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WO2010017299A3 - Plate-forme universelle de tests pour diagnostics médicaux et appareil de lecture de plates-formes de tests - Google Patents

Plate-forme universelle de tests pour diagnostics médicaux et appareil de lecture de plates-formes de tests Download PDF

Info

Publication number
WO2010017299A3
WO2010017299A3 PCT/US2009/052857 US2009052857W WO2010017299A3 WO 2010017299 A3 WO2010017299 A3 WO 2010017299A3 US 2009052857 W US2009052857 W US 2009052857W WO 2010017299 A3 WO2010017299 A3 WO 2010017299A3
Authority
WO
WIPO (PCT)
Prior art keywords
zone
optical sensing
test
module
identification data
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/052857
Other languages
English (en)
Other versions
WO2010017299A2 (fr
Inventor
Roger N. Piasio
Andrew Wheeler
Christopher Turmel
Ziv Geva
Ofer Leizerovich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alere Switzerland GmbH
Original Assignee
Inverness Medical Switzerland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/185,901 external-priority patent/US20100035357A1/en
Application filed by Inverness Medical Switzerland GmbH filed Critical Inverness Medical Switzerland GmbH
Priority to EP09791187A priority Critical patent/EP2346388A2/fr
Priority to CN2009801329757A priority patent/CN102164531A/zh
Publication of WO2010017299A2 publication Critical patent/WO2010017299A2/fr
Publication of WO2010017299A3 publication Critical patent/WO2010017299A3/fr
Priority to US13/020,485 priority patent/US20110318755A1/en
Anticipated expiration legal-status Critical
Priority to IL211091A priority patent/IL211091A0/en
Priority to US13/246,053 priority patent/US20120075626A1/en
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B10/0051Devices for taking samples of body liquids for taking saliva or sputum samples
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84Systems specially adapted for particular applications
    • G01N21/8483Investigating reagent band
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08Sensors provided with means for identification, e.g. barcodes or memory chips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/08Sensors provided with means for identification, e.g. barcodes or memory chips
    • A61B2562/085Sensors provided with means for identification, e.g. barcodes or memory chips combined with means for recording calibration data
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/143Quality control, feedback systems
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/021Identification, e.g. bar codes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/024Storing results with means integrated into the container
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/025Displaying results or values with integrated means
    • B01L2300/027Digital display, e.g. LCD, LED
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0681Filter
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0825Test strips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/12Specific details about materials
    • B01L2300/126Paper
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0644Valves, specific forms thereof with moving parts rotary valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/065Valves, specific forms thereof with moving parts sliding valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5029Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un procédé et un appareil destinés à lire optiquement des dispositifs de tests dotés d’une zone de données d’identification associée au dispositif de tests et une zone de test configurée de façon à recevoir un échantillon. L’appareil comporte un module de détection optique, un module de traitement d’image couplé au module de détection optique, un module de commande couplé au module de détection optique et au module de traitement d’image. Le module de détection optique est configuré de façon à détecter à la fois la zone de test et la zone de données d’identification et à transmettre les données détectées au module de traitement d’image en réponse au module de commande. En outre, le module de traitement d’image est configuré de façon à effectuer un traitement d’image sur les données détectées provenant de la zone de test et de la zone de données d’identification, et pour déterminer en outre l’échantillon en fonction des données détectées provenant de la zone de test et compte tenu des données détectées provenant de la zone de données d’identification en réponse au module de commande.
PCT/US2009/052857 2008-08-05 2009-08-05 Plate-forme universelle de tests pour diagnostics médicaux et appareil de lecture de plates-formes de tests Ceased WO2010017299A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP09791187A EP2346388A2 (fr) 2008-08-05 2009-08-05 Plate-forme universelle de tests pour diagnostics médicaux et appareil de lecture de plates-formes de tests
CN2009801329757A CN102164531A (zh) 2008-08-05 2009-08-05 一个通用的医疗诊断测试平台和读取测试平台的设备
US13/020,485 US20110318755A1 (en) 2008-12-15 2011-02-03 Universal Testing Platform for Medical Diagnostics
IL211091A IL211091A0 (en) 2008-08-05 2011-02-06 A universal testing platform for medical diagnostics and an apparatus for reading testing platforms
US13/246,053 US20120075626A1 (en) 2009-08-05 2011-09-27 Universal testing platform for medical diagnostics and an apparatus for reading testing platforms

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12/185,901 2008-08-05
US12/185,901 US20100035357A1 (en) 2008-08-05 2008-08-05 Apparatus For Optically Reading Test Kits And Identification Data Associated Therewith
US12261008P 2008-12-15 2008-12-15
US61/122,610 2008-12-15

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US13057866 A-371-Of-International 2009-08-05
US13/020,485 Continuation-In-Part US20110318755A1 (en) 2008-12-15 2011-02-03 Universal Testing Platform for Medical Diagnostics
US13/246,053 Continuation US20120075626A1 (en) 2009-08-05 2011-09-27 Universal testing platform for medical diagnostics and an apparatus for reading testing platforms

Publications (2)

Publication Number Publication Date
WO2010017299A2 WO2010017299A2 (fr) 2010-02-11
WO2010017299A3 true WO2010017299A3 (fr) 2010-04-15

Family

ID=41136958

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/052857 Ceased WO2010017299A2 (fr) 2008-08-05 2009-08-05 Plate-forme universelle de tests pour diagnostics médicaux et appareil de lecture de plates-formes de tests

Country Status (4)

Country Link
EP (1) EP2346388A2 (fr)
CN (1) CN102164531A (fr)
IL (1) IL211091A0 (fr)
WO (1) WO2010017299A2 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9140693B2 (en) 2011-12-23 2015-09-22 Abbott Point Of Care Inc. Integrated test device for optical detection of microarrays
US9194859B2 (en) 2011-12-23 2015-11-24 Abbott Point Of Care Inc. Reader devices for optical and electrochemical test devices
US9335290B2 (en) 2011-12-23 2016-05-10 Abbott Point Of Care, Inc. Integrated test device for optical and electrochemical assays
US9377475B2 (en) 2011-12-23 2016-06-28 Abbott Point Of Care Inc. Optical assay device with pneumatic sample actuation

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012012500A1 (fr) * 2010-07-20 2012-01-26 Nurx Pharmaceuticals, Inc. Systèmes de lecteur optique et tests à flux latéral
EP2596347B1 (fr) 2010-07-22 2017-09-06 Hach Company Analyse d'alcalinité en utiisant un laboratoire-sur-puce
WO2013020045A2 (fr) * 2011-08-03 2013-02-07 Coentre Ventures Llc Calibrage de nuage d'un dispositif d'essai
WO2013126824A1 (fr) 2012-02-22 2013-08-29 Life Technologies Corporation Appareil permettant de relever des empreintes digitales et des échantillons buccaux
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
CN104736247B (zh) * 2012-07-31 2018-02-23 康宁股份有限公司 微流体装置中的流体控制
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
CN108348913A (zh) * 2015-10-26 2018-07-31 幸福科技公司 侧向流测定装置和方法
EP3517957B1 (fr) * 2018-01-24 2019-12-18 Midge Medical GmbH Ensemble de test et dispositif de test pour dosage à écoulement latéral
WO2021151517A1 (fr) * 2020-01-31 2021-08-05 Medizinische Universität Graz Ensemble capteur et système de mesure d'un composant de salive
CN118546760B (zh) * 2023-02-27 2025-09-09 上海微创惟微诊断技术有限公司 一种核酸检测试剂盒

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US5869003A (en) * 1998-04-15 1999-02-09 Nason; Frederic L. Self contained diagnostic test unit
US6074606A (en) * 1998-10-19 2000-06-13 Sayles; Philip W. One-step test device
EP1225442A2 (fr) * 2001-01-17 2002-07-24 Bayer Corporation Méthode et appareil utilisant des mesures à infrarouge pour détecter des erreurs d'identification d'une bande de test diagnostique dans un spectromètre à réflectance
US20020173047A1 (en) * 2001-05-18 2002-11-21 Hudak Robert Thomas In line test device and methods of use
US20030022392A1 (en) * 2001-07-25 2003-01-30 Hudak Robert Thomas Specimen collection container
WO2003072254A1 (fr) * 2002-02-22 2003-09-04 Nanostream, Inc. Dispositifs et procedes de dilution quotientometrique
EP1359419A1 (fr) * 2002-05-01 2003-11-05 Lifescan, Inc. Dispositif et méthode pour la détermination de la concentration des analytes
EP1415788A1 (fr) * 2002-10-31 2004-05-06 Agilent Technologies, Inc. Dispositif de reseau microfluidique integre
WO2004081541A1 (fr) * 2003-03-14 2004-09-23 Allergenix Limited Dispositif de dosage
US20040241752A1 (en) * 1998-02-03 2004-12-02 Anderson Emory V. Point of care diagnostic systems
WO2005050165A2 (fr) * 2003-11-14 2005-06-02 Oakville Hong Kong Co., Limited Dispositifs de stockage et d'analyse rapides d'echantillon et leurs methodes d'utilisation
US20050163660A1 (en) * 2004-01-26 2005-07-28 Naishu Wang Disposable immunoassay sample-collector and chromatographic-testing device
US20060024843A1 (en) * 2004-07-29 2006-02-02 Savyon Diagnostics, Ltd. Assay device
US20060292034A1 (en) * 2005-06-28 2006-12-28 American Bio Medica Corporation Saliva sample testing device
US20060292036A1 (en) * 2005-06-28 2006-12-28 American Bio Medica Corporation Fluid specimen testing device
US7267799B1 (en) * 2002-08-14 2007-09-11 Detekt Biomedical, L.L.C. Universal optical imaging and processing system

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US6866822B1 (en) * 2000-08-11 2005-03-15 Lifescan, Inc. Gimbaled bladder actuator for use with test strips
WO2004104213A2 (fr) 2003-05-15 2004-12-02 The Rockefeller University Acides nucleiques et polypeptides de bacteriophages c1 et leurs utilisations
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0646784A1 (fr) * 1993-09-07 1995-04-05 Bayer Corporation Lecteur vidéo des bandes d'essai et procédé pour évaluer des bandes d'essai
US20040241752A1 (en) * 1998-02-03 2004-12-02 Anderson Emory V. Point of care diagnostic systems
US5869003A (en) * 1998-04-15 1999-02-09 Nason; Frederic L. Self contained diagnostic test unit
US6074606A (en) * 1998-10-19 2000-06-13 Sayles; Philip W. One-step test device
EP1225442A2 (fr) * 2001-01-17 2002-07-24 Bayer Corporation Méthode et appareil utilisant des mesures à infrarouge pour détecter des erreurs d'identification d'une bande de test diagnostique dans un spectromètre à réflectance
US20020173047A1 (en) * 2001-05-18 2002-11-21 Hudak Robert Thomas In line test device and methods of use
US20030022392A1 (en) * 2001-07-25 2003-01-30 Hudak Robert Thomas Specimen collection container
WO2003072254A1 (fr) * 2002-02-22 2003-09-04 Nanostream, Inc. Dispositifs et procedes de dilution quotientometrique
EP1359419A1 (fr) * 2002-05-01 2003-11-05 Lifescan, Inc. Dispositif et méthode pour la détermination de la concentration des analytes
US7267799B1 (en) * 2002-08-14 2007-09-11 Detekt Biomedical, L.L.C. Universal optical imaging and processing system
EP1415788A1 (fr) * 2002-10-31 2004-05-06 Agilent Technologies, Inc. Dispositif de reseau microfluidique integre
WO2004081541A1 (fr) * 2003-03-14 2004-09-23 Allergenix Limited Dispositif de dosage
WO2005050165A2 (fr) * 2003-11-14 2005-06-02 Oakville Hong Kong Co., Limited Dispositifs de stockage et d'analyse rapides d'echantillon et leurs methodes d'utilisation
US20050163660A1 (en) * 2004-01-26 2005-07-28 Naishu Wang Disposable immunoassay sample-collector and chromatographic-testing device
US20060024843A1 (en) * 2004-07-29 2006-02-02 Savyon Diagnostics, Ltd. Assay device
US20060292034A1 (en) * 2005-06-28 2006-12-28 American Bio Medica Corporation Saliva sample testing device
US20060292036A1 (en) * 2005-06-28 2006-12-28 American Bio Medica Corporation Fluid specimen testing device

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9140693B2 (en) 2011-12-23 2015-09-22 Abbott Point Of Care Inc. Integrated test device for optical detection of microarrays
US9194859B2 (en) 2011-12-23 2015-11-24 Abbott Point Of Care Inc. Reader devices for optical and electrochemical test devices
US9335290B2 (en) 2011-12-23 2016-05-10 Abbott Point Of Care, Inc. Integrated test device for optical and electrochemical assays
US9377475B2 (en) 2011-12-23 2016-06-28 Abbott Point Of Care Inc. Optical assay device with pneumatic sample actuation
US9488585B2 (en) 2011-12-23 2016-11-08 Abbott Point Of Care Inc. Reader devices for optical and electrochemical test devices
US10690664B2 (en) 2011-12-23 2020-06-23 Abbott Point Of Care Inc. Optical assay device with pneumatic sample actuation
US10852299B2 (en) 2011-12-23 2020-12-01 Abbott Point Of Care Inc. Optical assay device with pneumatic sample actuation

Also Published As

Publication number Publication date
IL211091A0 (en) 2011-04-28
WO2010017299A2 (fr) 2010-02-11
EP2346388A2 (fr) 2011-07-27
CN102164531A (zh) 2011-08-24

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