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WO2010027150A3 - New preparation of hydroxychloroquine - Google Patents

New preparation of hydroxychloroquine Download PDF

Info

Publication number
WO2010027150A3
WO2010027150A3 PCT/KR2009/004660 KR2009004660W WO2010027150A3 WO 2010027150 A3 WO2010027150 A3 WO 2010027150A3 KR 2009004660 W KR2009004660 W KR 2009004660W WO 2010027150 A3 WO2010027150 A3 WO 2010027150A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxychloroquine
new preparation
preparation
pentadiamine
dichloroquinoline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/004660
Other languages
French (fr)
Other versions
WO2010027150A2 (en
Inventor
Yun Sik Min
Hyun-Sung Cho
Kil Woong Mo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DAE HE CHEMICAL Co Ltd
Original Assignee
DAE HE CHEMICAL Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DAE HE CHEMICAL Co Ltd filed Critical DAE HE CHEMICAL Co Ltd
Publication of WO2010027150A2 publication Critical patent/WO2010027150A2/en
Publication of WO2010027150A3 publication Critical patent/WO2010027150A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention provides a process for the preparation of hydroxychloroquine by the reaction of 4,7-dichloroquinoline with N'-ethyl-N'-β-hydroxyethyl-1,4-pentadiamine under high pressure.
PCT/KR2009/004660 2008-09-08 2009-08-21 New preparation of hydroxychloroquine Ceased WO2010027150A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0088070 2008-09-08
KR1020080088070A KR101115412B1 (en) 2008-09-08 2008-09-08 New preparation of hydroxychloroquine

Publications (2)

Publication Number Publication Date
WO2010027150A2 WO2010027150A2 (en) 2010-03-11
WO2010027150A3 true WO2010027150A3 (en) 2010-06-17

Family

ID=41797613

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/004660 Ceased WO2010027150A2 (en) 2008-09-08 2009-08-21 New preparation of hydroxychloroquine

Country Status (2)

Country Link
KR (1) KR101115412B1 (en)
WO (1) WO2010027150A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102050781B (en) * 2010-12-21 2012-07-25 重庆康乐制药有限公司 Industrial preparation method of hydroxychloroquine sulfate
CN103724261B (en) * 2013-12-13 2016-05-25 武汉武药制药有限公司 A kind of industrialized process for preparing of hydroxychloroquine sulfate quinoline
CN104230803B (en) * 2014-08-28 2017-02-01 重庆康乐制药有限公司 Preparation method of hydroxychloroquine sulfate
WO2019165337A1 (en) * 2018-02-26 2019-08-29 Virginia Commonwealth University High-yielding continuous flow synthesis of antimalarial drug hydroxychloroquine
CN108727263A (en) * 2018-07-05 2018-11-02 上海中西三维药业有限公司 Hydroxychloroquine sulfate crystal form A and preparation method thereof
CN109456266A (en) * 2018-11-12 2019-03-12 南京天际联盟医药科技有限公司 The novel preparation method of hydroxychloroquine sulfate
CN109280029A (en) * 2018-12-11 2019-01-29 上海应用技术大学 A kind of preparation method of hydroxychloroquine sulfate
CN113072491B (en) * 2020-01-06 2024-06-18 欣凯医药化工中间体（上海）有限公司 Preparation method of hydroxychloroquine sulfate
CN111551645B (en) * 2020-04-30 2022-11-08 上海中西三维药业有限公司 Method for detecting hydroxychloroquine sulfate related substances and application thereof
CN112300071B (en) * 2020-11-25 2023-01-31 威胜生物医药(苏州)股份有限公司 Synthetic method of high-purity chloroquine phosphate
CN113149904B (en) * 2021-03-02 2024-07-09 南京海纳医药科技股份有限公司 A method for refining hydroxychloroquine crude product
CN114380744A (en) * 2021-12-22 2022-04-22 深圳市祥根生物医药有限公司 A kind of preparation method of hydroxychloroquine sulfate impurity
WO2024261606A1 (en) 2023-06-22 2024-12-26 Tübi̇tak Production process for hydroxychloroquine under concentrated conditions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2546658A (en) * 1949-07-23 1951-03-27 Sterling Drug Inc 7-chloro-4-[5-(n-ethyl-n-2-hydroxyethylamino)-2-pentyl] aminoquinoline, its acid addition salts, and method of preparation
US5314894A (en) * 1992-09-15 1994-05-24 Sterling Winthrop Inc. (S)-(+)-hydroxychloroquine
WO2005062723A2 (en) * 2003-11-24 2005-07-14 Ipca Laboratories Limited An improved process for the preparation of 7-chloro-4-(5-n-ehtyl-n-2-hydroxyethylamine)-2-pentyl] aminoquinoline and its intermediates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2561987A1 (en) * 2006-10-02 2008-04-02 Apotex Pharmachem Inc. Process for the preparation of highly pure hydroxychloroquine or a salt thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2546658A (en) * 1949-07-23 1951-03-27 Sterling Drug Inc 7-chloro-4-[5-(n-ethyl-n-2-hydroxyethylamino)-2-pentyl] aminoquinoline, its acid addition salts, and method of preparation
US5314894A (en) * 1992-09-15 1994-05-24 Sterling Winthrop Inc. (S)-(+)-hydroxychloroquine
WO2005062723A2 (en) * 2003-11-24 2005-07-14 Ipca Laboratories Limited An improved process for the preparation of 7-chloro-4-(5-n-ehtyl-n-2-hydroxyethylamine)-2-pentyl] aminoquinoline and its intermediates

Also Published As

Publication number Publication date
KR20100029332A (en) 2010-03-17
KR101115412B1 (en) 2012-06-12
WO2010027150A2 (en) 2010-03-11

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