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WO2011044202A1 - Système d'irradiation panoramique faisant appel à des sources de rayons x en panneaux plats - Google Patents

Système d'irradiation panoramique faisant appel à des sources de rayons x en panneaux plats Download PDF

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Publication number
WO2011044202A1
WO2011044202A1 PCT/US2010/051585 US2010051585W WO2011044202A1 WO 2011044202 A1 WO2011044202 A1 WO 2011044202A1 US 2010051585 W US2010051585 W US 2010051585W WO 2011044202 A1 WO2011044202 A1 WO 2011044202A1
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WIPO (PCT)
Prior art keywords
ray
irradiation chamber
irradiator
source
flux
Prior art date
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Ceased
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PCT/US2010/051585
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English (en)
Inventor
Mark Eaton
Mitali More
Mike Olla
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Stellarray Inc
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Stellarray Inc
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Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
    • G21K5/00—Irradiation devices
    • G21K5/10—Irradiation devices with provision for relative movement of beam source and object to be irradiated
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J35/00—X-ray tubes
    • H01J35/02—Details
    • H01J35/04—Electrodes ; Mutual position thereof; Constructional adaptations therefor
    • H01J35/06—Cathodes
    • H01J35/065—Field emission, photo emission or secondary emission cathodes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J35/00—X-ray tubes
    • H01J35/02—Details
    • H01J35/16—Vessels; Containers; Shields associated therewith
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J2235/00—X-ray tubes
    • H01J2235/06—Cathode assembly
    • H01J2235/062—Cold cathodes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J2235/00—X-ray tubes
    • H01J2235/06—Cathode assembly
    • H01J2235/068—Multi-cathode assembly
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J2235/00—X-ray tubes
    • H01J2235/16—Vessels
    • H01J2235/163—Vessels shaped for a particular application

Definitions

  • the present disclosure relates generally to an irradiation system and method, and more particularly, to a panoramic X-ray irradiator system and method wherein the X-ray flux generation area of a source is substantially equal to the proximate target surface area of material passing through the irradiator.
  • Ionizing radiation such as electron beams, gamma rays and X-rays
  • objects including: the sterilization of medical, pharmaceutical, food and cosmetic products; the cross- linking of polymers and other industrial processes; the inactivation of leukocytes in transfusion blood supplies; the sterilization of insects for phytosanitary; the attenuation of organism function for vaccine development, and many other applications.
  • irradiators are classified as either self-contained irradiators or panoramic irradiators.
  • self-contained irradiators the radiation source, radiation shielding, the objects to be treated, any systems for the movement of those objects, and sometimes the power supply, are all in one enclosure.
  • X-ray versions are regulated by the U.S. Food and Drug Administration under the category "X-ray cabinet irradiator" (Title 21 CFR ⁇ 1020.40).
  • Panoramic irradiators are generally larger than the self-contained irradiators and use a material transport system to move the materials to be treated from an area where people may safely operate to a separately-shielded irradiation area receiving flux from the radiation source. They are most commonly used for the irradiation of large volumes of material.
  • the radiation source used in either type of irradiator may include: gamma rays emitted by the decay of radioactive isotopes; electron beams produced by linear accelerators, electron tubes or other methods; or X-rays produced by the impact of high energy electrons upon a metal target, for example in an X-ray tube.
  • panoramic irradiators are radioactive isotopes and electron beams (e-beams). Both emit very high energy radiation of over 1 MV to as much as 10 MV and thus require massive metal and concrete shielding to protect workers at these facilities and surrounding populations.
  • Panoramic irradiator facilities have a separate, shielded area in which workers can safely load the material to be irradiated onto a material transport system which delivers the material into the irradiation area, where it can either remain stationary or be moved at a regulated pace for as long as is required for the desired dose of radiation to be delivered.
  • Typical materials processed at these facilities are packaged medical products, which are then not exposed to an outside environment or human handling until the package is opened at the point of use, mail or packages being shipped, and some foodstuffs.
  • the doses delivered to these materials are generally much higher than those delivered to materials in self-contained irradiators.
  • foodstuffs can require doses of a few hundred Gy to a few kGy in order to sterilize the bacteria, mold or yeasts which are commonly of concern for food safety.
  • Medical products typically require 15 kGy to 25 kGy in order to sterilize bacteria, mold, yeasts, mold and bacterial spores, viruses and prions which are of concern in medical product safety.
  • Radioactive isotope panoramic irradiators commonly use Cobalt- 60, emitting mostly 1.25 MV photon flux, which is formed into rods.
  • the rods line the perimeter of the irradiation area, which is commonly a pit dug into the ground for additional shielding.
  • Material to be irradiated is loaded into large "totes", commonly of 650 KG mass, in the safe loading area. These totes are then moved by hook and cable or other material conveyance apparatus into the radiation pit, where they remain until the required dose is delivered. The material is then removed from the pit and transferred by the material conveyance system to an unloading area.
  • These facilities are large and centralized to serve regional markets. There are under 100 of them in the United States.
  • E-beam irradiators do not rely on radioactivity but instead use very high energy (typically 5 to 10 MV) e- beams generated by large electrical sources such as linear accelerators or rhodotrons. They are used for irradiation processing of some of the same materials as the isotope irradiators. These electrical sources can be turned off, which stops generation of the e-beam flux, but e-beams have the disadvantage of less penetrating ability compared with gamma ray or X-ray photons. This limits the mass of material that can be processed with these facilities, and hence their economical throughput rates, so they are less common than the isotope irradiators.
  • Some e-beam facilities also have metal X-ray targets, the back sides of which are scanned by the e-beam source in order to generate high energy X-ray flux out the other side of the target, which is generally under 1 cm thick. These X-rays have greater penetrating ability than the e-beams which generated them, so they can be used for thicker materials. Both the e-beams and the X-rays have very high energies, which requires the radiation area to be heavily shielded with metal and concrete. Material is commonly loaded onto conveyor belts in a separate area and then transported into the radiation area. These facilities are also large and centralized to serve regional markets.
  • E-beam irradiators do not rely on radioactivity but instead use very high energy (typically 5 to 10 MV) e- beams generated by large electrical sources such as linear accelerators or rhodotrons. They are used for irradiation processing of some of the same materials as the isotope irradiators. These electrical sources can be turned off, which stops generation of the e-beam flux, but e-beams have the disadvantage of less penetrating ability compared with gamma ray or X-ray photons. This limits the mass of material that can be processed with these facilities, and hence their economical throughput rates, so they are less common than the isotope irradiators.
  • Some e-beam facilities also have metal X-ray targets, the back sides of which are scanned by the e-beam source in order to generate high energy X-ray flux out the other side of the target, which is generally under 1 cm thick. These X-rays have greater penetrating ability than the e-beams which generated them, so they can be used for thicker materials. Both the e-beams and the X-rays have very high energies, which requires the radiation area to be heavily shielded with metal and concrete. Material is commonly loaded onto conveyor belts in a separate area and then transported into the radiation area. These facilities are also large and centralized to serve regional markets.
  • a smaller form factor and more economical panoramic irradiator using radiation flux with substantially lower energies and requiring much less shielding than prior art irradiators is desirable.
  • Such an irradiator would not be limited to centralized locations, but could instead be used close to the point of production, the point of loading or transshipment or the point of consumption of the material to be irradiated, thereby saving substantial costs in time and money and enabling the more widespread application of beneficial radiation.
  • FIG. 1 shows the general architecture of prior art X-ray tubes.
  • X-ray tubes are point sources of radiation, as shown in FIG. 1, wherein X-rays are generated by the impact of a high voltage electron beam 50 from a heated filament or other cathode 10 at a point (sometimes called the spot) on a metal anode 30, typically disposed at an angle relative to the cathode so as to allow X-ray flux 60 to exit one side of the vacuum tube enclosing the cathode and anode.
  • This entire side may comprise the flux exit window of the tube, or a separate window 20 of a low Z material such as beryllium may be built into this side of the tube or housing for the tube.
  • tubes operating below cathode to anode voltages of 150 KV less than 2% of the energy from the electrons is converted into X-rays, while the rest is dissipated as heat on the anode.
  • X-ray tubes will deliver an uneven dose to the irradiation target, for example a blood bag, since the X-rays will first impinge on one surface of the target and then be attenuated as they pass through the target material and because the X-ray flux delivered from a point source will be weaker at the sides of the target coverage area than at the center. X-rays from a single point on the anode will be emitted in all directions. Those which go back into the target will not be useful for irradiation, but will instead generate heat. With the X-ray target angled as shown in FIG.
  • FIG. 2 shows the throw distance needed for prior art point sources used in irradiation.
  • the cabinet and shielding must also be enlarged to accommodate the throw distance 200 shown in FIG. 2 that is required to cover a target area 400 with length and width 410.
  • all the flux needed for the application must come from one spot on the anode, there is a tremendous thermal load on this small area, which in turn necessitates the use of complex liquid cooling systems for higher flux applications.
  • the dose required for transfusion blood irradiation is only 25 Gy, whereas the doses for medical product sterilization, such as is practiced in panoramic irradiators, can be as high as 25 kGy, so it will be appreciated that even a very large number of X-ray tubes would be insufficient for panoramic irradiation applications owing to thermal management limitations, apart from the cost and impracticality of using a very large number of tubes.
  • the anode has to be made very thin (14 micron Au on 4 mil Al) in order to generate the forward directed X-rays.
  • Flat panel versions of this kind of source using a transmissive anode are disclosed in US Patents 6,477,233 and 6,674,837.
  • Two major limitations of this kind of source are the thermal loading capacity of the thin-film anode, and the thermal matching of the anode to the exit window of the source. Even with externally-connected liquid cooling systems, only limited amounts of X-ray power can be obtained from this kind of source.
  • X-rays produced by the lower, "reflective" anode will be attenuated first by the cathode arrays and their support structures, and then the thin-film X-ray target, resulting in an inefficient system.
  • the second anode while it can be thicker and have higher heat dissipation capacity than a thin-film anode, is inside the vacuum enclosure. The heat must therefore be transferred through the vacuum enclosure, which will limit the amount of X- ray flux that can be achieved with this source.
  • Embodiments of the present disclosure provide an irradiation system and method wherein the X-ray flux generation area of a substantially planar source is substantially equal to the proximate target surface area facing X- ray flux generation area of the materials passing through the irradiator.
  • the system utilizes one or more substantially planar X-ray source(s), which generates high intensity X-ray flux over a large area.
  • this X-ray flux generation area is substantially planar, the X-ray flux remains substantially uniform within the irradiation chamber.
  • One or more flat panel X-ray sources are placed around the irradiation chamber to generate X-ray flux.
  • the design of the present disclosure provides a compact, efficient and safe irradiation system.
  • Embodiments of the present disclosure provide a safe, economical and efficient panoramic X-ray irradiation system that offers significant advantages over prior art approaches. More specifically, present disclosure provides a system for X-ray irradiation wherein the X-ray flux generation area of a source is substantially equal to the proximate facing surface area of the material as it is transported through the irradiation section of the irradiator.
  • the irradiator includes one or more flat panel X-ray source(s) which generate a wide source of X-ray flux, disposed inside a radiation shielding enclosure, with a material transport system provided to move the material to be irradiated from outside the enclosure to an irradiation section inside the enclosure.
  • the one or more flat panel X-ray sources are disposed in the irradiation section so as to have their flux emitting surfaces facing inwards towards the material being transported through that section. With flat panel X-ray sources on either side of the material, most X-ray flux which passes by or through the material being irradiated will be absorbed by the anode of the opposite flat panel X-ray source, providing a degree of self-shielding.
  • This and the much lower energies generated from the X-ray sources very substantially reduce the need for additional shielding materials as compared with prior art panoramic irradiators, one factor allowing the irradiator of this disclosure to be made in a relatively compact format. Since the X-ray sources are wide, and the flux generation area is substantially equal to the irradiation target area, minimal throw distance is needed compared with a point source, another factor allowing the irradiator to be made more compact.
  • the irradiator of this disclosure can be made small enough to fit in the shipping bay of a product manufacturing site, to be installed in-line with a manufacturing process, or be loaded onto or assembled into a trailer.
  • a conveyor belt can transport solids, including packaged products. Pipes can transport fluids. Sheets of material can be transported through on rollers.
  • the material transport mechanism provides uniform flux delivery in one dimension.
  • the flat panel X-ray sources can be designed to provide uniformity in the second dimension.
  • the configuration of the material being irradiated and the use of X-ray sources on multiple sides of the irradiation chamber can provide a more uniform flux dose map in the third dimension.
  • an apparatus and method for the X-ray irradiation of materials includes an irradiation chamber, a number of flat electromagnetic (X-ray) sources, a transport and support mechanism, a heat transfer system, and a shielding system.
  • the transport system allows materials to be transported to and from an interior volume of the irradiation chamber.
  • End covers provide shielding such that essentially all the electromagnetic flux remains within the irradiation system without irradiating the exterior environment.
  • a shielded portal within the shielding system allows access to an interior volume of the irradiation chamber. The shielded portal allows materials to be placed in and withdrawn from the irradiation chamber.
  • the electromagnetic sources are positioned on or embedded with interior surfaces of the irradiation chamber. These electromagnetic sources may generate an electromagnetic flux, such as an X-ray flux, where this flux is used to irradiate the interior volume of the irradiation chamber and any materials placed therein.
  • the materials placed within the interior of the chamber may be supported by a low attenuation support mechanism.
  • This low attenuation support mechanism does not substantially reduce the X-ray flux intended to irradiate the materials placed within the interior volume of the irradiation chamber.
  • the irradiation chamber may have a heat transfer system thermally coupled to the irradiation chamber and electromagnetic sources in order to remove heat from the interior surfaces of the irradiation chamber.
  • the shielding system and end covers external to the irradiation chamber prevents unwanted radiation from escaping from within the irradiation chamber.
  • Another embodiment of the present disclosure provides a method for the X-ray irradiation of materials.
  • This method involves transporting a work piece or material to be irradiated to and from an irradiation chamber.
  • the work piece or materials are placed within the irradiation chamber and supported with a mechanism such as a low attenuation support mechanism.
  • This low attenuation support mechanism does not substantially reduce the electromagnetic flux (X-ray) flux within the irradiation chamber.
  • One or more flat electromagnetic (X-ray) sources may be energized to irradiate the interior volume of the irradiation chamber. This allows the work piece or materials to be irradiated within the chamber.
  • Excess heat may be removed with a heat transfer system in order to prevent the irradiation chamber/electromagnetic source from overheating. Additionally the irradiation chamber may be shielded to prevent the irradiation of objects and materials external to the irradiation chamber.
  • Yet another embodiment of the present disclosure provides another system for the X-ray irradiation of materials.
  • This system includes an irradiation chamber, a number of flat X-ray sources, a transport mechanism, a low attenuation support mechanism, a heat transfer system, a shielding system, and a process controller.
  • the irradiation chamber has an inner volume wherein the flat X-ray sources are positioned within or on the interior surfaces of the irradiation chamber such that the flat X-ray sources may irradiate the interior volume of the irradiation chamber.
  • the transport mechanism allows materials to travel to and from the irradiation chamber.
  • the low attenuation support mechanism supports the work pieces or materials to be irradiated while not substantially reducing the X-ray flux available for the irradiation of these objects.
  • the heat transfer system removes heat from the X-ray source and the shielding system external to the irradiation chamber prevents inadvertent irradiation of materials and objects outside the irradiation chamber.
  • the process controller coordinates the operation of the irradiation chamber, X-ray source, heat transfer system and an interlock system which prevents irradiation while access to the interior volume is open.
  • FIG. 1 shows the general architecture of prior art X-ray tubes
  • FIG. 2 shows the throw distance needed for prior art point sources used in irradiation
  • FIG. 3 is a diagram that depicts one advantage of the irradiator provided by embodiments of the present disclosure, where the flux generation area of the source is substantially equal to the proximate facing surface area of the material being;
  • FIG. 4 is a diagram of the general architecture of an irradiator in accordance with embodiments of the present disclosure
  • FIG. 5 is another diagram of the general architecture of flat panel X-ray sources in accordance with embodiments of the present disclosure
  • FIG. 6 is a diagram of the X-ray flux distribution from two flat panel X-ray source provided in accordance with embodiments of the present disclosure
  • FIG. 7 is a diagram of another embodiment of an irradiator in accordance with embodiments of the present disclosure.
  • FIGs. 8A and 8B shows calculated dose-depth maps of X-ray flux delivered to material in an irradiator of the present disclosure having flat panel X-ray sources placed on opposite sides of the material;
  • FIG. 9 shows an embodiment of the present disclosure in which the cathodes in the array of a flat panel X- ray source are made more dense towards the edges of the array away from the center, thereby smoothing out the flux distribution of the source across its emitting area;
  • FIG. 10 shows an embodiment of the present disclosure in which the cathodes of the array in a flat panel X- ray source are supplied with greater current the further the cathodes are away from the center of the array and towards the edges of the array, thereby smoothing out the flux distribution of the source across its emitting area;
  • FIG. 11 is a diagram of a fluid transportation system for in accordance with embodiments of the present disclosure.
  • FIG. 12 is a diagram of a sheet roller transport system for use in accordance with embodiments of the present disclosure.
  • FIG. 13 provides a logic flow diagram of a method of irradiating materials in accordance with embodiments of the present disclosure.
  • FIGs. Preferred embodiments of the present disclosure are illustrated in the FIGs., like numerals being used to refer to like and corresponding parts of the various drawings.
  • Embodiments of the present disclosure provide an apparatus and method for the X-ray irradiation of materials.
  • This apparatus includes an irradiation chamber, a number of flat electromagnetic (X-ray) sources, a support mechanism, a heat transfer system, and a shielding system.
  • a shielded portal within the shielding system allows access to an interior volume of the irradiation chamber.
  • the shielded portal allows materials to be placed in and withdrawn from the irradiation chamber. When closed, the shielded portal allows a continuous shielded boundary of the interior volume of the irradiation chamber.
  • the electromagnetic sources are positioned on or embedded with interior surfaces of the irradiation chamber.
  • These electromagnetic sources may generate an electromagnetic flux, such as an X-ray flux, where this flux is used to irradiate the interior volume of the irradiation chamber and any materials placed therein.
  • the materials placed within the interior of the chamber may be supported by a low attenuation support mechanism. This low attenuation support mechanism does not substantially reduce the X-ray flux intended to irradiate the materials placed within the interior volume of the irradiation chamber.
  • the irradiation chamber may have a heat transfer system thermally coupled to the irradiation chamber and electromagnetic sources in order to remove heat from the interior surfaces of the irradiation chamber.
  • the shielding system external to the irradiation chamber prevents unwanted radiation from escaping from within the irradiation chamber.
  • Embodiments of the present disclosure improve upon prior art panoramic irradiators through the use of one or more flat-panel, broad-area X-ray sources capable of delivering more substantial flux dose rates in a format well- suited to efficient irradiation.
  • the most general aspect of the present disclosure is the generation of the X-ray flux in the self-contained irradiator from a broad area anode, including a broad area anode that can be easily cooled to dissipate the heat produced in X-ray generation.
  • FIG. 3 is a diagram of the general architecture of the irradiator with the flux generation area of a source substantially equal to the proximate facing surface area of the material being irradiated in accordance with embodiments of the present disclosure.
  • the flux generation area 300 on the surface of wide, flat anode 30 of a flat panel X-ray source is substantially equal to the proximate facing surface area 400 of the material to be irradiated 4, both of which are enclosed in cabinet 5 of the irradiator.
  • Flat panel X-ray source 2 may be made in any area format, for example, circular, rectangular or square, and in sizes ranging from a few square centimeters to a square meter or more.
  • flux generation area 300 and irradiation target area 400 are substantially the same, no extra throw distance is needed in the z-axis, so the X-ray sources may be placed in close proximity to the irradiation target material, allowing the irradiator to be made compact.
  • Embodiments of the present disclosure are well-suited for the irradiation of materials with contoured or irregular surfaces, since X-ray flux is emitted at all angles at a multitude of locations across source anode surface 300, allowing the flux to hit the target surface from many different directions, and since source 2 may be operated at high voltage and high power to generate X-rays with high penetrating ability.
  • FIG. 3 also shows the use of two flat panel X-ray sources, with source 2 on one side and source 2' on the other side of target material 4, which provides for more even distribution of X-ray flux through the material in the z direction.
  • the sources may be oriented above and below the material, or sources may be placed on all sides of the irradiation section.
  • the rectangular prism irradiator shown in FIG. 3 is an exemplary design; irradiator 1 may be made in circular, hexagonal, octagonal or other shapes.
  • Flat panel X-ray sources 2 may also be designed or operated to produce different power levels or X-ray energy distributions to suit a particular application.
  • a collimating grid may be placed in front of flat panel X-ray source 2, so as to allow the source to be used for imaging applications, with film or other X-ray detector means placed on the opposite side of material 4 from source 2.
  • Sources 2 can be operated with electrical current and anode potential calibrated to deliver as much of the generated X-ray flux as possible into the material to be irradiated. As depicted in FIG. 3, however, some of the X-rays 60' will pass through the material and exit the opposite side. These X-rays will then be absorbed, primarily by the anode of the opposite source 2', thereby reducing the need for additional shielding material in the irradiator. With more than two sources, for instance four sources in two opposing pairs, even more of the unused flux will be absorbed through self- shielding.
  • FIG. 4 is a diagram of the general architecture of an irradiator in accordance with embodiments of the present disclosure.
  • the overall architecture of the panoramic irradiator is shown in this case with one panel 2 above the material being irradiated 4 as it is moved through irradiation section 6 by material transportation system 501.
  • Enclosure 5 provides mechanical support for the system and is lined with shielding material, such as sheets of lead in thickness from 2 to 10 mm, to prevent X-ray flux from escaping into the surrounding area.
  • Shielding sections 9, before and after irradiation section 6, prevent stray radiation from escaping the entrance and exits of irradiator 1, where people load and unload the material.
  • Material transport system 501 in this case a conveyor belt on rollers, is preferably made of material with either low attenuation of X-rays or material with high coefficients of X-ray reflection. Low atomic number Z materials have low attenuation and high X-ray reflectance.
  • FIG. 5 is another diagram of the general architecture of flat panel X-ray sources in accordance with embodiments of the present disclosure. Detail as to a type of flat panel X-ray source which can be used in the irradiator of this disclosure is shown in FIG. 5.
  • Source 2 the preferred flat X-ray source of this disclosure has an array 100 of cathodes 10 on exit window 20 of the source, with open space between the cathodes in the array so as to provide a wide area source of electrons.
  • a wide, flat metallic X-ray target 30 is disposed opposite cathode array
  • Exit window 20 and X-ray target 30 are the integral major parts of the vacuum enclosure of the source, with side walls 90 completing the vacuum enclosure.
  • Cathode array 100 is operable to emit multiple electron beams 50 towards X-ray target 30 to generate X-ray flux 60, a portion of which will be emitted in the direction of cathode array 100 and pass through or by this array and out through exit window 20, and on to the material to be irradiated.
  • Exit window 20 of X-ray source 2 can be made of several different materials, including various types of glass, sapphire, ceramic, plastic that has been passivated for operation in vacuum, various forms of carbon sheet, beryllium and boron carbide. In general it is desirable for window 20 to be made of materials with a low atomic number Z and to be as thin as possible consistent with structural integrity under vacuum load, so as to allow as much of the X-ray flux as possible to pass through and be used for irradiation. Side walls 90 of the source can be made of the same materials as exit window 20.
  • Anode 30 which forms the X-ray target, can be made of any material, but is preferably made of a metal with a high Z number so as to increase X-ray generation.
  • An exemplary materials set for these primary components of source 2 is a sapphire window, Macor or alumina side walls and an anode/target made of an 80/20 tungsten-copper alloy, all of which have a coefficient of thermal expansion in the neighborhood of 8.5 or 9 xlO "6 in./in.*/°C.
  • Another exemplary materials set is soda lime glass for the window and side walls and plain tungsten for the anode, for matched coefficients of thermal expansion in the neig hborhood of 4.5 xlO "6 in./in.*/°C over the temperature range of interest.
  • a flat sheet or slab of tungsten or tungsten-copper alloy of 1 mm or more in thickness will have more than sufficient rigidity to support the atmospheric load on the package, which is pumped down to an internal pressure of 10 "5 to 10 "8 Torr. Sheets of 3 to 6 mm have been used in prototypes and found to have good mechanical and thermal properties. Exemplary thicknesses for the side walls are 2 to 10 mm for glass or ceramic. Exit window 20 should be as thin as possible, preferably in the range of 0.5 to 10 mm for glass or ceramic, with the thinness of the window determined in part by the unsupported span over which it must maintain structural integrity under vacuum. Internal spacers, not shown in FIG. 5, can be used to reduce this span, with the spacers made of the same materials as the side walls or exit window.
  • the overall thickness of flat panel X-ray source 2 is determined by the thickness of window 20, the thickness of anode 30 and the wall and spacer separation between them. This separation will be considerably larger than the window and anode thicknesses, since sufficient distance must be provided between cathode array 100 and anode plate 30 to prevent arcs both inside the vacuum envelope of source 2 and between any externally exposed cathode and anode connections.
  • Panel source 2 is operated at an anode to cathode voltage between 10 kV and 450KV, with 80 - 200 KV being an exemplary range for medical product sterilization.
  • a separation of 2 cm between cathode array 100 and anode 30 is more than sufficient to prevent vacuum breakdown and arcing inside the package.
  • a separation of 15 cm or more is desirable. It is advantageous therefore to attach an oil, gas, vacuum or other insulation section to the externally exposed major surface of anode 30 so as to electrically isolate the anode from external arcs.
  • This insulation section such as an oil pan, is also used as or as part of a cooling system for anode 30, which allows source 20 to be operated at higher power levels.
  • Exemplary thicknesses of source 20 for operation up to 150 KV and with an insulation and cooling structure attached are from 5 cm to 20 cm.
  • Cathode array 100 is formed directly on to, attached to or supported by window 20 of source 2.
  • Array 100 may be made of either field emission cold cathodes or thermal filament cathodes. Space between the cathodes 10 of array 100 is provided to spread out the electron source generating the X-ray flux. This space can also be used for the placement of support structures for thermal filament cathodes or for resistors, buss lines and gating or extractor structures for field emission cold cathodes.
  • Field emission cathode arrays are formed directly on window 20 using micro fabrication techniques. Alternatively, a field emission cathode array may be formed on a separate substrate which is then attached to or placed in front of flux exit window 20.
  • Thermal filaments are stretched across the surface of window 20 and held in place by metallic, glass, ceramic or other support structures which are fused, frit sealed, welded or otherwise bonded to the window.
  • a frame may be provided for the stretching and separation of thermal filament cathodes, and this frame may be attached to window 20 or placed in front of window 20 and supported by side walls 90.
  • the cathodes 10 in array 100 are caused to emit electrons, either through heating of the filament cathodes or through field emission extraction of current in cold cathode array.
  • Hundreds of thousands or millions of cold cathodes can be formed into array 100, and in the case of thermal cathodes, numerous filaments can be stretched or patterned to make the array, so a very large number of electron beams will be emitted from array 100 and accelerated by the cathode to anode potential to hit anode 30, where they will generate X-rays across the surface of the anode through the classical Bremsstrahlung and characteristic line emission processes. X-ray flux in generated in all directions through these processes.
  • FIG. 6 is a diagram of the X-ray flux distribution from two flat panel X-ray source provided in accordance with embodiments of the present disclosure.
  • This diagram shows the cross sections of the source provided in accordance with embodiments of the present disclosure and material being irradiated.
  • Dimension 110 shows the width of the cross section of the cathode array on window 20, or by that part of array which is caused to emit electrons, while dimension 310 shows the cross sectional width of the flux generation area on anode 30 and dimension 410 shows the cross sectional width of surface 400, the proximate facing area of the material being irradiated 4.
  • the flux generation area on anode 30, as indicated by cross sectional width 310, is essentially determined by the area of the cathode array on window 20, or by that part of array which is caused to emit electrons, as indicated by cross sectional width 110. This is because at high anode potential, and without any means of deliberately deflecting electron beams 50, these beams will head straight at anode 30 and diverge laterally by only a very small distance. Only those beams produced by cathodes at the outer perimeter of the emitting area of array 100 will fall outside of the corresponding area on the anode, and this by a very slight degree.
  • Most of the X-rays 60 which are generated on anode 30 will in turn be directed towards the corresponding area 400, over its cross sectional width 410, on the proximate surface of the material being irradiated 4.
  • Some of the X-rays, particularly those emitted around the perimeter of the anode, will be absorbed in the side walls, and a small percentage will be emitted at such a shallow angle as to cause them to miss irradiation target surface 400, but with a wide flux generation area, substantially all of the X-ray flux leaving anode 30 will be directed towards proximate surface 400 on the material to be irradiated.
  • anode 30 provides one of the major advantages of source 2, which is relatively easy thermal management of the heat generated on the anode, since the heat can be dissipated over a broad area and the exterior side of anode 30 can be directly coupled to atmosphere, forced air, oil bath or circulating fluid heat dissipation systems.
  • FIG. 7 is a diagram of another embodiment of an irradiator in accordance with embodiments of the present disclosure. Further aspects of irradiator 1 are shown in FIG. 7, in this case with multiple flat panel X-ray sources 2 arranged at the top and bottom of irradiation section 6 of enclosure or frame 5, with anodes 30 closest to the enclosure and windows 20, with the cathode arrays, facing inwards. Tiling the flat panel X-ray source together, which can done both along the axis of movement of the material to be irradiated and in the transverse direction, will provide a larger flux generation area. Numerous panels can be tiled together along the axis of movement of the material, for a very long irradiator.
  • the irradiators themselves may also be made modular so that more than one can be attached end to end, and share a common material transport system, so as to further lengthen the flux generation area.
  • the flat panel X-ray source can be activated via the irradiator control system to deliver radiation doses matched to the material to be irradiated. For example, with material having a large proximate surface area, all the panels on each side can be activated. For smaller doses, a smaller number of panels may be activated, to provide for an efficient use of power.
  • a further advantage of tiling several flat panel X-ray sources together on a side of an irradiator is redundancy, since if one panel fails the other can still be operated.
  • Material transport system 501 may be a conveyor belt using rollers, as shown in FIG. 7, a hook and gantry systems, pipes for transporting fluids, separately powered trucks or carts, or any other system which can move the material through the irradiator.
  • a means for rotating the material as it is transported through the irradiation section may also be incorporated to provide a more uniform radiation dose in the material. Power supply
  • Power supply 7 can be either internal to enclosure 5 or external. It will preferably incorporate a voltage amplifier to bring municipal power up to the high potential needed for X-ray generation, although it may also comprise a relay system for delivering current to the irradiator from high voltage transmission lines. Power supply 7 may also incorporate a generator to produce its own electricity from fuel or another source of power.
  • Enclosure 5 is lined with shielding material 3, such as lead sheet, to absorb any radiation which is not absorbed by material 4 or opposing anodes 30 of the flat panel X-ray sources.
  • Heat exchanger system 8 may be provided to remove heat from the flat panel X-ray source anodes during high power operation. The heat exchanger may be directly attached to the anode or may be displaced from the anode.
  • Flat panel X-ray sources 2 may have an oil-filled casing attached to cover anodes 30 and provide high voltage insulation. The oil can be circulated through tubings to a displaced heat exchanger 8 to allow operation at high power levels.
  • the heat exchanger system may incorporate fans, baffles or other means to dissipate heat to outside the irradiator.
  • Heat exchanger system 8 may be enclosed fully or partially by enclosure 5.
  • Other high voltage insulation such as plastic or ceramic sheets, may be used in place of an oil casing for the X-ray source anodes.
  • types of heat exchanger systems may be used, such as forced air passed over the high voltage insulation and the X-ray source, separate pumped water o oil cooling or gas insulation.
  • Thermal insulation structures may be built into material transport system 501 to isolate the material from the heat generated during X-ray production. Doors, flaps of lead sheet or serpentine shaped channels may be used at the entrance and exit of the irradiator as an additional means of keeping radiation from escaping the irradiator. Interlocks and other safety features may be incorporated for safer operation.
  • Interlocks on a door will shut off power when the door is opened.
  • An X-ray ON light on the outside of the box may be activated when power is supplied to the X-ray sources.
  • An emergency switch may be provided to turn off power in case of emergency.
  • Controls may provided to set the irradiation time, current levels and voltage to the X-ray sources.
  • a bar code scanner may also be attached to the irradiator to allow tracking of throughput.
  • An internal radiation dose measurement system may be provided for recording the dose delivered to each lot of material irradiated.
  • control system 502 a computing device which may be directly connected to the irradiator and provide a use -design face such as a touch screen that allows the user-operator to control all functions of the irradiator. Additionally, a computer for controlling one or more of the functions of the irradiator may connect the system to a local network for remote operation and data savings.
  • the size of irradiator 1 is determined primarily by its intended use. Small, desktop systems may be used, for example, to provide sterilization or other types of radiation processing to medical devices, human blood supplies, contact lenses or pharmaceuticals.
  • Floor-standing models in the size range of airport baggage scanners or larger may be used, for example, to sterilize large quantities of medical products inside a factory or factory shipping bay, or mail inside a sorting facility. Larger systems can be used for bulk quantities of medical products or foodstuffs, or example.
  • the irradiator may be stationary or mobile. For example, even a large irradiator can be placed onto a truck trailer or into a large (e.g. 40' long) shipping container and transported to a point of production, transshipment or distribution to reduce shipping and handling costs associated with irradiation.
  • FIGs. 8A and 8B shows calculated dose-depth maps of X-ray flux delivered to material in an irradiator of the present disclosure having flat panel X-ray sources placed on opposite sides of the material.
  • the material to be irradiated is blood contained in blood bags.
  • the normalized X-ray dose rate in Gy/min is plotted as a function of the distance from the X-ray sources.
  • the dashed lines show the dose rate as a function of the distance from one X-ray source and the dotted lines show the dose rate as a function of the distance from the other X-ray source.
  • the solid lines are the combined dose rate from both sources as a function of the distance.
  • the plots are shown for 100 kV and 150 kV operating voltage. As shown in FIG. 8, dose uniformity is substantially improved by irradiating the material from opposite sides.
  • FIG. 9 shows an embodiment of the present disclosure in which the cathodes in the array of a flat panel X- ray source are made denser towards the edges of the array away from the center, thereby smoothing out the flux distribution of the source across its emitting area.
  • the cathodes on array 100 on window 20 are made denser towards the edges of the array near source walls 90 and sparser towards the center, as defined by the axis of movement of the material being irradiated. This provides for a corresponding change in the density of X-ray flux generation on the anode.
  • the filaments are spaced closer together closer to the edge of the array.
  • the areal density the individual emitters can be increased closer to the edge of the array.
  • a cold cathode array used in a flat panel X-ray source might have an average of 24,000 individual cathodes per square centimeter, but the density of the cathode at the center of the array could be only 5,000/cm 2 , while the density at the edges of the array could be over 50,000/cm 2 .
  • the cathodes in the array may be supplied with increasingly higher current as they get closer to the edge of the array, as defined by the axis of movement of the material being irradiated.
  • FIG. 10 shows an embodiment of the present disclosure in which the cathodes of the array in a flat panel X- ray source are supplied with greater current the further the cathodes are away from the center of the array and towards the edges of the array, thereby smoothing out the flux distribution of the source across its emitting area.
  • Jl - J9 indicate increasingly higher current levels, these increasing levels can be done with an array of evenly dense emitters, in addition to the array shown in FIG. 9 where the density is higher towards the edges of the array.
  • variable cathode density or current density can be supplied to different panels, to smooth out X-ray flux density from the entire flux generation area.
  • FIG. 11 is a diagram that shows one of the several alternative material transport systems 501 that can be used in the irradiator in accordance with embodiments of the present disclosure.
  • a serpentine configuration of pipes transports fluids. Pumps may be provided on the entrance or exit sides of the irradiator to move the fluids.
  • Other configurations of pipes may be similarly used, such as coils, horizontally disposed serpentine or racks of serpentine piping.
  • Low Z materials are preferred for the pipes so as to allow more of the X-ray flux to reach the fluid.
  • FIG. 12 shows another material transport system 502, in this embodiment a roller configuration which allows flexible sheets of material to be moved through the irradiator section 6.
  • This configuration may be used in medical, food or other packaging or fabrication applications requiring sterile materials.
  • the position of the flat panel X-ray sources 2 or parts of the material transport system 5, such as the rollers shown in FIG. 12, may be made adjustable so as to bring the X-ray source closer to or further away from the materials being irradiated, or to increase or decrease the amount the material passing through irradiation section 6.
  • One effect of this adjustment will be to vary the amount of ozone being generated during irradiation by ionization of 0 2 in the air contained in the irradiator.
  • This ozone can be a useful byproduct of the irradiation process in some applications, such as sterilization.
  • FIG. 13 provides a logic flow diagram of a method of irradiating materials in accordance with embodiments of the present disclosure.
  • Operations 1300 begin with block 1302 where a work piece to be irradiated is transported to an irradiation chamber. This may involve placing materials directing within a chamber through a shielded portal that allows access as discussed with reference to the prior FIGs., placing the materials on a conveyor or transport system as discussed with reference to FIGs. 4, 7 and 12, or pumping fluids through the chamber as discussed with reference to FIG. 11.
  • a carousel within the irradiation chamber may be used to rotate the work piece within the irradiation chamber for uniform distribution of the electromagnetic flux to the work piece.
  • the work piece is supported within the irradiation chamber with a low attenuation support mechanism.
  • one or more flat electromagnetic sources positioned to irradiate an interior of the irradiation chamber are energized at a controlled energy level and time. Excess heat is removed from the one or more flat electromagnetic source with a heat transfer system in Block 1308.
  • the exterior is shielded from the electromagnetic flux within the irradiation chamber by a shielding system.
  • the electromagnetic flux comprising an X-ray flux or an ultraviolet flux.
  • a process controller may be used to coordinates the operation of the irradiation chamber; one or more flat electromagnetic sources, the heat transfer system; and the interlock system.
  • the present disclosure provides an apparatus and method for the X-ray irradiation of materials.
  • This apparatus includes an irradiation chamber, a number of flat electromagnetic (X-ray) sources, a support mechanism, a heat transfer system, and a shielding system.
  • a shielded portal within the shielding system allows access to an interior volume of the irradiation chamber.
  • the shielded portal allows materials to be placed in and withdrawn from the irradiation chamber. When closed, the shielded portal allows a continuous shielded boundary of the interior volume of the irradiation chamber.
  • the electromagnetic sources are positioned on or embedded with interior surfaces of the irradiation chamber.
  • These electromagnetic sources may generate an electromagnetic flux, such as an X-ray flux, where this flux is used to irradiate the interior volume of the irradiation chamber and any materials placed therein.
  • the materials placed within the interior of the chamber may be supported by a low attenuation support mechanism. This low attenuation support mechanism does not substantially reduce the X-ray flux intended to irradiate the materials placed within the interior volume of the irradiation chamber.
  • the irradiation chamber may have a heat transfer system thermally coupled to the irradiation chamber and electromagnetic sources in order to remove heat from the interior surfaces of the irradiation chamber.
  • the shielding system external to the irradiation chamber prevents unwanted radiation from escaping from within the irradiation chamber.
  • the term “substantially” or “approximately”, as may be used herein, provides an industry-accepted tolerance to its corresponding term. Such an industry-accepted tolerance ranges from less than one percent to twenty percent and corresponds to, but is not limited to, component values, integrated circuit process variations, temperature variations, rise and fall times, and/or thermal noise.
  • the term “operably coupled”, as may be used herein, includes direct coupling and indirect coupling via another component, element, circuit, or module where, for indirect coupling, the intervening component, element, circuit, or module does not modify the information of a signal but may adjust its current level, voltage level, and/or power level.
  • inferred coupling includes direct and indirect coupling between two elements in the same manner as “operably coupled”.
  • the term "compares favorably”, as may be used herein indicates that a comparison between two or more elements, items, signals, etc., provides a desired relationship. For example, when the desired relationship is that signal 1 has a greater magnitude than signal 2, a favorable comparison may be achieved when the magnitude of signal 1 is greater than that of signal 2 or when the magnitude of signal 2 is less than that of signal 1.

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  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • X-Ray Techniques (AREA)

Abstract

La présente invention concerne un système d'irradiation panoramique comprenant au moins une source de rayons X située dans une enceinte blindée, la ou les sources pouvant chacune émettre un flux de rayons X dans toute une zone sensiblement égale à la zone superficielle frontale voisine de la matière placée dans l'enceinte à irradier. Ce système d'irradiation peut comprendre de multiples sources de rayons X en panneaux plats disposées, conçues ou mises en oeuvre de façon à produire un flux uniforme en direction de la matière en cours d'irradiation. Le système d'irradiation de la présente invention se caractérise avantageusement par un faible encombrement, des doses de flux uniformes, une gestion thermique simplifiée, un blindage et une sécurité efficaces, la possibilité de fonctionner à des niveaux de puissance élevés pendant des durées prolongées, et un débit élevé.
PCT/US2010/051585 2009-10-06 2010-10-06 Système d'irradiation panoramique faisant appel à des sources de rayons x en panneaux plats Ceased WO2011044202A1 (fr)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111108578A (zh) * 2017-10-26 2020-05-05 莫克斯泰克公司 三轴x射线管
WO2024044159A1 (fr) * 2022-08-24 2024-02-29 Vj Electronix Système et procédé d'irradiation de cannabis pour atténuer une contamination biologique

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001084585A1 (fr) * 2000-05-05 2001-11-08 The Government Of The United States Of America As Represented By The Secretary Of The Navy Cathode de transmission pour production de rayons x
WO2002039792A2 (fr) * 2000-11-09 2002-05-16 Steris Inc. Cible pour la production de rayons x
US20020131554A1 (en) * 2001-03-15 2002-09-19 Ray Fleming Efficiency fluorescent x-ray source
US20060049359A1 (en) * 2003-04-01 2006-03-09 Cabot Microelectronics Corporation Decontamination and sterilization system using large area x-ray source
WO2007102979A2 (fr) * 2006-02-16 2007-09-13 Eaton Mark F Source de rayonnement

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001084585A1 (fr) * 2000-05-05 2001-11-08 The Government Of The United States Of America As Represented By The Secretary Of The Navy Cathode de transmission pour production de rayons x
WO2002039792A2 (fr) * 2000-11-09 2002-05-16 Steris Inc. Cible pour la production de rayons x
US20020131554A1 (en) * 2001-03-15 2002-09-19 Ray Fleming Efficiency fluorescent x-ray source
US20060049359A1 (en) * 2003-04-01 2006-03-09 Cabot Microelectronics Corporation Decontamination and sterilization system using large area x-ray source
WO2007102979A2 (fr) * 2006-02-16 2007-09-13 Eaton Mark F Source de rayonnement

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111108578A (zh) * 2017-10-26 2020-05-05 莫克斯泰克公司 三轴x射线管
WO2024044159A1 (fr) * 2022-08-24 2024-02-29 Vj Electronix Système et procédé d'irradiation de cannabis pour atténuer une contamination biologique

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