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WO2010012005A3 - Procédés et systèmes pour produire des nanoparticules - Google Patents

Procédés et systèmes pour produire des nanoparticules Download PDF

Info

Publication number
WO2010012005A3
WO2010012005A3 PCT/US2009/051881 US2009051881W WO2010012005A3 WO 2010012005 A3 WO2010012005 A3 WO 2010012005A3 US 2009051881 W US2009051881 W US 2009051881W WO 2010012005 A3 WO2010012005 A3 WO 2010012005A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoparticles
conduit
substance
systems
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2009/051881
Other languages
English (en)
Other versions
WO2010012005A2 (fr
Inventor
Julia Ann Kornfield
Richard Charles Flagen
Bahar Bingol
John Yol Park
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology
SK Pharmaceuticals Inc
Original Assignee
California Institute of Technology
SK Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology, SK Pharmaceuticals Inc filed Critical California Institute of Technology
Priority to US13/055,918 priority Critical patent/US20110182994A1/en
Publication of WO2010012005A2 publication Critical patent/WO2010012005A2/fr
Publication of WO2010012005A3 publication Critical patent/WO2010012005A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Les procédés et systèmes ci-décrits permettent de préparer des nanoparticules comme suit : une source de fluide porteur est connectée à l'entrée d'un conduit d'écoulement, tel qu'un tube pour l'administration d'une solution intraveineuse pourvu d'orifices d'injection, de façon que le fluide porteur s'écoule dans le conduit. Une substance (par exemple, médicament en solution ou autre substance en solution) est introduite dans le conduit en un premier emplacement pour que des nanoparticules de ladite substance se forment à l'intérieur du conduit tout en continuant à s'écouler. Un stabilisant est introduit dans le conduit en un second emplacement pour exercer un effet stabilisant sur les nanoparticules. Dans certains modes de réalisation, le stabilisant peut limiter ou prévenir l'agglomération ou la croissance des nanoparticules, limitant ainsi la taille des nanoparticules produites.
PCT/US2009/051881 2008-07-25 2009-07-27 Procédés et systèmes pour produire des nanoparticules Ceased WO2010012005A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/055,918 US20110182994A1 (en) 2008-07-25 2009-07-27 Methods and systems for production of nanoparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13594008P 2008-07-25 2008-07-25
US61/135,940 2008-07-25

Publications (2)

Publication Number Publication Date
WO2010012005A2 WO2010012005A2 (fr) 2010-01-28
WO2010012005A3 true WO2010012005A3 (fr) 2010-05-27

Family

ID=41570903

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/051881 Ceased WO2010012005A2 (fr) 2008-07-25 2009-07-27 Procédés et systèmes pour produire des nanoparticules

Country Status (2)

Country Link
US (1) US20110182994A1 (fr)
WO (1) WO2010012005A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5823405B2 (ja) 2009-11-04 2015-11-25 ザ ユニバーシティ オブ ブリティッシュ コロンビア 核酸含有脂質粒子および関連方法
EP3915545A1 (fr) 2011-10-25 2021-12-01 The University of British Columbia Nanoparticules lipides de taille limite, et procédés correspondants
JP6605446B2 (ja) 2013-03-15 2019-11-13 ザ ユニバーシティ オブ ブリティッシュ コロンビア 形質移入用の脂質ナノ粒子および関連方法
WO2015048020A2 (fr) * 2013-09-24 2015-04-02 Alnylam Pharmaceuticals, Inc. Compositions et procédés de fabrication de nanoparticules
KR101882737B1 (ko) * 2016-05-20 2018-07-27 한국원자력연구원 전자빔 조사에 의한 고분자 나노입자 합성장치 및 합성방법
US20210284998A1 (en) 2016-10-03 2021-09-16 Precision Nanosystems Inc. Compositions for Transfecting Resistant Cell Types

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6224794B1 (en) * 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
WO2002056866A1 (fr) * 2001-01-18 2002-07-25 Orion Corporation Procede de preparation de nanoparticules
WO2003057362A2 (fr) * 2002-01-14 2003-07-17 Imperial College Of Science, Technology & Medicine Preparation de nanoparticles
WO2007150030A2 (fr) * 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Synthèse microfluidique de nanoparticules organiques

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002060411A2 (fr) * 2001-01-30 2002-08-08 Board Of Regents University Of Texas System Procede de production de nanoparticules et de microparticules par congelation par pulverisation dans un liquide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6224794B1 (en) * 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
WO2002056866A1 (fr) * 2001-01-18 2002-07-25 Orion Corporation Procede de preparation de nanoparticules
WO2003057362A2 (fr) * 2002-01-14 2003-07-17 Imperial College Of Science, Technology & Medicine Preparation de nanoparticles
WO2007150030A2 (fr) * 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Synthèse microfluidique de nanoparticules organiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAHN, A. ET AL.: "Preparation of nanoparticles by continuous-flow microfluidics", J NANOPART RES, vol. 10, 15 February 2008 (2008-02-15), pages 925 - 934 *

Also Published As

Publication number Publication date
WO2010012005A2 (fr) 2010-01-28
US20110182994A1 (en) 2011-07-28

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