ko) * 2013-12-24 2015-06-29 광주과학기술원 Ｖｅｇｆ에 특이적으로 결합하는 ｖｅｇｆ－ｂｐｂ
KR20150118252A (ko) * 2014-04-11 2015-10-22 한국과학기술원 환형의 β-헤어핀 기반 펩타이드 바인더 및 이의 제조방법
KR102272213B1 (ko) 2014-07-08 2021-07-01 삼성전자주식회사 표적화 부위, 절단 부위, 및 세포막 투과 부위를 포함하는 융합 단백질 및 그의 용도
EA201991088A1 (ru) 2016-11-11 2019-10-31 Связывающие пептиды
KR101971092B1 (ko) * 2017-06-28 2019-04-23 한국세라믹기술원 아세틸콜린수용체 결합 펩타이드

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6180343B1 (en) * 1998-10-08 2001-01-30 Rigel Pharmaceuticals, Inc. Green fluorescent protein fusions with random peptides
JP2003502304A (ja) * 1999-06-14 2003-01-21 ジェネンテック・インコーポレーテッド ターンライブラリをファージ上に表示するための構造化ペプチド骨格
US20030166003A1 (en) * 1999-06-14 2003-09-04 Cochran Andrea G. Structured peptide scaffold for displaying turn libraries on phage
US20030103978A1 (en) * 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
US6914123B2 (en) * 2001-04-17 2005-07-05 Genentech, Inc. Hairpin peptides with a novel structural motif and methods relating thereto
US7994118B2 (en) * 2003-11-15 2011-08-09 Polyphor Ltd. Template fixed beta-hairpin loop mimetics and their use in phage display
CA2585927A1 (fr) * 2004-11-04 2006-05-18 Genentech, Inc. Polypeptides se liant avec baff et/ou april
AU2007272452A1 (en) * 2006-07-12 2008-01-17 Oncotx, Inc. Compositions and methods for targeting cancer-specific transcription complexes
JP2008200011A (ja) * 2007-02-22 2008-09-04 Toray Ind Inc 細胞内移行性ペプチド、それを含有する医薬組成物及びその使用方法
EP3443976A1 (fr) * 2007-06-29 2019-02-20 Sarepta Therapeutics, Inc. Conjugués peptidiques spécifiques d'un tissu et procédés

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEECHONGKIT, S. ET AL.: "Beta-sheet folding mechanisms from perturbation energetics.", CURRENT OPINION IN STRUCTURAL BIOLOGY., vol. 16, no. 1., February 2006 (2006-02-01), pages 94 - 101, XP024959916, DOI: doi:10.1016/j.sbi.2006.01.014 *
GANGULY, S. ET AL.: "Pharmacokinetic analysis of polyamide nucleic-acid-cell penetrating peptide conjugates targeted against HIV-1 transactivation response element.", OLIGONUCLEOTIDES., vol. 18, no. 3, September 2008 (2008-09-01), pages 277 - 86, XP002667828, DOI: doi:10.1089/OLI.2008.0140 *
ROBINSON, J. A. ET AL.: "Properties and structure-activity studies of cyclic beta-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I.", BIOORGANIC & MEDICINAL CHEMISTRY., vol. 13, no. 6, 15 March 2005 (2005-03-15), pages 2055 - 64 *
ROBINSON, J. A.: "Beta-hairpin peptidomimetics: design, structures and biological activities.", ACCOUNTS OF CHEMICAL RESEARCH., vol. 41, no. 10, October 2008 (2008-10-01), pages 1278 - 88, XP002667826, DOI: doi:10.1021/AR700259K *

Also Published As

Publication number Publication date
JP2013513382A (ja) 2013-04-22
JP5677454B2 (ja) 2015-02-25
KR20120125455A (ko) 2012-11-15
WO2011071280A9 (fr) 2011-08-25
US20120309934A1 (en) 2012-12-06
WO2011071280A2 (fr) 2011-06-16

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