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WO2011053861A8 - Kinase inhibitors - Google Patents

Kinase inhibitors Download PDF

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Publication number
WO2011053861A8
WO2011053861A8 PCT/US2010/054853 US2010054853W WO2011053861A8 WO 2011053861 A8 WO2011053861 A8 WO 2011053861A8 US 2010054853 W US2010054853 W US 2010054853W WO 2011053861 A8 WO2011053861 A8 WO 2011053861A8
Authority
WO
WIPO (PCT)
Prior art keywords
provides
protein kinase
present
pyrido
pyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/054853
Other languages
French (fr)
Other versions
WO2011053861A1 (en
Inventor
Hong Woo Kim
Jong Sung Koh
Jaekyoo Lee
Ho-Juhn Song
Youngsam Kim
Hee Kyu Lee
Jang-Sik Choi
Sun-Hee Lim
Sunhwa Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oscotec Inc
Genosco
Original Assignee
Oscotec Inc
Genosco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43922599&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2011053861(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP10827573.6A priority Critical patent/EP2493313B1/en
Priority to ES10827573.6T priority patent/ES2658290T3/en
Priority to JP2012537147A priority patent/JP5993742B2/en
Priority to CN201080049613.4A priority patent/CN102695416B/en
Priority to BR112012010085A priority patent/BR112012010085B1/en
Priority to KR1020127011750A priority patent/KR101690358B1/en
Priority to AU2010313240A priority patent/AU2010313240B2/en
Application filed by Oscotec Inc, Genosco filed Critical Oscotec Inc
Priority to EA201290237A priority patent/EA029273B1/en
Priority to NZ599040A priority patent/NZ599040A/en
Priority to CA2779105A priority patent/CA2779105C/en
Priority to MX2012004846A priority patent/MX2012004846A/en
Publication of WO2011053861A1 publication Critical patent/WO2011053861A1/en
Publication of WO2011053861A8 publication Critical patent/WO2011053861A8/en
Priority to IL219447A priority patent/IL219447A/en
Anticipated expiration legal-status Critical
Priority to ZA2012/03842A priority patent/ZA201203842B/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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Abstract

The present invention provides a new group of protein kinase inhibitors, pyrido[4,3,-d]pyrimidin-5-one derivatives, and pharmaceutically acceptable salts thereof that are useful for intreating cell proliferative disease and disorder such as cancer, autoimmune diseases, infection, cardiovascular disease and neurodegenerative disease and disorder. The present invention provides methods for synthesizing and administering the protein kinase inhibitor compounds. The present invention also provides pharmaceutical formulations comprising at least one of the protein kinase inhibitor compounds together with a pharmaceutically acceptable carrier, diluent or excipient therefor. The invention also provides useful intermediates generated during the syntheses of the pyrido[4,3,-d]pyrimidin-5-one derivatives.
PCT/US2010/054853 2009-10-29 2010-10-29 Kinase inhibitors Ceased WO2011053861A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
MX2012004846A MX2012004846A (en) 2009-10-29 2010-10-29 Kinase inhibitors.
EA201290237A EA029273B1 (en) 2009-10-29 2010-10-29 Kinase inhibitors
JP2012537147A JP5993742B2 (en) 2009-10-29 2010-10-29 Kinase inhibitor
CN201080049613.4A CN102695416B (en) 2009-10-29 2010-10-29 Kinase inhibitor
BR112012010085A BR112012010085B1 (en) 2009-10-29 2010-10-29 compound, therapeutically effective amount of a compound, pharmaceutical formulation
KR1020127011750A KR101690358B1 (en) 2009-10-29 2010-10-29 Kinase inhibitors
AU2010313240A AU2010313240B2 (en) 2009-10-29 2010-10-29 Kinase inhibitors
EP10827573.6A EP2493313B1 (en) 2009-10-29 2010-10-29 Kinase inhibitors
NZ599040A NZ599040A (en) 2009-10-29 2010-10-29 2,4-disubstituted pyrido[4,3-d]pyrimidin-5(6h)-one compounds for selective inhibitors of lrrk2 and syk kinases
CA2779105A CA2779105C (en) 2009-10-29 2010-10-29 Kinase inhibitors
ES10827573.6T ES2658290T3 (en) 2009-10-29 2010-10-29 Kinase inhibitors
IL219447A IL219447A (en) 2009-10-29 2012-04-29 Kinase inhibitors
ZA2012/03842A ZA201203842B (en) 2009-10-29 2012-05-25 Kinase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25622209P 2009-10-29 2009-10-29
US61/256,222 2009-10-29

Publications (2)

Publication Number Publication Date
WO2011053861A1 WO2011053861A1 (en) 2011-05-05
WO2011053861A8 true WO2011053861A8 (en) 2011-10-27

Family

ID=43922599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/054853 Ceased WO2011053861A1 (en) 2009-10-29 2010-10-29 Kinase inhibitors

Country Status (18)

Country Link
US (1) US8404677B2 (en)
EP (1) EP2493313B1 (en)
JP (1) JP5993742B2 (en)
KR (1) KR101690358B1 (en)
CN (1) CN102695416B (en)
BR (1) BR112012010085B1 (en)
CA (1) CA2779105C (en)
CL (1) CL2012001073A1 (en)
EA (1) EA029273B1 (en)
ES (1) ES2658290T3 (en)
IL (1) IL219447A (en)
MX (1) MX2012004846A (en)
MY (1) MY173494A (en)
NZ (2) NZ599040A (en)
SG (1) SG10201407012XA (en)
TR (1) TR201802464T4 (en)
WO (1) WO2011053861A1 (en)
ZA (1) ZA201203842B (en)

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