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WO2010113176A3 - Novel copolymers for controlled release delivery system - Google Patents

Novel copolymers for controlled release delivery system Download PDF

Info

Publication number
WO2010113176A3
WO2010113176A3 PCT/IN2010/000204 IN2010000204W WO2010113176A3 WO 2010113176 A3 WO2010113176 A3 WO 2010113176A3 IN 2010000204 W IN2010000204 W IN 2010000204W WO 2010113176 A3 WO2010113176 A3 WO 2010113176A3
Authority
WO
WIPO (PCT)
Prior art keywords
controlled release
delivery system
copolymers
release delivery
vinylcaprolactam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2010/000204
Other languages
French (fr)
Other versions
WO2010113176A2 (en
Inventor
Vidhya Rangaswamy
Tejraj Malleshappa Aminabhavi
Vadde Ramesh Babu
Raghavendra Chaluvayya Mundargi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reliance Life Sciences Pvt Ltd
Original Assignee
Reliance Life Sciences Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reliance Life Sciences Pvt Ltd filed Critical Reliance Life Sciences Pvt Ltd
Publication of WO2010113176A2 publication Critical patent/WO2010113176A2/en
Publication of WO2010113176A3 publication Critical patent/WO2010113176A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/04—Acids; Metal salts or ammonium salts thereof
    • C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/02—Acids; Metal salts or ammonium salts thereof, e.g. maleic acid or itaconic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present disclosure relates to pH-sensitive copolymers poly(methacrylic acid-co-N-vinylcaprolactam), designated as P(MAA-co-VCL). The disclosure in particular provides the synthesis of a copolymer of poly(methacrylic acid-co-N-vinylcaprolactam) and its application for pH sensitive oral delivery of active ingredients in vitro and in vivo. The invention in particular provides microparticles comprising the copolymers for controlled release of drug delivery. Methods for delivering drug to the lower GI tract, while avoiding exposure to the stomach acids is provided, methods for treating diabetes using controlled release insulin delivery particles are provided.
PCT/IN2010/000204 2009-03-31 2010-03-30 Novel copolymers for controlled release delivery system Ceased WO2010113176A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN857/MUM/2009 2009-03-31
IN857MU2009 2009-03-31

Publications (2)

Publication Number Publication Date
WO2010113176A2 WO2010113176A2 (en) 2010-10-07
WO2010113176A3 true WO2010113176A3 (en) 2010-11-18

Family

ID=42740388

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000204 Ceased WO2010113176A2 (en) 2009-03-31 2010-03-30 Novel copolymers for controlled release delivery system

Country Status (1)

Country Link
WO (1) WO2010113176A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108066313B (en) * 2017-12-29 2021-02-19 成都恒瑞制药有限公司 Preparation method of metformin hydrochloride clathrate
CN114431339B (en) * 2022-02-14 2023-06-27 浙江汇能生物股份有限公司 Low-additive stability-increasing microencapsulated potassium diformate feed additive and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130080A1 (en) * 1983-06-27 1985-01-02 Johnson & Johnson Products Inc. Pressure sensitive adhesive
WO1990012041A1 (en) * 1989-04-07 1990-10-18 Gaf Chemicals Corporation Precipitation polymerization of copolymers of a vinyl lactam and a polymerizable carboxylic acid in an aliphatic hydrocarbon solvent
WO1999056782A1 (en) * 1998-05-01 1999-11-11 Minnesota Mining And Manufacturing Company Adhesive microsphere drug delivery composition
WO2001091729A1 (en) * 2000-05-30 2001-12-06 Basf Aktiengesellschaft Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2117492C1 (en) 1997-07-03 1998-08-20 Закрытое акционерное общество "ПОЛИСТОМ" Wound-healing and osteoplastic agent (variants)
US6110434A (en) 1998-02-25 2000-08-29 Alumitech Of Cleveland, Inc. Recovery of products from non-metallic products derived from aluminum dross

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0130080A1 (en) * 1983-06-27 1985-01-02 Johnson & Johnson Products Inc. Pressure sensitive adhesive
WO1990012041A1 (en) * 1989-04-07 1990-10-18 Gaf Chemicals Corporation Precipitation polymerization of copolymers of a vinyl lactam and a polymerizable carboxylic acid in an aliphatic hydrocarbon solvent
WO1999056782A1 (en) * 1998-05-01 1999-11-11 Minnesota Mining And Manufacturing Company Adhesive microsphere drug delivery composition
WO2001091729A1 (en) * 2000-05-30 2001-12-06 Basf Aktiengesellschaft Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DAMGE ET AL: "Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.JCONREL.2006.10.023, vol. 117, no. 2, 30 January 2007 (2007-01-30), pages 163 - 170, XP005864305, ISSN: 0168-3659 *

Also Published As

Publication number Publication date
WO2010113176A2 (en) 2010-10-07

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