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WO2010078651A1 - Dispositif de transfert de fluide - Google Patents

Dispositif de transfert de fluide Download PDF

Info

Publication number
WO2010078651A1
WO2010078651A1 PCT/CA2010/000011 CA2010000011W WO2010078651A1 WO 2010078651 A1 WO2010078651 A1 WO 2010078651A1 CA 2010000011 W CA2010000011 W CA 2010000011W WO 2010078651 A1 WO2010078651 A1 WO 2010078651A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
transfer device
container
further including
latch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA2010/000011
Other languages
English (en)
Inventor
Steven Raymond
Daniel Macdonald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duoject Medical Systems Inc
Original Assignee
Duoject Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duoject Medical Systems Inc filed Critical Duoject Medical Systems Inc
Publication of WO2010078651A1 publication Critical patent/WO2010078651A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/062—Carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding

Definitions

  • the present invention relates to a transfer device for transferring fluid from a first container to a second container.
  • a further occasion for transferring fluid (usually liquid) to a second container is for the reconstitution of a drug.
  • a dried form of the drug may be supplied in the second container and it is desirable to transfer the liquid from the first container to reconstitute the drug.
  • a transfer device comprising a first member having an exterior housing, an interior cavity within the exterior housing , and an upper post member at a distal end of the first member, a second member designed to fit within the interior cavity of the first member, the second member having a needle retained at a distal end thereof, a first end of the needle extending exteriorly of the second member and a second end of the needle extending interiorly of the second member, and a cartridge holder, the cartridge holder being secured to an upper portion of the first member, the arrangement being such that a container may be placed within the second member to have a septum thereof pierced by the second end of the needle, and a cartridge placed on the cartridge holder will have a piston pierced by the first end of the needle to establish fluid contact between the container and the cartridge to permit transfer of fluid therebetween.
  • a transfer arrangement for transferring a fluid between containers, the transfer assembly comprising a first donor container, a receiving container, a first member having an exterior housing, an interior cavity within the exterior housing, and an upper post member at a distal end of the first member, a second member located within the interior cavity of the first member, the second member having a needle retained at a distal end thereof, a first end of the needle extending exteriorly of the second member and a second end of the needle extending interiorly of the second member, the donor container being mounted interiorly of the second member a cartridge holder secured to an upper portion of the first member, the receiving container being mounted in the holder, the receiving container having a piston therein, the piston being located proximate a neck of the receiving container.
  • Figure 1 is a perspective view of a transfer device according to the present invention.
  • Figure 2 is a front elevational view thereof
  • Figure 3 is a side elevational view thereof
  • Figure 4 is a rear elevational view thereof
  • Figure 5 is an exploded view illustrating the various components of the transfer device along with the containers
  • Figures 6a and 6b are side sectional views of the device as it may be used with an automated mechanism for effecting the transfer of fluid between the containers;
  • Figure 7 is a sectional view illustrating assembly of the transfer device
  • Figure 8 illustrates a partial assembly of the device
  • Figure 9 is a side sectional view showing the insertion of the donor container into the transfer device.
  • Figures 10 to 14 are side sectional views illustrating operation of the device.
  • Figure 15 illustrates the completion of the transfer of the fluid to the recipient container and removal thereof.
  • transfer device for transferring fluid from a first donor container to a second receiving container and which transfer device is generally designated by reference numeral 10.
  • Transfer device 10 includes a first member 12, a sleeve 14, a second member 16, an O-ring 18, and a cartridge holder generally designated by reference numeral 20.
  • First member 12 includes a lower cylindrical portion 24 which has a window or opening 26 therein for providing visual access to an interior cavity 28.
  • Post 34 is hollow in nature and thus has an interior cavity which communicates with cavity 28.
  • a first leg 30 and a parallel second leg 32 extend upwardly to receive cartridge holder 20 as will be discussed in greater detail hereinbelow.
  • Sleeve 14 is formed with plurality of circumferential ribs 44 to provide a bellows type structure. Sleeve 14 is mounted over cylindrical post 34.
  • Second member 16 includes a cylindrical body 48. At the upper distal end thereof, there is provided a first cylindrical portion 50 which terminates in a second cylindrical portion 52. O-ring 18 fits over first cylindrical portion 50.
  • Second member 16 also includes a lower flange 54 and an intermediate flange 56. Mounted on the opposite side from flanges 54 and 56 is a protrusion 58.
  • second member 16 has a lower latch 60 which extends diagonally inwardly from body 48 and an upper latch 62 which extends inwardly from an upper portion of body 48.
  • a protrusion 63 is also provided.
  • a needle 64 is mounted within cylindrical portions 50, 52 and has first upper piercing end 66 extending exteriorly of second member 16 and a second lower piercing end 68 which extends exteriorly of body 48.
  • Cartridge holder 20 includes a top wall 76, a bottom wall 78, and a side wall 80 which define a cavity 81.
  • a downwardly extending leg 82 has a plurality of protrusions 84 formed on either side thereof for reasons which will become apparent hereinbelow.
  • a vent member 86 fits within cavity 81 and has a base 88 with end 21 and a diagonally extending plate 90.
  • a vent tube 92 has a needle 94 mounted therein with a sheath 96 extending thereabout.
  • a hydrophobic membrane 108 covers vent tube 92 to permit the passage of gas therethrough while preventing the passage of liquid.
  • Receiving cartridge 100 includes a cylindrical body 102 having a piston 104 mounted therein.
  • piston 104 is located proximate the distal or upper end of cartridge 100.
  • a probiscus 106 is provided; the arrangement is similar to that shown in U.S. Patent Publication 2008/0215030, Inventor Kenneth Owen Ritsher, the teachings of which are hereby incorporated by reference.
  • a lower or donor cartridge 110 may be a standard 3 ml glass cartridge as is well known in the art.
  • Donor cartridge 110 includes a piston 112 and has a recessed neck 120 as is conventional.
  • a cap 114 may be utilized in conjunction with a septum 116 which is designed to be pierced by lower piercing end 68 of needle 64.
  • the assembly is connected with cartridge holder 20 being connected to first member 12.
  • Leg 82 of cartridge holder 20 is slid downwardly between legs 30 and 32 such that protrusions 84 will engage apertures in legs 30, 32.
  • Vent member 86 is assembled by placing the vent sheath 96 over needle 94 and vent member 86 is slid within cavity 81. Naturally, this assembly of the vent member may occur prior to placement of cartridge holder 20 on first member 12.
  • Sleeve 14 is then placed over cylindrical post 34.
  • the pre-assembled cartridge 100 may be then snapped into place in cartridge holder 20 whereby needle 94 will pierce sheath 96 and a resealable portion of probiscus 106 when end 21 is moved.
  • Donor cartridge 110 is then slid within second member 16 as shown in Figures 9 and 10. The original engagement and retention is provided by lower latch 60 as may be seen in Figure 10. This will prevent withdrawal of donor cartridge 110.
  • a plunger rod 124 may be attached to piston 112 and typically, this may be done by means of a screwthreaded arrangement.
  • the device could use an automated system as shown in Figures 6a and 6b and which will be referred to hereinbelow.
  • donor cartridge 110 will cause the same to be moved upwardly and subsequently grasped and held by upper latch 62.
  • upper piercing end 66 of needle or cannula 64 will pierce piston 104 of receiving cartridge 100 while second piercing end 68 of cannula 64 will pierce septum 116 of donor cartridge 110.
  • a continued movement will then cause transfer of the liquid from donor cartridge 110 to receiving cartridge 100 following which the same may be removed as seen in Figure 15.
  • the transfer device of the present invention is primarily suited for transferring a liquid from a donor container to a receiving container.
  • the transfer device could, however, be used for reconstitution of a drug if so desired.
  • the terms “upper” and “lower” are merely used for ease of explanation and the device may be oriented in any manner desired. Similarly, the term “distal” refers to the end of the device having the receiving container located thereat.
  • Figures 6a and 6b illustrate use of the device of the present invention in an automated arrangement.
  • the device shown therein is described in Canadian Patent Application S.N. 2,662,331, the teachings of which are hereby incorporated by reference.
  • the automated device illustrated in Figures 6a and 6b is designed to receive the transfer device 10 of the present invention.
  • the cartridge pack is placed in the apparatus and retained by means of a metal clasp 282.
  • the device utilizes preloaded springs 222 which will act on a pusher rod 276.
  • flange 54 On placement of the cartridge pack in position, flange 54 will release a stopper 218 which will permit the activation of pusher rod 276.
  • the original pushing motion is supplied by closing of a cover 230 and movement of an S-shaped rod 228 to cause engagement of the donor container within the second member.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un dispositif de transfert destiné à transférer un liquide depuis un premier récipient jusqu'à un second récipient. Ledit dispositif comprend un premier élément (12) doté d'une cavité interne (28) dans un boîtier externe (24) et un second élément (16) conçu pour s'adapter à l'intérieur de ladite cavité interne (28). Le second élément (16) est pourvu d'une aiguille (64) fixée dessus, une première extrémité (66) de l'aiguille (64) s'étendant à l'extérieur du second élément (16) et une seconde extrémité (68) s'étendant à l'intérieur de celui-ci. Le dispositif comprend également un élément de retenue de cartouche (20) qui est fixé à une partie supérieure du premier élément (12). Un récipient (110) peut alors être placé dans ledit second élément (16) pour qu'un septum (116) de celui-ci puisse être percé par la seconde extrémité (68) de l'aiguille (64) ; par ailleurs, une cartouche (100) placée sur l'élément de retenue de cartouche (20) sera dotée d'un piston (104) percé par la première extrémité (66) de l'aiguille (64), pour permettre l'établissement d'un contact fluidique (110) entre ledit récipient (110) et ladite cartouche (100).
PCT/CA2010/000011 2009-01-09 2010-01-07 Dispositif de transfert de fluide Ceased WO2010078651A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA2,649,160 2009-01-09
CA2649160A CA2649160A1 (fr) 2009-01-09 2009-01-09 Dispositif de transfert de fluide

Publications (1)

Publication Number Publication Date
WO2010078651A1 true WO2010078651A1 (fr) 2010-07-15

Family

ID=42315984

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2010/000011 Ceased WO2010078651A1 (fr) 2009-01-09 2010-01-07 Dispositif de transfert de fluide

Country Status (2)

Country Link
CA (1) CA2649160A1 (fr)
WO (1) WO2010078651A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020097715A1 (fr) * 2018-11-16 2020-05-22 Duoject Medical Systems Inc. Dispositif de transfert de fluide

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030153895A1 (en) * 2002-02-08 2003-08-14 Leinsing Karl R. Vial adapter having a needle-free valve for use with vial closures of different sizes
EP1398053A1 (fr) * 1997-02-02 2004-03-17 Alaris Medical Systems, Inc. Raccord médical à canule tranchante
WO2005025636A2 (fr) * 2003-09-17 2005-03-24 Dali Medical Devices Ltd. Dispositif d'injection automatique
US6902543B1 (en) * 1999-10-13 2005-06-07 Societe De Conseils De Recherches Et Applications Scientifiques (S.C.R.A.S.) Device for reconstituting a therapeutic solution, suspension or dispersion
WO2006120461A1 (fr) * 2005-05-13 2006-11-16 Btg International Limited Préparation d'une mousse thérapeutique
EP1911432A1 (fr) * 2006-10-10 2008-04-16 Novo Nordisk A/S Unite de melange
US20080142388A1 (en) * 2006-12-19 2008-06-19 Cardinal Health 303, Inc. Pressure equalizing device for vial access
US7435246B2 (en) * 2006-02-16 2008-10-14 Disetronic Licensing Ag System and device for removing pharmaceutical products
WO2008151431A1 (fr) * 2007-06-13 2008-12-18 Duoject Medical Systems Inc. Dispositif de transfert de liquides depuis une cartouche dans un récipient

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1398053A1 (fr) * 1997-02-02 2004-03-17 Alaris Medical Systems, Inc. Raccord médical à canule tranchante
US6902543B1 (en) * 1999-10-13 2005-06-07 Societe De Conseils De Recherches Et Applications Scientifiques (S.C.R.A.S.) Device for reconstituting a therapeutic solution, suspension or dispersion
US20030153895A1 (en) * 2002-02-08 2003-08-14 Leinsing Karl R. Vial adapter having a needle-free valve for use with vial closures of different sizes
WO2005025636A2 (fr) * 2003-09-17 2005-03-24 Dali Medical Devices Ltd. Dispositif d'injection automatique
WO2006120461A1 (fr) * 2005-05-13 2006-11-16 Btg International Limited Préparation d'une mousse thérapeutique
US7435246B2 (en) * 2006-02-16 2008-10-14 Disetronic Licensing Ag System and device for removing pharmaceutical products
EP1911432A1 (fr) * 2006-10-10 2008-04-16 Novo Nordisk A/S Unite de melange
US20080142388A1 (en) * 2006-12-19 2008-06-19 Cardinal Health 303, Inc. Pressure equalizing device for vial access
WO2008151431A1 (fr) * 2007-06-13 2008-12-18 Duoject Medical Systems Inc. Dispositif de transfert de liquides depuis une cartouche dans un récipient

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020097715A1 (fr) * 2018-11-16 2020-05-22 Duoject Medical Systems Inc. Dispositif de transfert de fluide

Also Published As

Publication number Publication date
CA2649160A1 (fr) 2010-07-09

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