[go: up one dir, main page]

WO2010085039A3 - 노긴―유래 펩타이드 및 그의 용도 - Google Patents

노긴―유래 펩타이드 및 그의 용도 Download PDF

Info

Publication number
WO2010085039A3
WO2010085039A3 PCT/KR2009/006930 KR2009006930W WO2010085039A3 WO 2010085039 A3 WO2010085039 A3 WO 2010085039A3 KR 2009006930 W KR2009006930 W KR 2009006930W WO 2010085039 A3 WO2010085039 A3 WO 2010085039A3
Authority
WO
WIPO (PCT)
Prior art keywords
present
noggin
peptide
preventing
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/006930
Other languages
English (en)
French (fr)
Other versions
WO2010085039A2 (ko
Inventor
정용지
김영덕
김은미
송상수
홍일
조경미
김수미
한상민
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Caregen Co Ltd
Original Assignee
Caregen Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caregen Co Ltd filed Critical Caregen Co Ltd
Priority to EP09838926.5A priority Critical patent/EP2383283B1/en
Priority to US13/145,390 priority patent/US8729028B2/en
Priority to JP2011547757A priority patent/JP5492226B2/ja
Priority to ES09838926.5T priority patent/ES2548982T3/es
Priority to CN200980157908.0A priority patent/CN102348716B/zh
Publication of WO2010085039A2 publication Critical patent/WO2010085039A2/ko
Publication of WO2010085039A3 publication Critical patent/WO2010085039A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 노긴-유래 펩타이드 및 이를 포함하는 발모 촉진용, 피부 상태 개선용, 항염증 또는 골질환 예방 또는 치료용 조성물에 관한 것이다. 본 발명의 노긴(Noggin)-유래 펩타이드는 천연의 인간 노긴과 동일하거나 유사한 기능을 하며 노긴과 비교하여 안정성이 보다 더 우수하며, 피부 투과도가 매우 뛰어나다. 본 발명에 따르면, 본 발명의 펩타이드를 유효성분으로 포함하는 조성물은 성장인자-관련 증후, 즉 탈모, 피부 개선 또는 창상, 성장인자 과발현 증후의 치료, 예방 또는 개선하는 데 매우 우수한 효능을 발휘한다. 따라서 상술한 본 발명의 펩타이드의 우수한 활성 및 안정성은, 의약, 의약외품 및 화장품에 매우 유리하게 적용될 수 있도록 한다.
PCT/KR2009/006930 2009-01-20 2009-11-24 노긴―유래 펩타이드 및 그의 용도 Ceased WO2010085039A2 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP09838926.5A EP2383283B1 (en) 2009-01-20 2009-11-24 Noggin-derived peptide and use thereof
US13/145,390 US8729028B2 (en) 2009-01-20 2009-11-24 Noggin-derived peptide and use thereof
JP2011547757A JP5492226B2 (ja) 2009-01-20 2009-11-24 ノギン由来のペプチド及びその用途
ES09838926.5T ES2548982T3 (es) 2009-01-20 2009-11-24 Péptido derivado de nogina y uso del mismo
CN200980157908.0A CN102348716B (zh) 2009-01-20 2009-11-24 头蛋白-来源的肽及其用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090004668A KR101163171B1 (ko) 2009-01-20 2009-01-20 노긴?유래 펩타이드 및 그의 용도
KR10-2009-0004668 2009-01-20

Publications (2)

Publication Number Publication Date
WO2010085039A2 WO2010085039A2 (ko) 2010-07-29
WO2010085039A3 true WO2010085039A3 (ko) 2010-09-16

Family

ID=42356286

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/006930 Ceased WO2010085039A2 (ko) 2009-01-20 2009-11-24 노긴―유래 펩타이드 및 그의 용도

Country Status (7)

Country Link
US (1) US8729028B2 (ko)
EP (1) EP2383283B1 (ko)
JP (1) JP5492226B2 (ko)
KR (1) KR101163171B1 (ko)
CN (1) CN102348716B (ko)
ES (1) ES2548982T3 (ko)
WO (1) WO2010085039A2 (ko)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101198918B1 (ko) * 2009-09-01 2012-11-07 (주)케어젠 Ｗｎｔ１０?유래 펩타이드 및 그의 용도
KR101329411B1 (ko) * 2012-05-31 2013-11-14 주식회사 엘지생활건강 피부투과성 펩타이드
KR101578901B1 (ko) 2013-09-11 2015-12-28 (주)셀아이콘랩 발모 촉진 펩타이드, 이의 제조방법, 및, 이를 함유하는 탈모방지 또는 발모촉진용 조성물
KR101600032B1 (ko) * 2013-09-26 2016-03-04 (주)피앤피바이오팜 Ｂｍｐ 활성 억제 기능을 갖는 신규 펩타이드 및 그의 용도
KR101632948B1 (ko) * 2014-05-13 2016-06-27 (주)케어젠 항염증, 골 형성 및 발모 촉진 활성을 갖는 펩타이드 및 이의 용도
KR101610861B1 (ko) * 2014-07-28 2016-04-11 (주)케어젠 골분화 촉진능 및 치주인대섬유모세포 활성 촉진능을 갖는 펩타이드 및 이의 용도
KR101576904B1 (ko) 2014-07-31 2015-12-14 (주)케어젠 파골세포 분화 및 활성 억제능을 갖는 펩타이드 및 이의 용도
KR101772574B1 (ko) * 2015-07-14 2017-08-30 (주)피앤피바이오팜 모낭 세포의 재생과 성장을 촉진하는 성장인자, 고안정성 섬유아세포 성장인자 변이체 및 노긴 펩타이드를 함유한 헤어케어 화장품 조성물
CN109311957A (zh) 2015-08-25 2019-02-05 伊斯迪德股份公司 诱导组织形成的化合物及其应用
CN109311956A (zh) 2015-08-25 2019-02-05 伊斯迪德股份公司 诱导组织形成的化合物及其应用
KR101791526B1 (ko) * 2016-02-18 2017-11-01 (주)케어젠 발모 촉진 활성을 나타내는 펩타이드 및 이의 용도
KR101800877B1 (ko) * 2016-02-18 2017-11-27 (주)케어젠 발모 촉진 활성 및 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도
KR101831887B1 (ko) * 2016-03-09 2018-02-27 (주)케어젠 발모 촉진 활성 및 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도
JP6835867B2 (ja) * 2016-03-18 2021-02-24 ケアジェン カンパニー, リミテッドCaregen Co., Ltd. フィナステリドとペプチドの結合体
KR101948238B1 (ko) * 2016-08-19 2019-02-14 (주)케어젠 미녹시딜과 펩타이드의 결합체
CN106727682A (zh) * 2017-01-20 2017-05-31 李玉红 一种用于治疗脱发的制剂
EA201991699A1 (ru) * 2017-02-16 2020-01-21 Кареджен Ко., Лтд. Конъюгат салициловой кислоты и пептида
KR101951283B1 (ko) * 2017-11-13 2019-02-22 양미경 탈모의 예방 또는 치료용, 또는 발모 또는 육모 촉진용 약학 또는 화장료 조성물
KR102160566B1 (ko) 2019-01-16 2020-09-28 (주)케어젠 미녹시딜과 펩타이드의 결합체
KR102221365B1 (ko) * 2019-05-07 2021-03-02 (주)케어젠 트롤록스-펩타이드 결합체 및 그의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821124A (en) * 1992-09-03 1998-10-13 Regeneron Pharmaceuticals, Inc. Hybridoma cell lines and antibodies that bind noggin
US20030170656A1 (en) * 1995-10-16 2003-09-11 Chiron Corporation Method of screening for factors that modulate gene expression
KR20060103159A (ko) * 2005-03-23 2006-09-28 정용지 모발과 피부의 치료를 위한 성장인자

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07508025A (ja) 1992-05-08 1995-09-07 トーマス・ジェファーソン・ユニバーシティ インスリン様増殖因子（ｉｇｆ−１）類似体
US6075007A (en) * 1997-07-17 2000-06-13 Regeneron Pharmaceuticals, Inc. Modified noggin polypeptide and compositions
US20030225021A1 (en) * 2001-11-14 2003-12-04 Mckay William F. Methods of inducing the expression of bone morphogenetic proteins (BMPs) and transforming growth factor-beta proteins (TGF-betas) in cells
WO1999061044A1 (en) 1998-05-28 1999-12-02 The Board Of Trustees Of The University Of Arkansas Noggin and antagonists of bone morphogenetic proteins to suppress pathologic bone resorption
JP2002524425A (ja) * 1998-09-04 2002-08-06 サイオス インコーポレイテッド 増殖因子の徐放性投与のためのヒドロゲル組成物
TWI305778B (en) 2001-12-03 2009-02-01 Nishida Teruo Peptides of an expressing unit for igf-i minimal activity and their pharmaceutical use
WO2004062621A2 (en) 2003-01-13 2004-07-29 Georgia Tech Research Corporation Anti-inflammatory agents and methods of their use
ES2379689T3 (es) * 2003-03-14 2012-04-30 Ucb Manufacturing, Inc. A Company Incorporated Under The Laws Of The State Of Delaware Complejo de esclerostina y nogina o cordina, y agentes que modulan la formación de dicho complejo
US20070224150A1 (en) * 2005-03-24 2007-09-27 Yongji Chung Growth factor for hair and skin treatment
EP2949328B1 (en) * 2005-03-29 2022-07-20 The Trustees of The University of Pennsylvania Minoxidil for generating new hair follicles and treating baldness
CN101395179B (zh) * 2006-03-06 2013-01-02 凯尔杰有限公司 具有胰岛素样生长因子-i活性的肽及其用途
KR100824396B1 (ko) * 2006-10-10 2008-04-22 (주)케어젠 상피세포 성장인자의 활성을 가지는 펩타이드 및 그의 용도
KR101198918B1 (ko) * 2009-09-01 2012-11-07 (주)케어젠 Ｗｎｔ１０?유래 펩타이드 및 그의 용도

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821124A (en) * 1992-09-03 1998-10-13 Regeneron Pharmaceuticals, Inc. Hybridoma cell lines and antibodies that bind noggin
US20030170656A1 (en) * 1995-10-16 2003-09-11 Chiron Corporation Method of screening for factors that modulate gene expression
KR20060103159A (ko) * 2005-03-23 2006-09-28 정용지 모발과 피부의 치료를 위한 성장인자

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
REETTA RAAG ET AL.: "An improved linker for single-chain Fv with reduced aggregation and enhanced proteolytic stability", FASEB, vol. 9, no. 1, January 1995 (1995-01-01), pages 73 - 80, XP000982464 *

Also Published As

Publication number Publication date
US20110312884A1 (en) 2011-12-22
EP2383283A2 (en) 2011-11-02
WO2010085039A2 (ko) 2010-07-29
EP2383283A4 (en) 2012-07-04
KR20100085407A (ko) 2010-07-29
JP5492226B2 (ja) 2014-05-14
JP2012515769A (ja) 2012-07-12
ES2548982T3 (es) 2015-10-22
EP2383283B1 (en) 2015-07-08
CN102348716A (zh) 2012-02-08
CN102348716B (zh) 2014-07-16
KR101163171B1 (ko) 2012-07-19
US8729028B2 (en) 2014-05-20

Similar Documents

Publication Publication Date Title
WO2010085039A3 (ko) 노긴―유래 펩타이드 및 그의 용도
WO2009125925A3 (ko) 성장인자―미미킹 펩타이드 및 그의 용도
PH12012500756A1 (en) Peptides used in the treatment and/or care of the skin, mucous membranes and/or hair and its use in cosmetic or pharmaceutical compositions
WO2009101503A3 (fr) Utilisation de substances actives naturelles dans des compositions cosmétiques ou thérapeutiques
MX2011010859A (es) Peptidos utiles en el tratamiento y/o cuidado de la piel y/o cabello y su uso en composiciones cosmeticas o farmaceuticas.
IL214462A0 (en) Peptides used in the treatment and/or care of the skin, mucous membranes and/or scalp and their use in cosmetic or pharmaceutical compositions
WO2012068515A3 (en) Compositions and methods for hair growth
EP1295893A4 (en) REGENERATION PROMOTERS OF CUTANE TISSUE CONTAINING GINSENOSIDE RB1
MY167691A (en) A pharmaceutical spray composition comprising a vitamin d analogue and a corticosteroid
WO2011009712A3 (de) Haarkonditionierende mittel mit ausgewählten kationischen siliconen und dimethicon
GB201001602D0 (en) Oligopeptidic compounds and uses therof
WO2014141210A3 (en) Multifunctional immature dental pulp stem cells and therapeutic applications
WO2012047951A3 (en) Human lung stem cells and uses thereof
WO2017200659A3 (en) A method to enhance wound healing using silk-derived protein
WO2011119009A3 (en) Peptides for promoting angiogenesis and an use thereof
WO2012014081A3 (en) Use of a composition comprising a peptidic fava bean extract for the stimulation of hair growth
MX2020010807A (es) Peptidos promotores del crecimiento y usos de los mismos.
WO2010081800A3 (en) Hylauronic acid containing compositions for treatment of wounds, scars, post-surgical adhesion formation
WO2010119997A1 (ko) 형질전환 성장인자의 활성을 가지는 펩타이드 및 그의 용도
PH12019500345A1 (en) Conjugate of minoxidil and peptide
SG11201909144VA (en) Bacterial secretome for use in the treatment of skin lesions
WO2011119008A3 (en) Peptides for promoting angiogenesis and an use thereof
WO2011079971A3 (de) Kosmetische mittel, enthaltend euk-134 und/oder euk-118 und mindestens einen pflegestoff
WO2010005256A3 (ko) 산사나무의 열매 또는 씨앗으로부터 얻어진 추출물을 포함하는 탈모방지 또는 발모촉진용 조성물
AU2017434946A8 (en) Pharmaceutical composition to be used for modification of scalp or skin, healing of wound or modification of hair

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200980157908.0

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09838926

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2011547757

Country of ref document: JP

Ref document number: 5251/CHENP/2011

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2009838926

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 13145390

Country of ref document: US