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WO2010017586A1 - Inhalateur avec flacon à percer et médicament sous forme liquide - Google Patents

Inhalateur avec flacon à percer et médicament sous forme liquide Download PDF

Info

Publication number
WO2010017586A1
WO2010017586A1 PCT/AU2009/001029 AU2009001029W WO2010017586A1 WO 2010017586 A1 WO2010017586 A1 WO 2010017586A1 AU 2009001029 W AU2009001029 W AU 2009001029W WO 2010017586 A1 WO2010017586 A1 WO 2010017586A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug
vial
barrel
piercing means
mouthpiece
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2009/001029
Other languages
English (en)
Inventor
Alexander James Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SILPHION Pty Ltd
Original Assignee
SILPHION Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2008904085A external-priority patent/AU2008904085A0/en
Application filed by SILPHION Pty Ltd filed Critical SILPHION Pty Ltd
Publication of WO2010017586A1 publication Critical patent/WO2010017586A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0035—Piercing means
    • A61M15/0036—Piercing means hollow piercing means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0087—Environmental safety or protection means, e.g. preventing explosion
    • A61M16/009—Removing used or expired gases or anaesthetic vapours
    • A61M16/0093—Removing used or expired gases or anaesthetic vapours by adsorption, absorption or filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/105—Filters
    • A61M16/106—Filters in a path
    • A61M16/1065—Filters in a path in the expiratory path
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0468—Liquids non-physiological
    • A61M2202/048—Anaesthetics

Definitions

  • the invention described herein relates generally to a device and method for the administration of volatile drugs in liquid form.
  • the invention is directed to a device and method for inhalation administration of volatile drugs in liquid form, although the scope of the invention is not necessarily limited thereto.
  • Opioid analgesics are known to have the potential to cause dependency, and are therefore not always the drug of choice for these medical circumstances.
  • Intravenous administration is a difficult mode of administration under many conditions, including for example emergency roadside incidents, non-compliant patients, or non-sterile environments.
  • a further device which is a hand-held device, currently available in at least
  • the invention provides a device for facilitating inhalation of an inhalable drug in liquid form, the device comprising a barrel for holding a vial of the inhalable drug in liquid form, a piercing means substantially in the barrel, and a mouthpiece attached to an end of the barrel.
  • the invention provides a method of providing an inhalable drug in liquid form comprising inserting a vial of the drug into the barrel of the device of the first embodiment, piercing the seal of the vial with the piercing means, applying the mouthpiece to a subject wherein the subject inhales through the mouthpiece the drug released upon piercing of the seal.
  • the drug can be any inhalable drug in liquid form that is sufficiently volatile to be available for inhalation upon release from the vial.
  • the device is particularly suited to drugs such as analgesics, including but not limited to inhalable fiuorocarbon-based analgesics such as sevoflurane, methoxyflurane, desflurane, isoflurane, enfiurane, diethyl ether, methoxypropane, chloroform, and halothane.
  • the barrel of the device can be any configuration which will accommodate a vial of inhalable drug in liquid form.
  • the barrel is a substantially straight tube, or a tube including a substantially right angled bend towards the mouthpiece.
  • the vial can be a standard commercially available vial, or a vial made specifically for the device of the invention.
  • the vial is a standard 1-5OmL vial.
  • the device of the invention can be a disposable, single-use device, or can be configured for repeated use.
  • the barrel can be configured such that the vial is sealed inside the barrel upon manufacture of the device, or the barrel can be configured to reversibly open at one end to receive a vial when needed.
  • the latter option can include any practicable reversible opening means, including a screw-type device, clip device or snap-lock device.
  • the piercing means can be any means capable of piercing the seal of a drug vial.
  • the piercing means is a plastic needle-type device, attached near to the vial end inside the barrel.
  • the piercing means preferably is an integral part of the barrel moulding itself. When the vial is moved towards the piercing means, this can be effected in any practicable manner.
  • the barrel has a rotatable actuator mechanism in contact with the base of the vial which, when twisted, forces the vial along the barrel until the piercing means pierces the seal of the vial.
  • the piercing means can be moved towards the seal of the vial.
  • the barrel can have any practicable mechanism for activation to move the needle towards the piercing means, such as a depressable actuator or more than one depressable actuators on the exterior of the device which, when depressed, moves the needle towards the seal of the vial and forces the needle to pierce that seal.
  • the device of the invention can also include a wick of any practicable material inside the barrel. Upon piercing of the seal of the vial, the contents of the vial run or disperse onto the wick, increasing the available surface area for active evaporation. This assists vaporization and retention of the drug for inhalation.
  • the mouthpiece is attached to an end of the barrel by any means, and can be fixed or movable. If the mouthpiece is movable, which is generally when the barrel is a straight tube, preferably that mouthpiece is movable through approximately 180°, allowing the subject to access the mouthpiece and thereby the drug from any body position or recline.
  • the mouthpiece can also be fitted into a standard medical mask to assist with administration of the drug to an incapacitated patient.
  • the device can also include a filter in communication with the mouthpiece.
  • the filter can be located in any practicable position on the device but is preferably located in an exhalation port on the barrel of the device.
  • the filter can be made any material capable of absorbing vapours of the inhalable drug in liquid form.
  • the filter is preferably made of activated carbon matrix or another equivalent solvent-retaining medium.
  • the device of the invention can be made of any practicable material but is preferably made from solvent-resistant plastic.
  • the device can be any colour, including different colours to indicate the nature of the inhalable drug in liquid form in the vial in the barrel of the device.
  • the device can also be colourless or coloured translucent plastic so that the level of drug in the vial in the barrel of the device is visible.
  • the material of manufacture can also have an additive to render the device able to glow in the dark. This would assist patients and care providers in emergency situations where lighting is not available.
  • the device of the invention can also include a strap reversibly or irreversibly attached to any practicable position on the barrel.
  • the strap can be intended for use around the wrist or neck of a patient.
  • the strap is preferably attached to the end of the barrel furthest from the mouthpiece.
  • the strap is preferably attached by one or more snap- tag to prevent trapping or strangulation of the patient.
  • the snap-tag can be easily removed with a sharp pull to release the strap from the barrel.
  • the device can also include a nozzle or port on the barrel for attachment of a medical standard oxygen hose if required.
  • Figure 1 is a representation of a first embodiment of the device showing internal and external features.
  • Figure 2 is a perspective view of the external features of a first embodiment of the device.
  • Figure 3 is a top view of the external features of a first embodiment of the device.
  • Figure 4 is a side view of the external features of a first embodiment of the device.
  • Figure 5 is a top view of the external features of a second embodiment of the device.
  • Figure 6 is a side view of the external features of a second embodiment of the device.
  • Figure 7 is an exploded view of a second embodiment of the device.
  • DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS Figures 1 to 4 refer to a first embodiment of the invention.
  • FIG. 1 which shows internal and external features of the device (1)
  • the vial (2) containing the inhalable drug in liquid form is loaded in the barrel (3) of the device.
  • any wastage or potentially harmful spillage of the drug is avoided. This also ensures that the patient dose is accurately known.
  • the actuator (4) is turned, forcing the seal of the vial (2) onto a piercing means (5).
  • the piercing means (5) pierces the seal of the vial (2) and releases the drug in the barrel (3) and onto a wick (not shown).
  • the patient places the mouth around the mouthpiece (6), which can be swiveled around an axis (7). This function of the mouthpiece allows for administration of the drug to a patient in any physical position.
  • the patient then inhales through the mouthpiece (6), inhalation made possible by inlet air vents included in the actuator section (8).
  • the snap-tags (10) for attachment of a strap are shown in the Figures, as is the optional nozzle (11) for attachment of an oxygen hose.
  • Figures 5 to 7 refer to a second embodiment of the invention.
  • the vial (12) containing the inhalable drug in liquid form is loaded in the barrel (13) of the device.
  • the sealed vial By loading the sealed vial into the barrel, any wastage or potentially harmful spillage of the drug is avoided. This also ensures that the patient dose is accurately known.
  • the depressable actuators (14) are depressed and the piercing means (15) pierces the seal of the vial (12) and releases the drug in the barrel (13).
  • Figure 7 represents the piercing means (15) after piercing the vial seal.
  • the patient places the mouth around the mouthpiece (16), which is at the end of a substantially right angle in the barrel, furthest from the depressable actuators. This position of the mouthpiece allows for administration of the drug to a patient in any physical position. The patient then inhales through the mouthpiece (16), inhalation made possible by inlet air vents included in the actuator portion (17).
  • any remaining drug is absorbed by the filter (18) in the outlet vents (not shown) in the actuator portion (17), thereby preventing escape of any drug into the environment of the patient and caregiver.
  • Attachment of a strap is preferably on the side of the mouthpiece (20), opposite the air inlet (see Figure 6).
  • the optional nozzle (19) for attachment of an oxygen hose is also shown in the Figures.
  • the invention therefore provides a novel and efficient way of administering an inhalable drug in liquid form to a patient, without wastage or spillage of the drug, contamination of the surroundings, or discomfort to the patient.
  • the device also provides a portable administration unit which is easy to operate, allowing a patient to self-administer should the need arise.
  • the device can be disposable which improves the safety and reproducibility of administration of the drug.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Ecology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif pour faciliter l'inhalation d'un médicament à inhaler sous forme liquide qui comprend un boîtier pour contenir un flacon de médicament, un moyen de percement pratiquement contenu dans le boîtier, et une pièce buccale fixée à une extrémité du boîtier, et un procédé permettant l'administration d'un médicament à inhaler sous forme liquide en employant le dispositif de l'invention.
PCT/AU2009/001029 2008-08-11 2009-08-11 Inhalateur avec flacon à percer et médicament sous forme liquide Ceased WO2010017586A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2008904085 2008-08-11
AU2008904085A AU2008904085A0 (en) 2008-08-11 Inhaler

Publications (1)

Publication Number Publication Date
WO2010017586A1 true WO2010017586A1 (fr) 2010-02-18

Family

ID=41668576

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2009/001029 Ceased WO2010017586A1 (fr) 2008-08-11 2009-08-11 Inhalateur avec flacon à percer et médicament sous forme liquide

Country Status (2)

Country Link
TW (1) TW201010750A (fr)
WO (1) WO2010017586A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017011865A1 (fr) * 2015-07-20 2017-01-26 Medical Developments International Limited Dispositif d'inhalateur pour liquides à inhaler
WO2018045418A1 (fr) * 2016-09-06 2018-03-15 Medical Developments International Limited Dispositif inhalateur pour liquides inhalables
US10036574B2 (en) 2013-06-28 2018-07-31 British American Tobacco (Investments) Limited Devices comprising a heat source material and activation chambers for the same
JP2018520833A (ja) * 2015-07-20 2018-08-02 メディカル、ディベロップメンツ、インターナショナル、リミテッドＭｅｄｉｃａｌ Ｄｅｖｅｌｏｐｍｅｎｔｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 吸入可能な液体のための吸入器デバイス
US20190143053A1 (en) * 2016-12-05 2019-05-16 Microbase Technology Corp. Aerosol generating apparatus with replaceable parts
US10542777B2 (en) 2014-06-27 2020-01-28 British American Tobacco (Investments) Limited Apparatus for heating or cooling a material contained therein
US11064725B2 (en) 2015-08-31 2021-07-20 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US11241042B2 (en) 2012-09-25 2022-02-08 Nicoventures Trading Limited Heating smokeable material
US11452313B2 (en) 2015-10-30 2022-09-27 Nicoventures Trading Limited Apparatus for heating smokable material
US11659863B2 (en) 2015-08-31 2023-05-30 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11672279B2 (en) 2011-09-06 2023-06-13 Nicoventures Trading Limited Heating smokeable material
US11825870B2 (en) 2015-10-30 2023-11-28 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3565071A (en) * 1968-09-19 1971-02-23 Abbott Lab Self-regulating therapeutic inhaler
US20020092520A1 (en) * 2001-01-12 2002-07-18 Casper Robert A. Medicament respiratory delivery device and method
US20030034033A1 (en) * 2000-06-30 2003-02-20 Medihale Ltd. System and method for aerosol delivery of a drug
WO2006125577A2 (fr) * 2005-05-24 2006-11-30 Boehringer Ingelheim International Gmbh Nebuliseur
WO2007020073A1 (fr) * 2005-08-16 2007-02-22 Pari Pharma Gmbh Dispositif de therapie par inhalation pourvu d'une ampoule destinee a contenir un medicament a nebuliser
US20070119450A1 (en) * 2003-09-24 2007-05-31 Wharton David P Medication holder

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3565071A (en) * 1968-09-19 1971-02-23 Abbott Lab Self-regulating therapeutic inhaler
US20030034033A1 (en) * 2000-06-30 2003-02-20 Medihale Ltd. System and method for aerosol delivery of a drug
US20020092520A1 (en) * 2001-01-12 2002-07-18 Casper Robert A. Medicament respiratory delivery device and method
US20070119450A1 (en) * 2003-09-24 2007-05-31 Wharton David P Medication holder
WO2006125577A2 (fr) * 2005-05-24 2006-11-30 Boehringer Ingelheim International Gmbh Nebuliseur
WO2007020073A1 (fr) * 2005-08-16 2007-02-22 Pari Pharma Gmbh Dispositif de therapie par inhalation pourvu d'une ampoule destinee a contenir un medicament a nebuliser

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11672279B2 (en) 2011-09-06 2023-06-13 Nicoventures Trading Limited Heating smokeable material
US12041968B2 (en) 2011-09-06 2024-07-23 Nicoventures Trading Limited Heating smokeable material
US11241042B2 (en) 2012-09-25 2022-02-08 Nicoventures Trading Limited Heating smokeable material
US10036574B2 (en) 2013-06-28 2018-07-31 British American Tobacco (Investments) Limited Devices comprising a heat source material and activation chambers for the same
US10542777B2 (en) 2014-06-27 2020-01-28 British American Tobacco (Investments) Limited Apparatus for heating or cooling a material contained therein
JP7044702B2 (ja) 2015-07-20 2022-03-30 メディカル、ディベロップメンツ、インターナショナル、リミテッド 吸入可能な液体のための吸入器デバイス
JP2018520833A (ja) * 2015-07-20 2018-08-02 メディカル、ディベロップメンツ、インターナショナル、リミテッドＭｅｄｉｃａｌ Ｄｅｖｅｌｏｐｍｅｎｔｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ 吸入可能な液体のための吸入器デバイス
US20210001060A1 (en) * 2015-07-20 2021-01-07 Medical Developments International Limited Inhaler device for inhalable liquids
US11672925B2 (en) 2015-07-20 2023-06-13 Medical Developments International Limited Inhaler device for inhalable liquids
US20180200459A1 (en) * 2015-07-20 2018-07-19 Medical Developments International Limited Inhaler device for inhalable liquids
WO2017011865A1 (fr) * 2015-07-20 2017-01-26 Medical Developments International Limited Dispositif d'inhalateur pour liquides à inhaler
US11659863B2 (en) 2015-08-31 2023-05-30 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11064725B2 (en) 2015-08-31 2021-07-20 British American Tobacco (Investments) Limited Material for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11452313B2 (en) 2015-10-30 2022-09-27 Nicoventures Trading Limited Apparatus for heating smokable material
US11825870B2 (en) 2015-10-30 2023-11-28 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US12016393B2 (en) 2015-10-30 2024-06-25 Nicoventures Trading Limited Apparatus for heating smokable material
US12219986B2 (en) 2015-10-30 2025-02-11 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
US11571526B2 (en) 2016-09-06 2023-02-07 Medical Developments International Limited Inhaler device for inhalable liquids
WO2018045418A1 (fr) * 2016-09-06 2018-03-15 Medical Developments International Limited Dispositif inhalateur pour liquides inhalables
US20190143053A1 (en) * 2016-12-05 2019-05-16 Microbase Technology Corp. Aerosol generating apparatus with replaceable parts
US10994081B2 (en) * 2016-12-05 2021-05-04 Microbase Technology Corp. Aerosol generating apparatus with replaceable parts

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