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WO2010084088A3 - Starch nanoparticles for drug delivery systems - Google Patents

Starch nanoparticles for drug delivery systems Download PDF

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Publication number
WO2010084088A3
WO2010084088A3 PCT/EP2010/050488 EP2010050488W WO2010084088A3 WO 2010084088 A3 WO2010084088 A3 WO 2010084088A3 EP 2010050488 W EP2010050488 W EP 2010050488W WO 2010084088 A3 WO2010084088 A3 WO 2010084088A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
delivery systems
starch
starch nanoparticles
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/050488
Other languages
French (fr)
Other versions
WO2010084088A2 (en
Inventor
Manuel J. Santander Ortega
Thomas Stauner
Brigitta Loretz
Gerhard Wenz
Ulrich Schaefer
Claus-Michael Lehr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of WO2010084088A2 publication Critical patent/WO2010084088A2/en
Publication of WO2010084088A3 publication Critical patent/WO2010084088A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/08—Ethers
    • C08B31/10—Alkyl or cycloalkyl ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/04—Starch derivatives, e.g. crosslinked derivatives
    • C08L3/06—Esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/04—Starch derivatives, e.g. crosslinked derivatives
    • C08L3/08—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Polymeric nanoparticles comprising hydrophobic and/or amphiphilic starch derivatives, their preparation and their use for the preparation of drug delivery systems are described. Preferred nanoparticles comprise at least one starch derivate, wherein the starch derivative is a hydrophobic starch derivative with an average degree of substitution of the hydroxyl-groups (Ds) in the range of 0.5 to 2.75.
PCT/EP2010/050488 2009-01-21 2010-01-18 Starch nanoparticles for drug delivery systems Ceased WO2010084088A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09151010 2009-01-21
EP09151010.7 2009-01-21

Publications (2)

Publication Number Publication Date
WO2010084088A2 WO2010084088A2 (en) 2010-07-29
WO2010084088A3 true WO2010084088A3 (en) 2011-04-14

Family

ID=42061054

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/050488 Ceased WO2010084088A2 (en) 2009-01-21 2010-01-18 Starch nanoparticles for drug delivery systems

Country Status (1)

Country Link
WO (1) WO2010084088A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10285943B2 (en) * 2010-12-02 2019-05-14 Greenmark Biomedical Inc. Aptamer bioconjugate drug delivery device
US20120309246A1 (en) 2011-06-03 2012-12-06 Alexander Tseitlin Curable biopolymer nanoparticle latex binder for mineral, natural organic, or synthetic fiber products and non-woven mats
US9616696B2 (en) 2013-10-23 2017-04-11 Ecosynthetix Inc. Coating for paper adapted for inkjet printing
US11453798B2 (en) 2013-12-05 2022-09-27 Ecosynthetix Ltd. Formaldehyde free binder and multi-component nanoparticle
KR20230042391A (en) 2014-10-03 2023-03-28 나노틱스 엘엘씨 Compositions and methods for inhibiting the biological activity of soluble biomolecules
CN113876600B (en) 2015-10-21 2024-05-17 密歇根大学董事会 Detection and treatment of caries and microcavities with nanoparticles
WO2017176762A1 (en) 2016-04-06 2017-10-12 Nanotics, Llc Particles comprising subparticles or nucleic acid scaffolds
US10993910B2 (en) 2016-12-07 2021-05-04 Seoul National University R&Db Foundation Biopatch, bioheater, biosensor and bioelectronic patch device
JP2021519310A (en) 2018-03-28 2021-08-10 グリーンマーク バイオメディカル インコーポレイテッドＧｒｅｅｎＭａｒｋ Ｂｉｏｍｅｄｉｃａｌ， Ｉｎｃ． Phosphate cross-linked starch nanoparticles and dental treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19857995A1 (en) * 1998-12-16 2000-06-21 Buna Sow Leuna Olefinverb Gmbh Process for the preparation of precipitated starch esters
WO2005030844A1 (en) * 2003-10-02 2005-04-07 Valtion Teknillinen Tutkimuskeskus Pigment and filler and a method of manufacturing it

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW493991B (en) 1995-05-08 2002-07-11 Novartis Ag Pharmaceutical composition for oral administration of active agent having low water solubility and process for preparation of the same
US20050227911A1 (en) 2001-09-28 2005-10-13 Solubest Ltd. Hydrophilic dispersions of nanoparticles of inclusion complexes of macromolecules

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19857995A1 (en) * 1998-12-16 2000-06-21 Buna Sow Leuna Olefinverb Gmbh Process for the preparation of precipitated starch esters
WO2005030844A1 (en) * 2003-10-02 2005-04-07 Valtion Teknillinen Tutkimuskeskus Pigment and filler and a method of manufacturing it

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NURMI ET AL: "Controlled grafting of acetylated starch by atom transfer radical polymerization of MMA", EUROPEAN POLYMER JOURNAL, PERGAMON PRESS LTD. OXFORD, GB, vol. 43, no. 4, 29 March 2007 (2007-03-29), pages 1372 - 1382, XP022008176, ISSN: 0014-3057, DOI: DOI:10.1016/J.EURPOLYMJ.2007.01.038 *
SIMI C K ET AL: "Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery", BIOPROCESS AND BIOSYSTEMS ENGINEERING, SPRINGER, BERLIN, DE, vol. 30, no. 3, 4 February 2007 (2007-02-04), pages 173 - 180, XP019518083, ISSN: 1615-7605, DOI: DOI:10.1007/S00449-007-0112-5 *
TUOVINEN L ET AL: "Starch acetate microparticles for drug delivery into retinal pigment epithelium-in vitro study", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 98, no. 3, 27 August 2004 (2004-08-27), pages 407 - 413, XP004527193, ISSN: 0168-3659, DOI: DOI:10.1016/J.JCONREL.2004.05.016 *

Also Published As

Publication number Publication date
WO2010084088A2 (en) 2010-07-29

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