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WO2010011117A3 - Ｎｄｇａ를 포함하는 트란스글루타미나제 억제용 조성물 - Google Patents

Ｎｄｇａ를 포함하는 트란스글루타미나제 억제용 조성물 Download PDF

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Publication number
WO2010011117A3
WO2010011117A3 PCT/KR2009/004175 KR2009004175W WO2010011117A3 WO 2010011117 A3 WO2010011117 A3 WO 2010011117A3 KR 2009004175 W KR2009004175 W KR 2009004175W WO 2010011117 A3 WO2010011117 A3 WO 2010011117A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
transglutaminase
ndga
present
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/004175
Other languages
English (en)
French (fr)
Other versions
WO2010011117A2 (ko
Inventor
김수열
이창훈
정경채
이병일
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Cancer Center Japan
National Cancer Center Korea
Original Assignee
National Cancer Center Japan
National Cancer Center Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Cancer Center Japan, National Cancer Center Korea filed Critical National Cancer Center Japan
Publication of WO2010011117A2 publication Critical patent/WO2010011117A2/ko
Publication of WO2010011117A3 publication Critical patent/WO2010011117A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 NDGA(Nordihydroguaiaretic acid)의 신규한 트란스글루타미나제 억제 용도에 관한 것으로, 더욱 상세하게는 NDGA를 유효성분으로 포함하는 트란스글루타미나제 활성 증가에 의해 초래되는 질병인 신경계 질환, 염증성 질환, 암 질환을 예방 또는 치료하기 위한 약제학적 조성물 및 상기 약제학적 조성물을 투여하여 트란스글루타미나제 활성 증가에 의해 초래되는 신경계 질환, 염증성 질환, 암 질환을 예방 또는 치료하는 방법에 관한 것이다. 본 발명에 따른 NDGA를 이용하여 트란스글루타미나제를 억제하는 신규한 방법은 트란스글루타미나제가 이상 발현되는 질환을 가진 대상에게 부작용없이 안전하게 적용되어 상기 질환을 효과적으로 치료 또는 예방 하는 데 유용하다.
PCT/KR2009/004175 2008-07-25 2009-07-27 Ｎｄｇａ를 포함하는 트란스글루타미나제 억제용 조성물 Ceased WO2010011117A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080072912 2008-07-25
KR10-2008-0072912 2008-07-25

Publications (2)

Publication Number Publication Date
WO2010011117A2 WO2010011117A2 (ko) 2010-01-28
WO2010011117A3 true WO2010011117A3 (ko) 2010-03-25

Family

ID=41570759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/004175 Ceased WO2010011117A2 (ko) 2008-07-25 2009-07-27 Ｎｄｇａ를 포함하는 트란스글루타미나제 억제용 조성물

Country Status (2)

Country Link
KR (1) KR20100011963A (ko)
WO (1) WO2010011117A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107449848A (zh) * 2017-09-22 2017-12-08 完美（中国）有限公司 一种鉴别化妆品原料中拉瑞阿提取物的方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008294A (en) * 1985-02-11 1991-04-16 Chemex Pharmaceuticals, Inc. Methods of treating tumors with compositions of catecholic butanes
US6214874B1 (en) * 1999-10-15 2001-04-10 John Hopkins University Treatment of HPV induced cancer using in situ application of two nordihydroguiaretic acid derivatives, tetramethyl NDGA M4N and tetraglycinal NDGA G4N
WO2003103583A2 (en) * 2002-06-10 2003-12-18 Oklahoma Medical Research Foundation A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system
US20060141029A1 (en) * 2003-05-20 2006-06-29 Erimos Pharmaceuticals Llc Methods and compositions for delivery of catecholic butanes for treatment of diseases
WO2008042921A2 (en) * 2006-10-02 2008-04-10 Erimos Pharmaceuticals Llc Tetra-o-substituted butane-bridge modified ndga derivatives, their synthesis and pharmaceutical use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008294A (en) * 1985-02-11 1991-04-16 Chemex Pharmaceuticals, Inc. Methods of treating tumors with compositions of catecholic butanes
US6214874B1 (en) * 1999-10-15 2001-04-10 John Hopkins University Treatment of HPV induced cancer using in situ application of two nordihydroguiaretic acid derivatives, tetramethyl NDGA M4N and tetraglycinal NDGA G4N
WO2003103583A2 (en) * 2002-06-10 2003-12-18 Oklahoma Medical Research Foundation A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system
US20060141029A1 (en) * 2003-05-20 2006-06-29 Erimos Pharmaceuticals Llc Methods and compositions for delivery of catecholic butanes for treatment of diseases
WO2008042921A2 (en) * 2006-10-02 2008-04-10 Erimos Pharmaceuticals Llc Tetra-o-substituted butane-bridge modified ndga derivatives, their synthesis and pharmaceutical use

Also Published As

Publication number Publication date
WO2010011117A2 (ko) 2010-01-28
KR20100011963A (ko) 2010-02-03

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