WO2010130824A3 - Collections and uses thereof - Google Patents
Collections and uses thereof Download PDFInfo
- Publication number
- WO2010130824A3 WO2010130824A3 PCT/EP2010/056637 EP2010056637W WO2010130824A3 WO 2010130824 A3 WO2010130824 A3 WO 2010130824A3 EP 2010056637 W EP2010056637 W EP 2010056637W WO 2010130824 A3 WO2010130824 A3 WO 2010130824A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- proteinaceous binding
- binding molecules
- collections
- candidate
- parental
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
Abstract
The present disclosure relates to synthetic collections of candidate proteinaceous binding molecules, for example, antibodies, wherein one or more candidate proteinaceous binding molecules comprise an optimized property as compared to a parental proteinaceous binding molecule. In particular, the collections of candidate proteinaceous binding molecules are made by gene synthesis, and are based upon the sequence of the parental proteinaceous binding molecule, for example, antibody, therefore a custom collection of candidate proteinaceous binding molecules can be made specifically for one parental proteinaceous binding molecules. The present disclosure also relates to methods of making and using such collections for optimizing parental proteinaceous binding molecules, for example, antibodies. The present disclosure also relates to the candidate proteinaceous binding molecules of the synthetic collections comprising optimized properties.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17850709P | 2009-05-15 | 2009-05-15 | |
| US61/178,507 | 2009-05-15 | ||
| EP09160413 | 2009-05-15 | ||
| EP09160413.2 | 2009-05-15 | ||
| US18433809P | 2009-06-05 | 2009-06-05 | |
| US61/184,338 | 2009-06-05 | ||
| US29134609P | 2009-12-30 | 2009-12-30 | |
| US61/291,346 | 2009-12-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2010130824A2 WO2010130824A2 (en) | 2010-11-18 |
| WO2010130824A3 true WO2010130824A3 (en) | 2011-01-27 |
Family
ID=41136678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2010/056637 Ceased WO2010130824A2 (en) | 2009-05-15 | 2010-05-14 | Collections and uses thereof |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2010130824A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ596603A (en) | 2009-05-29 | 2013-07-26 | Morphosys Ag | A collection of antibodies or fragments having properties relevant to developability |
| DK2640742T3 (en) | 2010-11-19 | 2018-12-03 | Morphosys Ag | COLLECTION OF ANTIBODY SEQUENCES AND THEIR APPLICATIONS |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993017105A1 (en) * | 1992-02-19 | 1993-09-02 | Scotgen Limited | Altered antibodies, products and processes relating thereto |
-
2010
- 2010-05-14 WO PCT/EP2010/056637 patent/WO2010130824A2/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993017105A1 (en) * | 1992-02-19 | 1993-09-02 | Scotgen Limited | Altered antibodies, products and processes relating thereto |
Non-Patent Citations (4)
| Title |
|---|
| BARDERAS RODRIGO ET AL: "Affinity maturation of antibodies assisted by in silico modeling", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105, no. 26, July 2008 (2008-07-01), pages 9029 - 9034, XP002592575, ISSN: 0027-8424 * |
| SODERLIND E ET AL: "RECOMBINING GERMLINE-DERIVED CDR SEQUENCES FOR CREATING DIVERSE SINGLE-FRAMEWORK ANTIBODY LIBRARIES", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 18, no. 8, 1 August 2000 (2000-08-01), pages 852 - 856, XP009010618, ISSN: 1087-0156 * |
| STEIDL STEFAN ET AL: "In vitro affinity maturation of human GM-CSF antibodies by targeted CDR-diversification", MOLECULAR IMMUNOLOGY, vol. 46, no. 1, November 2008 (2008-11-01), pages 135 - 144, XP002549867, ISSN: 0161-5890 * |
| WU H: "SIMULTANEOUS HUMANIZATION AND AFFINITY OPTIMIZATION OF MONOCLONAL ANTIBODIES", METHODS IN MOLECULAR BIOLOGY. EMBRYONIC STEM CELL PROTOCOLS, HUMANA PRESS INC, NJ, US, vol. 207, 1 January 2003 (2003-01-01), pages 197 - 212, XP009052628, ISSN: 1064-3745 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010130824A2 (en) | 2010-11-18 |
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