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WO2010030811A3 - CARBACEPHEM β-LACTAM ANTIBIOTICS - Google Patents

CARBACEPHEM β-LACTAM ANTIBIOTICS Download PDF

Info

Publication number
WO2010030811A3
WO2010030811A3 PCT/US2009/056555 US2009056555W WO2010030811A3 WO 2010030811 A3 WO2010030811 A3 WO 2010030811A3 US 2009056555 W US2009056555 W US 2009056555W WO 2010030811 A3 WO2010030811 A3 WO 2010030811A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbacephem
lactam antibiotics
methicillin
prodrugs
esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/056555
Other languages
French (fr)
Other versions
WO2010030811A2 (en
Inventor
Allan Scott Wagman
Heinz Ernst Moser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Achaogen Inc
Original Assignee
Achaogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achaogen Inc filed Critical Achaogen Inc
Publication of WO2010030811A2 publication Critical patent/WO2010030811A2/en
Publication of WO2010030811A3 publication Critical patent/WO2010030811A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Carbacephem -lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar1, Ar2, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.
PCT/US2009/056555 2008-09-10 2009-09-10 CARBACEPHEM β-LACTAM ANTIBIOTICS Ceased WO2010030811A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9582008P 2008-09-10 2008-09-10
US61/095,820 2008-09-10
US17167509P 2009-04-22 2009-04-22
US61/171,675 2009-04-22

Publications (2)

Publication Number Publication Date
WO2010030811A2 WO2010030811A2 (en) 2010-03-18
WO2010030811A3 true WO2010030811A3 (en) 2010-08-12

Family

ID=41413340

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/056555 Ceased WO2010030811A2 (en) 2008-09-10 2009-09-10 CARBACEPHEM β-LACTAM ANTIBIOTICS

Country Status (1)

Country Link
WO (1) WO2010030811A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101835777A (en) 2007-10-25 2010-09-15 尔察祯有限公司 Carbacephem β-lactam antibiotics
WO2010123997A1 (en) * 2009-04-22 2010-10-28 Achaogen, Inc. Carbacephem beta-lactam antibiotics
AU2015284307A1 (en) 2014-07-01 2017-02-02 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CN109336810A (en) * 2018-11-02 2019-02-15 浙江星月药物科技股份有限公司 A kind of preparation method of haloperidid class nitrogen oxides
CN117417293B (en) * 2023-12-18 2024-03-19 齐鲁晟华制药有限公司 Synthesis method of fluopyram

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362724A (en) * 1992-09-30 1994-11-08 Shionogi & Co., Ltd. Thioalkylthio carbacephalosporin derivatives
WO2004098500A2 (en) * 2003-04-30 2004-11-18 Trine Pharmaceuticals, Inc. CARBACEPHEM ss-LACTAM ANTIBIOTICS
US20080146535A1 (en) * 2003-04-30 2008-06-19 Tomasz Glinka Compositions comprising carbacephem beta-lactam antibiotics and beta-lactamase inhibitors
WO2009055696A1 (en) * 2007-10-25 2009-04-30 Achaogen, Inc. CARBACEPHEM β-LACTAM ANTIBIOTICS

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5362724A (en) * 1992-09-30 1994-11-08 Shionogi & Co., Ltd. Thioalkylthio carbacephalosporin derivatives
WO2004098500A2 (en) * 2003-04-30 2004-11-18 Trine Pharmaceuticals, Inc. CARBACEPHEM ss-LACTAM ANTIBIOTICS
US20050004095A1 (en) * 2003-04-30 2005-01-06 Glinka Tomasz W. Carbacephem beta-lactam antibiotics
US20080146535A1 (en) * 2003-04-30 2008-06-19 Tomasz Glinka Compositions comprising carbacephem beta-lactam antibiotics and beta-lactamase inhibitors
WO2009055696A1 (en) * 2007-10-25 2009-04-30 Achaogen, Inc. CARBACEPHEM β-LACTAM ANTIBIOTICS

Also Published As

Publication number Publication date
WO2010030811A2 (en) 2010-03-18

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