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WO2010010435A3 - Dérivés oxazole et thiazole fusionnés en tant que modulateurs de trpm8 - Google Patents

Dérivés oxazole et thiazole fusionnés en tant que modulateurs de trpm8 Download PDF

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Publication number
WO2010010435A3
WO2010010435A3 PCT/IB2009/006237 IB2009006237W WO2010010435A3 WO 2010010435 A3 WO2010010435 A3 WO 2010010435A3 IB 2009006237 W IB2009006237 W IB 2009006237W WO 2010010435 A3 WO2010010435 A3 WO 2010010435A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
thiazole derivatives
trpms
trpm8
fused oxazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2009/006237
Other languages
English (en)
Other versions
WO2010010435A2 (fr
Inventor
Nagoswara Rao Irlapati
Abraham Thomas
Deepak Kantilal Kurhe
Sandeep Yadunath Shelke
Joshi Neelima Khairatkar
Srikant Viswanadha
Indranil Mukhopadhyay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ichnos Sciences SA
Original Assignee
Glenmark Pharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals SA filed Critical Glenmark Pharmaceuticals SA
Publication of WO2010010435A2 publication Critical patent/WO2010010435A2/fr
Publication of WO2010010435A3 publication Critical patent/WO2010010435A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La présente invention concerne l’utilisation de dérivés oxazole et thiazole fusionnés en tant que modulateurs de TRPM8 (Transient Receptor Potential subfamily M, membre 8). Les composés décrits dans le présent document sont notamment utiles pour le traitement de maladies, de troubles, et de conditions modulés par TRPM8. La présente invention concerne en outre des procédés de préparation des composés décrits dans le présent document, des intermédiaires utilisés pour leur synthèse, des compositions pharmaceutiques les comprenant, et des procédés de traitement ou de prévention des maladies, des conditions et/ou des troubles modulés par TRPM8.
PCT/IB2009/006237 2008-07-22 2009-07-15 Dérivés oxazole et thiazole fusionnés en tant que modulateurs de trpm8 Ceased WO2010010435A2 (fr)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
IN1559/MUM/2008 2008-07-22
IN1559MU2008 2008-07-22
US8787708P 2008-08-11 2008-08-11
US61/087,877 2008-08-11
IN1735MU2008 2008-08-14
IN1735/MUM/2008 2008-08-14
US9535408P 2008-09-09 2008-09-09
US61/095,354 2008-09-09
IN2608/MUM/2008 2008-12-15
IN2608MU2008 2008-12-15
US14110208P 2008-12-29 2008-12-29
US61/141,102 2008-12-29

Publications (2)

Publication Number Publication Date
WO2010010435A2 WO2010010435A2 (fr) 2010-01-28
WO2010010435A3 true WO2010010435A3 (fr) 2010-12-23

Family

ID=41570660

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/006237 Ceased WO2010010435A2 (fr) 2008-07-22 2009-07-15 Dérivés oxazole et thiazole fusionnés en tant que modulateurs de trpm8

Country Status (1)

Country Link
WO (1) WO2010010435A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5591238B2 (ja) 2008-08-26 2014-09-17 ビーエーエスエフ ソシエタス・ヨーロピア 冷メントール受容体ｔｒｐｍ８の低分子量モジュレーターの検出および使用
DE102010002558A1 (de) 2009-11-20 2011-06-01 Symrise Ag Verwendung physiologischer Kühlwirkstoffe und Mittel enthaltend solche Wirkstoffe
WO2012124825A1 (fr) 2011-03-16 2012-09-20 Mitsubishi Tanabe Pharma Corporation Composés sulfonamides ayant une activité d'antagoniste de trpm8
CN102391207B (zh) * 2011-07-26 2014-04-09 贵州大学 N-(2-(取代苯并噻唑-2-氨基甲酰基)-苯基)-苯甲酰胺及其制备方法和用途
JP5985453B2 (ja) * 2012-09-14 2016-09-06 田辺三菱製薬株式会社 医薬組成物
TW201418221A (zh) 2012-09-14 2014-05-16 Mitsubishi Tanabe Pharma Corp 磺胺化合物
WO2015091584A1 (fr) * 2013-12-18 2015-06-25 F. Hoffmann-La Roche Ag Composés de thiazolopyridine, compositions et leur utilisation comme inhibiteurs de la kinase tyk2
EP3675809B1 (fr) 2017-08-31 2023-09-27 Basf Se Utilisation de substances actives de refroidissement physiologiques et moyen comportant des telles substances actives
WO2023203254A2 (fr) * 2022-04-22 2023-10-26 Fundamental Pharma Gmbh Moyens efficaces pour moduler la toxicité médiée par le récepteur nmda
WO2024223617A1 (fr) * 2023-04-24 2024-10-31 Fundamental Pharma Gmbh Moyens efficaces pour moduler la toxicité médiée par le récepteur nmda

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006066173A2 (fr) * 2004-12-17 2006-06-22 Eli Lilly And Company Nouveaux antagonistes de recepteur mch
EP1674466A1 (fr) * 2004-12-27 2006-06-28 4Sc Ag Derives benzazoles 2,5- et 2-6-disubstitues utiles comme des inhibiteurs de la proteine kinase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006066173A2 (fr) * 2004-12-17 2006-06-22 Eli Lilly And Company Nouveaux antagonistes de recepteur mch
EP1674466A1 (fr) * 2004-12-27 2006-06-28 4Sc Ag Derives benzazoles 2,5- et 2-6-disubstitues utiles comme des inhibiteurs de la proteine kinase

Also Published As

Publication number Publication date
WO2010010435A2 (fr) 2010-01-28

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