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WO2011067348A3 - Sels d'inhibiteurs de mek et leurs solvates - Google Patents

Sels d'inhibiteurs de mek et leurs solvates Download PDF

Info

Publication number
WO2011067348A3
WO2011067348A3 PCT/EP2010/068763 EP2010068763W WO2011067348A3 WO 2011067348 A3 WO2011067348 A3 WO 2011067348A3 EP 2010068763 W EP2010068763 W EP 2010068763W WO 2011067348 A3 WO2011067348 A3 WO 2011067348A3
Authority
WO
WIPO (PCT)
Prior art keywords
solvates
mek inhibitor
indolizine
phenylamino
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/068763
Other languages
English (en)
Other versions
WO2011067348A2 (fr
Inventor
Liladhar Murlidhar Waykole
Piotr H. Karpinski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of WO2011067348A2 publication Critical patent/WO2011067348A2/fr
Publication of WO2011067348A3 publication Critical patent/WO2011067348A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention a pour objet des formes de sels de sodium du (2-hydroxyéthoxy)-amide de l'acide 7-(4-bromo-2-fluoro-phénylamino)-6-méthyl-5-oxo-1,3,5-tétrahydro- indolizine-8-carboxylique et du cyclopropylméthoxy-amide de l'acide 7-(4-bromo-2-fluoro-phénylamino)-5-oxo-1,2,3,5-tétrahydro-indolizine-8- carboxylique et leurs solvates et polymorphes correspondants, qui sont utiles dans le traitement d'une maladie, d'un trouble ou d'un syndrome associé à l'inhibition de MEK, tel qu'un cancer, chez les mammifères.
PCT/EP2010/068763 2009-12-03 2010-12-02 Sels d'inhibiteurs de mek et leurs solvates Ceased WO2011067348A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26641009P 2009-12-03 2009-12-03
US61/266,410 2009-12-03
US26684209P 2009-12-04 2009-12-04
US61/266,842 2009-12-04

Publications (2)

Publication Number Publication Date
WO2011067348A2 WO2011067348A2 (fr) 2011-06-09
WO2011067348A3 true WO2011067348A3 (fr) 2011-08-04

Family

ID=44009944

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/068763 Ceased WO2011067348A2 (fr) 2009-12-03 2010-12-02 Sels d'inhibiteurs de mek et leurs solvates

Country Status (1)

Country Link
WO (1) WO2011067348A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013109142A1 (fr) 2012-01-16 2013-07-25 Stichting Het Nederlands Kanker Instituut Inhibition de la voie des mapk/erk et pdk combinée dans des cas de néoplasie
WO2015041534A1 (fr) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut P90rsk en combinaison avec raf/erk/mek
US9629851B2 (en) 2013-09-20 2017-04-25 Stitching Het Nederlands Kanker Institut—Antoni Van Leeuwenhoek Ziekenhuis ROCK in combination with MAPK pathway
US20170027940A1 (en) 2014-04-10 2017-02-02 Stichting Het Nederlands Kanker Instituut Method for treating cancer
WO2015178770A1 (fr) 2014-05-19 2015-11-26 Stichting Het Nederlands Kanker Instituut Compositions pour le traitement du cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090275606A1 (en) * 2008-04-21 2009-11-05 Novartis Ag Heterocyclic Compounds as MEK Inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200626610A (en) 2004-10-13 2006-08-01 Wyeth Corp Analogs of 17-hydroxywortmannin as PI3K inhibitors
WO2006090169A1 (fr) 2005-02-25 2006-08-31 Kudos Pharmaceuticals Limited Derives de 2 , 4-diamino-pyridopyrimidine et leur utilisation comme inhibiteurs mtor
KR20070108916A (ko) 2005-02-25 2007-11-13 쿠도스 파마슈티칼스 리미티드 Ｍｔｏｒ 억제제로서 작용하는 하이드라지노메틸,하이드라조노메틸 및 5-원 복소환 화합물 및 이의항암제로서의 용도
WO2007060404A1 (fr) 2005-11-22 2007-05-31 Kudos Pharmaceuticals Limited Dérivés de pyrido-, pyrazo- et pyrimido-pyrimidine en tant qu'inhibiteurs de mtor
KR20080083188A (ko) 2006-01-11 2008-09-16 아스트라제네카 아베 모르폴리노 피리미딘 유도체 및 요법에서의 그 유도체의용도
HUE033894T2 (en) 2006-08-23 2018-01-29 Kudos Pharm Ltd 2-Methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as MTOR inhibitors
US8022057B2 (en) 2007-11-12 2011-09-20 Takeda Pharmaceutical Company Limited MAPK/ERK kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090275606A1 (en) * 2008-04-21 2009-11-05 Novartis Ag Heterocyclic Compounds as MEK Inhibitors

Also Published As

Publication number Publication date
WO2011067348A2 (fr) 2011-06-09

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