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WO2010010412A8 - Method for the preparation of n-methyl-aryloxy-propanamine derivatives - Google Patents

Method for the preparation of n-methyl-aryloxy-propanamine derivatives Download PDF

Info

Publication number
WO2010010412A8
WO2010010412A8 PCT/HU2009/000063 HU2009000063W WO2010010412A8 WO 2010010412 A8 WO2010010412 A8 WO 2010010412A8 HU 2009000063 W HU2009000063 W HU 2009000063W WO 2010010412 A8 WO2010010412 A8 WO 2010010412A8
Authority
WO
WIPO (PCT)
Prior art keywords
aryloxy
methyl
preparation
propanamine derivatives
propanamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/HU2009/000063
Other languages
French (fr)
Other versions
WO2010010412A3 (en
WO2010010412A2 (en
Inventor
Tibor Mezei
Györgyi KOVÁNYINÉ LAX
József Barkóczy
Balázs VOLK
Márta PORCS-MAKKAY
Gyula LUKÁCS
Enikű MOLNÁR
László Józsefné KOCSIS
György Krasznai
Imre KŐHEGYI
Judit Broda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egis Pharmaceuticals PLC
Original Assignee
Egis Pharmaceuticals PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Pharmaceuticals PLC filed Critical Egis Pharmaceuticals PLC
Publication of WO2010010412A2 publication Critical patent/WO2010010412A2/en
Publication of WO2010010412A3 publication Critical patent/WO2010010412A3/en
Publication of WO2010010412A8 publication Critical patent/WO2010010412A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention is related to a method for the preparation of N-methyl-aryloxy-propanamine derivatives, which comprises reacting a suitable uretane derivative of the Formula (XXIV) with a Grignard reagent.
PCT/HU2009/000063 2008-07-25 2009-07-24 Method for the preparation of n-methyl-aryloxy-propanamine derivatives Ceased WO2010010412A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP0800467 2008-07-25
HU0800467A HU230480B1 (en) 2008-07-25 2008-07-25 Process for producing n-methyl-aryloxy-propan-amine derivatives

Publications (3)

Publication Number Publication Date
WO2010010412A2 WO2010010412A2 (en) 2010-01-28
WO2010010412A3 WO2010010412A3 (en) 2010-05-27
WO2010010412A8 true WO2010010412A8 (en) 2010-07-22

Family

ID=89988421

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2009/000063 Ceased WO2010010412A2 (en) 2008-07-25 2009-07-24 Method for the preparation of n-methyl-aryloxy-propanamine derivatives

Country Status (2)

Country Link
HU (1) HU230480B1 (en)
WO (1) WO2010010412A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104163811A (en) * 2013-05-16 2014-11-26 重庆圣华曦药业股份有限公司 New method for preparation of duloxetine hydrochloride

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE169819C (en) *
DE1044103B (en) * 1956-06-12 1958-11-20 Hoffmann La Roche Process for the production of xanthene or thioxanthene derivatives
US3758620A (en) * 1969-11-06 1973-09-11 Nat Patent Dev Corp Process for the preparation of grignard reagents
KR880007433A (en) * 1986-12-22 1988-08-27 메리 앤 터커 3-aryloxy-3-substituted propanamine
IL98108A0 (en) * 1990-05-17 1992-06-21 Lilly Co Eli Chiral synthesis of 1-aryl-3-aminopropan-1-ols
EP1730132A2 (en) * 2004-12-23 2006-12-13 Teva Pharmaceutical Industries Ltd Process for preparing pharmaceutically acceptable salts of duloxetine and intermediates thereof

Also Published As

Publication number Publication date
HUP0800467A2 (en) 2011-03-28
HU230480B1 (en) 2016-07-28
WO2010010412A3 (en) 2010-05-27
HU0800467D0 (en) 2008-10-28
WO2010010412A2 (en) 2010-01-28

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