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WO2010001407A8 - Synthesis of 11-(4-[2-(2-hydroxyethoxy)ethyl]- piperazinyl)dibenzo[b,f][1,4]thiazepine and its fumarate salt - Google Patents

Synthesis of 11-(4-[2-(2-hydroxyethoxy)ethyl]- piperazinyl)dibenzo[b,f][1,4]thiazepine and its fumarate salt Download PDF

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Publication number
WO2010001407A8
WO2010001407A8 PCT/IN2009/000315 IN2009000315W WO2010001407A8 WO 2010001407 A8 WO2010001407 A8 WO 2010001407A8 IN 2009000315 W IN2009000315 W IN 2009000315W WO 2010001407 A8 WO2010001407 A8 WO 2010001407A8
Authority
WO
WIPO (PCT)
Prior art keywords
thiazepine
dibenzo
hydroxyethoxy
piperazinyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2009/000315
Other languages
French (fr)
Other versions
WO2010001407A2 (en
WO2010001407A3 (en
Inventor
Reguri Buchir Reddy
Purna Chandra Ray
Ghanta Mahesh Reddy
Kurma Kota Satyanarayana
Perumandla Nagaraju
Nallamothu Vanajarani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inogent Laboratories Pvt Ltd
Original Assignee
Inogent Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inogent Laboratories Pvt Ltd filed Critical Inogent Laboratories Pvt Ltd
Publication of WO2010001407A2 publication Critical patent/WO2010001407A2/en
Publication of WO2010001407A3 publication Critical patent/WO2010001407A3/en
Publication of WO2010001407A8 publication Critical patent/WO2010001407A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

This invention broadly relates to a method for synthesizing ll-(4-[2-(2- hydroxyethoxy)ethyl]-piperazinyl)-dibenzo[b,f][l,4]thiazepine hemifumarate salt (Quetiapine hemifumarate) and the intermediate 11- piperazinyldibenzo[b,f][l,4]thiazepine dihydrochloride using phosphorous oxychloride in presence of non-aromatic solvent and condensing with piperazine.
PCT/IN2009/000315 2008-06-05 2009-06-01 Synthesis of 11-(4-[2-(2-hydroxyethoxy)ethyl]- piperazinyl)dibenzo[b,f][1,4]thiazepine and its fumarate salt Ceased WO2010001407A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1370/CHE/2008 2008-06-05
IN1370CH2008 2008-06-05

Publications (3)

Publication Number Publication Date
WO2010001407A2 WO2010001407A2 (en) 2010-01-07
WO2010001407A3 WO2010001407A3 (en) 2010-03-25
WO2010001407A8 true WO2010001407A8 (en) 2010-05-20

Family

ID=41466392

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000315 Ceased WO2010001407A2 (en) 2008-06-05 2009-06-01 Synthesis of 11-(4-[2-(2-hydroxyethoxy)ethyl]- piperazinyl)dibenzo[b,f][1,4]thiazepine and its fumarate salt

Country Status (1)

Country Link
WO (1) WO2010001407A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104710383A (en) * 2013-12-11 2015-06-17 上海医药工业研究院 Quetiapine fumarate related substance, preparation method and applications thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101038389B1 (en) * 2004-06-23 2011-06-01 에스케이바이오팜 주식회사 11- (4- [2- (2-hydroxyethoxy) ethyl] -1-piperazinyl) -dibenzo [VII, VII] [1,4] thiazepine

Also Published As

Publication number Publication date
WO2010001407A2 (en) 2010-01-07
WO2010001407A3 (en) 2010-03-25

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