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WO2010093191A3 - Nouveaux composés efficaces en tant qu'inhibiteurs de xanthine oxydase, leur procédé de préparation et composition pharmaceutique les contenant - Google Patents

Nouveaux composés efficaces en tant qu'inhibiteurs de xanthine oxydase, leur procédé de préparation et composition pharmaceutique les contenant Download PDF

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Publication number
WO2010093191A3
WO2010093191A3 PCT/KR2010/000893 KR2010000893W WO2010093191A3 WO 2010093191 A3 WO2010093191 A3 WO 2010093191A3 KR 2010000893 W KR2010000893 W KR 2010000893W WO 2010093191 A3 WO2010093191 A3 WO 2010093191A3
Authority
WO
WIPO (PCT)
Prior art keywords
same
preparing
pharmaceutical composition
novel compounds
xanthine oxidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2010/000893
Other languages
English (en)
Other versions
WO2010093191A2 (fr
Inventor
Sung Pil Choi
Geun Tae Kim
Jeong Uk Song
Tae Hun Kim
Dong Chul Lim
Seung Wan Kang
Hyung Jin Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LG Chem Ltd
Original Assignee
LG Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LG Life Sciences Ltd filed Critical LG Life Sciences Ltd
Publication of WO2010093191A2 publication Critical patent/WO2010093191A2/fr
Publication of WO2010093191A3 publication Critical patent/WO2010093191A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne de nouveaux composés qui sont efficaces en tant qu'inhibiteur de la xanthine oxydase, leur procédé de préparation et une composition pharmaceutique comportant une quantité efficace desdits composés.
PCT/KR2010/000893 2009-02-13 2010-02-12 Nouveaux composés efficaces en tant qu'inhibiteurs de xanthine oxydase, leur procédé de préparation et composition pharmaceutique les contenant Ceased WO2010093191A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090011963 2009-02-13
KR10-2009-0011963 2009-02-13

Publications (2)

Publication Number Publication Date
WO2010093191A2 WO2010093191A2 (fr) 2010-08-19
WO2010093191A3 true WO2010093191A3 (fr) 2010-12-09

Family

ID=42562195

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/000893 Ceased WO2010093191A2 (fr) 2009-02-13 2010-02-12 Nouveaux composés efficaces en tant qu'inhibiteurs de xanthine oxydase, leur procédé de préparation et composition pharmaceutique les contenant

Country Status (2)

Country Link
KR (1) KR20100092909A (fr)
WO (1) WO2010093191A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9156845B2 (en) 2012-06-29 2015-10-13 Pfizer Inc. 4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011036130A1 (fr) * 2009-09-24 2011-03-31 F. Hoffmann-La Roche Ag Dérivés d'indole utilisés comme modulateurs de crac
WO2012103436A1 (fr) 2011-01-28 2012-08-02 E. I. Du Pont De Nemours And Company Procédé de préparation de dérivés de 2-aminobenzamide
EP2545964A1 (fr) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Nouveaux composés se liant au fxr (nr1 h4) et modulant son activité
ES2698359T3 (es) 2013-02-20 2019-02-04 Lg Chemical Ltd Agonistas del receptor de la esfingosina-1-fosfato, métodos para preparar los mismos y composiciones farmacéuticas que los contienen como agentes activos
ES2807907T3 (es) 2013-08-13 2021-02-24 Natreon Inc Extracto de Terminalia bellerica para la inhibición de xantina oxidasa y disminución de ácido úrico en suero
ES2663622T3 (es) 2013-12-17 2018-04-16 Pfizer Inc. Novedosas 1H-pirrolo[2,3-b]piridinas 3,4-disustituidas y 7H-pirrolo[2,3-c]piridacinas 4,5-disustituidas como inhibidores de LRRK2
JP6086105B2 (ja) 2014-09-24 2017-03-01 信越半導体株式会社 Ｓｏｉウェーハの製造方法
CN106478619B (zh) * 2015-08-29 2019-09-24 江苏新元素医药科技有限公司 一类黄嘌呤氧化酶抑制剂及其应用
ES2839201T3 (es) * 2015-09-02 2021-07-05 Sunshine Lake Pharma Co Ltd Derivados de anillo (hetero)aromático sustituidos en carboxilo y método de preparación y usos de los mismos
MX377305B (es) 2015-09-14 2025-03-07 Pfizer DERIVADOS DE IMIDAZO[4,5-c]QUINOLINA E IMIDAZO[4,5-c][1,5]NAFTIRIDINA NOVEDOSOS COMO INHIBIDORES DE LRRK2.
KR102269305B1 (ko) 2016-06-13 2021-06-25 길리애드 사이언시즈, 인코포레이티드 Fxr (nr1h4) 조정 화합물
CA2968836C (fr) 2016-06-13 2025-09-02 Gilead Sciences Inc Composes modulant fxr (nr1h4)
CN110612286A (zh) * 2017-02-28 2019-12-24 广东东阳光药业有限公司 氰基取代的稠合双环衍生物及其制备方法和用途
PL3600309T3 (pl) 2017-03-28 2022-11-07 Gilead Sciences, Inc. Skojarzenia terapeutyczne do leczenia chorób wątroby
HRP20240265T1 (hr) 2019-01-15 2024-05-10 Gilead Sciences, Inc. Spoj izoksazola kao fxr agonist i farmaceutski pripravci koji ga sadrže
CN118388473A (zh) 2019-02-19 2024-07-26 吉利德科学公司 Fxr激动剂的固体形式
WO2020256430A1 (fr) * 2019-06-19 2020-12-24 주식회사 엘지화학 Procédé de production d'un composé d'indole ou d'indazole
CN114080386B (zh) * 2019-06-19 2024-05-31 株式会社Lg化学 制备吲哚或吲唑化合物的方法
CN111072634B (zh) * 2020-01-03 2022-07-22 中国医科大学 1-取代-3-取代-5-取代酰胺-1h-吲哚类化合物及其制备方法和应用
WO2022233264A1 (fr) * 2021-05-07 2022-11-10 江苏新元素医药科技有限公司 Classe d'inhibiteurs de xanthine oxydase
CN117355513A (zh) * 2021-05-21 2024-01-05 江苏恒瑞医药股份有限公司 一种btk抑制剂中间体的制备方法
CN115925682B (zh) * 2021-10-04 2025-11-25 山东新时代药业有限公司 一种托匹司他的合成方法
US20250282753A1 (en) * 2022-04-27 2025-09-11 Atom Bioscience America Corporation Compounds useful for reducing uric acid
CN116283946B (zh) * 2023-03-27 2024-05-07 武汉工程大学 5-(n-取代吲哚-5-基)异噁唑-3-甲酸衍生物及其合成方法和应用
WO2025188963A1 (fr) 2024-03-06 2025-09-12 Fmc Corporation Synthèse catalysée par métal de dérivés de 2-aminobenzamide

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2003055882A1 (fr) * 2001-12-24 2003-07-10 Merck Patent Gmbh Pyrrolopyrimidines en tant d'agents d'inhibition de phosphodiesterase-vii
US20040034009A1 (en) * 2002-08-13 2004-02-19 Roark William Howard 1,6-Fused uracil derivatives as matrix metalloproteinase inhibitors
WO2008126898A1 (fr) * 2007-04-11 2008-10-23 Kissei Pharmaceutical Co., Ltd. Dérivé d'(aza)indole et ses usages médicaux

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003055882A1 (fr) * 2001-12-24 2003-07-10 Merck Patent Gmbh Pyrrolopyrimidines en tant d'agents d'inhibition de phosphodiesterase-vii
US20040034009A1 (en) * 2002-08-13 2004-02-19 Roark William Howard 1,6-Fused uracil derivatives as matrix metalloproteinase inhibitors
WO2008126898A1 (fr) * 2007-04-11 2008-10-23 Kissei Pharmaceutical Co., Ltd. Dérivé d'(aza)indole et ses usages médicaux

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RACHID BENHIDA ET AL., TETRAHEDRON LETTERS, vol. 40, 1999, pages 5701 - 5703 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9156845B2 (en) 2012-06-29 2015-10-13 Pfizer Inc. 4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors

Also Published As

Publication number Publication date
KR20100092909A (ko) 2010-08-23
WO2010093191A2 (fr) 2010-08-19

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