[go: up one dir, main page]

WO2010085609A3 - Système à libération contrôlée de mélange polymères - Google Patents

Système à libération contrôlée de mélange polymères Download PDF

Info

Publication number
WO2010085609A3
WO2010085609A3 PCT/US2010/021746 US2010021746W WO2010085609A3 WO 2010085609 A3 WO2010085609 A3 WO 2010085609A3 US 2010021746 W US2010021746 W US 2010021746W WO 2010085609 A3 WO2010085609 A3 WO 2010085609A3
Authority
WO
WIPO (PCT)
Prior art keywords
controlled release
polymer blends
release systems
polymer
microparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2010/021746
Other languages
English (en)
Other versions
WO2010085609A2 (fr
Inventor
Heather Nettles
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Surmodics SMP Inc
Original Assignee
Surmodics Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics Pharmaceuticals Inc filed Critical Surmodics Pharmaceuticals Inc
Priority to EP10701600A priority Critical patent/EP2389161A2/fr
Priority to CA2750003A priority patent/CA2750003A1/fr
Priority to JP2011548120A priority patent/JP2012515791A/ja
Publication of WO2010085609A2 publication Critical patent/WO2010085609A2/fr
Publication of WO2010085609A3 publication Critical patent/WO2010085609A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des microparticules améliorées. Dans un aspect, les microparticules comprennent un premier polymère et un second polymère, le second polymère étant différent du premier polymère. Dans d'autres aspects, un agent bioactif est encapsulé à l'intérieur des microparticules.
PCT/US2010/021746 2009-01-23 2010-01-22 Système à libération contrôlée de mélange polymères Ceased WO2010085609A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP10701600A EP2389161A2 (fr) 2009-01-23 2010-01-22 Système à libération contrôlée de mélange polymères
CA2750003A CA2750003A1 (fr) 2009-01-23 2010-01-22 Systeme a liberation controlee de melange polymeres
JP2011548120A JP2012515791A (ja) 2009-01-23 2010-01-22 ポリマー混成物由来の放出制御システム

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14698009P 2009-01-23 2009-01-23
US61/146,980 2009-01-23

Publications (2)

Publication Number Publication Date
WO2010085609A2 WO2010085609A2 (fr) 2010-07-29
WO2010085609A3 true WO2010085609A3 (fr) 2011-06-16

Family

ID=42028097

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/021746 Ceased WO2010085609A2 (fr) 2009-01-23 2010-01-22 Système à libération contrôlée de mélange polymères

Country Status (5)

Country Link
US (1) US20100189763A1 (fr)
EP (1) EP2389161A2 (fr)
JP (1) JP2012515791A (fr)
CA (1) CA2750003A1 (fr)
WO (1) WO2010085609A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10092524B2 (en) 2008-06-11 2018-10-09 Edge Therapeutics, Inc. Compositions and their use to treat complications of aneurysmal subarachnoid hemorrhage
CA2749997A1 (fr) * 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Melanges de polymeres comprenant des polymeres ayant differentes unites non repetitives et leurs procedes de fabrication et d'utilisation
US9364518B2 (en) * 2010-06-24 2016-06-14 Torrent Pharmaceuticals Limited Pharmaceutical composition containing goserelin for in-situ implant
UA111162C2 (uk) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
WO2012138854A1 (fr) 2011-04-05 2012-10-11 Edge Therapeutics Système d'administration de médicament intraventriculaire pour améliorer le résultat après une lésion cérébrale affectant le flux sanguin cérébral
CA2843139C (fr) * 2011-08-04 2019-09-24 Flexion Therapeutics, Inc. Corticosteroides destines a traiter une douleur articulaire
EP3241933B1 (fr) 2012-04-06 2020-12-23 Poly-Med Inc. Produits maillés en polymères et procédé de fabrication
US20130267972A1 (en) * 2012-04-06 2013-10-10 Poly-Med, Inc. Polymeric mesh products, method of making and use thereof
US9399019B2 (en) * 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
US9717797B2 (en) * 2013-12-05 2017-08-01 International Business Machines Corporation Polycarbonates bearing aromatic N-heterocycles for drug delivery

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009956A1 (fr) * 1997-08-29 1999-03-04 Corixa Corporation Agents bioactifs encapsules a liberation rapide servant a provoquer ou a potentialiser une reponse immunitaire, et procedes d'utilisation de ceux-ci
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
US20080131484A1 (en) * 2006-12-01 2008-06-05 Allergan, Inc. Intraocular drug delivery systems

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3169945A (en) * 1956-04-13 1965-02-16 Union Carbide Corp Lactone polyesters
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US5366734A (en) * 1981-02-16 1994-11-22 Zeneca Limited Continuous release pharmaceutical compositions
US6309669B1 (en) * 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US4897268A (en) * 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
DE69024953T3 (de) * 1989-05-04 2005-01-27 Southern Research Institute, Birmingham Einkapselungsverfahren
JP2911732B2 (ja) * 1992-10-01 1999-06-23 田辺製薬株式会社 徐放性多核マイクロスフェア製剤およびその製法
GB9412273D0 (en) * 1994-06-18 1994-08-10 Univ Nottingham Administration means
US6902743B1 (en) * 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
GB9518950D0 (en) * 1995-09-15 1995-11-15 Solvay Interox Ltd Polymers having improved processability
US5942253A (en) * 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
US20030096940A1 (en) * 2001-06-08 2003-05-22 Ray Drumright Copolymers of monocyclic esters and carbonates and methods for making same
EP2548550A1 (fr) * 2003-04-10 2013-01-23 Surmodics Pharmaceuticals, Inc. Microparticules à base d'émulsion
KR100466637B1 (ko) * 2003-06-26 2005-01-13 주식회사 펩트론 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법
US8119154B2 (en) * 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20050244469A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US7538179B2 (en) * 2004-11-04 2009-05-26 Kureha Corporation Process for producing aliphatic polyester
CN103251929A (zh) * 2005-12-22 2013-08-21 诺瓦提斯公司 包含奥曲肽和两种或更多种聚丙交酯-共-乙交酯聚合物的缓释制剂
WO2009064442A1 (fr) * 2007-11-13 2009-05-22 Brookwood Pharmaceuticals, Inc. Terpolymères visqueux en tant que plateforme de délivrance de médicaments
CA2749997A1 (fr) * 2009-01-23 2010-07-29 Surmodics Pharmaceuticals, Inc. Melanges de polymeres comprenant des polymeres ayant differentes unites non repetitives et leurs procedes de fabrication et d'utilisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009956A1 (fr) * 1997-08-29 1999-03-04 Corixa Corporation Agents bioactifs encapsules a liberation rapide servant a provoquer ou a potentialiser une reponse immunitaire, et procedes d'utilisation de ceux-ci
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
US20080131484A1 (en) * 2006-12-01 2008-06-05 Allergan, Inc. Intraocular drug delivery systems

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MING-KUNG Y ET AL: "Improving the delivery capacity of microparticle systems using blends of poly(DL-lactide co-glycolide) and poly(ethylene glycol)", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 37, no. 1, 1 November 1995 (1995-11-01), pages 1 - 9, XP004037435, ISSN: 0168-3659, DOI: DOI:10.1016/0168-3659(95)00039-B *

Also Published As

Publication number Publication date
CA2750003A1 (fr) 2010-07-29
EP2389161A2 (fr) 2011-11-30
JP2012515791A (ja) 2012-07-12
US20100189763A1 (en) 2010-07-29
WO2010085609A2 (fr) 2010-07-29

Similar Documents

Publication Publication Date Title
WO2010085609A3 (fr) Système à libération contrôlée de mélange polymères
GB2488075B (en) Polymer composition, swellable composition comprising the polymer composition, and articles including the swellable composition
IL211180A0 (en) Multi-arm polymeric alkanoate conjugates, compositions comprising the same and uses thereof
EP2249922A4 (fr) Dispositifs, procédés et systèmes pour récupérer l'énergie du corps
SG10201606508VA (en) Patient-specific bin systems, methods and devices
EP2361069A4 (fr) Pansement et systèmes de traitement de plaies à pression réduite
IL220283A0 (en) 4-oxo-ih-quinoline-3- carboxamides, compositions comprising the same and uses thereof
EP2113532A4 (fr) Composition de résine et article moulé obtenu à partir de cette composition
IL209193A0 (en) Bronchial catheters, systems comprising the same and uses thereof
BRPI1011422A8 (pt) composições de polímero, artigos fabricados a partir de tais composições, e métodos para moldar tais composições.
BRPI0919007A2 (pt) copolímero em bloco a base de propileno, composição contendo o copolímero, e produtos moldados obtidos a partir do mesmo.
HK1214127A1 (zh) 包含填充物质的生物可降解的微胶囊
IL217782A0 (en) Non surface active agent non polymeric agent hydro-alcoholic fomable compositions, breakable foams and their uses
LT2077976T (lt) Biologiškai aktyvi, rutenio turinti danga ir prietaisas
EP2323480A4 (fr) Compositions de mousses antimicrobiennes, articles et procédés associés
WO2011142858A3 (fr) Variants de la chlorotoxine, conjugués, et leurs méthodes d'utilisation
EG26112A (en) An integrated water sprinkler, and a fire extinguishing system that uses the sprinkler
EP2525678A4 (fr) Système de moulage perfectionné, procédé et articles formés au moyen de ceux-ci
EP2643408A4 (fr) Composition comprenant un copolymère d'alpha-oléfine et de propylène, un copolymère bloc d'oléfine, et de la matière fondue moléculaire de dpo-bsa
IL215592A (en) Compounds, preparations containing them and their uses in the treatment or prevention of conditions in the eyes
ZA200806201B (en) Methods, articles and systems for delivering superabsorbent polymers in agricultural settings
EP2291450A4 (fr) Compositions polymères, leurs procédés de fabrication et articles préparés à partir de celles-ci
EP2506893A4 (fr) Dispositifs d'administration d'adhésifs, systèmes et procédés associés
WO2010138547A3 (fr) Films contenant du zinc et à chargement supérieur
EP1973954A4 (fr) Procédés, articles et systèmes pour distribuer des polymères superabsorbants dans des contextes agricoles

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10701600

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2750003

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2011548120

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2010701600

Country of ref document: EP