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WO2010019701A3 - Dérivés de diaryl urée - Google Patents

Dérivés de diaryl urée Download PDF

Info

Publication number
WO2010019701A3
WO2010019701A3 PCT/US2009/053595 US2009053595W WO2010019701A3 WO 2010019701 A3 WO2010019701 A3 WO 2010019701A3 US 2009053595 W US2009053595 W US 2009053595W WO 2010019701 A3 WO2010019701 A3 WO 2010019701A3
Authority
WO
WIPO (PCT)
Prior art keywords
diaryl urea
urea derivatives
derivatives
sorafenib
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/053595
Other languages
English (en)
Other versions
WO2010019701A2 (fr
Inventor
Julie Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Concert Pharmaceuticals Inc
Original Assignee
Concert Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concert Pharmaceuticals Inc filed Critical Concert Pharmaceuticals Inc
Publication of WO2010019701A2 publication Critical patent/WO2010019701A2/fr
Publication of WO2010019701A3 publication Critical patent/WO2010019701A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention porte sur des nouveaux composés de diaryl urée, leurs dérivés et des sels pharmaceutiquement acceptables de ceux-ci. Plus spécifiquement, l'invention porte sur de nouveaux composés de diaryl urée qui sont des dérivés de sorafenib. L’invention porte également sur des compositions comprenant un composé de cette invention et sur l'utilisation de telles compositions dans des méthodes de traitement de maladies et de pathologies qui sont traitées avantageusement par l'administration d'inhibiteurs de multikinase, tels que le sorafenib.
PCT/US2009/053595 2008-08-14 2009-08-12 Dérivés de diaryl urée Ceased WO2010019701A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18892708P 2008-08-14 2008-08-14
US61/188,927 2008-08-14
US20357808P 2008-12-23 2008-12-23
US61/203,578 2008-12-23

Publications (2)

Publication Number Publication Date
WO2010019701A2 WO2010019701A2 (fr) 2010-02-18
WO2010019701A3 true WO2010019701A3 (fr) 2010-08-26

Family

ID=41508104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/053595 Ceased WO2010019701A2 (fr) 2008-08-14 2009-08-12 Dérivés de diaryl urée

Country Status (1)

Country Link
WO (1) WO2010019701A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10568965B2 (en) 2009-06-09 2020-02-25 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010135579A1 (fr) * 2009-05-22 2010-11-25 Concert Pharmaceuticals, Inc. Dérivés fluorés de diaryl urée
CN102803221B (zh) * 2010-03-18 2014-09-10 苏州泽璟生物制药有限公司 氘代的ω-二苯基脲及衍生物以及包含该化合物的药物组合物
WO2011113203A1 (fr) * 2010-03-18 2011-09-22 苏州泽璟生物制药有限公司 Oméga-diphénylurée substituée par du deutérium et ses dérivés et compositions pharmaceutiques comprenant les composés
CN102190616B (zh) * 2010-03-18 2015-07-29 苏州泽璟生物制药有限公司 一种氘代的ω-二苯基脲的合成及生产的方法和工艺
US9145390B2 (en) 2011-03-03 2015-09-29 Concert Pharmaceuticals, Inc. Derivatives of pyrazole-substituted amino-heteroaryl compounds
CN105348186B (zh) * 2015-10-15 2018-05-22 青岛海洋生物医药研究院股份有限公司 氘代双芳基脲类化合物及其制备方法和在制备抗肿瘤的药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009961A2 (fr) * 2003-07-23 2005-02-03 Bayer Pharmaceuticals Corporation Omega-carboxyaryldiphenyluree fluoro-subtituee pour le traitement et la prevention de maladies et d'etats pathologiques
WO2007059155A1 (fr) * 2005-11-14 2007-05-24 Bayer Pharmaceuticals Corporation Traitement de cancers a resistance a des agents chimiotherapeutiques
WO2007059154A2 (fr) * 2005-11-14 2007-05-24 Bayer Healthcare Llc Traitement de cancers a resistance acquise a des inhibiteurs de kit

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009961A2 (fr) * 2003-07-23 2005-02-03 Bayer Pharmaceuticals Corporation Omega-carboxyaryldiphenyluree fluoro-subtituee pour le traitement et la prevention de maladies et d'etats pathologiques
WO2007059155A1 (fr) * 2005-11-14 2007-05-24 Bayer Pharmaceuticals Corporation Traitement de cancers a resistance a des agents chimiotherapeutiques
WO2007059154A2 (fr) * 2005-11-14 2007-05-24 Bayer Healthcare Llc Traitement de cancers a resistance acquise a des inhibiteurs de kit

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DUMONT ET AL: "Prospects in the use of deuterated molecules as therapeutic agents", REVUE IRE, INSTITUT NATIONAL DES RADIOELEMENTS, BELGIUM, vol. 6, no. 4, 1 January 1982 (1982-01-01), pages 2 - 10, XP009125461, ISSN: 0770-1160 *
FOSTER A B: "Deuterium isotope effects in the metabolism of drugs and xenobiotics: implications for drug design", ADVANCES IN DRUG RESEARCH, ACADEMIC PRESS, LONDON, GB, vol. 14, 1 January 1985 (1985-01-01), pages 1 - 40, XP009086953, ISSN: 0065-2490 *
KUSHNER DJ ET AL: "Pharmacological uses and perspectives of heavy water and deuterated compounds", CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, OTTAWA, ONT, CA, vol. 77, no. 2, 1 February 1999 (1999-02-01), pages 79 - 88, XP009086918 *
PLEISS, U. ET AL.: "Syntheses of [2H3, 15N], [14C]Nexavar and its labeled metabolites", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 49, 2006, pages 603 - 613, XP002589132, DOI: 10.1002/jlcr.1079 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10568965B2 (en) 2009-06-09 2020-02-25 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase

Also Published As

Publication number Publication date
WO2010019701A2 (fr) 2010-02-18

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