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WO2010096886A3 - Composition of a liposomal gel containing hydrocortisone, its metabolites, precursors or mixtures thereof and the use thereof - Google Patents

Composition of a liposomal gel containing hydrocortisone, its metabolites, precursors or mixtures thereof and the use thereof Download PDF

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Publication number
WO2010096886A3
WO2010096886A3 PCT/BE2010/000015 BE2010000015W WO2010096886A3 WO 2010096886 A3 WO2010096886 A3 WO 2010096886A3 BE 2010000015 W BE2010000015 W BE 2010000015W WO 2010096886 A3 WO2010096886 A3 WO 2010096886A3
Authority
WO
WIPO (PCT)
Prior art keywords
metabolites
precursors
mixtures
composition
hydrocortisone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BE2010/000015
Other languages
French (fr)
Other versions
WO2010096886A2 (en
Inventor
Gina Van Bogaert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to US13/203,059 priority Critical patent/US20110308985A1/en
Priority to EP10716254A priority patent/EP2400952A2/en
Publication of WO2010096886A2 publication Critical patent/WO2010096886A2/en
Publication of WO2010096886A3 publication Critical patent/WO2010096886A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Liposomal gel which, apart from liposomes and a continuous phase, comprises at least one thickening agent, at least one biologically active material and, optionally, at least one additive, whereby the biologically active material is encapsulated in the liposomes, and whereby this material consists of hydrocortisone, its metabolites or precursors, or a mixture thereof, and is applied on the skin for therapeutic purposes, characterised in that the weight ratio phosphatidylcholine/hydrocortisone amounts to at least 2/1 and/or in that the weight ratio phosphatidylcholine/carbomer hydrogel amounts to at least 20/1.
PCT/BE2010/000015 2009-02-26 2010-02-26 Composition of a liposomal gel containing hydrocortisone, its metabolites, precursors or mixtures thereof and the use thereof Ceased WO2010096886A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/203,059 US20110308985A1 (en) 2009-02-26 2010-02-26 Composition of a liposomal gel containing hydrocortisone, its metabolites, precursors or mixtures thereof and the use thereof
EP10716254A EP2400952A2 (en) 2009-02-26 2010-02-26 Composition of a liposomal gel containing hydrocortisone, its metabolites, precursors or mixtures thereof and the use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE2009/0120A BE1018506A3 (en) 2009-02-26 2009-02-26 COMPOSITION OF A HYDROCORTISONE, ITS DERIVATIVES, METABOLITES, PRODRUGS OR MIXTURES, LIPOSOMAL GEL AND ITS USE.
BE2009/0120 2009-02-26

Publications (2)

Publication Number Publication Date
WO2010096886A2 WO2010096886A2 (en) 2010-09-02
WO2010096886A3 true WO2010096886A3 (en) 2011-06-16

Family

ID=41129255

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE2010/000015 Ceased WO2010096886A2 (en) 2009-02-26 2010-02-26 Composition of a liposomal gel containing hydrocortisone, its metabolites, precursors or mixtures thereof and the use thereof

Country Status (3)

Country Link
EP (1) EP2400952A2 (en)
BE (1) BE1018506A3 (en)
WO (1) WO2010096886A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1030538B1 (en) 2022-05-18 2023-12-19 Bogaert Gina Van Liposomal preparation containing encapsulated hormones, method of production and use
CN116602921A (en) * 2023-04-20 2023-08-18 江苏艾迪纳米生物医药有限公司 Chloroquine phosphate cationic flexible liposome gel and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190936A (en) * 1989-06-15 1993-03-02 L'oreal Process for improving the therapeutic efficacy of fat-soluble corticosteroids and composition for carrying out this process
DE19940227A1 (en) * 1999-08-25 2001-03-08 Merckle Gmbh Phospholipid gel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190936A (en) * 1989-06-15 1993-03-02 L'oreal Process for improving the therapeutic efficacy of fat-soluble corticosteroids and composition for carrying out this process
DE19940227A1 (en) * 1999-08-25 2001-03-08 Merckle Gmbh Phospholipid gel

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "MedlinePlus Medical Encyclopedia: Cortisol - urine", 8 October 2008 (2008-10-08), pages 1 - 3, XP002629132, Retrieved from the Internet <URL:http://replay.waybackmachine.org/20081008094639/http://www.nlm.nih.gov/medlineplus/ency/article/003703.htm> [retrieved on 20110318] *
K. PARFITT (ED.): "Martindale. The comple drug reference. 32nd edition.", 1999, PHARMACEUTICAL PRESS, LONDON, XP002549295 *
KIM M-K ET AL: "Targeted and sustained delivery of hydrocortisone to normal and stratum corneum-removed skin without enhanced skin absorption using a liposome gel", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 46, no. 3, 2 June 1997 (1997-06-02), pages 243 - 251, XP004092170, ISSN: 0168-3659 *
NAUNTON MARK ET AL: "Estradiol gel: review of the pharmacology, pharmacokinetics, efficacy, and safety in menopausal women.", MENOPAUSE (NEW YORK, N.Y.) 2006 MAY-JUN, vol. 13, no. 3, May 2006 (2006-05-01), pages 517 - 527, XP002549294, ISSN: 1072-3714 *

Also Published As

Publication number Publication date
WO2010096886A2 (en) 2010-09-02
EP2400952A2 (en) 2012-01-04
BE1018506A3 (en) 2011-02-01

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