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WO2010073327A1 - Timbre transdermique - Google Patents

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Publication number
WO2010073327A1
WO2010073327A1 PCT/JP2008/073488 JP2008073488W WO2010073327A1 WO 2010073327 A1 WO2010073327 A1 WO 2010073327A1 JP 2008073488 W JP2008073488 W JP 2008073488W WO 2010073327 A1 WO2010073327 A1 WO 2010073327A1
Authority
WO
WIPO (PCT)
Prior art keywords
patch
support
release sheet
bending resistance
patch according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/073488
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English (en)
Japanese (ja)
Inventor
誠二郎 山
直樹 村井
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lead Chemical Co Ltd
Original Assignee
Lead Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lead Chemical Co Ltd filed Critical Lead Chemical Co Ltd
Priority to PCT/JP2008/073488 priority Critical patent/WO2010073327A1/fr
Publication of WO2010073327A1 publication Critical patent/WO2010073327A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene

Definitions

  • the present invention is a patch in which a portion having a high bending resistance is provided on a support and a pressure-sensitive adhesive layer is present on the support, and more specifically, bending of a preparation or adhesion between pastes is performed.
  • An object of the present invention is to provide a patch that is easy and easy to control, with little failure in the work of applying to the affected area.
  • the preparation described above has improved followability, the shape-retaining property of the preparation itself is reduced, and as a result, the portion exposed by the removal of the release sheet is likely to be bent or twisted, and applied to the affected area.
  • the preparation is used in a state where the preparation is bent or wrinkled in the preparation as it is, the application area is reduced and the medicinal effect as a patch cannot be fully exhibited.
  • the bent part or wrinkled part is the starting point, and during the application period, the exfoliation and removal of the preparation was promoted, and the application time prescribed in the usage could not be completed.
  • a preparation using a support with high stiffness is also sold.
  • a patch with high stiffness is applied, (1) it is pulled during application due to a decrease in followability to the skin. There may be a sense of incongruity, such as a feeling of feeling or tension.
  • the formulation may be sheared, peeled off or dropped during application. In order to improve this problem, it may be possible to increase the adhesive strength to the skin. In this case, however, (3) after use, when the preparation is peeled off, the skin is damaged by peeling off the stratum corneum and the pain at the peeling is caused. It becomes a problem such as increasing.
  • Patent Document 3 Patent Document 4, Patent Document 5 and Patent Document 6.
  • the plaster exposed during the pasting operation may adhere to each other.
  • the exposed plaster part may adhere to the release sheet side of the preparation, and the problem has not been solved.
  • JP 2000-297032 A specification JP 2001-328935 A International Publication No. 00-69422 Pamphlet Japanese Patent Application Laid-Open No. 2002-306530 Japanese Utility Model Publication No. 3-59327 Japanese Utility Model Publication No. 5-54515
  • the present invention provides a highly flexible part on the support of the preparation, prevents bending of the preparation and adhesion of the plaster during the application work, and reduces the failure of the application work.
  • An object of the present invention is to provide a patch capable of simply and easily performing a pasting operation.
  • the inventors of the present invention have reached the present invention as a result of diligent search to solve the above-mentioned problems.
  • the present invention solves the above-mentioned problems and provides a patch that can reduce the failure of the pasting operation to the affected area without being restricted by the application area or shape of the preparation.
  • the present invention is to provide the following patches.
  • a patch in which a paste layer is provided on the surface of a support, and a release sheet is bonded to the paste layer so as to cover substantially the entire surface;
  • a patch wherein two or more parts having different stiffness are formed on one support.
  • the part having different bending resistance of the support is a part having higher bending resistance than the other part of the support.
  • the highly flexible portion is localized at a support portion corresponding to a portion where the release sheet is divided and the plaster is exposed.
  • a patch in which a paste layer is provided on the surface of a support, and a release sheet is bonded to the paste layer so as to cover substantially the entire surface; a) A patch for forming two or more parts having different stiffness on a single support, b) A portion of the support having higher rigidity than other portions is localized at a support portion corresponding to a portion where the release sheet is divided and the plaster is exposed, c) A patch characterized in that the bending resistance of the low stretchable part is 120% or more higher than the bending resistance of other parts.
  • a patch having two cuts substantially parallel to the release sheet The patch according to any one of items (1) to (4), wherein the highly flexible portion of the support is located in a central portion of the support sandwiched between cuts substantially parallel to the release sheet.
  • a support made of a knitted fabric having a bending resistance of 5 mm or more according to a 45 ° cantilever method specified in JIS L 1096-1999 is used for the portion having high bending resistance.
  • the patch according to Item The support according to any one of the patches, which has different stiffness and softness, wherein the area of the portion having high stiffness and softness is 5% to 60% of the whole, (1) to (5) Patch.
  • the patch is a patch in which portions with high flexibility are scattered over the entire surface, b) having a portion where the release sheet is divided and the plaster is exposed; c)
  • the support is a support having a bending resistance of 6 mm or more according to a 45 ° cantilever method defined in JIS L 1096-1999.
  • a patch characterized by that.
  • the patch comprises a release sheet adhered to the surface of the pressure-sensitive adhesive layer, and the bending resistance of the release sheet is 60 to 160 mm.
  • the patch according to (13) to (14), wherein the support is made of polyester fiber having a fiber thickness of 30 to 75 denier and having a basis weight of 80 to 120 g / m 2 .
  • An embodiment of the present invention is a patch in which a pressure-sensitive adhesive layer is spread on a support having portions having different stiffness and flexibility in one preparation.
  • a single preparation is a patch in which a pressure-sensitive adhesive layer is spread on a highly rigid support.
  • the part having high stiffness and softness is preferably a part, that is, a part that is localized in a part where the plaster is first exposed at the time of application near the cut of the release sheet.
  • a highly rigid portion it may be provided in accordance with the cut portion of the release sheet, and there may be one or two cuts. In the case of two, what can cover the part pinched by the cut
  • the release sheet part to be peeled off first described in the sticking method or the like that is, the part where the plaster is first exposed at the time of sticking can be covered by a highly rigid part, and the shape of the part is not limited.
  • preferred examples include the range of the pattern portion shown in FIGS. 5 (a) and 5 (b).
  • the support of the part having high rigidity and softness covers the part where the plaster is first exposed at the time of application, so that the rigidity of the support is suppressed.
  • the shape of the portion having high bending resistance is not particularly limited.
  • the portion having high stiffness and softness may be on one side or both sides of the support (FIG. 6). In the case of localizing partly, it is preferable to make the part to be localized solid, spot or linear.
  • one whole preparation has high rigidity and flexibility.
  • a pattern as shown in FIG. 5 for maintaining the height of bending resistance may be applied to the entire support.
  • the pattern of the part where the stiffness of the support is changed, but considering the stiffness in the biaxial directions (longitudinal and lateral directions), the uniform longitudinal and lateral stiffness is considered. Then, a dot, a lattice pattern, etc. like FIG. 5 etc. are preferable. In addition, it is also preferable to use a stripe pattern or the like in consideration of bending / softening only in the vertical direction or only in the horizontal direction. Furthermore, it is also preferable to use another pattern that utilizes the difference in flexibility, for example, a logo pattern.
  • the highly flexible part of the present invention is such that the pastes adhere to each other at the time of applying the patch, and the exposed part of the paste does not adhere to the release sheet side on the preparation. It means having the bending and softness. In addition, if the bending resistance is too high, it is not preferable because it causes wrinkles due to application of the patch, uncomfortable feeling during application, and a decrease in motility.
  • the bending resistance in the highly flexible portion of the present invention refers to a property having moderate stretchability.
  • the bending resistance can be measured by a 45 ° cantilever method defined in JIS L 1096-1999.
  • the preferred bending resistance of the support of the present invention is 5 mm or more.
  • the bending resistance of the portion having high bending resistance is 6 mm or more. It is preferable that the bending resistance of the portion having high bending resistance is 120% or more higher than that of the untreated portion.
  • the means for changing the stiffness of the support is not particularly limited.
  • the method of changing the structure of the support fibers, materials, etc.
  • the method of pressing the method of applying resin, ink, etc., than the support The method etc. which stick a tape etc. with high bending resistance are mentioned.
  • a method by pressing, a method of applying a resin or ink, or a method of changing the structure of the support is preferable.
  • Examples of means for applying a resin or ink in order to change the bending resistance of the support include, but are not limited to, the following methods. Although it does not specifically limit as resin applied in order to change the bending resistance of the support body which can be used in this invention, A natural resin or a synthetic resin is mentioned. These resins can be used alone or in combination of two or more.
  • Examples of the ink applied to change the stiffness of the support that can be used in the present invention include pigments (organic pigments, inorganic pigments), dyes (dispersion dyes, acid dyes, reactive dyes, etc.), pearls (mica), Although foil (aluminum etc.) is mentioned, it is not limited to these.
  • organic pigments and inorganic pigments that do not require a washing step are preferably used.
  • the resin treatment method may be any of textile printing, gravure, thermal transfer, ink jet, spraying, and the like, and textile printing is particularly preferred, but is not limited thereto.
  • Examples of the tape or the like when a tape is applied to change the bending resistance of the support include, but are not limited to, polyolefin film, polyester film, polyurethane film, and the like.
  • the method of sticking a film can consider the method of using an adhesive, the method of heat processing, etc.
  • the pressure-sensitive adhesive component that can be used in the present invention is not particularly limited, and both a non-hydrated base and a hydrous base can be used.
  • non-water-containing base examples include, but are not limited to, rubber adhesives, acrylic adhesives, silicone adhesives, and the like.
  • the rubber component of the rubber-based adhesive was selected from, for example, natural rubber, polyisoprene, styrene-isoprene-styrene block copolymer, styrene-butanediene-styrene block copolymer, styrene-butadiene rubber, and polyisobutylene. Although it is preferable to use one kind alone or two or more kinds in combination, it is not limited to these.
  • acrylic adhesive examples include (acrylic acid-2-ethylhexyl acrylate) copolymer, (acrylic acid-butyl acrylate) copolymer, (acrylic acid-octyl acrylate) copolymer, (acrylic) Acid-acrylic acid 2-ethylhexyl-vinyl acetate) copolymer, (acrylic acid-2-ethylhexyl acrylate-hydroxyethyl acrylate) copolymer, (acrylic acid-hydroxyethyl acrylate-vinyl pyrrolidone) copolymer, (Acrylic acid-2-ethylhexyl acrylate-hydroxyethyl acrylate-vinyl pyrrolidone) copolymer and the like.
  • DURO-TAK 87-2194 commercial products such as DURO-TAK 87-2194, 87-2510, 87-2516 (manufactured by National Starch and Chemical Co., Ltd.) can also be used.
  • a copolymer containing an acrylate ester having a hydroxy group in the side chain in the monomer structural unit is preferred.
  • the crosslinking agent include amino compounds, phenol compounds, epoxy compounds, isocyanate compounds, organic peroxides, metal alcoholates, and metal chelates.
  • silicone pressure-sensitive adhesive examples include silicone rubber such as polyorganosiloxane.
  • the plasticizer that can be used in the present invention is not particularly limited, and examples thereof include petroleum oil (paraffinic process oil, naphthenic process oil, aromatic process oil, etc.), squalane, squalene, vegetable oil (olive oil). , Camellia oil, castor oil, tall oil, peanut oil), silicon oil, dibasic esters (dibutyl phthalate, dioctyl phthalate, etc.), liquid rubber (polybutene, liquid isoprene rubber), liquid fatty acid esters (isopropyl myristate, lauric acid) Hexyl, diethyl sebacate, diisopropyl sebacate, etc.), diethylene glycol, polyethylene glycol, polyethylene glycol, glycol salicylate, propylene glycol, dipropylene glycol, triacetylene, quee Triethyl citrate, crotamiton and the like.
  • liquid paraffin, isopropyl myristate liquid paraffin, is
  • plasticizers may be used alone or in combination of two or more.
  • the blending amount of these plasticizers is not particularly limited, but is preferably 5 to 70% by weight, more preferably 10 to 60% by weight based on the total amount of compounds contained in the pressure-sensitive adhesive layer, and 10 to 50%. It is particularly preferred that it is wt%. If the blending amount of the plasticizer is less than 5% by weight, the effect of improving the cohesive force of the patch by blending the plasticizer tends to be insufficient. On the other hand, if it exceeds 70% by weight, the skin permeability of the drug is poor. It tends to be sufficient.
  • the adhesive layer in the transdermal absorption preparation of the present invention can further contain a tackifier.
  • the tackifier that can be used in the present invention is not limited, and examples thereof include rosin derivatives (such as rosin, rosin glycerin ester, hydrogenated rosin, hydrogenated rosin glycerin ester, rosin pentaerythrester).
  • Aromatic saturated hydrocarbon resin (Alcon P100 (Arakawa Chemical Industries, Ltd.)), aliphatic hydrocarbon resin (Quinton B-170 (Nippon Zeon Corporation, etc.)), terpene resin (Clearon P-125 (Yasuhara Chemical Co., Ltd.)) Etc.), maleic acid resin, etc., among which glycerin ester of hydrogenated rosin, aliphatic hydrocarbon resin, and terpene resin are preferable.
  • tackifiers may be used alone or in combination of two or more, and the blending amount is not particularly limited, but is 5 to 5 on the basis of the total amount of compounds contained in the pressure-sensitive adhesive layer. It is preferably 70% by weight, more preferably 5 to 60% by weight, and particularly preferably 10 to 50% by weight. If the amount of the tackifier is less than 5% by weight, the effect of improving the adhesive strength of the patch due to the addition of the tackifier tends to be insufficient. On the other hand, if the amount exceeds 70% by weight, the patch is peeled off. The skin irritation tends to increase.
  • the pressure-sensitive adhesive layer of the percutaneous absorption preparation of the present invention can also contain an absorption enhancer for the purpose of improving the skin permeability of the drug.
  • the absorption promoter is not particularly limited as long as it is a compound that has been conventionally recognized as having an absorption promoting action on the skin, and specifically, a fatty acid, aliphatic alcohol, fatty acid ester, amide or ether having 6 to 20 carbon atoms. , Aromatic organic acids, aromatic alcohols, aromatic organic acid esters or ethers. These compounds may be saturated or unsaturated, and may be linear, branched, or cyclic.
  • absorption promoters may be used alone or in combination of two or more.
  • the amount of these absorption accelerators is not particularly limited, but is preferably 0.01 to 20% by weight, particularly 0.05 to 10% by weight, based on the total amount of compounds contained in the pressure-sensitive adhesive layer. preferable. If the blending amount of the absorption accelerator is less than 0.01% by weight, the effect of improving the skin permeability of the drug due to the blending of the absorption promoter tends to be insufficient. The skin irritation tends to increase, and the adhesion to the skin tends to decrease.
  • an antioxidant a filler, a crosslinking agent, an antiseptic, an ultraviolet absorber and the like can be blended in the pressure-sensitive adhesive layer as necessary.
  • antioxidant for example, tocopherol and their ester derivatives, ascorbic acid, ascorbic acid stearic acid ester, nordihuman rogayaretic acid, dibutylhydroxytoluene (BHT), and butylhydroxyanisole are preferable; Calcium, magnesium carbonate, silicate (for example, aluminum silicate, magnesium silicate, etc.), silicic acid, barium sulfate, calcium sulfate, calcium zincate, zinc oxide, titanium oxide are preferable; Thermosetting resins such as phenol resins, epoxy resins, alkyd resins, unsaturated polyesters, isocyanate compounds, block isocyanate compounds, organic crosslinking agents, inorganic crosslinking agents such as metals or metal compounds are preferably used. Not intended to be constant.
  • ethyl paraoxybenzoate, propyl paraoxybenzoate and butyl paraoxybenzoate are preferable; as the ultraviolet absorber, p-aminobenzoic acid derivatives, anthranilic acid derivatives, salicylic acid derivatives, coumarin derivatives, amino acid compounds , An imidazoline derivative, a pyrimidine derivative, and a dioxane derivative are preferable.
  • the formulation of each of the above antioxidant, filler, crosslinking agent, preservative, and ultraviolet absorber is not particularly limited, the total amount of the antioxidant, filler, crosslinking agent, preservative, and ultraviolet absorber is It is preferably 0 to 10% by weight, more preferably 0 to 5% by weight, and particularly preferably 0 to 2% by weight, based on the total amount of compounds contained in the pressure-sensitive adhesive layer.
  • the water-containing base contains water so that the medicinal effect on the skin can be sufficiently obtained, has adhesiveness, and softens even at room temperature or higher so that the plaster does not remain on the skin. Formed to have.
  • a thickener it is desirable that moisture can be stably maintained at 30% to 80% and that it has water retention.
  • Specific examples include guar gum, locust bean gum, carrageenan, alginic acid, sodium alginate, agar, gum arabic, tragacanth gum, karaya gum, pectin, starch and other microbial systems, sansan gum, acacia gum and other microbial systems, gelatin, collagen and the like.
  • Natural polymers such as animal systems, cellulose systems such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose sodium, semi-synthetic polymers such as starch systems such as soluble starch, carboxymethyl starch, and dialdehyde starch, polyvinyl alcohol, polyvinyl pyrrolidone, Vinyl-based materials such as polyvinyl methacrylate, acrylic-based materials such as polyacrylic acid and sodium polyacrylate, other polyethylene oxide, methyl vinyl ether / Water-soluble polymer of water-soluble polymers such as synthetic polymers such as water-maleic acid copolymers are suitably used. In particular, sodium polyacrylate is preferable.
  • sodium polyacrylate having an average degree of polymerization of 20000 to 70000 is preferred. As the average degree of polymerization becomes smaller than 20000, the thickening effect becomes poor and sufficient gel strength tends to be obtained. As the average degree of polymerization becomes larger than 70000, the thickening effect becomes too strong and workability tends to decrease. It appears and neither is desirable. Further, by using three or more kinds of the water-soluble polymers in combination, for example, a polymer complex with a strong ionic polymer of sodium polyacrylate can be formed, and an elastic gel with higher gel strength can be obtained.
  • Polyhydric alcohols such as glycerin, propylene glycol and sorbitol as wetting agents, and kaolin, zinc oxide, talc, titanium, bentonite, aluminum silicate, titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate, calcium phosphate as fillers Etc. may be added.
  • a solubilizer or absorption promoter propylene carbonate, crotamiton, 1-menthol, mint oil, limonene, diisopropyl adipate and the like
  • methyl salicylate, glycol salicylate, 1-menthol, thymol, mint oil, Nonyl acid vanillylamide, pepper extract, etc. may be added.
  • you may add a stabilizer, an antioxidant, an emulsifier, etc. as needed.
  • cross-linking agents and polymerizing agents may be added as necessary.
  • the plaster can be strengthened and water retention can be provided.
  • This crosslinking agent and polymerization agent are appropriately selected according to the type of thickener and the like.
  • compounds having at least two epoxy groups in the molecule hydrochlorides such as Ca, Mg, Al, sulfates, phosphates, Inorganic acid salts such as carbonate, organic acid salts such as citrate, tartrate, gluconate and stearate, oxides such as zinc oxide and anhydrous silicic acid, hydroxides such as aluminum hydroxide and magnesium hydroxide
  • a polyvalent metal compound such as is preferably used.
  • polyvinyl alcohol When polyvinyl alcohol is applied as a thickener, adipic acid, thioglycolic acid, epoxy compound (epichlorohydrin), aldehydes, N-methylol compound, Al, Ti, Zr, Sn, V, Cu, B, Cr Complexes such as compounds such as are preferably used.
  • polyvinylpyrrolidone When polyvinylpyrrolidone is applied as the thickener, methyl vinyl ether / maleic anhydride copolymer, polyacid compound or alkali metal salt thereof (polyacrylic acid, tannic acid and derivatives thereof), etc. are preferably used.
  • polyethylene oxide when polyethylene oxide is applied to the thickener, peroxide, polysulfone azide, and the like are preferably used.
  • a methyl vinyl ether / maleic anhydride copolymer when applied to the thickener, polyfunctional hydroxy compounds, polyamines, iodine, gelatin, polyvinyl pyrrolidone, iron, mercury, lead salts and the like are preferably used.
  • aldehydes such as formaldehyde, glutaraldehyde, and dialdehyde starch
  • diepoxides such as glyoxal and butadiene oxide
  • diketones such as divinyl ketone
  • diisocyanates are preferably used.
  • a polyvalent metal salt such as lithium hydroxide, zinc hydroxide, aluminum hydroxide or sodium borate is preferably added as a crosslinking agent. Particularly preferred are zinc salts and aluminum salts.
  • Cross-linking reaction is promoted.
  • the concentration of the polyvalent metal salt added as a crosslinking agent is preferably 0.5 to 1.5 equivalents relative to 1 equivalent of the thickener (or water-soluble polymer). As the concentration of the polyvalent metal salt becomes smaller than 0.5 equivalent, the reaction tends to be too slow and the gel strength tends to decrease, and as the concentration of the polyvalent metal salt becomes larger than 1.5 equivalent, the reaction becomes too fast. There is a tendency for gelation to become non-uniform and workability to deteriorate, both of which are not preferred.
  • the plaster comprises 5 to 20% by weight of a thickener, preferably 10 to 15% by weight, 5 to 40% by weight of a wetting agent, 20% by weight or less of a filler, 10 to 10% by weight of water. 80% by weight, solubilizing agent 0 to 8% by weight, drug 5% by weight or less, preferably 0.5% to 5% by weight.
  • the rigid / soft support used in the patch of the present invention can be used without any limitation as long as it can support the pressure-sensitive adhesive layer.
  • Specific examples of such a support include cloth, nonwoven fabric, polyurethane, polyethylene, polyvinyl acetate, polyvinylidene chloride, polyethylene, polyethylene terephthalate, aluminum sheet, or a laminate or composite material thereof.
  • the fiber material of the cloth or nonwoven fabric is not particularly limited, but may be a thermoplastic fiber alone or a blend of thermoplastic fiber and non-thermoplastic fiber.
  • thermoplastic fiber examples include materials made of a thermoplastic resin such as polyurethane, polyester, polypropylene, acrylic, and nylon, for example, polyester fiber, polyamide fiber, and polyvinyl chloride fiber. These may be used alone or in combination of two or more. It can be used by mixing.
  • non-thermoplastic fibers include rayon, cupola, hemp and silk.
  • the thickness of the support is not particularly limited, but the thickness is preferably in the range of 5 to 1000 ⁇ m. If the thickness of the support is less than 5 ⁇ m, the workability at the time of peeling tends to be reduced. On the other hand, if the thickness exceeds 1000 ⁇ m, it becomes difficult to cut the support or the pressure-sensitive adhesive layer in the preparation production process. The manufacturing ease tends to decrease.
  • the thermoplastic fibers of the support used in the patch of the present invention it is preferable that the basis weight of the support is in the range of from 50 200g / m 2.
  • the range is preferably 60 to 160 g / m 2 , more preferably 80 to 120 g / m 2 .
  • the thermoplastic fiber of the support used in the patch of the present invention preferably has a basis weight of 80 to 120 g / m 2 made of polyester fiber having a fiber thickness of 30 to 75 denier.
  • the basis weight is 90 to 110 g / m 2 made of 50 denier polyester fibers, and more preferably the basis weight is about 100 g / m 2 made of 50 denier polyester fibers.
  • the bending resistance of the support used in the patch of the present invention is preferably 5 mm or more according to the 45 ° cantilever method specified in JIS L 1096-1999.
  • the release sheet in which the patch is attached to the surface of the pressure-sensitive adhesive layer preferably has, for example, a bending softness of 60 to 160 mm.
  • the thickness of the adhesive layer in the patch of the present invention is not particularly limited, but is preferably 20 to 3000 ⁇ m.
  • the method for arranging the pressure-sensitive adhesive layer on the support is not particularly limited.
  • the patch of the present invention is provided with a release paper
  • a release paper it is not particularly limited. Specifically, a film such as polyester such as polyethylene terephthalate, polyvinyl chloride, polyvinylidene chloride, a laminate film of fine paper and polyolefin, etc. Can be used.
  • a silicone treatment may be applied to the surface on the side in contact with the pressure-sensitive adhesive layer.
  • Drugs include methyl salicylate, glycol salicylate, 1-menthol, red pepper extract, nonylic acid vanillylamide, mint oil, diclofenac, ibupufen, indomethacin, ketoprofen, loxoprofen, sulindac, tolmetine, lobenzalite, penicillamine, fempfen, flurbiprofen, prolbiprofen , Pranoprofen, thiaprofen, suprofen, felbinac, ketorolac, oxaprozin, etodolac, zaltoprofine, piroxicam, pentazocine, buprenorphine hydrochloride, butorphanol tartrate, etc.
  • prednisolone dexamethasone, hydrocortisone, betamethasone, fluocinide, Luocinolone acetonide, prednisolone acetate valerate, dexamethasone dipropionate, diflucortron valerate, difluprednate, betamethasone valerate, hydrocortisone acetate, clobetasone butyrate, betamethasone butyrate, clobetasone propionate, dexamethasone succinate, prednisolone 21- (2E, 6E) steroidal anti-inflammatory drugs such as falsinate, hydrocortisone valerate, diflorazone acetate, dexamethasone propionate, betamethasone dipropionate, amsinonide, dexamethasone valerate, harsinonide, butesonide, alcrometasone propionate, etc.
  • steroidal anti-inflammatory drugs such as falsinate
  • Two or more kinds of drugs can be used in combination as necessary.
  • these drugs can be applied in the form of an ester-derived compound, an amide-derived compound, an acetal-derived compound, or a medically acceptable inorganic salt or organic salt as necessary. It may be contained or attached to the body.
  • the amount of the drug is appropriately selected according to the type and use of the patch so that an effective amount preset when applied to the patient can be applied to the affected area.
  • the above ingredients are mixed and mixed Then, it was coated on a release sheet, coated with the support mentioned in the above Production 1 to 4 and pressure-bonded. Furthermore, it cut
  • Comparative Example 1 Manufactured in the same manner as in Example 1 except that unprocessed circular knitted woven fabric was used.
  • Test Example 1 Method for measuring bending resistance The bending resistance of each support was measured by the 45 ° cantilever method defined in JIS L 1096-1999. In addition, for Example 1, Example 2, and Example 3, the bending resistance of the processed part was measured.
  • Test Example 2 Sticking test A sticking test was performed using the preparations produced in the above Examples and Comparative Examples. In the sticking test, each Example and Comparative Example 1 were cut into a size of 10 cm ⁇ 14 cm and used. The pasting work was carried out on the lumbar region of 10 healthy people aged 30 to 60 years old. Evaluation was performed according to the evaluation criteria shown in Table 2. Table 3 shows the evaluation results for the ease of sticking work and the uncomfortable feeling when sticking.
  • Example 2 and Example 3 were almost the same evaluation as Comparative Example 1.
  • FIG. 1 shows an example of failure in a state in which pastes are stuck to each other after removal of a release sheet during a pasting operation of a patch (state in which pastes exposed when there is one liner break are stuck together) ).
  • Fig. 2 shows an example of failure in a state where the pastes are stuck to each other after the release sheet is removed during the pasting operation of the patch (the plaster exposed when the liner has one cut sticks to the release paper)
  • FIG. FIG. 3 shows an example of failure in a state in which the pastes are stuck to each other after the release sheet is removed during the pasting operation of the patch (a state in which the exposed pastes are stuck to each other when there are two liner breaks) ).
  • FIG. 1 shows an example of failure in a state in which pastes are stuck to each other after removal of a release sheet during a pasting operation of a patch (state in which pastes exposed when there is one liner break are stuck together) ).
  • Fig. 2 shows an example of failure in a state where the
  • FIG. 4 shows an example of failure in a state in which the pastes are stuck to each other after removing the release sheet during the pasting operation of the patch (exposed paste is stuck to the release paper when there are two liner breaks.
  • FIG. 5 is a front view ((a), (b)) of the patch in the embodiment of the present invention.
  • FIG. 6 is a perspective view and a diagram schematically showing a cross section of the patch in the embodiment of the present invention.
  • 1 is a patch such as an ointment or a poultice in the embodiment of the present invention
  • 2 is a plaster layer of the patch
  • 3 is a support having rigidity and flexibility made of a woven fabric, etc.
  • FIG. 7 is a diagram showing the pattern of the support used in Production Example 1.
  • FIG. 8 is a diagram showing the pattern of the support used in Production Example 2.
  • FIG. 9 is a diagram showing the pattern of the support used in Production Example 3.
  • FIG. 10 is a diagram showing the pattern of the support used in Production Example 4.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

Le problème à résoudre dans le cadre de la présente invention est de produire un timbre transdermique dont la pliure due à la préparation pharmaceutique et l'adhérence des surfaces d'enduit les unes aux autres lors de l'application sont prévenues, et qui peut être aisément et simplement appliqué presque sans incident. La solution proposée est un timbre transdermique comportant un substrat, une couche d'enduit appliquée sur le substrat, et un papier anti-adhérent reposant sur la couche d'enduit de manière à recouvrir presque toute la surface de la couche d'enduit, le timbre étant caractérisé en ce que des sections dont la résistance à la pliure diffère sont formées dans un substrat et une section présentant une résistance à la pliure supérieure à celle des autres sections est localisée dans une surface où l'enduit doit d'abord être rendu apparent lors de l'application, ce par quoi l'adhérence des surfaces d'enduit les unes aux autres est prévenue lors de l'application.
PCT/JP2008/073488 2008-12-24 2008-12-24 Timbre transdermique Ceased WO2010073327A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2008/073488 WO2010073327A1 (fr) 2008-12-24 2008-12-24 Timbre transdermique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2008/073488 WO2010073327A1 (fr) 2008-12-24 2008-12-24 Timbre transdermique

Publications (1)

Publication Number Publication Date
WO2010073327A1 true WO2010073327A1 (fr) 2010-07-01

Family

ID=42286996

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/073488 Ceased WO2010073327A1 (fr) 2008-12-24 2008-12-24 Timbre transdermique

Country Status (1)

Country Link
WO (1) WO2010073327A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3263097A4 (fr) * 2015-02-24 2018-08-15 Hisamitsu Pharmaceutical Co., Inc. Cataplasme adhésif pour la peau
US11903915B2 (en) 2019-02-14 2024-02-20 Hisamitsu Pharmaceutical Co., Inc. Poultice

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60140732U (ja) * 1984-11-21 1985-09-18 旭化成株式会社 積層湿布材
JPS6314530U (fr) * 1987-02-14 1988-01-30
JP2004059489A (ja) * 2002-07-29 2004-02-26 Toray Ind Inc 貼付剤用布帛および貼布剤
JP2005170828A (ja) * 2003-12-10 2005-06-30 Toray Ind Inc 貼付剤用布帛および貼付剤
JP2007176854A (ja) * 2005-12-28 2007-07-12 Lion Corp 貼付剤支持体とその製造方法および貼付剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60140732U (ja) * 1984-11-21 1985-09-18 旭化成株式会社 積層湿布材
JPS6314530U (fr) * 1987-02-14 1988-01-30
JP2004059489A (ja) * 2002-07-29 2004-02-26 Toray Ind Inc 貼付剤用布帛および貼布剤
JP2005170828A (ja) * 2003-12-10 2005-06-30 Toray Ind Inc 貼付剤用布帛および貼付剤
JP2007176854A (ja) * 2005-12-28 2007-07-12 Lion Corp 貼付剤支持体とその製造方法および貼付剤

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3263097A4 (fr) * 2015-02-24 2018-08-15 Hisamitsu Pharmaceutical Co., Inc. Cataplasme adhésif pour la peau
US10940121B2 (en) 2015-02-24 2021-03-09 Hisamitsu Pharmaceutical Co., Inc. Gel patch
US11903915B2 (en) 2019-02-14 2024-02-20 Hisamitsu Pharmaceutical Co., Inc. Poultice

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