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WO2010013012A3 - Hypothermia inducing polypeptides and uses thereof - Google Patents

Hypothermia inducing polypeptides and uses thereof Download PDF

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Publication number
WO2010013012A3
WO2010013012A3 PCT/GB2009/001885 GB2009001885W WO2010013012A3 WO 2010013012 A3 WO2010013012 A3 WO 2010013012A3 GB 2009001885 W GB2009001885 W GB 2009001885W WO 2010013012 A3 WO2010013012 A3 WO 2010013012A3
Authority
WO
WIPO (PCT)
Prior art keywords
hypothermia
fragment
fusion
variant
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2009/001885
Other languages
French (fr)
Other versions
WO2010013012A9 (en
WO2010013012A4 (en
WO2010013012A2 (en
Inventor
Carin SJÖLUND
Björn Ulrik WALSE
Tadeusz Wieloch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LUND UNIVERSITY BIOSCIENCE AB
Original Assignee
LUND UNIVERSITY BIOSCIENCE AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LUND UNIVERSITY BIOSCIENCE AB filed Critical LUND UNIVERSITY BIOSCIENCE AB
Publication of WO2010013012A2 publication Critical patent/WO2010013012A2/en
Publication of WO2010013012A3 publication Critical patent/WO2010013012A3/en
Publication of WO2010013012A4 publication Critical patent/WO2010013012A4/en
Publication of WO2010013012A9 publication Critical patent/WO2010013012A9/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides a polypeptide capable of binding to a receptor for glucagon-like peptide-1 (GLP-1) for use in inducing or maintaining hypothermia in a subject in need thereof, wherein the polypeptide comprises or consists of an amino acid sequence of SEQ ID NO: 1 or a fragment, variant, derivative or fusion thereof (or a fusion of said fragment, variant or derivative) which retains the hypothermia-inducing activity of said amino acid sequence. The invention further provides pharmaceutical compositions comprising the polypeptides of the invention, together with methods and uses of the same.
PCT/GB2009/001885 2008-08-01 2009-07-31 Novel polypeptides and uses thereof Ceased WO2010013012A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE0801752 2008-08-01
SE0801752-7 2008-08-01
US19179108P 2008-09-12 2008-09-12
US61/191,791 2008-09-12

Publications (4)

Publication Number Publication Date
WO2010013012A2 WO2010013012A2 (en) 2010-02-04
WO2010013012A3 true WO2010013012A3 (en) 2010-04-01
WO2010013012A4 WO2010013012A4 (en) 2010-06-10
WO2010013012A9 WO2010013012A9 (en) 2010-08-12

Family

ID=41463119

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/001885 Ceased WO2010013012A2 (en) 2008-08-01 2009-07-31 Novel polypeptides and uses thereof

Country Status (1)

Country Link
WO (1) WO2010013012A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2413955A4 (en) * 2009-04-01 2012-12-26 Amylin Pharmaceuticals Inc AGONIST COMPOUNDS OF GLP-1 RECEPTORS HAVING CONFORMATIONAL CONSTRAINTS AT THEIR N-TERMINAL END
SI2718318T1 (en) 2011-06-10 2018-11-30 Hanmi Science Co., Ltd. Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
ES2710356T3 (en) 2011-06-17 2019-04-24 Hanmi Science Co Ltd A conjugate comprising oxintomodulin and an immunoglobulin fragment, and use thereof
KR101968344B1 (en) 2012-07-25 2019-04-12 한미약품 주식회사 A composition for treating hyperlipidemia comprising oxyntomodulin analog
UA116217C2 (en) 2012-10-09 2018-02-26 Санофі Exendin-4 derivatives as dual glp1/glucagon agonists
TWI652071B (en) 2012-11-06 2019-03-01 韓美藥品股份有限公司 Liquid preparation containing protein conjugate of acid modulator and immunoglobulin fragment
KR101993393B1 (en) 2012-11-06 2019-10-01 한미약품 주식회사 A composition for treating diabetes or diabesity comprising oxyntomodulin analog
CA2895875A1 (en) 2012-12-21 2014-06-26 Sanofi Exendin-4 derivatives
EP3080154B1 (en) 2013-12-13 2018-02-07 Sanofi Dual glp-1/gip receptor agonists
EP3080150B1 (en) 2013-12-13 2018-08-01 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
WO2015086730A1 (en) * 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
WO2015086733A1 (en) 2013-12-13 2015-06-18 Sanofi Dual glp-1/glucagon receptor agonists
TW201625670A (en) 2014-04-07 2016-07-16 賽諾菲公司 Dual GLP-1/glucagon receptor agonists derived from EXENDIN-4
TW201625668A (en) 2014-04-07 2016-07-16 賽諾菲公司 Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists
TW201625669A (en) 2014-04-07 2016-07-16 賽諾菲公司 Peptidic dual GLP-1/glucagon receptor agonists derived from Exendin-4
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
TWI802396B (en) 2014-09-16 2023-05-11 南韓商韓美藥品股份有限公司 Use of a long acting glp-1/glucagon receptor dual agonist for the treatment of non-alcoholic fatty liver disease
KR102418477B1 (en) 2014-12-30 2022-07-08 한미약품 주식회사 Gluagon Derivatives
KR101661332B1 (en) * 2015-05-28 2016-09-29 (의료)길의료재단 Pharmaceutical composition for treating muscle atrophy comprising glucagon like-peptide-1 receptor agonist
AR105319A1 (en) 2015-06-05 2017-09-27 Sanofi Sa PROPHARMS THAT INCLUDE A DUAL AGONIST GLU-1 / GLUCAGON CONJUGATE HIALURONIC ACID CONNECTOR
AR105284A1 (en) 2015-07-10 2017-09-20 Sanofi Sa DERIVATIVES OF EXENDINA-4 AS SPECIFIC DUAL PEPTIDE AGONISTS OF GLP-1 / GLUCAGÓN RECEPTORS

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066142A2 (en) * 1999-04-30 2000-11-09 Bionebraska, Inc. Metabolic intervention with glp-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066142A2 (en) * 1999-04-30 2000-11-09 Bionebraska, Inc. Metabolic intervention with glp-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
AL-BARAZANJI K A ET AL: "Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker rats.", OBESITY RESEARCH JUL 2000, vol. 8, no. 4, July 2000 (2000-07-01), pages 317 - 323, XP002565056, ISSN: 1071-7323 *
BABCOCK A M ET AL: "Neurotensin-induced hypothermia prevents hippocampal neuronal damage and increased locomotor activity in ischemic gerbils", BRAIN RESEARCH BULLETIN, ELSEVIER SCIENCE LTD, OXFORD, GB, vol. 32, no. 4, 1 January 1993 (1993-01-01), pages 373 - 378, XP024389182, ISSN: 0361-9230, [retrieved on 19930101] *
BAGGIO L L ET AL: "A Recombinant Human Glucagon-Like Peptide (GLP)-1-Albumin Protein (Albugon) Mimics Peptidergic Activation of GLP-1 Receptor-Dependent Pathways Coupled With Satiety, Gastrointestinal Motility, and Glucose Homeostasis", DIABETES, AMERICAN DIABETES ASSOCIATION, US, vol. 53, 1 September 2004 (2004-09-01), pages 2492 - 2500, XP003004469, ISSN: 0012-1797 *
DATABASE EPO Proteins [online] 24 November 2000 (2000-11-24), "Sequence 8 from Patent WO0066142.", XP002565057, retrieved from EBI accession no. EPOP:AX045426 Database accession no. AX045426 *
DEGN KRISTINE B ET AL: "One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes", DIABETES, AMERICAN DIABETES ASSOCIATION, US, vol. 53, no. 5, 1 May 2004 (2004-05-01), pages 1187 - 1194, XP002512806, ISSN: 0012-1797 *
HAYES MATTHEW R ET AL: "Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation", ENDOCRINOLOGY, vol. 149, no. 8, 17 April 2008 (2008-04-17), pages 4059 - 4068, XP002565048, ISSN: 0013-7227 *
LAWRENCE B ET AL: "NOVEL DAC:GLP-1 ANALOGUE, CJC-1131, EXHIBITS PROLONGED EFFICACY, SAFETY AND TOLERABILITY FOLLOWING SUBCUTANEOUS ADMINISTRATION IN NORMAL AND DIABETIC ANIMALS", DIABETOLOGIA, SPRINGER, BERLIN, DE, vol. 45, no. SUPPL. 02, 1 August 2002 (2002-08-01), pages A213/A214, XP008042635, ISSN: 0012-186X *
O'SHEA DONAL ET AL: "A role for central glucagon-like peptide-1 in temperature regulation", NEUROREPORT, vol. 7, no. 3, 1996, pages 830 - 832, XP009128440, ISSN: 0959-4965 *
SOWDEN GILLIAN L ET AL: "Oxyntomodulin increases intrinsic heart rate in mice independent of the glucagon-like peptide-1 receptor", AMERICAN JOURNAL OF PHYSIOLOGY - REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, vol. 292, no. 2, February 2007 (2007-02-01), pages R962 - R970, XP002565049, ISSN: 0363-6119 *

Also Published As

Publication number Publication date
WO2010013012A9 (en) 2010-08-12
WO2010013012A4 (en) 2010-06-10
WO2010013012A2 (en) 2010-02-04

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