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WO2010029363A3 - Cathepsin s propeptide fragments - Google Patents

Cathepsin s propeptide fragments Download PDF

Info

Publication number
WO2010029363A3
WO2010029363A3 PCT/GB2009/051169 GB2009051169W WO2010029363A3 WO 2010029363 A3 WO2010029363 A3 WO 2010029363A3 GB 2009051169 W GB2009051169 W GB 2009051169W WO 2010029363 A3 WO2010029363 A3 WO 2010029363A3
Authority
WO
WIPO (PCT)
Prior art keywords
cathepsin
propeptides
fragments
propeptide fragments
propeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2009/051169
Other languages
French (fr)
Other versions
WO2010029363A2 (en
Inventor
James Johnston
Richard Buick
Christopher Scott
Roberta Burden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fusion Antibodies Ltd
Original Assignee
Fusion Antibodies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fusion Antibodies Ltd filed Critical Fusion Antibodies Ltd
Publication of WO2010029363A2 publication Critical patent/WO2010029363A2/en
Publication of WO2010029363A3 publication Critical patent/WO2010029363A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22027—Cathepsin S (3.4.22.27)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to novel fragments of cathepsin propeptides and their use in methods of treatment of diseases such as cancer. Also described are derivatives of such propeptides and pharmaceutical compositions comprising such propeptides and derivatives.
PCT/GB2009/051169 2008-09-10 2009-09-10 Peptide and uses thereof Ceased WO2010029363A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0816561.5 2008-09-10
GB0816561A GB0816561D0 (en) 2008-09-10 2008-09-10 Peptides and uses thereof

Publications (2)

Publication Number Publication Date
WO2010029363A2 WO2010029363A2 (en) 2010-03-18
WO2010029363A3 true WO2010029363A3 (en) 2010-11-04

Family

ID=39889134

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/051169 Ceased WO2010029363A2 (en) 2008-09-10 2009-09-10 Peptide and uses thereof

Country Status (2)

Country Link
GB (1) GB0816561D0 (en)
WO (1) WO2010029363A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007099348A2 (en) * 2006-03-02 2007-09-07 Fusion Antibodies Limited Cathepsin propeptide and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007099348A2 (en) * 2006-03-02 2007-09-07 Fusion Antibodies Limited Cathepsin propeptide and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BURDEN ROBERTA E ET AL: "Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment", MOLECULAR CANCER THERAPEUTICS, vol. 7, no. 3, March 2008 (2008-03-01), pages 538 - 547, XP002597506, ISSN: 1535-7163 *
KAULMANN GUIDO ET AL: "The crystal structure of a Cys25 -> Ala mutant of human procathepsin S elucidates enzyme-prosequence interactions", PROTEIN SCIENCE, vol. 15, no. 11, November 2006 (2006-11-01), pages 2619 - 2629, XP002597507, ISSN: 0961-8368 *

Also Published As

Publication number Publication date
GB0816561D0 (en) 2008-10-15
WO2010029363A2 (en) 2010-03-18

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