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WO2010029288A3 - Facteur de croissance - Google Patents

Facteur de croissance Download PDF

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Publication number
WO2010029288A3
WO2010029288A3 PCT/GB2009/002142 GB2009002142W WO2010029288A3 WO 2010029288 A3 WO2010029288 A3 WO 2010029288A3 GB 2009002142 W GB2009002142 W GB 2009002142W WO 2010029288 A3 WO2010029288 A3 WO 2010029288A3
Authority
WO
WIPO (PCT)
Prior art keywords
epithelial cells
culture
growth factor
retinal epithelial
wnt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2009/002142
Other languages
English (en)
Other versions
WO2010029288A2 (fr
Inventor
James Walsh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Axordia Ltd
Original Assignee
Axordia Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axordia Ltd filed Critical Axordia Ltd
Publication of WO2010029288A2 publication Critical patent/WO2010029288A2/fr
Publication of WO2010029288A3 publication Critical patent/WO2010029288A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cette invention concerne des lignées cellulaires et les utilisations des lignées cellulaires qui expriment Wingless [Wnt] ou des homologues de celui-ci; des procédés pour amplifier les cellules progénitrices rétiniennes; et la différenciation desdites cellules progénitrices en cellules de l'épithélium pigmentaire rétinien.
PCT/GB2009/002142 2008-09-11 2009-09-08 Facteur de croissance Ceased WO2010029288A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0816577A GB0816577D0 (en) 2008-09-11 2008-09-11 Growth factor
GB0816577.1 2008-09-11

Publications (2)

Publication Number Publication Date
WO2010029288A2 WO2010029288A2 (fr) 2010-03-18
WO2010029288A3 true WO2010029288A3 (fr) 2010-08-12

Family

ID=39889147

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/002142 Ceased WO2010029288A2 (fr) 2008-09-11 2009-09-08 Facteur de croissance

Country Status (2)

Country Link
GB (1) GB0816577D0 (fr)
WO (1) WO2010029288A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011043592A2 (fr) 2009-10-06 2011-04-14 Snu R&Db Foundation Compositions pour induire une différenciation en cellules rétiniennes à partir de cellules progénitrices rétiniennes ou pour induire une prolifération de cellules rétiniennes comprenant des activateurs de la voie de signalisation wnt
EP2486126B1 (fr) * 2009-10-06 2017-12-06 SNU R & DB Foundation Procédé pour la différenciation en cellules rétiniennes à partir de cellules souches
EP2554662A1 (fr) * 2011-08-05 2013-02-06 M Maria Pia Cosma Procédés pour le traitement de maladies rétiniennes dégénératives
KR101535639B1 (ko) * 2014-04-30 2015-07-09 건국대학교 산학협력단 노년황반변성의 진단, 예후 판단, 치료, 예방용 조성물 및 노년황반변성에 대한 진단 방법
JP2022543347A (ja) * 2019-07-10 2022-10-12 イエール ユニバーシティ ヒト化抗ｄｋｋ２抗体を使用した組成物および使用する方法
CN112592402B (zh) * 2020-12-02 2022-04-26 杭州奕安济世生物药业有限公司 抗dkk2抗体、包含该抗dkk2抗体的组合物及其用途
IL307831A (en) * 2021-04-23 2023-12-01 Asimov Inc Stable production systems work on lentiviral vector production

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AOKI H ET AL: "Embryonic stem cells that differentiate into RPE cell precursors in vitro develop into RPE cell monolayers in vivo", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD, LONDON, vol. 82, no. 2, 1 February 2006 (2006-02-01), pages 265 - 274, XP024945331, ISSN: 0014-4835, [retrieved on 20060201] *
KUBO FUMI ET AL: "Wnt2b controls retinal cell differentiation at the ciliary marginal zone.", DEVELOPMENT (CAMBRIDGE), vol. 130, no. 3, February 2003 (2003-02-01), pages 587 - 598, XP002563630, ISSN: 0950-1991 *
NAKAGAWA S ET AL: "Identification of the laminar-inducing factor: Wnt-signal from the anterior rim induces correct laminar formation of the neural retina in vitro", DEVELOPMENTAL BIOLOGY 20030815 US, vol. 260, no. 2, 15 August 2003 (2003-08-15), pages 414 - 425, XP002563629, ISSN: 0012-1606 *

Also Published As

Publication number Publication date
GB0816577D0 (en) 2008-10-15
WO2010029288A2 (fr) 2010-03-18

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