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WO2010143196A1 - Nouvelle composition synergique d'hydrogel transparent/translucide, sa méthode de préparation, et pellicule ou film fabriqué(e) avec cette composition - Google Patents

Nouvelle composition synergique d'hydrogel transparent/translucide, sa méthode de préparation, et pellicule ou film fabriqué(e) avec cette composition Download PDF

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Publication number
WO2010143196A1
WO2010143196A1 PCT/IN2010/000215 IN2010000215W WO2010143196A1 WO 2010143196 A1 WO2010143196 A1 WO 2010143196A1 IN 2010000215 W IN2010000215 W IN 2010000215W WO 2010143196 A1 WO2010143196 A1 WO 2010143196A1
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Prior art keywords
composition
weight
range
concentration
acrylic acid
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English (en)
Inventor
Narayanan Meenakshi
Balasubramanain Rukhmanikrishnan
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Cavinkare Pvt Ltd
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Cavinkare Pvt Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/26—Optical properties
    • A61K2800/262—Transparent; Translucent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions

Definitions

  • This invention relates to novel synergistic transparent / translucent hydrogel composition method of preparing the composition and sheet / film made therefrom.
  • the transparent / translucent hydrogel sheet / film made from the novel hydrogel composition are useful for cosmetic and / or medical purposes.
  • the novel synergistic hydrogel composition and the transparent / translucent sheet / film made from such a hydrogel composition have excellent skin adhesivity (clingability) and ability to mould itself to the body contours without falling off from the skin.
  • the novel transparent / translucent hydrogel sheet / films made from the synergistic hydrogel composition has good elasticity, excellent break strength (can be folded several times without breaking off) thereby making it easy to handle & has no tackiness.
  • 'hydrogel' we mean that it is a gel that contains water.
  • the present invention relates to a novel synergistic transparent / translucent hydrogel composition which is capable of forming sheet / film.
  • the sheet or film made from the novel hydrogel composition can be applied directly on to the skin for a desired period of time and capable of containing functional component useful for cosmetic benefits or can contain a component with drug actives to deliver functional benefits.
  • the synergistic hydrogel composition of the present invention can be a binary or a ternary composition of gellable polysaccharides and / or polymers & copolymers of acrylic acid / acrylate esters, in specific ratios.
  • binary it is meant that the composition is a combination of either (a) 2 gellable polysaccharides or (b) a gellable polysaccharide and polymer & copolymer of acrylic acid / acrylate esters.
  • ternary composition it is meant that the composition is a combination of either (a) 3 gellable polysaccharides or (b) 2 gellable polysaccharides and polymer & copolymer of acrylic acid / acrylate esters.
  • the composition is preferably a ternary composition
  • the term 'cosmetic' referred to in this specification includes but not limited to, use in relation to personal care and hygiene, for all external application to the body (including inside the mouth e.g. dentrifices), including in relation to cleaning, perfumery, essential oils, aromatherapy oils, cosmetics, deodorants, deodorisers, antiperspirants, soothing & cooling skin care products including for eyelids application, suntan and after sun preparations, skin lightening, skin brightening, anti-aging, anti-acne / pimple, anti-pollution, skin firming, skin tightening, anti- cellulite preparations, toilet preparations and preparations for care of the body, skin, nail, hair & mouth.
  • the invention can be used for medicated preparations and may be used in 'non-cosmetic medical applications' because of its dermatologically acceptable properties e.g. its feel when applied to the skin.
  • the invention may be used in intact skin as well as skin damaged due to cuts, bruises, burns, wounds and the like.
  • a number of cosmetic, medicated and food products are required in gel form. Most of the gel products are flowable in nature due to its viscoelasticity properties and this is made use of for applying and spreading products on the skin or suitable substrate. Food products make use of gelatin and other gums to get specific feel of the product like springiness, elasticity, firmness & gumminess.
  • JP patent No. 10-092366 of Akihiro et al. describes a transparent sheet type cosmetic for non lips. It consists of a gelling agent (chosen from copolymer of acrylamide [5 - 40%, preferably 10 - 25%] and a cross linking monomer [0.3% or less], a polyacrylamide over which the bridge was constructed by the epoxy cross linking agent [3% or less], a carrageenan [0.5 - 20%, preferably 1 - 10%], hylauronic acid and its salt, a deoxyribonucleic acid and its salt); a wetting agent (glycerol [0.1 - 80%], diglycerol, polyethylene glycol, 1,3 - butylene glycol, sorbitol); a bioactive component [0.001 - 80%] (slimming agent, moisturizer, dark circle remover etc.) and water.
  • a gelling agent chosen from copolymer of acrylamide [5 - 40%, preferably 10 - 25%] and
  • the liquefied gel is poured into a mould - solidified by back cooling, applying heat or heating and carrying out a polymerizing reaction (thermal polymerization, azo polymerization initiators) or irradiating light ( UV irradiation) and carrying out a polymerization.
  • a polymerizing reaction thermal polymerization, azo polymerization initiators
  • UV irradiation irradiating light
  • JP patent No. 63301805A by Takashi et al. describes addition of cosmetic pack material to a substrate capable of forming a thin film composed of KONJAK (Starch of Devil's Tongue) gel, carrageenan and hydrolyzed gelatine and subjecting the mixture to heating, cooling, drying and rolling. This is a dry pack which can be peeled off after pasting to the skin.
  • KONJAK Starch of Devil's Tongue
  • JP patent No. 2000-119166 by Yoichi et al. describes a fluid gel comprising of (A) a polysaccharide to form a disintegrable gel as a gel main agent, and (B) a water soluble thickening agent to improve feel & stability.
  • Component A comprises of agar, carrageenan, gellan gum and sodium alginate and
  • Component B comprises of native Gellan gum, Xanthan gum, Locust bean gum, a carboxyvinyl polymer, an acrylic acid / alkyl methacrylic acid methacrylate copolymer, Hydroxy ethyl cellulose, and Hydroxy propyl cellulose.
  • This composition is used as a skin care constituent. During manufacturing, ingredients are heated, cooled and sheared to make a uniform and smooth viscosity gel to give good homogeneity and good spreading properties.
  • GB patent No.2384705 by Levy et al. is a cosmetic composition comprising of gellan gum and carrageenan along with a structuring agent (like polyhydric alcohols, glycerine sorbitol and glycolic acids) to reduce gel brittleness; sequestering agents and pH regulator.
  • the ratio of gellan gum: carrageenan is 1:1 - 1:8, preferably, 1:2 - 1:6 & more preferably 1: 2 - 1:3.
  • Concentration of gellan gum is 0.1 - 0.5% by weight, preferably 0.1 - 0.2%.
  • Carrageenan is used in a concentration of 0.2 - 1.0%, preferably 0.2 - 0.5%. pH of the composition 3.5 - 7.5. It has been specifically mentioned that other gums like Xanthan gum, Locust bean gum, and tragacanth are not suitable as they give a cloudy product.
  • JP patent No.04279509 A2 by Tadanobu et al. have described the use of Xanthan gum (0.2 - 1.5% by weight, preferably 0.3 - 0.5% by weight) and or Locust bean gum and iota carrageenan (0.2 - 1.0% weight, preferably 0.4 - 0.8% weight) in the preparation of an oil in water type emulsion for cosmetic purposes. This composition renders the cosmetic emulsion to exhibit elasticity and semi fluidity in the stationary phase.
  • JP patent No.2000-273033 by Tadashi et al. describes a gel having salt tolerance, capable of having inorganic salt at high concentration and freely adjusting viscoelasticity thereof to give high adhesiveness to the skin.
  • the composition contains carrageenan as a gelling component, an alkali metal ion such as potassium or caesium ion, a functional component such as deep sea water containing natural mineral component, functional water ionized with electrolysis and / or Tourmaline impalpable powder, oil & plant extracts and trehalose.
  • an alkali metal ion such as potassium or caesium ion
  • a functional component such as deep sea water containing natural mineral component, functional water ionized with electrolysis and / or Tourmaline impalpable powder, oil & plant extracts and trehalose.
  • Sullivan Jr. (USP 3944427) have disclosed gellable or gelled composition
  • a liquid medium agar (0.5 - 5.0% weight) and natural gum - gel forming agents like Xanthan gum and Locust bean gum (0.1 - 0.5% weight).
  • Gels are formed by heating the composition to a temperature above the gel critical temperature and subsequently cooling to a temperature below the setting temperature. The gels are used as carriers for different types of photo- processing solutions and therapeutic solutions.
  • the polymers used for these preparations are - Polyoxyethylene - polyoxypropylene block copolymer of poly (oxyethylene) - poly (oxypropylene) and other viscoelastic polymers like Hyaluronic acid, Carboxymethyl Cellulose, Chondroitin sulphate, heparin, Carboxymethyl Guar, Xanthan gum, guar gum, agarose, welan gum, carrageenans, starch phosphates, polysaccharides, polypeptides, and polymers and copolymers of acrylamide, acrylic acid, methacrylic acid and the like. Therapeutic drugs / anaesthetic agents are incorporated and this system provides sustained drug delivery to the eye without flowing out.
  • WO 00/19838 describes a hydrocolloid confectionery product with iota - carrageenan or mix of carrageenans and other hydrocolloids containing >50% iota - carrageenan.
  • the other hydrocolloids used may be Xanthan gum, gellan gum, Locust bean gum etc. to give elastic, bouncy, long lasting and non sticky characteristics similar to gelatine like structures.
  • the concentration of iota - carrageenan in the mix of carrageenan should be at least 60%, preferably 70% and more preferably 80 - 90%.
  • the amount of carrageenan in the confectionery product may be from 0.1 - 5%, preferably 0.25 - 4.0%, and more preferably 0.5 - 3.0% by weight.
  • the other components of this invention comprises in addition to iota carrageenan, water, sugar, glucose syrup, flavours and acids. This product is cooked to form jams, jellies etc.
  • Gellan gum, Locust bean gum etc is not mentioned. Neither any specific ratios between iota - carrageenan and other hydrocolloids is mentioned. Moreover, in our present invention, kappa carrageenan is mainly preferred.
  • WO 02/30214 A1 by Grazela et al. describe a gelatin free gummy confectionery product using combination of Gellan gum and Carrageenan (especially nu &/or nu/iota carrageenan).
  • the ratio of Gellan gum: Carrageenan used is 1: 2 — 1:12, with pH 3 - 4.5, preferably 3.7 - 4.0.
  • the composition also contains sugar, glucose syrup, corn syrup, high fructose corn syrup, juice concentrate etc.
  • US Patent No. 6685978 by Hauksson describes processes and composition for treating uncooked food products like meat, sea food, poultry etc by adding an aqueous composition comprising of thixotropic gel which has been shear thinned and added in the shear thinned condition. Also the composition doe not form a gel externally of the food product. This is basically a brining of meat wherein the salt is added along with a gelling material so as to maintain the product aesthetics.
  • Gellable polysaccharides include carrageenans in combination with Locust bean gum, Xanthan gum, Cassia gum or Konjak gum, flour of sea weeds, fruit or vegetable powder containing polysaccharides gelling pectins, gellan gums and the like.
  • the main objective of the present invention is to provide novel synergistic transparent / translucent hydrogel composition capable of converting to sheet / film which is useful for cosmetic and / or medical purposes
  • Another objective of the present invention is to provide novel synergistic transparent / translucent hydrogel composition capable of converting to sheet / film which has excellent skin adhesivity (clingability) and ability to mould itself to the body contours without falling off from the skin.
  • Yet another objective of the present invention is to provide novel synergistic transparent / translucent hydrogel composition capable of converting to sheet / film which has good elasticity, excellent break strength (can be folded several times without breaking off) & no tackiness
  • Another objective of the present invention is to provide novel synergistic transparent / translucent hydrogel composition capable of converting to sheet / film which can be readily applied as a cosmetic / medicinal product in any part of the body for a length of time and can be easily removed without damaging or affecting the underlying cells or tissues.
  • Another objective of the present invention is to provide a method of preparing novel synergistic transparent / translucent hydrogel composition which is capable of converting into sheet / film form useful for cosmetic and / or medical purposes.
  • Another objective of the present invention is to provide a method of preparing novel hydrogel sheet / film from novel synergistic transparent / translucent hydrogel composition which has excellent skin adhesivity (clingability) and ability to mould itself to the body contours without falling off from the skin.
  • novel synergistic transparent / translucent hydrogel composition resulting from such combinations are binary or ternary and are the following:
  • gellable polysaccharide Any one of the gellable polysaccharide which do not form elastic gels or non gelling individually and kappa carrageenan ( a gellable polysaccharide)
  • gellable polysaccharide Polymer & copolymer of acrylic acid / acrylate esters which do not solidify to be cast into sheets, individually and kappa carrageenan (a gellable polysaccharide).
  • compositions are binary compositions
  • gellable polysaccharide which do not form elastic gels or non gelling individually
  • kappa carrageenan a gellable polysaccharide
  • polymer & copolymer of acrylic acid / acrylate esters which do not solidify to be cast into sheets, individually.
  • gellable polysaccharide Any two gellable polysaccharides which do not form elastic gels or non gelling individually and kappa carrageenan (a gellable polysaccharide).
  • compositions are ternary compositions
  • synergistic transparent / translucent hydrogel composition is hitherto unknown in the prior art.
  • the sheet / film prepared from such a synergistic hydrogel composition has excellent skin adhesivity (clingability) and ability to mould itself to the body contours without falling off from the skin , is also not hitherto known in the prior art
  • the novel hydrogel composition is not a mere admixture of the components used resulting only the aggregation of the properties of the components thereof or for a process for making the said composition.
  • the admixture of the components in a specific ratio imparts synergy to the resulting translucent / transparent composition which facilitates forming a film / sheet which is extremely soft, elastic and having excellent skin adhesivity.
  • the film / sheet so prepared have excellent skin adhesivity (clingability) and ability to mould itself to the body contours without falling off from the skin.
  • the novel transparent / translucent synergistic hydrogel composition made in the form of sheet / film has excellent break strength (can be folded several times without breaking off) thereby making it easy to handle & has no tackiness.
  • Such a unique synergistic hydrogel composition made in the form of sheet / film is not hitherto known
  • the present invention provides novel synergistic transparent / translucent hydrogel composition capable of making it into sheet / film useful for cosmetic and / or medical purposes having excellent skin adhesion, with ability to mould to the contours of the body without falling off, with good elasticity, excellent break strength and no tackiness, which comprises any one of the gellable polysaccharide which do not form elastic gels or non gelling individually and (ii) kappa carrageenan ( a gellable polysaccharide) in the ratio in the range of 1- : 7 to 1 : 20 the concentration of Kappa carrageenan being in the range of 0.001% to 10% by weight of the composition , and that of other gellable polysaccharides being in the range of 0.0001% to 5% by weight of the composition , the pH of the above said compositions being in the range of 3 to 12
  • novel synergistic transparent / translucent hydrogel composition capable of making it into sheet / film useful for cosmetic and / or medical purposes having excellent skin adhesion, with ability to mould to the contours of the body without falling off, with good elasticity, excellent break strength and no tackiness, which comprises a polymer & copolymer of acrylic acid / acrylate esters which do not solidify to be cast into sheets individually and (ii) kappa carrageenan ( a gellable polysaccharide), in the ratio range of 1 : 2 to 1 : 20 and the concentration of the polymer / copolymer of acrylic acid / acrylate esters being in the range of 0.001% to 4.8% by weight of the composition and the concentration of kappa carrageenan, being in the range of 0.001% to 10% by weight of the composition the pH of the composition being in the range of 3 to 12
  • novel synergistic transparent / translucent hydrogel composition capable of making it into sheet / film useful for cosmetic and / or medical purposes having excellent skin adhesion, with ability to mould to the contours of the body without falling off, with good elasticity, excellent break strength and no tackiness, which comprises of (i) One or two of the other gellable polysaccharide which do not form elastic gels or non gelling individually, (ii) kappa carrageenan ( a gellable polysaccharide), and / or (iii) a polymer & copolymer of acrylic acid / acrylate esters which do not solidify to be cast into sheets , individually , in the ratio in the range of 1: (4:1 to 20 :1 ) and the concentration of gellable polysaccharide being in the range of 0.0001% to 5.0% by weight of the composition; the concentration of kappa carrageenan being in the range of 0.001% to
  • compositions 5.0% by weight of the composition , and the concentration of polymer and copolymer of acrylic acid / acrylate esters being in the range of 0.0001% to 4.8% by weight of the composition ,the pH of the above said compositions being in the range of 3 to 12
  • step (v) Cooling the resulting molten mixture to a temperature above the solidification temperature of the gums used, to give the novel synergistic hydrogel composition
  • a process for the preparation of transparent / translucent hydrogel sheet / film which comprises pouring the homogenous molten mixture obtained in step (iv) in the process defined above into a mould of appropriate shape of the desired sheet / film by conventional manner and allowing it to solidify at room temperature and removing the transparent / translucent hydrogel sheet / film from the mould.
  • Carrageenan is naturally occurring family of carbohydrates extracted from red seaweed (Rhodophycae spp.) and available in three distinct forms:
  • Kappa Carrageenan - forms strong rigid gels which are brittle and undergoes syneresis. It forms slightly opaque gels.
  • lota Carrageenan - forms clear, soft elastic gels with no syneresis and are freeze - thaw stable.
  • the other gellable polysaccharide which do not form elastic gels or non gelling individually used in the composition may be selected from one or more of Gellan gum, Xanthan gum, Gelatin, pectin, Locust bean gum, Cassia gum, preferably, gellan gum and xanthan gum.
  • Gellan gum is a polysaccharide manufactured by microbial fermentation of the micro organism Sphingomonas elodea. Gellan gum is available in 2 types - Low and high acyl content. Low acyl gellan gum which is preferred in our composition forms hard, non-elastic, brittle gels; while high acyl gellan gum forms very soft, elastic and non-brittle gels.
  • Xanthan gum is a high molecular weight polysaccharide produced by microbial fermentation of a carbohydrate by the micro organism Xanthomonas campestris. It is considered to be non gelling and used as a viscosity modifier as it has weak gel shear thinning properties.
  • the polymer & copolymer of acrylic acid / acrylate esters which do not solidify to be cast into sheets, individually, used in the composition of the present invention may be selected from the class of polyacrylic acid, cross linked polymers of acrylic acid, copolymers of acrylic acid, copolymers of carboxylic acid containing acrylic esters, cross linked copolymers of acrylic acid and acrylate esters and the like, e.g., Carbopol.
  • the preferred ratio of gellan gum / xanthan gum: Carrageenan may be between 1:8 - 1:15, and more preferably between 1:8 - 1:10.
  • the preferred ratio of polyacrylic acid, cross linked polymers of acrylic acid, copolymers of acrylic acid, copolymers of carboxylic acid containing acrylic esters, cross linked copolymers of acrylic acid and acrylate esters, e.g., Carbopol : Carrageenan may be between 1:3- 1:10 and more preferably between 1:4 — 1 :7.
  • the preferred concentration of gellan gum used in the binary composition may be between 0.01% - 2% by weight and more preferably between 0.05% - 1% by weight of the composition.
  • the preferred concentration of Xanthan gum in the binary composition may vary between
  • the preferred concentration of carrageenan in the binary composition may be between 0.01% - 5% by weight and more preferably between 0.1% - 3% by weight of the composition.
  • the preferred concentration of carbopol in the binary composition may be between 0.01% - 3% by weight and more preferably between 0.05% - 2% by weight of the composition.
  • the preferred ratio of gellan gum / carbopol: (carrageenan: xanthan gum) may be 1: (5:1 - 12:1) and more preferably in the ratio 1: (6:1 - 10:1).
  • the preferred concentration of gellan gum / carbopol in the ternary combination may be between 0.001% - 2% by weight and more preferably between 0.01% - 1% by weight of the composition.
  • the preferred concentration of carrageenan in the ternary composition may be between 0.01% - 3% by weight, and more preferably between 0.1% - 2% by weight of the composition.
  • the preferred concentration of xanthan gum in the composition may vary between 0.001% - 2% by weight, and more preferably between 0.01% - 1% by weight of the composition.
  • the pH of the novel synergistic composition of the present invention may be, preferably between 4.0 - 10.0, and more preferably between 5.0 - 8.0.
  • the pH may be adjusted by adding suitable acid or buffer or both.
  • Suitable acids which can be used include, but not limited to citric, adipic, malic, lactic acid and the like.
  • Suitable buffers which can be used include but not limited to sodium citrate, potassium citrate and the like.
  • the novel synergistic hydrogel composition of the present invention may also contain sequestering agent like, but not limited to EDTA.
  • the novel synergistic composition of the present invention may also comprise the use of preservatives to prevent microbial contamination.
  • Preservatives may include but not limited to methyl chloro isothiocyanate / methyl isothiocyanate (Kathon CG), DMDM Hydantoin (Glydant), Methyl paraben, triclosan and the like. They may be used in a concentration range of about 0.0001% to 0.5% of the composition.
  • the novel synergistic hydrogel composition of the present invention may also comprise of functional ingredients to impart specific benefits to the applied part.
  • This may include but not limited to natural (including plant & marine origin) and / or synthetic ingredients like vegetable oils like Avocado oil, Olive oil, Wheat germ oil, Safflower oil, Castor oil, Canola oil etc.; volatile / essential oil like Tea tree oil, Lemon grass oil, Orange oil, etc.; extracts of plant and plant parts like Gingko biloba extract, Aloe extract or juice, Stevia extract, Potato extract, Rose extract, cucumber extract / juice, Strawberry extract, Papaya extract etc.; estradiol and its derivatives; ⁇ / ⁇ - hydroxyl acids like glycolic acid, citric acid, lactic acid, salicylic acid etc.; Perfumes, Hyaluronic acid, Chondroitin sulphate; Dermatan sulphate; Mucopolysaccharides and its salts such as heparin sulphate, heparin, keratin
  • the translucent / transparent hydrogel sheet / film made from the novel synergistic transparent / translucent hydrogel composition can be applied to any external part of the body where it clings to the skin with high adhesivity.
  • the presence of functional ingredients with their actives as described above, would deliver their active on the applied area e.g. on applying to face or eyes, it delivers non limiting benefits like moisturizing effect, a cooling effect, fresh feel to the skin etc.
  • the present invention differs from the patent of Akihiro et al., (JP 10-092366) referred to earlier in that it does not contain copolymer of acrylamide, a cross linking monomer, an epoxy cross linking agent and a wetting agent in its composition. It is also different from this patent in that it does not require special reactions for solidification of the hydrogel like back - cooling, polymerization reaction or irradiation. As compared to the above prior art the present invention contains Xanthan gum) and the film / sheet formation from the composition is by simple air cooling below 50° C which solidifies the product into sheets / films when poured into appropriate sheet shaped moulds.
  • the composition of the present invention does not contain KONJAK starch and it is also not in a dried form.
  • the composition of the present invention is a wet hydrogel sheet / film which can be readily applied on to the skin immediately.
  • the present invention is a not in a fluid gel form, but it forms a solid sheet/ film. Also, during preparation, it is not sheared to form a viscous product which can be applied and spread on to the skin.
  • the composition described in the present invention is a ready to apply & use product in a sheet / film form.
  • the composition described in the patent by Levy et al. is not a gel in a sheet / film form.
  • the product disclosed in the patent of Levy et al. is to be applied and spread on to the skin by making a lotion or cream and pumped out through a dispenser.
  • the product forms between the present invention and that described by Levy et al are totally different in character.
  • the invention as described in the patent of Tadanobu et al. describes oil in water emulsion, while the composition of the present invention is not an emulsion at all, but a hydrogel in a sheet / film form. Hence the two inventions are different.
  • the invention disclosed in the JP patent no 2000-273033 of Tadashi et al. differs from the present invention in that, the present invention does not describe the use of alkali metal ion, functional water ionized with electrolysis and / or Tourmaline impalpable powder or trehalose in its composition.
  • the composition of the present invention also need not be applied and spread on the skin. It can be placed directly as a sheet / film on the skin.
  • composition of the present invention does not contain agar as a solidifying agent.
  • compositions as described by Grazela e al., in their patent WO 02/30214 A1 is a composition not a sheet like structure, but a gummy structure. Also, they are using specifically nu or iota carrageenan, while the composition of the present invention is a sheet / film and uses Kappa carrageenan.
  • compositions used for food processing in a shear thinned condition which gels in situ, not externally.
  • the composition of the present invention is totally different from that disclosed in the US Patent As compared to many other prior art inventions referred earlier, the composition of the present invention does not exhibit a sol - gel property. It exists as a hydrogel which can be moulded into a sheet / film at room temperature which can be readily applied on the skin.
  • the molten mixture is poured into a flat sheet shaped mould of desired shape and size and allowed to cool.
  • the mixture begins to solidify and takes the form of a sheet in the mould below 50° C. Allow it to cool to room temperature.
  • the hydro gel sheet is removed from the mould.
  • the hydro gel sheet is found to have extremely good elasticity, flexibility, break strength and no tackiness.
  • the molten mixture is poured into a flat sheet shaped mould of desired shape and size and allowed to cool.
  • the mixture begins to solidify and takes the form of a sheet in the mould below 50° C. Allow it to cool to room temperature.
  • the hydro gel sheet is removed from the mould. The hydro gel sheet is found to have extremely good elasticity/ flexibility, break strength and no tackiness.
  • preservative Kathon CG
  • the molten mixture is poured into a flat sheet shaped mould of desired shape and size and allowed to cool.
  • the mixture begins to solidify and takes the form of a sheet in the mould below 50° C. Allow it to cool to room temperature.
  • the hydro gel sheet is removed from the mould.
  • the hydro gel sheet is found to have extremely good elasticity, flexibility, break strength and no tackiness.
  • the molten mixture is poured into a flat sheet shaped mould of desired shape and size and allowed to cool. 10.
  • the mixture begins to solidify and takes the form of a sheet in the mould below 50° C. Allow it to cool to room temperature.
  • the hydro gel sheet is removed from the mould. The hydro gel sheet is found to have extremely good elasticity, flexibility, break strength and no tackiness.
  • the molten mixture is poured into a flat sheet shaped mould of desired shape and size and allowed to cool.
  • the mixture begins to solidify and takes the form of a sheet in the mould below 50° C. Allow it to cool to room temperature.
  • the hydro gel sheet is removed from the mould. The hydro gel sheet is found to have extremely good elasticity, flexibility, break strength and no tackiness.
  • the molten mixture is poured into a flat sheet shaped mould of desired shape and size and allowed to cool.
  • the mixture begins to solidify and takes the form of a sheet in the mould below 50° C. Allow it to cool to room temperature.
  • the hydro gel sheet is removed from the mould.
  • the hydro gel sheet is found to have extremely good elasticity, flexibility, break strength and no tackiness.
  • the molten mixture is poured into a flat sheet shaped mould of desired shape and size and allowed to cool.
  • the mixture begins to solidify and takes the form of a sheet in the mould below 50° C. Allow it to cool to room temperature.
  • the hydro gel sheet is removed from the mould. The hydro gel sheet is found to have extremely good elasticity, flexibility, break strength and no tackiness.
  • the molten mixture is poured into a flat sheet shaped mould of desired shape and size and allowed to cool.
  • the mixture begins to solidify and takes the form of a sheet in the mould below 50° C. Allow it to cool to room temperature.
  • the hydro gel sheet is removed from the mould.
  • the hydro gel sheet is found to have extremely good elasticity, flexibility, break strength and no tackiness
  • the mixture begins to solidify and takes the form of a sheet in the mould below 50° C. Allow it to cool to room temperature.
  • the hydro gel sheet is removed from the mould. The hydro gel sheet is found to have extremely good elasticity, flexibility, break strength and no tackiness.
  • the molten mixture is poured into a flat sheet shaped mould of desired shape and size and allowed to cool.
  • the mixture begins to solidify and takes the form of a sheet in the mould below 50° C. Allow it to cool to room temperature.
  • the hydro gel sheet is removed from the mould. The hydro gel sheet is found to have extremely good elasticity, flexibility, break strength and no tackiness.
  • novel synergistic hydrogel composition of the present invention is,
  • a ready to use gel which may be used in cosmetic / medical applications.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

Cette invention concerne une nouvelle composition synergique d'hydrogel transparent/translucide pouvant être transformée en pellicule ou film d'hydrogel utile pour un usage cosmétique et/ou médical et présentant une excellente adhérence à la peau. Cette composition comprend: i) tout polysaccharide gélifiable qui ne forme pas des gels élastiques et/ou un polymère ou copolymère d'acide acrylique et d'esters d'acrylate; et ii) du kappa-carraghénane (un polysaccharide gélifiable), le pH desdites compositions étant compris entre 3 et 12. L'invention concerne également une méthode de préparation de la nouvelle composition synergique d'hydrogel, une pellicule ou film d'hydrogel transparent/translucide, et une méthode de préparation de la pellicule ou film.
PCT/IN2010/000215 2009-04-03 2010-04-01 Nouvelle composition synergique d'hydrogel transparent/translucide, sa méthode de préparation, et pellicule ou film fabriqué(e) avec cette composition Ceased WO2010143196A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN778/CHE/2009 2009-04-03
IN778CH2009 2009-04-03

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WO2010143196A1 true WO2010143196A1 (fr) 2010-12-16

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CN102273639A (zh) * 2011-08-12 2011-12-14 姜红成 燕窝香体制品及其制备方法
CN102660417A (zh) * 2012-05-10 2012-09-12 福建农林大学 一种清洁凝胶及其制备方法
US8388541B2 (en) 2007-11-26 2013-03-05 C. R. Bard, Inc. Integrated system for intravascular placement of a catheter
US8388546B2 (en) 2006-10-23 2013-03-05 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US8437833B2 (en) 2008-10-07 2013-05-07 Bard Access Systems, Inc. Percutaneous magnetic gastrostomy
US8478382B2 (en) 2008-02-11 2013-07-02 C. R. Bard, Inc. Systems and methods for positioning a catheter
US8512256B2 (en) 2006-10-23 2013-08-20 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
CN103432621A (zh) * 2013-08-04 2013-12-11 南京天纵易康生物科技有限公司 一种透明质酸敷料及其应用方法
CN103463634A (zh) * 2013-09-09 2013-12-25 镇江万山红遍农业园 免疫增强剂及其使用方法
USD699359S1 (en) 2011-08-09 2014-02-11 C. R. Bard, Inc. Ultrasound probe head
US8781555B2 (en) 2007-11-26 2014-07-15 C. R. Bard, Inc. System for placement of a catheter including a signal-generating stylet
US8784336B2 (en) 2005-08-24 2014-07-22 C. R. Bard, Inc. Stylet apparatuses and methods of manufacture
US8801693B2 (en) 2010-10-29 2014-08-12 C. R. Bard, Inc. Bioimpedance-assisted placement of a medical device
US20140239536A1 (en) * 2011-10-04 2014-08-28 Genic Co., Ltd. Hydrogel composition for a mask base and method for manufacturing a hydrogel using same
US8849382B2 (en) 2007-11-26 2014-09-30 C. R. Bard, Inc. Apparatus and display methods relating to intravascular placement of a catheter
US9125578B2 (en) 2009-06-12 2015-09-08 Bard Access Systems, Inc. Apparatus and method for catheter navigation and tip location
US9211107B2 (en) 2011-11-07 2015-12-15 C. R. Bard, Inc. Ruggedized ultrasound hydrogel insert
US9339206B2 (en) 2009-06-12 2016-05-17 Bard Access Systems, Inc. Adaptor for endovascular electrocardiography
CN105601956A (zh) * 2015-12-01 2016-05-25 大连工业大学 一种新型Iota-卡拉胶凝胶及其制备方法
CN105920660A (zh) * 2016-05-25 2016-09-07 天津嘉氏堂医美科技有限公司 用于治疗慢性伤口的组合物及制剂
US9445734B2 (en) 2009-06-12 2016-09-20 Bard Access Systems, Inc. Devices and methods for endovascular electrography
US9456766B2 (en) 2007-11-26 2016-10-04 C. R. Bard, Inc. Apparatus for use with needle insertion guidance system
US9492097B2 (en) 2007-11-26 2016-11-15 C. R. Bard, Inc. Needle length determination and calibration for insertion guidance system
US9521961B2 (en) 2007-11-26 2016-12-20 C. R. Bard, Inc. Systems and methods for guiding a medical instrument
US9532724B2 (en) 2009-06-12 2017-01-03 Bard Access Systems, Inc. Apparatus and method for catheter navigation using endovascular energy mapping
US9554716B2 (en) 2007-11-26 2017-01-31 C. R. Bard, Inc. Insertion guidance system for needles and medical components
US9636031B2 (en) 2007-11-26 2017-05-02 C.R. Bard, Inc. Stylets for use with apparatus for intravascular placement of a catheter
US9649048B2 (en) 2007-11-26 2017-05-16 C. R. Bard, Inc. Systems and methods for breaching a sterile field for intravascular placement of a catheter
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WO2018191244A1 (fr) * 2017-04-10 2018-10-18 TheWell Bioscience Hydrogel pour applications biomédicales et de culture cellulaire
US10349890B2 (en) 2015-06-26 2019-07-16 C. R. Bard, Inc. Connector interface for ECG-based catheter positioning system
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CN110522680A (zh) * 2019-07-18 2019-12-03 广州雅心化妆品有限公司 一种护肤品载体及其制备方法
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US10820885B2 (en) 2012-06-15 2020-11-03 C. R. Bard, Inc. Apparatus and methods for detection of a removable cap on an ultrasound probe
US10973584B2 (en) 2015-01-19 2021-04-13 Bard Access Systems, Inc. Device and method for vascular access
US10992079B2 (en) 2018-10-16 2021-04-27 Bard Access Systems, Inc. Safety-equipped connection systems and methods thereof for establishing electrical connections
US11000207B2 (en) 2016-01-29 2021-05-11 C. R. Bard, Inc. Multiple coil system for tracking a medical device
WO2021127681A1 (fr) * 2019-12-20 2021-06-24 Colgate-Palmolive Company Compositions de soins personnels et leurs procédés
US11103213B2 (en) 2009-10-08 2021-08-31 C. R. Bard, Inc. Spacers for use with an ultrasound probe

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US11207496B2 (en) 2005-08-24 2021-12-28 C. R. Bard, Inc. Stylet apparatuses and methods of manufacture
US8784336B2 (en) 2005-08-24 2014-07-22 C. R. Bard, Inc. Stylet apparatuses and methods of manufacture
US8774907B2 (en) 2006-10-23 2014-07-08 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US9833169B2 (en) 2006-10-23 2017-12-05 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US8388546B2 (en) 2006-10-23 2013-03-05 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
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US8858455B2 (en) 2006-10-23 2014-10-14 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US8781555B2 (en) 2007-11-26 2014-07-15 C. R. Bard, Inc. System for placement of a catheter including a signal-generating stylet
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US10342575B2 (en) 2007-11-26 2019-07-09 C. R. Bard, Inc. Apparatus for use with needle insertion guidance system
US10449330B2 (en) 2007-11-26 2019-10-22 C. R. Bard, Inc. Magnetic element-equipped needle assemblies
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US11707205B2 (en) 2007-11-26 2023-07-25 C. R. Bard, Inc. Integrated system for intravascular placement of a catheter
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US10524691B2 (en) 2007-11-26 2020-01-07 C. R. Bard, Inc. Needle assembly including an aligned magnetic element
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US9549685B2 (en) 2007-11-26 2017-01-24 C. R. Bard, Inc. Apparatus and display methods relating to intravascular placement of a catheter
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US9125578B2 (en) 2009-06-12 2015-09-08 Bard Access Systems, Inc. Apparatus and method for catheter navigation and tip location
US9445734B2 (en) 2009-06-12 2016-09-20 Bard Access Systems, Inc. Devices and methods for endovascular electrography
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US10046139B2 (en) 2010-08-20 2018-08-14 C. R. Bard, Inc. Reconfirmation of ECG-assisted catheter tip placement
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CN102273639B (zh) * 2011-08-12 2016-09-14 姜红成 燕窝香体制品及其制备方法
CN102273639A (zh) * 2011-08-12 2011-12-14 姜红成 燕窝香体制品及其制备方法
JP2014528443A (ja) * 2011-10-04 2014-10-27 ジェニック カンパニー リミテッドＧｅｎｉｃ Ｃｏ．，Ｌｔｄ． マスク基材用ヒドロゲル組成物及びそれを用いたヒドロゲルの製造方法
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US10011712B2 (en) 2011-10-04 2018-07-03 Genic Co., Ltd. Hydrogel composition for a mask base and method for manufacturing a hydrogel using same
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US11026630B2 (en) 2015-06-26 2021-06-08 C. R. Bard, Inc. Connector interface for ECG-based catheter positioning system
US10349890B2 (en) 2015-06-26 2019-07-16 C. R. Bard, Inc. Connector interface for ECG-based catheter positioning system
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US10603406B2 (en) 2017-04-10 2020-03-31 TheWell Bioscience Hydrogel for cell culture and biomedical applications
US10992079B2 (en) 2018-10-16 2021-04-27 Bard Access Systems, Inc. Safety-equipped connection systems and methods thereof for establishing electrical connections
US11621518B2 (en) 2018-10-16 2023-04-04 Bard Access Systems, Inc. Safety-equipped connection systems and methods thereof for establishing electrical connections
CN110522680A (zh) * 2019-07-18 2019-12-03 广州雅心化妆品有限公司 一种护肤品载体及其制备方法
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