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WO2010151619A2 - Dispositifs, systèmes et procédés pour le traitement de tissu mou - Google Patents

Dispositifs, systèmes et procédés pour le traitement de tissu mou Download PDF

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Publication number
WO2010151619A2
WO2010151619A2 PCT/US2010/039749 US2010039749W WO2010151619A2 WO 2010151619 A2 WO2010151619 A2 WO 2010151619A2 US 2010039749 W US2010039749 W US 2010039749W WO 2010151619 A2 WO2010151619 A2 WO 2010151619A2
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WO
WIPO (PCT)
Prior art keywords
energy
delivered
tissue
fluid
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/039749
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English (en)
Other versions
WO2010151619A3 (fr
Inventor
Paul Dunleavy
George Adaniya
Stephen May
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OPTOGEN MEDICAL LLC
Original Assignee
OPTOGEN MEDICAL LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OPTOGEN MEDICAL LLC filed Critical OPTOGEN MEDICAL LLC
Publication of WO2010151619A2 publication Critical patent/WO2010151619A2/fr
Publication of WO2010151619A3 publication Critical patent/WO2010151619A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/148—Probes or electrodes therefor having a short, rigid shaft for accessing the inner body transcutaneously, e.g. for neurosurgery or arthroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin
    • A61B2018/00458—Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
    • A61B2018/00464—Subcutaneous fat, e.g. liposuction, lipolysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1861—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter

Definitions

  • Embodiments of the present invention relate generally to devices and method for the treatment of soft tissue.
  • embodiments of the present invention provide energy platform devices for soft tissue treatments such as lipolysis and skin tightening.
  • Liposuction is the removal of unwanted fat tissue through minimally invasive surgery.
  • the surgical procedure is generally described as follows. After providing general anesthesia to the patient, an incision is made near the treatment site to allow a hollow surgical probe, also known as a cannula, to enter the body.
  • the cannula's distal tip is shaped for minimal mechanical tissue resistance.
  • inlet ports typically along the side of the distal end of the cannula, the proximal end is connected to a negative pressure pump for fat tissue aspiration. After inserting the cannula into the incision, the surgeon begins to aspirate the fatty tissue.
  • the surgeon moves the cannula forward and backward through the adipose layer, slightly changing angular direction periodically.
  • This method forms sweeping fan shape radiating from the incision point.
  • This method of treatment requires significant physical force to manually tear and break up adipose tissue for aspiration and often resulted in unwanted medical complications such as bruising and extensive bleeding.
  • the procedure is also fatiguing to the surgeon.
  • a new adjunct procedure, the tumescent technique was introduced in 1986 by Dr. Jeffrey Klein. This technique introduced the use of an aqueous saline solution, known as Tumescent. Tumescent is injected into the treatment area prior to liposuction.
  • Tumescent contains dilute amounts of lidocaine for local anesthesia and epinephrine to constrict capillaries.
  • the use of Tumescent eliminated the need for general anesthesia and reduced blood loss.
  • energy based lipolysis such as ultrasound assisted, power assisted and laser assisted lipolysis, has sparked new interest from the consumer.
  • Laser lipolysis in particular, enabled physicians to perform traditional liposuction by treating many patients who wanted more than lotions or laser skin tightening, but were unwilling to make the leap to liposuction.
  • the wavelength is selected for maximum absorption by a singular chromophore of choice.
  • Fibroblast and scar tissue are the most physically demanding tissue to treat for the physician.
  • Fibroblast tissue and multilocular fat cells have an abundance of cytoplasm versus lipids.
  • water is the chromophore of choice.
  • unilocular fat tissue these cells have an abundance of lipid and is the chromophore of choice.
  • tumescent is infused into the patient, the volume of tumescent introduced to the treatment area can be equal to the amount of fatty tissue removed. Wavelengths that are highly absorbed by both water and fat are desirable in this case.
  • a device for treating soft tissue includes an elongate member with a proximal end and a distal end; an energy delivery source; and a source of temperature controlled infusate, such as heated saline.
  • the device may be used for bulk tissue skin tightening or heating.
  • the device delivers heated infusate at temperatures that cause apoptosis of the target tissue.
  • the device delivers optical energy, such as optical energy at a reduced amount due to the infusion of heated fluid.
  • the device includes an elongate member with a proximal end and a distal end and an energy delivery source.
  • the energy deliver source delivers optical energy at a wavelength is chosen to maximize and/or optimize (hereinafter optimize) tissue heating density at the distal end of the elongate member.
  • the energy delivered results in optimized spatial selectivity of energy delivery.
  • a wavelength of 1400nm or longer is used.
  • multiple wavelengths of optical energy are delivered.
  • yet another device for treating soft tissue includes an elongate member with a proximal end and a distal end and an energy delivery source.
  • the energy deliver source is configured to optimize spatial selectivity of energy delivery.
  • yet another device for treating soft tissue includes an elongate member with a proximal end and a distal end and an energy delivery source.
  • the elongate member includes at least two infusion lumens, such as infusion lumens configured to deliver two or more different fluids, fluids at different temperatures, or fluids delivered at different infusion rate profiles.
  • yet another device for treating soft tissue includes an elongate member with a proximal end and a distal end, an energy delivery source, and a hollow core waveguide configured to deliver optical energy.
  • the hollow core waveguide is filled with fluid and the optical energy is delivered through the walls of the wave guide.
  • the optical energy is delivered through the hollow core waveguide by means of a reflective surface of the waveguide.
  • multiple hollow cores are used to deliver and/or retrieve material.
  • the hollow core includes an optical fiber configured to provide independent delivery of optical energy.
  • yet another device for treating soft tissue includes an elongate member with a proximal end and a distal end and an energy delivery source.
  • the energy delivery source delivers radiofrequency energy configured to perform skin tightening, such as unidirectional, omnidirectional, monopolar and/or bipolar delivery of radiofrequency energy.
  • Fig. 1 illustrates a side sectional view of a basic embodiment of a multiple lumen cannula device, consistent with embodiments of the present invention.
  • Fig. 2 illustrates a side sectional view of a multiple lumen cannula device with alternative optical coupling, consistent with embodiments of the present invention.
  • Fig. 3 illustrates a side sectional view of the distal end of a cannula tip, consistent with embodiments of the present invention.
  • Fig. 4 illustrates side and end views of the distal end of a cannula tip with radiofrequency electrodes configured to provide omni-directional treatment, consistent with embodiments of the present invention.
  • Fig. 5 illustrates a side view of the distal end of a cannula tip with radiofrequency electrodes configured to provide uni-directional treatment, consistent with embodiments of the present invention.
  • Fig. 6 illustrates a side view of the distal end of a cannula tip with radiofrequency electrodes configured to provide omni-directional treatment, consistent with embodiments of the present invention.
  • Fig. 7 illustrates a side sectional view of a cannula tip with radiofrequency electrodes configured to provide uni-directional treatment, consistent with embodiments of the present invention.
  • Fig. 8 is a plot of absorption coefficients of water and human fatty tissue versus wavelength consistent with embodiments of the present invention.
  • Fig. 9 is a plot of absorption coefficients of water versus wavelength, consistent with embodiments of the present invention.
  • Fig. 10 is a plot representing optical modeling of fat tissue illustrating the relative peak irradiation at multiple wavelengths, consistent with embodiments of the present invention.
  • Fig. 11 is a chart of cumulative absorption at maxima wavelengths, consistent with embodiments of the present invention.
  • Fig. 12 is a chart illustrating the benefit of treatment using heated infusate, such as heated saline, consistent with embodiments of the present invention.
  • the terms “subject” and “patient” refer to any animal, such as a mammal like livestock, pets, and preferably a human. Specific examples of “subjects” and “patients” include, but are not limited, to individuals requiring medical assistance, and in particular, requiring tissue fixation.
  • Embodiments disclosed herein provide devices, systems and methods for the treatment of soft tissue.
  • energy platform devices are provided for soft tissue treatments such as lipolysis and skin tightening.
  • a device combines laser, radio frequency and temperature controlled saline delivery modalities to provide a complete solution that offers greater safety, speed and efficacy within a single device for the treatment of soft tissue.
  • This embodiment is intended for but not limited to energy assisted liposuction.
  • the novel approach can be expanded to treat soft tissue consistent with optically targeting multiple chromophores and the heating of tissue with multiple energy sources.
  • Energy sources may be selected from the group consisting of: optical; radiofrequency; laser; microwave; ultrasound; chemical; radiation; cryogenic; thermal, and combinations of these..
  • local peak water absorptions of interest are centered around 960nm, 1180nm, 1440nm and 1920nm.
  • Local peak fat absorption wavelengths of interest are centered at 930nm, HOOnm, 1200nm, 1400nm, 1725nm and 2300nm.
  • wavelengths 1470nm (wavelength 1) & 1700nm (wavelength 2) have twice the energy density as compared to 920 nm & 980 nm.
  • 2000nm (wavelength 3) has 5x energy density compared to 920 nm & 980 nm.
  • 920 nm & 980 nm have comparable energy densities.
  • tissue heating density is maximized by selecting the wavelengths that provide the maximum cumulative absorption characteristics.
  • the optimal wavelengths for the treatment are determined by the required spatial tissue heating density.
  • Another benefit to our proprietary approach is the use of multiple lumen cannula.
  • This cannula is designed for multiple treatment modalities such as lipolysis, infusion of temperature controlled aqueous solution and aspiration.
  • This aqueous solution may be a therapeutic solution such as Tumescent or simply saline.
  • Energy assisted lipolysis can be considered to an extent as a thermal treatment. Reynaud et al. stated that to achieve optimal lipolysis, enough energy must be cumulatively delivered throughout the different fat layer and into the sub dermal plane so as to reach the collagenous layer. They continue to state that the mechanism of cellular damage is not due to photomechanical action, but instead thermal.
  • the infusing of temperature-controlled aqueous solution minimizes the required optical energy to bring tissue temperatures to >70C.
  • ⁇ E is the amount of optical energy saved by infusing heated saline.
  • Radio Frequency energy combined with temperature controlled aqueous solution is optimal for skin tightening.
  • temperature controlled saline will raise the bulk tissue to desired base temperature that provides controlled slow bulk tissue tightening.
  • Application of RF will raise the target tissue to required temperatures for localized skin tightening.
  • the cannula is designed with electrodes uniquely positioned for either uni-directional or omni-directional treatment. This embodiment of combining RF and heated saline can be used for collagen coagulation or skin tightening.
  • RF and/or temperature controlled aqueous solution (such as heated saline or tumescence) can be used as adjuncts to laser assisted lipolysis or as independent treatment modalities.
  • the amount and temperature of the infusate delivered may be based on the treatment requirements. Alternatively or additionally, the amount of infusate delivered may be based on the area of treatment. For example, in the case of a small area such as the area under the chin, only a small amount of infusate is required. The abdomen area would require significantly more volume in comparison to under the chin.
  • the temperature of the infusate depends on the treatment duration and the desired effect. Lipolysis apoptosis is achievable both at 45 0 C and at 50 0 C, but the treatment exposure time is longer with the 45°C infusate in comparison with the 50 0 C infusate.
  • Figure 1 and Figure 2 illustrate a multiple lumen soft tissue aspirating device.
  • Fig. 3 illustrates a side sectional view of the distal end of a cannula tip, consistent with embodiments of the present invention.
  • Fig. 4 illustrates side and end views of the distal end of a cannula tip with radiofrequency electrodes configured to provide omni-directional treatment, consistent with embodiments of the present invention.
  • Fig. 5 illustrates a side view of the distal end of a cannula tip with radiofrequency electrodes configured to provide unidirectional treatment, consistent with embodiments of the present invention.
  • Fig. 3 illustrates a side sectional view of the distal end of a cannula tip, consistent with embodiments of the present invention.
  • Fig. 4 illustrates side and end views of the distal end of a cannula tip with radiofrequency electrodes configured to provide omni-directional treatment, consistent with embodiments of the present invention.
  • Fig. 5 illustrates a side view of the distal end of
  • FIG. 6 illustrates a side view of the distal end of a cannula tip with radiofrequency electrodes configured to provide omni-directional treatment, consistent with embodiments of the present invention.
  • Fig. 7 illustrates a side sectional view of a cannula tip with radiofrequency electrodes configured to provide uni-directional treatment, consistent with embodiments of the present invention.
  • the embodiments 1 and 2 of Figures 1 and 2 are representative of preferred embodiments for, but not limited to, body sculpting. Derivations are apparent to those skilled in the art and are thereby included herein.
  • the device utilizes multiple energy sources for treatment of lipolysis and skin tightening.
  • the cannula is a probe assembly that is protected by a mechanically robust exterior tubular wall 3, 4, 5 and 6.
  • the cannula tube 3, 4, 5, and 6 can be made from metals such as stainless steel or biocompatible polymers.
  • the cannula includes a hollow core waveguide 7, 8, 9 and 30 that communicates optical energy from laser source to distal end of cannula.
  • the hollow waveguide can be made from optical transparent material similar to but not limited to material such as quartz, fused silica and optically transparent plastic such as Teflon.
  • An obvious derivation to those skilled in the art is to provide an optically reflective inner surface of the hollow waveguide 7, 8, 9 and 30.
  • hollow waveguides can be metal with reflective surface or polymer such as Teflon with lower index of refraction relative to the aqueous solution flowing through hollow core.
  • Port 14 can be used for aspiration or the infusion of temperature controlled aqueous solution.
  • Port 15 provides infusion of temperature controlled aqueous solution that is delivered through the hollow waveguide 7 and 8. Port 15 can also be used for aspiration of treated tissue as well.
  • Optical energy is delivered proximally from an optical fiber 16, 17 and 21, to connector 18 and 19.
  • Said fibers are connected to laser sources.
  • a derivative embodiment is to provide direct laser coupling to the optical waveguides within the cannula, thus eliminating the need for delivery fibers.
  • the optical energy can be coupled concentrically to hollow waveguide 7 and 9 or coupled directly to the walls 20 of the hollow waveguide. Such configuration can provide a singular energy source or a plurality of energy sources with varying wavelengths and energy levels.
  • a multiplicity of optical fibers similar to 21 can be optically coupled to the waveguide 9.
  • Such embodiment can include a multiplicity of optical waveguides, both hollow and solid core.
  • Optical fiber 16 and 17 can extend through the center of the hollow waveguide 7, 8 and 9 to the distal end of the cannula.
  • Such multiplicity of optical waveguides allows unique spatial distribution both in energy density and geometry along with wavelength spatial distribution.
  • Optical Port 18 and 19 can be designed to provide a source of aqueous solution as well.
  • Distal spatial selectivity is achieved through wavelength selection and optical-mechanical design.
  • Optical waveguide tip 22 and 31 optical-mechanical design can be engineered such that the optical energy is collimated, focused or divergent. Such derivations are apparent to those skilled in the art.
  • the shape of the distal tip 11 also determines the mechanical force of the liposuction treatment and provides protection against treating untargeted tissue.
  • Such design of 11 can include optically reflective features within the distal tip.
  • Temperature controlled aqueous solution can be delivered through or around the hollow waveguide 7, 8 and 9. Multiple additional lumens can be designed into the embodiment. Additional lumens can provide a multiplicity of aqueous solutions that provide varying treatment benefits and at varying controlled temperatures. Such derivation to this embodiment is apparent to those skilled in the art. Delivery of temperature controlled aqueous solution can be concurrent to energy treatment and aspiration or delivered independently. Energy treatment can be delivered concurrently with aspiration and aqueous solution or delivered independently. Treated tissue can be aspirated concurrently to energy treatment and aqueous solution delivery or aspirate independently. Additional aspiration ports can be included in the side of the cannula of the probe.
  • RF energy is delivered through contacts 23, 24, 25 and 29.
  • RF energy spatial distribution is determined by parameters including but not limited to: the radio carrier frequency, geometry of the electrodes and the impedance characteristics of surrounding tissue.
  • the dispersion of electrically conductive aqueous solution can modify the spatial distribution of RF energy.
  • Delivery of aqueous solution is provided through ports 26, 27 and 28.
  • RF energy can be delivered uni-directional by electrode configuration 24 and 29, or omni-directional for electrodes 23 and 25.
  • Electrodes 24 illustrate a lateral uni-directional delivery of RF energy.
  • Electrodes 29 illustrate the forward uni-directional delivery of RF energy.
  • Electrodes 23 and 25 illustrate the lateral omni-directional delivery of RF energy. Derivations of location, spacing and geometry of RF electrodes are apparent to those skilled in the art, and are thus covered and included herein.
  • kits are also to be considered within the scope of this application. Multiple configurations of cannula and other device components can be provided in a single kit to treat one or multiple patients.

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Abstract

L'invention concerne des dispositifs, des systèmes et des procédés pour le traitement de tissu mou. Elle concerne un dispositif comprenant un élément allongé avec une extrémité proximale et une extrémité distale. Un perfusat à température contrôlée est administré par une source d'énergie pour traiter le tissu mou.
PCT/US2010/039749 2009-06-24 2010-06-24 Dispositifs, systèmes et procédés pour le traitement de tissu mou Ceased WO2010151619A2 (fr)

Applications Claiming Priority (2)

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US26937309P 2009-06-24 2009-06-24
US61/269,373 2009-06-24

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WO2010151619A2 true WO2010151619A2 (fr) 2010-12-29
WO2010151619A3 WO2010151619A3 (fr) 2011-06-16

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Cited By (21)

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WO2012142291A1 (fr) 2011-04-12 2012-10-18 Thermedical, Inc. Dispositifs et procédés de mise en forme d'un traitement dans une élimination amplifiée de liquide
EP1711849B1 (fr) * 2004-01-08 2013-02-27 Biolase, Inc. Pointes de fibres optiques a sorties modifiees
US9033972B2 (en) 2013-03-15 2015-05-19 Thermedical, Inc. Methods and devices for fluid enhanced microwave ablation therapy
US9610396B2 (en) 2013-03-15 2017-04-04 Thermedical, Inc. Systems and methods for visualizing fluid enhanced ablation therapy
US9743984B1 (en) 2016-08-11 2017-08-29 Thermedical, Inc. Devices and methods for delivering fluid to tissue during ablation therapy
US10022176B2 (en) 2012-08-15 2018-07-17 Thermedical, Inc. Low profile fluid enhanced ablation therapy devices and methods
US11083871B2 (en) 2018-05-03 2021-08-10 Thermedical, Inc. Selectively deployable catheter ablation devices
US11109880B2 (en) 2015-06-17 2021-09-07 Stryker European Operations Holdings Llc Surgical instrument with ultrasonic tip for fibrous tissue removal
US20220080194A1 (en) * 2016-05-23 2022-03-17 Btl Medical Technologies S.R.O. Systems and methods for tissue treatment
US11794029B2 (en) 2016-07-01 2023-10-24 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11806528B2 (en) 2020-05-04 2023-11-07 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11826565B2 (en) 2020-05-04 2023-11-28 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11883643B2 (en) 2016-05-03 2024-01-30 Btl Healthcare Technologies A.S. Systems and methods for treatment of a patient including RF and electrical energy
US11896816B2 (en) 2021-11-03 2024-02-13 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11918277B2 (en) 2018-07-16 2024-03-05 Thermedical, Inc. Inferred maximum temperature monitoring for irrigated ablation therapy
US12064163B2 (en) 2021-10-13 2024-08-20 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US12076576B2 (en) 2019-04-11 2024-09-03 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US12109426B2 (en) 2016-05-10 2024-10-08 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US12109427B2 (en) 2016-07-01 2024-10-08 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US12156689B2 (en) 2019-04-11 2024-12-03 Btl Medical Solutions A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US12274494B2 (en) 2016-08-16 2025-04-15 Btl Healthcare Technologies A.S. Treatment device

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Publication number Priority date Publication date Assignee Title
EP1711849B1 (fr) * 2004-01-08 2013-02-27 Biolase, Inc. Pointes de fibres optiques a sorties modifiees
JP2018030000A (ja) * 2011-04-12 2018-03-01 サーメディカル・インコーポレイテッド 流体補助アブレーションの成形治療のためのデバイス
US11871979B2 (en) 2011-04-12 2024-01-16 Thermedical, Inc. Methods and devices for controlling ablation therapy
JP2014518520A (ja) * 2011-04-12 2014-07-31 サーメディカル・インコーポレイテッド 流体補助アブレーションの成形治療のためのデバイスおよび方法
EP2696789A4 (fr) * 2011-04-12 2014-11-12 Thermedical Inc Dispositifs et procédés de mise en forme d'un traitement dans une élimination amplifiée de liquide
US8945121B2 (en) 2011-04-12 2015-02-03 Thermedical, Inc. Methods and devices for use of degassed fluids with fluid enhanced ablation devices
WO2012142291A1 (fr) 2011-04-12 2012-10-18 Thermedical, Inc. Dispositifs et procédés de mise en forme d'un traitement dans une élimination amplifiée de liquide
US9138287B2 (en) 2011-04-12 2015-09-22 Thermedical, Inc. Methods and devices for heating fluid in fluid enhanced ablation therapy
US9138288B2 (en) 2011-04-12 2015-09-22 Thermedical, Inc. Methods and devices for use of degassed fluids with fluid enhanced ablation devices
US9445861B2 (en) 2011-04-12 2016-09-20 Thermedical, Inc. Methods and devices for controlling ablation therapy
US11583330B2 (en) 2011-04-12 2023-02-21 Thermedical, Inc. Devices and methods for remote temperature monitoring in fluid enhanced ablation therapy
US9730748B2 (en) 2011-04-12 2017-08-15 Thermedical, Inc. Devices and methods for shaping therapy in fluid enhanced ablation
CN107753098A (zh) * 2011-04-12 2018-03-06 热医学公司 用于控制消融治疗的方法和装置
CN103764056A (zh) * 2011-04-12 2014-04-30 热医学公司 在流体增强消融中用于塑形治疗的装置和方法
US9877768B2 (en) 2011-04-12 2018-01-30 Thermedical, Inc. Methods and devices for heating fluid in fluid enhanced ablation therapy
US11950829B2 (en) 2011-04-12 2024-04-09 Thermedical, Inc. Methods and devices for use of degassed fluids with fluid enhanced ablation devices
US9937000B2 (en) 2011-04-12 2018-04-10 Thermedical, Inc. Methods and devices for controlling ablation therapy
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