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WO2010036086A2 - Ct-attachable pet - Google Patents

Ct-attachable pet Download PDF

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Publication number
WO2010036086A2
WO2010036086A2 PCT/KR2009/005579 KR2009005579W WO2010036086A2 WO 2010036086 A2 WO2010036086 A2 WO 2010036086A2 KR 2009005579 W KR2009005579 W KR 2009005579W WO 2010036086 A2 WO2010036086 A2 WO 2010036086A2
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Prior art keywords
pet
attached
image
scanner
detector
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PCT/KR2009/005579
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French (fr)
Korean (ko)
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WO2010036086A3 (en
Inventor
최용
민병준
최준영
최연성
이경한
김병태
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Samsung Life Public Welfare Foundation
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Samsung Life Public Welfare Foundation
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Priority claimed from KR1020090091734A external-priority patent/KR101136609B1/en
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Publication of WO2010036086A2 publication Critical patent/WO2010036086A2/en
Publication of WO2010036086A3 publication Critical patent/WO2010036086A3/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computed tomography [CT]
    • A61B6/032Transmission computed tomography [CT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computed tomography [CT]
    • A61B6/037Emission tomography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5235Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01TMEASUREMENT OF NUCLEAR OR X-RADIATION
    • G01T1/00Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation

Definitions

  • the present invention relates to a CT attached PET and a method for providing a CT-PET fusion image using the same.
  • Computed Tomography is a device that uses a computer to image a certain cross-section of the human body, and it is widely used today by using X-ray developed by G. Housefield and J. Abrose of England in 1972.
  • the principle is to divide a cross section of the human body into a small matrix, transmit a thin X-ray beam in various directions, and measure X-ray absorption values of each matrix and reconstruct them into images.
  • the reconstruction method uses Fourier transform method and superposition integral method.
  • PET Positron emission tomography
  • PET has the affinity of certain neuro-receptors for metabolism and neurotransmitter ligands of certain substrates such as glucose and ganciclovir. It has the ability to measure gene phenomena as well as affinity / distribution.
  • PET can provide molecular and functional information of human tissue with very high contrast.
  • CT can provide detailed anatomical information about human tissue, but it cannot provide molecular and functional information as opposed to PET.
  • CT and PET have been developed as an integrated device.
  • an expensive integrated PET / CT fusion image device needs to be introduced, which causes a high cost.
  • Another object of the present invention to provide a method for providing a CT-PET fusion image using the CT attached PET.
  • the present invention includes a PET detector 30 located at 0 cm to 150 cm depth 35 from one side of the PET attached to the CT scanner 20, the anatomical image of the CT scanner And CT attached PET 33 for providing a fusion image of the functional image of the PET detector.
  • the PET detector is located at a depth of 0 cm from one side of the PET attached to the CT scanner when the PET detector is located on one side of the PET.
  • the inner diameter 34 of the PET detector is 2 cm to 130 cm.
  • the elliptical short radius 35 of one side of the PET attached to the CT scanner is 0 cm to 200 cm.
  • the oval short radius 35 of one side of the PET attached to the CT scanner is 0 cm, which corresponds to the case where one side of the PET is vertical.
  • the support further comprises a support 32 for maintaining the CT attached PET attachment.
  • the support 32 is inclined at 0 to 45 degrees with respect to the vertical plane. The inclination of the support to 0 ° with respect to the vertical plane corresponds to the case where the support is perpendicular to the floor.
  • the bed is inserted into the CT port 21 and the PET port 31 and photographed with the CT scanner 20 and the PET detector 33 to move the pointers 41a, 42a, 43a provided on the marker. Recognizing;
  • the markers are X-axis 41, Y-axis 42 and Z-axis 43 and pointers 41a, 42a, 43a provided on each axis as reference points on the coordinates. Is done.
  • CT attached PET of the present invention can be detachably mounted on the existing CT without the use of expensive equipment in which the CT and PET used in the hospital is integrally integrated, and it is possible to fuse anatomical and functional images Done Therefore, it is very economical by increasing the utilization of the existing CT device through the CT-attached PET of the present invention without purchasing an expensive PET / CT integrated device, and at the same time, it is highly reliable in the diagnosis of various tumors, brain neurological diseases, heart diseases, etc. There is an effect to be improved.
  • Figure 1 is a schematic diagram of a PET / CT system attached CT attached PET which is a preferred embodiment of the present invention.
  • Figure 2 is a side view (b) and cross-sectional view (a, c) showing a CT-attached PET which is a preferred embodiment of the present invention.
  • Figure 3 is a side view showing a CT attached PET is another preferred embodiment of the present invention.
  • FIG. 4 is a cross-sectional view showing that the CT attached PET 33, which is a preferred embodiment of the present invention, is attached to the CT scanner 20. As shown in FIG.
  • FIG. 5 is a schematic diagram showing before (a, b) and after (c) the CT attached PET is attached to the CT scanner.
  • FIG. 6 is a perspective view schematically showing the marker 40.
  • PET detector 31 PET shooting port
  • CT attached PET which is an embodiment of the present invention in more detail as follows.
  • Figure 1 is a schematic diagram of a PET / CT system attached CT attached PET which is a preferred embodiment of the present invention.
  • PET / CT system according to an embodiment of the present invention as shown is a bed 11 made of a flat plate shape so that the patient can lie down and transportably mounted along the longitudinal direction at the upper end of the support means (10);
  • a CT scanner 20 which is paired with the support means 10 and has a CT port 21 into which the bed 11 can be introduced, and takes an anatomical image of the patient;
  • PET detector 30 is formed in communication with the CT imaging port 21 and the PET detector 30 is mounted on one side of the CT scanner 20;
  • a marker 40 detachably mounted at one end of the bed 11.
  • FIG. 2 is a side view (b) and cross-sectional views (a, c) showing a CT-attached PET 33, which is a preferred embodiment of the present invention.
  • CT-attached PET 33 includes a PET detector 30 attached to the CT scanner 20.
  • the position of the PET detector 30 may vary depending on the usage of the PET / CT system, but is located at a depth of 0 cm to 50 cm from one side of the PET attached to the CT scanner 20.
  • the inner diameter 34 of the PET detector 30 may vary depending on the usage of the PET / CT system, but preferably 2 cm to 130 cm.
  • the elliptical short radius 35 of one side of the PET attached to the CT scanner 20 may vary depending on the usage of the PET / CT system, but is preferably 0 cm to 200 cm.
  • the CT-attached PET may further include a support 32 for maintaining the attachment.
  • the support 32 is preferably inclined at 0 to 45 degrees with respect to the vertical plane so that the PET detector 30 is attached to the CT scanner 20 well.
  • FIG. 3 is a side view showing a CT attached PET 33 according to another preferred embodiment of the present invention.
  • One side opposite to the one side of the PET attached to the CT scanner 20 may be concave as shown in FIG.
  • FIG. 4 is a cross-sectional view showing that the CT attached PET 33, which is a preferred embodiment of the present invention, is attached to the CT scanner 20. As shown in FIG.
  • FIG. 5 is a schematic view showing the CT attached PET 33 before (a, b) and after (c) being attached to the CT scanner 20.
  • PET detector 30 is preferably detachably mounted on one side of the CT scanner 20 to enable additional installation to the existing CT scanner 20 equipment, PET detector 30 is fastened with a bolt Any structure that can be detachably mounted, such as a method or a fixed clamp or a socket structure to be inserted and fixed, can be used, and the CT imaging port 21 and the PET imaging port 31 can communicate with each other through the bed 11. Has a structure.
  • FIG. 6 is a perspective view schematically showing the marker 40.
  • the marker 40 mounted on one end of the CT 11 of the bed 11 has a predetermined frame shape, and the X axis 41, the Y axis 42, and the Z axis 43 are formed in a wire shape. Pointers 41a, 42a, 43a are formed on the axis line, respectively.
  • the method for providing CT-PET fusion images by attaching the CT-attached PET 33 of the present invention to the CT scanner 20 includes the following steps:
  • the bed is inserted into the CT port 21 and the PET port 31 and photographed with the CT scanner 20 and the PET detector 33 to move the pointers 41a, 42a, 43a provided on the marker. Recognizing;
  • the marker 40 is installed on the bed 11 prior to imaging the affected area, and then inserted into the CT imaging tool 21 and the PET imaging tool 31.
  • the CT scanner 20 and the PET detector 30 take a picture to recognize the pointers 41a, 42a, and 43a provided in the marker 40.
  • the reference point of coordinates is found through the positions of the pointers 41a, 42a and 43a captured by the CT scanner 20 and the pointers 41a, 42a and 43a captured by the PET detector 30, and the reference points are fused to two images. When adjusted to the center point.
  • the marker 40 is used when the PET detector 30 is first attached to the CT scanner 20 and installed.
  • the marker 40 is separated when the patient image is taken after installation.
  • the marker 40 can be mounted and used as necessary for equipment defect check and quality control.
  • the patient lies on the bed 11 and moves the bed 11 to allow the affected part to be taken into the CT scanner 20.
  • the lesion to be taken passes the CT imaging port 21 and simultaneously captures the anatomical image of the affected part, and passes the PET port 31 and simultaneously captures the functional image of the affected part.
  • the photographed output signal is transferred to CT image processor and PET image processor, respectively, and is converted into anatomical image and functional image, and each converted image is transferred to fusion image processor and fused into one image. That is, it is possible to obtain an image in which the anatomical image and the functional image are fused.
  • the center point at which the anatomical image and the functional image are fused is already set in three dimensions through the pointers 41a, 42a, and 43a of the marker 40, and thus can be easily fused.

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Abstract

The present invention provides a CT-attachable PET (33) for providing a fusion image combining an anatomical image from a CT scanner and a functional image from a PET detector, the CT-attachable PET comprising the PET detector (30) which is positioned in a depth (35) of 0cm to 150cm from one side of the PET attached on the CT scanner (20). Also, the present invention provides a method for providing a CT-PET fusion image by attaching the CT-attachable PET to the CT scanner. The CT-attachable PET of the present invention can be detachably mounted to a conventional CT and enables fusion of anatomical images and functional images without an expensive CT and PET-integrated equipment which has been used in hospitals. Thus, the CT-attachable PET of the present invention is very economical by increasing availability of a conventional CT device without purchasing an expensive PET/CT integrated device. At the same time, the CT-attachable PET improves reliability of diagnosing various tumors, neurological disorders, and heart disease.

Description

CT 부착형 PETCT attached type PET

본 발명은 CT 부착형 PET 및 이를 이용하여 CT-PET 융합영상을 제공하는 방법에 관한 것이다. The present invention relates to a CT attached PET and a method for providing a CT-PET fusion image using the same.

CT(Computed Tomography)는 컴퓨터를 이용해서 인체의 어떤 단면을 화상화하는 장치로서, 현재 많이 보급되어 있는 것은 1972년 영국의 G.하우스필드와 J.애브로스가 개발한 X선을 사용한 장치이다. 원리는 인체의 어느 단면을 작은 매트릭스로 구분하고, 여기에 여러 방향에서 가는 X선 빔(beam)을 투과시킨 후 각 매트릭스의 X선 흡수값을 측정하여 이것들을 화상으로 재구성하는 일이다. 재구성하는 방법으로는 푸리에변환법과 중첩적분법을 이용하고 있다. Computed Tomography (CT) is a device that uses a computer to image a certain cross-section of the human body, and it is widely used today by using X-ray developed by G. Housefield and J. Abrose of England in 1972. The principle is to divide a cross section of the human body into a small matrix, transmit a thin X-ray beam in various directions, and measure X-ray absorption values of each matrix and reconstruct them into images. The reconstruction method uses Fourier transform method and superposition integral method.

PET(Positron Emission Tomography)는 1970년대 중반 미저리 주, 세인트루이스에 위치한 워싱턴 대학의 M. 티르-포고시안(Ter-Pogossian) 및 M. 펠프스(Phelps) 등에 의해 소멸방사선동시검출 원리를 이용하여 개발되었다. 그 후, PET는 CPS-CTI를 포함하는 몇몇 상업 회사들에 의해서 발전하여 왔고, 최근에는 피이티/씨티 융합영상기기 형태로 활용도가 큰 폭으로 증가하고 있다. Positron emission tomography (PET) was developed using M. Tyre-Pogossian and M. Phelps at the University of Washington, St. Louis, Missouri, in the mid-1970s, using the principle of extinction radiation detection. Since then, PET has been developed by several commercial companies including CPS-CTI, and in recent years, the utilization of PET in the form of PTI / CTI converged image device has been greatly increased.

본 기술 분야에서 잘 알려진 바와 같이, PET는 포도당(glucose) 및 갠사이크로비르(ganciclovir)와 같은 특정 기질의 대사 및 신경 전달 물질 배위자(ligands)에 대한 특정 신경-수용체(neuro-receptors)의 친화력/분포(affinity/distribution) 뿐만 아니라 유전자 수준의 생체현상을 측정할 수 있는 능력이 있다. As is well known in the art, PET has the affinity of certain neuro-receptors for metabolism and neurotransmitter ligands of certain substrates such as glucose and ganciclovir. It has the ability to measure gene phenomena as well as affinity / distribution.

상기와 같이 종래의 CT와 PET는 각각 고유한 장점과 단점이 있다. PET는 인체 조직의 분자학적 그리고 기능적 정보를 매우 높은 대조도(contrast)를 통해 제공할 수 있다. 하지만 본질적으로 낮은 해상도를 갖기 때문에 해부학적 정보를 제공하는 데는 한계가 있다. CT의 경우 인체 조직에 대한 상세한 해부학적 정보를 제공할 수는 있지만, PET와는 반대로 분자학적 그리고 기능적 정보를 제공할 수 없다. As described above, the conventional CT and PET each have inherent advantages and disadvantages. PET can provide molecular and functional information of human tissue with very high contrast. However, due to its inherently low resolution, there is a limit to providing anatomical information. CT can provide detailed anatomical information about human tissue, but it cannot provide molecular and functional information as opposed to PET.

이를 해결하기 위하여 CT와 PET가 일체형으로 구성된 장치를 개발하고 있다. 그러나 상기와 같이 기능적 정보와 해부학적 정보가 융합된 영상을 얻기 위해서는 고가의 일체형 PET/CT 융합영상기기를 도입해야되므로 많은 비용이 소요되는 문제점이 있다. In order to solve this problem, CT and PET have been developed as an integrated device. However, in order to obtain an image in which functional information and anatomical information are fused as described above, an expensive integrated PET / CT fusion image device needs to be introduced, which causes a high cost.

본 발명의 목적은 CT 부착형 PET를 제공하는 것이다.  It is an object of the present invention to provide a CT attached PET.

본 발명의 다른 목적은 상기 CT 부착형 PET를 이용하여 CT-PET 융합영상을 제공하는 방법을 제공하는 것이다.  Another object of the present invention to provide a method for providing a CT-PET fusion image using the CT attached PET.

상기 목적을 달성하기 위하여, 본 발명은 CT 스캐너(20)에 부착되는 PET의 일측면으로부터 0 cm 내지 150 cm 깊이(35)에 위치하는 PET 검출기(30)를 포함하여, CT 스캐너의 해부학적 영상과 PET 검출기의 기능적 영상의 융합영상을 제공하기 위한 CT 부착형 PET(33)을 제공한다. PET 검출기가 CT 스캐너에 부착되는 PET의 일측면으로부터 0 cm 깊이에 위치한다는 것은 PET 검출기가 상기 PET의 일측면 상에 위치한 경우에 해당한다. In order to achieve the above object, the present invention includes a PET detector 30 located at 0 cm to 150 cm depth 35 from one side of the PET attached to the CT scanner 20, the anatomical image of the CT scanner And CT attached PET 33 for providing a fusion image of the functional image of the PET detector. The PET detector is located at a depth of 0 cm from one side of the PET attached to the CT scanner when the PET detector is located on one side of the PET.

본 발명의 바람직한 일 구체예에서, 상기 PET 검출기의 내측 직경(34)은 2 cm 내지 130 cm이다. In one preferred embodiment of the invention, the inner diameter 34 of the PET detector is 2 cm to 130 cm.

본 발명의 바람직한 일 구체예에서, 상기 CT 스캐너에 부착되는 PET의 일측면의 타원 단반경(35)은 0 cm 내지 200 cm이다. CT 스캐너에 부착되는 PET의 일측면의 타원 단반경(35)이 0 cm라는 것은 상기 PET의 일측면이 수직인 경우에 해당한다. In one preferred embodiment of the present invention, the elliptical short radius 35 of one side of the PET attached to the CT scanner is 0 cm to 200 cm. The oval short radius 35 of one side of the PET attached to the CT scanner is 0 cm, which corresponds to the case where one side of the PET is vertical.

본 발명의 바람직한 일 구체예에서, 상기 CT 부착형 PET 부착을 유지하기 위한 지지대(32)를 추가로 포함한다. 상기 지지대(32)는 수직면을 기준으로 0 내지 45°로 기울어진다. 지지대가 수직면을 기준으로 0°로 기울어진다는 것은 상기 지지대가 바닥에 수직인 경우에 해당한다.  In a preferred embodiment of the invention, the support further comprises a support 32 for maintaining the CT attached PET attachment. The support 32 is inclined at 0 to 45 degrees with respect to the vertical plane. The inclination of the support to 0 ° with respect to the vertical plane corresponds to the case where the support is perpendicular to the floor.

본 발명의 다른 양태로서, 본 발명은  As another aspect of the present invention,

(i) 마커(40)를 환자를 이송하는 베드(11)의 일측 끝단부에 장착하는 단계; (i) mounting the marker 40 at one end of the bed 11 carrying the patient;

(ii) 상기 CT 부착형 PET(33)를 CT 스캐너(20)에 부착하는 단계; (ii) attaching the CT attached PET 33 to a CT scanner 20;

(iii) 상기 베드를 CT 촬영구(21) 및 PET 촬영구(31) 내부로 인입시키고 CT 스캐너(20) 및 PET 검출기(33)로 촬영하여 마커에 구비된 포인터(41a, 42a, 43a)를 인식하는 단계; (iii) the bed is inserted into the CT port 21 and the PET port 31 and photographed with the CT scanner 20 and the PET detector 33 to move the pointers 41a, 42a, 43a provided on the marker. Recognizing;

(iv) CT 스캐너에 촬영된 포인터 위치와 PET 검출기에 촬영된 포인터 위치를 통해 찾은 좌표의 기준점을 CT 영상과 PET 영상을 융합시키는 중심점으로 조절하는 단계; (iv) adjusting a reference point of coordinates found through the pointer position photographed on the CT scanner and the pointer position photographed on the PET detector to a center point where the CT image and the PET image are fused;

(v) CT 및 PET 촬영하는 단계; 및 (v) CT and PET imaging; And

(vi) 융합영상처리기를 통해 CT 영상과 PET 영상을 융합하는 단계를 포함하는, CT-PET 융합영상을 제공하는 방법을 제공한다. (vi) a method of providing a CT-PET fusion image, comprising fusing a CT image and a PET image through a fusion image processor.

본 발명의 바람직한 일 구체예에서, 상기 마커는 좌표상의 기준이 되는 X축(41), Y축(42) 및 Z축(43)과 각 축선상에 설치되는 포인터(41a, 42a, 43a)로 이루어진다.  In a preferred embodiment of the present invention, the markers are X-axis 41, Y-axis 42 and Z-axis 43 and pointers 41a, 42a, 43a provided on each axis as reference points on the coordinates. Is done.

본 발명의 CT 부착형 PET는 기존에 병원에서 사용되고 있는 CT와 PET가 일체로 형성된 고가의 장비를 사용하지 않고도 기존에 사용되고 있는 CT에 탈부착 가능하게 장착하고 해부학적 영상과 기능적 영상을 융합하는 것이 가능해졌다. 따라서, 고가의 PET/CT 일체형 장치를 구매하지 않고도 본 발명의 CT 부착형 PET를 통하여 기존의 CT 장치의 활용도를 높여 매우 경제적임과 동시에 각종 종양, 뇌 신경계질환, 심장질환 등의 진단 시 신뢰도가 향상되는 효과가 있다.CT attached PET of the present invention can be detachably mounted on the existing CT without the use of expensive equipment in which the CT and PET used in the hospital is integrally integrated, and it is possible to fuse anatomical and functional images Done Therefore, it is very economical by increasing the utilization of the existing CT device through the CT-attached PET of the present invention without purchasing an expensive PET / CT integrated device, and at the same time, it is highly reliable in the diagnosis of various tumors, brain neurological diseases, heart diseases, etc. There is an effect to be improved.

도 1은 본 발명의 바람직한 일 실시예인 CT 부착형 PET를 부착한 PET/CT 시스템의 개략도이다.  Figure 1 is a schematic diagram of a PET / CT system attached CT attached PET which is a preferred embodiment of the present invention.

도 2는 본 발명의 바람직한 일 실시예인 CT 부착형 PET를 도시한 측면도(b) 및 단면도(a, c)이다. Figure 2 is a side view (b) and cross-sectional view (a, c) showing a CT-attached PET which is a preferred embodiment of the present invention.

도 3은 본 발명의 바람직한 다른 일 실시예인 CT 부착형 PET를 도시한 측면도이다.  Figure 3 is a side view showing a CT attached PET is another preferred embodiment of the present invention.

도 4은 본 발명의 바람직한 일 실시예인 CT 부착형 PET(33)가 CT 스캐너(20)에 부착된 것을 도시한 단면도이다.  4 is a cross-sectional view showing that the CT attached PET 33, which is a preferred embodiment of the present invention, is attached to the CT scanner 20. As shown in FIG.

도 5는 CT 부착형 PET가 CT 스캐너에 부착되기 전(a, b)과 부착된 후(c)를 도시한 개략도이다.  5 is a schematic diagram showing before (a, b) and after (c) the CT attached PET is attached to the CT scanner.

도 6은 마커(40)를 개략적으로 도시한 사시도이다.  6 is a perspective view schematically showing the marker 40.

**도면의 주요 부분에 대한 부호의 설명** ** Description of the symbols for the main parts of the drawings **

10: 지지수단 11: 베드 10: support means 11: bed

20: CT 스캐너 21: CT 촬영구 20: CT scanner 21: CT shooting port

30: PET 검출기 31: PET 촬영구 30: PET detector 31: PET shooting port

32: 지지대 33: CT 부착형 PET 32: support 33: CT attached PET

34: PET 검출기의 내측직경 35: PET 검출기의 위치 34: inner diameter of PET detector 35: position of PET detector

36: CT 스캐너에 부착되는 PET 일측면의 타원 단반경 36: Elliptical short radius on one side of PET attached to CT scanner

40: 마커  40: marker

이하, 본 발명의 바람직한 일 실시예인 CT 부착형 PET를 첨부된 도면을 참조하여 보다 상세히 설명하면 다음과 같다. Hereinafter, with reference to the accompanying drawings CT attached PET which is an embodiment of the present invention in more detail as follows.

도 1은 본 발명의 바람직한 일 실시예인 CT 부착형 PET를 부착한 PET/CT 시스템의 개략도이다.  Figure 1 is a schematic diagram of a PET / CT system attached CT attached PET which is a preferred embodiment of the present invention.

도시된 바와 같이 본 발명의 일 실시예에 따른 PET/CT 시스템은 환자가 누울 수 있도록 평판형상으로 이루어지고 지지수단(10) 상단부에 길이방향을 따라 이송가능하게 장착되는 베드(11); 지지수단(10)과 짝을 이루며 베드(11)가 유입될 수 있는 CT 촬영구(21)가 형성되어 있고 환자의 해부학적 영상을 촬영하는 CT 스캐너(20); CT 촬영구(21)와 연통되는 PET 촬영구(31)가 형성되고 CT 스캐너(20)의 일측면에 장착되는 PET 검출기(30); 및 베드(11)의 일측 끝단부에 탈부착 가능하게 장착되는 마커(40)로 이루어진다.  PET / CT system according to an embodiment of the present invention as shown is a bed 11 made of a flat plate shape so that the patient can lie down and transportably mounted along the longitudinal direction at the upper end of the support means (10); A CT scanner 20 which is paired with the support means 10 and has a CT port 21 into which the bed 11 can be introduced, and takes an anatomical image of the patient; PET detector 30 is formed in communication with the CT imaging port 21 and the PET detector 30 is mounted on one side of the CT scanner 20; And a marker 40 detachably mounted at one end of the bed 11.

도 2는 본 발명의 바람직한 일 실시예인 CT 부착형 PET(33)를 도시한 측면도(b) 및 단면도(a, c)이다.  2 is a side view (b) and cross-sectional views (a, c) showing a CT-attached PET 33, which is a preferred embodiment of the present invention.

본 발명에 따른 CT 부착형 PET(33)는 CT 스캐너(20)에 부착되는 PET 검출기(30)를 포함한다. PET 검출기(30)의 위치는 PET/CT 시스템의 사용용도에 따라 달라질 수 있으나, CT 스캐너(20)에 부착되는 PET의 일측면으로부터 0 cm 내지 50 cm 깊이(36)에 위치한다. PET 검출기(30)의 내측 직경(34)은 PET/CT 시스템의 사용용도에 따라 달라질 수 있으나, 2 cm 내지 130 cm가 바람직하다. CT 스캐너(20)에 부착되는 PET의 일측면의 타원 단반경(35)은 PET/CT 시스템의 사용용도에 따라 달라질 수 있으나, 0 cm 내지 200 cm가 바람직하다. 또한, 상기 CT 부착형 PET는 부착을 유지하기 위한 지지대(32)를 추가로 포함할 수 있다. 상기 지지대(32)는 PET 검출기(30)가 CT 스캐너(20)에 잘 부착되도록 수직면을 기준으로 0 내지 45°로 기울어지는 것이 바람직하다.  CT-attached PET 33 according to the present invention includes a PET detector 30 attached to the CT scanner 20. The position of the PET detector 30 may vary depending on the usage of the PET / CT system, but is located at a depth of 0 cm to 50 cm from one side of the PET attached to the CT scanner 20. The inner diameter 34 of the PET detector 30 may vary depending on the usage of the PET / CT system, but preferably 2 cm to 130 cm. The elliptical short radius 35 of one side of the PET attached to the CT scanner 20 may vary depending on the usage of the PET / CT system, but is preferably 0 cm to 200 cm. In addition, the CT-attached PET may further include a support 32 for maintaining the attachment. The support 32 is preferably inclined at 0 to 45 degrees with respect to the vertical plane so that the PET detector 30 is attached to the CT scanner 20 well.

도 3은 본 발명의 바람직한 다른 일 실시예인 CT 부착형 PET(33)를 도시한 측면도이다. CT 스캐너(20)에 부착되는 PET의 일측면에 반대편 일측면은 도 3과 같이 오목하게 구성될 수 있다.  3 is a side view showing a CT attached PET 33 according to another preferred embodiment of the present invention. One side opposite to the one side of the PET attached to the CT scanner 20 may be concave as shown in FIG.

도 4는 본 발명의 바람직한 일 실시예인 CT 부착형 PET(33)가 CT 스캐너(20)에 부착된 것을 도시한 단면도이다.  4 is a cross-sectional view showing that the CT attached PET 33, which is a preferred embodiment of the present invention, is attached to the CT scanner 20. As shown in FIG.

도 5는 CT 부착형 PET(33)가 CT 스캐너(20)에 부착되기 전(a, b)과 부착된 후(c)를 도시한 개략도이다.  FIG. 5 is a schematic view showing the CT attached PET 33 before (a, b) and after (c) being attached to the CT scanner 20.

PET 검출기(30)는 기존에 사용되고 있는 CT 스캐너(20) 장비에 추가적인 설치가 가능하도록 CT 스캐너(20)의 일측면에 탈부착 가능하게 장착되는 것이 바람직하며, PET 검출기(30)는 볼트로 체결되는 방법이나 고정식 클램프 또는 삽입시켜 고정하는 소켓 구조 등 탈부착 가능하게 장착할 수 있는 모든 구조를 사용할 수 있으며 CT 촬영구(21)와 PET 촬영구(31)는 연통된 상태로 베드(11)가 통과 가능한 구조를 갖는다. PET detector 30 is preferably detachably mounted on one side of the CT scanner 20 to enable additional installation to the existing CT scanner 20 equipment, PET detector 30 is fastened with a bolt Any structure that can be detachably mounted, such as a method or a fixed clamp or a socket structure to be inserted and fixed, can be used, and the CT imaging port 21 and the PET imaging port 31 can communicate with each other through the bed 11. Has a structure.

도 6은 마커(40)를 개략적으로 도시한 사시도이다.  6 is a perspective view schematically showing the marker 40.

베드(11)의 CT 일측 끝단부에 장착되는 마커(40)는 소정의 틀 형상을 가지며 내부에는 X축(41), Y축(42) 및 Z축(43)이 와이어 형상으로 구성되고, 각 축선 상에는 포인터(41a, 42a, 43a)가 각각 형성된다. The marker 40 mounted on one end of the CT 11 of the bed 11 has a predetermined frame shape, and the X axis 41, the Y axis 42, and the Z axis 43 are formed in a wire shape. Pointers 41a, 42a, 43a are formed on the axis line, respectively.

본 발명의 CT 부착형 PET(33)를 CT 스캐너(20)에 부착하여 CT-PET 융합영상을 제공하는 방법은 다음과 같은 단계를 포함한다: The method for providing CT-PET fusion images by attaching the CT-attached PET 33 of the present invention to the CT scanner 20 includes the following steps:

(i) 마커(40)를 환자를 이송하는 베드(11)의 일측 끝단부에 장착하는 단계; (i) mounting the marker 40 at one end of the bed 11 carrying the patient;

(ii) 상기 CT 부착형 PET(33)를 CT 스캐너(20)에 부착하는 단계; (ii) attaching the CT attached PET 33 to a CT scanner 20;

(iii) 상기 베드를 CT 촬영구(21) 및 PET 촬영구(31) 내부로 인입시키고 CT 스캐너(20) 및 PET 검출기(33)로 촬영하여 마커에 구비된 포인터(41a, 42a, 43a)를 인식하는 단계; (iii) the bed is inserted into the CT port 21 and the PET port 31 and photographed with the CT scanner 20 and the PET detector 33 to move the pointers 41a, 42a, 43a provided on the marker. Recognizing;

(iv) CT 스캐너에 촬영된 포인터 위치와 PET 검출기에 촬영된 포인터 위치를 통해 찾은 좌표의 기준점을 CT 영상과 PET 영상을 융합시키는 중심점으로 조절하는 단계; (iv) adjusting a reference point of coordinates found through the pointer position photographed on the CT scanner and the pointer position photographed on the PET detector to a center point where the CT image and the PET image are fused;

(v) CT 및 PET 촬영하는 단계; 및 (v) CT and PET imaging; And

(vi) 융합영상처리기를 통해 CT 영상과 PET 영상을 융합하는 단계. (vi) fusing the CT image and the PET image through a fusion image processor;

보다 구체적으로, 환자의 환부 촬영에 앞서 마커(40)를 베드(11) 위에 설치한 후, CT 촬영구(21)와 PET 촬영구(31) 내부로 인입시킨다. 이때, CT 스캐너(20)와 PET 검출기(30)가 촬영을 실시하여 마커(40)에 구비된 포인터(41a, 42a, 43a)를 인식하게 된다. CT 스캐너(20)에 촬영된 포인터(41a, 42a, 43a) 위치와 PET 검출기(30)에 촬영된 포인터(41a, 42a, 43a)를 통해 좌표의 기준점을 찾고, 그 기준점을 두 영상을 융합시킬 때 중심점으로 조절한다. 마커(40)는 CT 스캐너(20)에 PET 검출기(30)를 처음 부착하여 설치할 때에 사용하고, 설치 후 환자영상 촬영 시 분리해 둔다. 그러나 장비 결함 점검, 정도관리 등 필요에 의해 마커(40)를 장착하여 사용할 수 있다. More specifically, the marker 40 is installed on the bed 11 prior to imaging the affected area, and then inserted into the CT imaging tool 21 and the PET imaging tool 31. At this time, the CT scanner 20 and the PET detector 30 take a picture to recognize the pointers 41a, 42a, and 43a provided in the marker 40. The reference point of coordinates is found through the positions of the pointers 41a, 42a and 43a captured by the CT scanner 20 and the pointers 41a, 42a and 43a captured by the PET detector 30, and the reference points are fused to two images. When adjusted to the center point. The marker 40 is used when the PET detector 30 is first attached to the CT scanner 20 and installed. The marker 40 is separated when the patient image is taken after installation. However, the marker 40 can be mounted and used as necessary for equipment defect check and quality control.

상기와 같이 융합되는 두 영상의 중심점을 지정한 후, 환자가 베드(11)위에 눕고 촬영하고자 하는 환부가 CT 스캐너(20) 내부로 인입될 수 있도록 베드(11)를 이동시킨다. After designating the center points of the two images to be fused as described above, the patient lies on the bed 11 and moves the bed 11 to allow the affected part to be taken into the CT scanner 20.

촬영하고자 하는 환부가 CT 촬영구(21) 내부를 지나감과 동시에 환부의 해부학적 영상을 촬영하게 되고, PET 촬영구(31)를 지나감과 동시에 환부의 기능적 영상을 촬영하게 된다. The lesion to be taken passes the CT imaging port 21 and simultaneously captures the anatomical image of the affected part, and passes the PET port 31 and simultaneously captures the functional image of the affected part.

촬영된 출력신호가 각각 CT 영상처리기와 PET 영상처리기로 전달되어 해부학적 영상과 기능적 영상으로 변환되고 변환된 각각의 영상은 융합영상처리기로 전달되어 하나의 영상으로 융합된다. 즉, 해부학적 영상과 기능적 영상이 융합된 영상을 얻을 수 있게 되는 것이다. 이때 해부학적 영상과 기능적 영상이 융합되는 중심점은 이미 마커(40)의 포인터(41a, 42a, 43a)를 통해 3차원적으로 설정된 상태이므로 용이하게 융합될 수 있게 된다. The photographed output signal is transferred to CT image processor and PET image processor, respectively, and is converted into anatomical image and functional image, and each converted image is transferred to fusion image processor and fused into one image. That is, it is possible to obtain an image in which the anatomical image and the functional image are fused. At this time, the center point at which the anatomical image and the functional image are fused is already set in three dimensions through the pointers 41a, 42a, and 43a of the marker 40, and thus can be easily fused.

지금까지 예시적인 실시 태양을 참조하여 본 발명을 기술하여 왔지만, 본 발명의 속하는 기술 분야의 당업자는 본 발명의 범주를 벗어나지 않고서도 다양한 변화를 실시할 수 있으며 그의 요소들을 등가물로 대체할 수 있음을 알 수 있을 것이다. 또한, 본 발명의 본질적인 범주를 벗어나지 않고서도 많은 변형을 실시하여 특정 상황 및 재료를 본 발명의 교시내용에 채용할 수 있다. 따라서, 본 발명이 본 발명을 실시하는데 계획된 최상의 양식으로서 개시된 특정 실시 태양으로 국한되는 것이 아니며, 본 발명이 첨부된 특허청구의 범위에 속하는 모든 실시 태양을 포함하는 것으로 해석되어야 한다.  While the invention has been described with reference to exemplary embodiments so far, those skilled in the art will appreciate that various changes can be made therein and equivalents may be substituted for elements thereof without departing from the scope of the invention. You will know. In addition, many modifications may be made to adapt a particular situation and material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the present invention not be limited to the particular embodiments disclosed as the best mode contemplated for carrying out the invention, but that the invention will include all embodiments falling within the scope of the appended claims.

Claims (7)

CT 스캐너(20)에 부착되는 PET의 일측면으로부터 0 cm 내지 150 cm 깊이(35)에 위치하는 PET 검출기(30)를 포함하여, CT 스캐너의 해부학적 영상과 PET 검출기의 기능적 영상의 융합영상을 제공하기 위한 CT 부착형 PET(33).Including a PET detector 30 located at 0 cm to 150 cm depth 35 from one side of the PET attached to the CT scanner 20, a fusion image of the anatomical image of the CT scanner and the functional image of the PET detector CT attached PET 33 to provide. 제1항에 있어서,  The method of claim 1, PET 검출기의 내측 직경(34)은 2 내지 130 cm임을 특징으로 하는 CT 부착형 PET.CT attached PET, characterized in that the inner diameter 34 of the PET detector is 2 to 130 cm. 제1항에 있어서, The method of claim 1, CT 스캐너에 부착되는 PET의 일측면의 타원 단반경(35)은 0 내지 200 cm임을 특징으로 하는 CT 부착형 PET.CT attached PET, characterized in that the elliptical short radius (35) of one side of the PET attached to the CT scanner is 0 to 200 cm. 제1항에 있어서, The method of claim 1, 부착을 유지하기 위한 지지대(32)를 추가로 포함함을 특징으로 하는 CT 부착형 PET.CT-attached PET, characterized in that it further comprises a support (32) for maintaining the attachment. 제4항에 있어서,  The method of claim 4, wherein 지지대(32)는 수직면을 기준으로 0 내지 45°로 기울어짐을 특징으로 하는 CT 부착형 PET.Support 32 is CT-attached PET, characterized in that inclined to 0 to 45 ° relative to the vertical plane. (i) 마커(40)를 환자를 이송하는 베드(11)의 일측 끝단부에 장착하는 단계; (i) mounting the marker 40 at one end of the bed 11 carrying the patient; (ii) 제1항 내지 제5항 중 어느 한 항의 CT 부착형 PET(33)를 CT 스캐너(20)에 부착하는 단계; (ii) attaching the CT attached PET 33 of any one of claims 1 to 5 to the CT scanner 20; (iii) 상기 베드를 CT 촬영구(21) 및 PET 촬영구(31) 내부로 인입시키고 CT 스캐너(20) 및 PET 검출기(33)로 촬영하여 마커에 구비된 포인터(41a, 42a, 43a)를 인식하는 단계; (iii) the bed is inserted into the CT port 21 and the PET port 31 and photographed with the CT scanner 20 and the PET detector 33 to move the pointers 41a, 42a, 43a provided on the marker. Recognizing; (iv) CT 스캐너에 촬영된 포인터 위치와 PET 검출기에 촬영된 포인터 위치를 통해 찾은 좌표의 기준점을 CT 영상과 PET 영상을 융합시키는 중심점으로 조절하는 단계; (iv) adjusting a reference point of coordinates found through the pointer position photographed on the CT scanner and the pointer position photographed on the PET detector to a center point where the CT image and the PET image are fused; (v) CT 및 PET 촬영하는 단계; 및 (v) CT and PET imaging; And (vi) 융합영상처리기를 통해 CT 영상과 PET 영상을 융합하는 단계를 포함하는, CT-PET 융합영상을 제공하는 방법.(vi) a method of providing a CT-PET fusion image, comprising fusing a CT image and a PET image through a fusion image processor. 제6항에 있어서, The method of claim 6, 마커는 좌표상의 기준이 되는 X축(41), Y축(42) 및 Z축(43)과 각 축선상에 설치되는 포인터(41a, 42a, 43a)로 이루어짐을 특징으로 하는, CT-PET 융합영상을 제공하는 방법.The marker is composed of the X-axis 41, Y-axis 42 and Z-axis 43 and the pointers 41a, 42a, 43a provided on each axis as reference points on the coordinate, CT-PET fusion How to give a video.
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* Cited by examiner, † Cited by third party
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CN104490415A (en) * 2015-01-12 2015-04-08 天津医科大学第二医院 Stereotactic frame for fusion of PET, CT and MR images of the abdomen and pelvis
CN106890000A (en) * 2016-12-28 2017-06-27 赛诺联合医疗科技(北京)有限公司 The coordinate registration die body of multi-modal detection system
CN107374656A (en) * 2017-05-26 2017-11-24 赛诺联合医疗科技(北京)有限公司 The coordinate registration die body of multi-modal detection system

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US6917666B2 (en) * 2002-12-19 2005-07-12 General Electric Company System and method for table/gantry alignment in imaging systems
US7374337B2 (en) * 2005-06-17 2008-05-20 Siemens Medical Solutions Usa, Inc. Releasably interconnected CT and SPECT scanners
US7652256B2 (en) * 2006-07-03 2010-01-26 Siemens Medical Solutions Usa, Inc. Solid state based PET retrofit for a CT scanner

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Publication number Priority date Publication date Assignee Title
CN104490415A (en) * 2015-01-12 2015-04-08 天津医科大学第二医院 Stereotactic frame for fusion of PET, CT and MR images of the abdomen and pelvis
CN106890000A (en) * 2016-12-28 2017-06-27 赛诺联合医疗科技(北京)有限公司 The coordinate registration die body of multi-modal detection system
CN107374656A (en) * 2017-05-26 2017-11-24 赛诺联合医疗科技(北京)有限公司 The coordinate registration die body of multi-modal detection system

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