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WO2010104307A3 - Pharmaceutical compositions for treating or preventing diseases caused by the translocation of gsk3 from the cell nucleus to the cytoplasm, containing compounds for inhibiting the translocation of gsk3 from the cell nucleus to the cytoplasm - Google Patents

Pharmaceutical compositions for treating or preventing diseases caused by the translocation of gsk3 from the cell nucleus to the cytoplasm, containing compounds for inhibiting the translocation of gsk3 from the cell nucleus to the cytoplasm Download PDF

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Publication number
WO2010104307A3
WO2010104307A3 PCT/KR2010/001446 KR2010001446W WO2010104307A3 WO 2010104307 A3 WO2010104307 A3 WO 2010104307A3 KR 2010001446 W KR2010001446 W KR 2010001446W WO 2010104307 A3 WO2010104307 A3 WO 2010104307A3
Authority
WO
WIPO (PCT)
Prior art keywords
gsk3
translocation
cytoplasm
cell nucleus
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2010/001446
Other languages
French (fr)
Korean (ko)
Other versions
WO2010104307A2 (en
Inventor
육종인
김현실
김남희
노경태
김수연
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioinformatics & Molecular Design Research Center
MEDIGENTEK CO Ltd
Original Assignee
Bioinformatics & Molecular Design Research Center
MEDIGENTEK CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioinformatics & Molecular Design Research Center, MEDIGENTEK CO Ltd filed Critical Bioinformatics & Molecular Design Research Center
Publication of WO2010104307A2 publication Critical patent/WO2010104307A2/en
Publication of WO2010104307A3 publication Critical patent/WO2010104307A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to pharmaceutical compositions for treating or preventing diseases caused by the translocation of GSK3 from the cell nucleus to the cytoplasm, containing compounds for inhibiting the translocation of GSK3 from the cell nucleus to the cytoplasm. More particularly, the present invention relates to pharmaceutical compositions for inhibiting the growth or the metastatis of cancer cells and pharmaceutical compositions for treating autoimmune diseases, containing novel compounds for inhibiting the translocation of GSK3 from the cell nucleus to the cytoplasm. The present invention provides compositions for inhibiting the outbreak and progression of diseases caused by a decrease in the concentration of GSK3 in the nucleus and the translocation of GSK from the cell nucleus to the cytoplasm. The compounds according to the present invention inhibit the nuclear export function of GSK3 performed by Axin, and increase the concentration of GSK3 in the nucleus, and can thus be valuably used in treating or preventing a variety of diseases caused by a decrease in the concentration of GSK3 in the nucleus.
PCT/KR2010/001446 2009-03-07 2010-03-08 Pharmaceutical compositions for treating or preventing diseases caused by the translocation of gsk3 from the cell nucleus to the cytoplasm, containing compounds for inhibiting the translocation of gsk3 from the cell nucleus to the cytoplasm Ceased WO2010104307A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0019533 2009-03-07
KR20090019533 2009-03-07

Publications (2)

Publication Number Publication Date
WO2010104307A2 WO2010104307A2 (en) 2010-09-16
WO2010104307A3 true WO2010104307A3 (en) 2011-01-27

Family

ID=42728928

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/KR2010/001444 Ceased WO2010104306A2 (en) 2009-03-07 2010-03-08 Pharmaceutical compositions for treating or preventing diseases caused by the translocation of gsk3 from the cell nucleus to the cytoplasm, containing compounds for inhibiting the translocation of gsk3 from the cell nucleus to the cytoplasm
PCT/KR2010/001446 Ceased WO2010104307A2 (en) 2009-03-07 2010-03-08 Pharmaceutical compositions for treating or preventing diseases caused by the translocation of gsk3 from the cell nucleus to the cytoplasm, containing compounds for inhibiting the translocation of gsk3 from the cell nucleus to the cytoplasm

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/001444 Ceased WO2010104306A2 (en) 2009-03-07 2010-03-08 Pharmaceutical compositions for treating or preventing diseases caused by the translocation of gsk3 from the cell nucleus to the cytoplasm, containing compounds for inhibiting the translocation of gsk3 from the cell nucleus to the cytoplasm

Country Status (2)

Country Link
KR (3) KR20100101055A (en)
WO (2) WO2010104306A2 (en)

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Citations (5)

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US20010052137A1 (en) * 2000-03-01 2001-12-13 Trustees Of The University Of Pennsylvania Axin domain-like polypeptide inhibitors of glycogen synthase kinase 3 beta activity and activators of wnt signaling
KR20050032105A (en) * 2002-08-02 2005-04-06 버텍스 파마슈티칼스 인코포레이티드 Pyrazole compositions useful as inhibitors of gsk-3
US20070032474A1 (en) * 2003-06-10 2007-02-08 Biondi Ricardo M Use of a compound of formula 1 for making a pharmaceutical composition
KR20080038047A (en) * 2006-10-27 2008-05-02 김정문 Methods and Substances That Inhibit Uss3 Migration from Cell Nucleus to Cytoplasm
US20080161251A1 (en) * 2005-01-21 2008-07-03 Astex Therapeutics Limited Pharmaceutical Compounds

Patent Citations (5)

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US20010052137A1 (en) * 2000-03-01 2001-12-13 Trustees Of The University Of Pennsylvania Axin domain-like polypeptide inhibitors of glycogen synthase kinase 3 beta activity and activators of wnt signaling
KR20050032105A (en) * 2002-08-02 2005-04-06 버텍스 파마슈티칼스 인코포레이티드 Pyrazole compositions useful as inhibitors of gsk-3
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KR20080038047A (en) * 2006-10-27 2008-05-02 김정문 Methods and Substances That Inhibit Uss3 Migration from Cell Nucleus to Cytoplasm

Also Published As

Publication number Publication date
WO2010104306A3 (en) 2010-12-16
KR20100101055A (en) 2010-09-16
WO2010104306A2 (en) 2010-09-16
WO2010104307A2 (en) 2010-09-16
KR20100101056A (en) 2010-09-16
KR20100101054A (en) 2010-09-16

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