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WO2010068744A2 - Système et procédé de génération de cartes de contour de dbe hybride - Google Patents

Système et procédé de génération de cartes de contour de dbe hybride Download PDF

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Publication number
WO2010068744A2
WO2010068744A2 PCT/US2009/067483 US2009067483W WO2010068744A2 WO 2010068744 A2 WO2010068744 A2 WO 2010068744A2 US 2009067483 W US2009067483 W US 2009067483W WO 2010068744 A2 WO2010068744 A2 WO 2010068744A2
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WIPO (PCT)
Prior art keywords
dose
bed
physical
array
module
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PCT/US2009/067483
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WO2010068744A3 (fr
Inventor
Richard Stock
Yeh-Chi Lo
Rendi Sheu
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Icahn School of Medicine at Mount Sinai
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Mount Sinai School of Medicine
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Publication of WO2010068744A2 publication Critical patent/WO2010068744A2/fr
Publication of WO2010068744A3 publication Critical patent/WO2010068744A3/fr
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems
    • A61N5/1031—Treatment planning systems using a specific method of dose optimization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1089—Electrons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy

Definitions

  • the present invention concerns radiation therapy and more particularly concerns a system and methods for manipulating and presenting radiotherapy data concerning multiple radiation therapy delivery modes in support of treatment planning.
  • the objective of radiation therapy is to kill cancer cells for a maximum probability of cure with a minimum of side effects.
  • Radiation is usually delivered in the form of high-energy beams that deposit the radiation dose directly to the location of cancer cells in the body. Radiation therapy, unlike chemotherapy, is considered a local treatment. Cancer cells can only be killed where the actual radiation is delivered to the body. If cancer exists outside the radiation field, the cancer cells are not destroyed by the radiation.
  • brachytherapy Two common local treatments are brachytherapy and radiotherapy.
  • brachytherapy permanent or temporary radioactive "seeds" are implanted in the tumor. The seeds are actually needles or tubes containing a radioactive isotope. This form of treatment has been used widely to treat prostate cancers and other cancers.
  • brachytherapy is followed by radiotherapy, either in the form of electron beam radiation therapy (EBRT) or intensity- modulated radiotherapy (IMRT).
  • EBRT electron beam radiation therapy
  • IMRT intensity- modulated radiotherapy
  • Radiation can also be linked to elements such as iodine or monoclonal antibodies and injected into a vein. Monoclonal antibodies home to specific cancer cells, allowing delivery of radiation to a specific target area.
  • BED biological effective dosage
  • Ro is the initial dose rate of implant and varies with the vendor in terms of the concentration of nuclear isotopes in a given seed (and so, the vendor has a distribution of seeds that can be ordered, in which "hot seeds" are at the high-end of Gray concentrations)
  • ⁇ is the isotope decay constant (0.693/ isotope half-life)
  • ⁇ is repair rate constant (0.693 /repair half-time)
  • ⁇ / ⁇ is the ratio of how tissue respond to radiation damage (e.g. rate of absorption and repair).
  • I-Plan One known treatment planning program is called Brainlab, Inc. This program provides treatment planning for multiple beam therapy treatments. It manages physical dose parameters and in an additive manner (or really subtraction) , it identifies the amount of beam radiation to apply in a follow-up treatment strictly on the basis of physical dose considerations and not with regard to the more complex yet accurate combinatory impact of biologically effective dose delivery computations.
  • a computer- implemented system for generating a hybrid biological effective dose (BED) data presentation is provided.
  • the hybrid BED data presentation concerns a patient and is generated from physical dose array data concerning a plurality of treatment modalities.
  • Such a system includes a computer having a processor, a memory, and an associated output device.
  • a program stored in the memory and executing in the processor has a plurality of modules, among which: a user interface module is operative to present a user interface and receive an identification of a first physical dose array and a second physical dose array; a first physical-dose conversion module is responsive to the identification of the first physical dose array and operative to convert the first physical dose array into a corresponding first array of BED values; a second physical-dose conversion module is responsive to the identification of the second physical dose array and operative to convert the second physical dose array into a corresponding second array of BED values; a BED summation module is operative to sum a respective point in each of the first and second arrays of BED values and generate a combined BED array; and a rendering module is operative on the combined BED array to output the hybrid BED data presentation on the associated output device in relation to at least one biological structure.
  • a method implements the steps performed by the computer program described herein.
  • Fig. 1 is a block diagram of a system in accordance with an embodiment of the invention.
  • Fig. 2 illustrates certain preliminary steps that can be taken using a conventional treatment planning (TP) software package.
  • TP treatment planning
  • Fig. 3 illustrates certain functional blocks operative to process and output dual mode radiotherapy information in 2D or 3D renderings, alone or in relation to a CT image.
  • Fig. 4A illustrates a prior art display of a physical dose array generated by a conventional treatment planning software package.
  • Fig. 4B illustrates a display of a physical dose array and contour map generated by a system in accordance with an embodiment of the invention in which physical dose data is imported from a conventional treatment planning software package.
  • Fig. 4C illustrates a display of BED data associated with a dual-mode therapy for one CT slice, in accordance with a broad aspect of the invention.
  • Fig. 5 illustrates a portion of a data file in the DICOM format.
  • Fig. 6 illustrates an exemplary control panel that may be used in an embodiment of the invention.
  • Figs. 7 A and 7B illustrate DVH curves for bradytherapy and EBRT of the imported physical dose data.
  • Fig. 7C illustrates the BED DVH curves for combined bradytherapy and EBRT.
  • the present invention provides a planning system 100 configured for dual-modality BED data presentation.
  • the dual-modalities are brachytherapy and EBRT providing a combination radiotherapy suitable for treating a variety of cancers, but the invention is not limited to those particular modalities.
  • the system 100 preferably comprises modules of code stored in a memory of a machine and executing within one or more processors.
  • FIG. 1 is a block diagram of a computer system 100 configured for employment of method 300, discussed below.
  • System 100 includes a user interface 105, a processor 1 10, and a memory 1 15.
  • System 100 may be implemented on a general purpose microcomputer, such as one of the members of the Sun® Microsystems family of computer systems, one of the members of the IBM® Personal Computer family, one of the members of the Apple® Computer family, or a myriad other conventional workstation, desktop computer, laptop computer, a netbook computer, a personal digital assistant, or a smart phone.
  • system 100 is represented herein as a standalone system, it is not limited to such, but instead can be coupled to other computer systems via a network (not shown) .
  • Memory 1 15 is a memory for storing data and instructions suitable for controlling the operation of processor 1 10.
  • An implementation of memory 1 15 would include a random access memory (RAM), a hard drive, a read only memory (ROM), or a combination of these.
  • RAM random access memory
  • ROM read only memory
  • One of the components stored in memory 1 15 is a program 120.
  • Program 120 includes instructions for controlling processor 1 10 to execute method 300.
  • Program ' 120 may be implemented as a single module or as a plurality of modules that operate in cooperation with one another.
  • Program 120 is contemplated as representing a software embodiment of the method described herein.
  • User interface 105 includes an input device, such as a keyboard, touch screen, tablet, or speech recognition subsystem, for enabling a user to communicate information and command selections to processor 1 10.
  • User interface 105 also includes an output device such as a display or a printer. In the case of a touch screen, the input and output functions are provided by the same structure.
  • a cursor control such as a mouse, track-ball, or joy stick, allows the user to manipulate a cursor on the display for communicating additional information and command selections to processor 1 10. Details of exemplary user interface components are described below.
  • Storage media 125 can be any conventional storage media such as a magnetic tape, an optical storage media, a compact disc, or a floppy disc. Alternatively, storage media 125 can be a random access memory, or other type of electronic storage, located on a remote storage system (e.g., a flash-memory USB device).
  • FIG. 2 certain preliminary steps can be taken using a conventional treatment planning (TP) software package.
  • TP treatment planning
  • FIG. 2 is discussed in connection with harnessing a conventional TP software package, but it should be understood that the system 100 can be adapted to provide the functionality indicated in the "blocks of Fig. 2, and thereby eliminate the need for a software package other than provided by the system 100.
  • Treatment planning begins by a clinician inputting physical dose parameters into the TP software such as through control panels 630, 640 (Fig. 6) .
  • the treatment parameters include, without limitation, the physical dose in Gray, the isotope decay constant ⁇ , and a repair rate constant ⁇ , in the case of a brachytherapy treatment plan, or the prescription dose in Gray, in the case of an EBRT or IMRT treatment plan.
  • the physical parameters there is data that can be subjectively interpreted by the planner, and so an input-assistant module can be provided to guide the clinician in data entry.
  • such parameters are provided to the system through an interface with the clinician, such as the interface 105.
  • the clinician identifies organ contours upon review of CT images of the patient, which are provided to the TP software in a conventional manner prior to the treatment planning beginning.
  • organs that might have their contours identified to the system are the prostate, bladder, rectum and penile bulb.
  • the software captures this input information, and it can be input in a variety of ways such as by providing tools in the form of software modules programmed to support onhe or more processes.
  • the contours can be input by a process such as by outlining the organs on each CT slice using a mouse, tablet or other input device, or by applying a template process to rough fit body structures, or by applying an auto-contouring process that uses an image-analysis module configured to identify expected anatomical structures within the CT image using a library of reference images for comparison.
  • a process such as by outlining the organs on each CT slice using a mouse, tablet or other input device, or by applying a template process to rough fit body structures, or by applying an auto-contouring process that uses an image-analysis module configured to identify expected anatomical structures within the CT image using a library of reference images for comparison.
  • prostate treatment commonly has CT slices taken at a 3mm spacing. As such, 30 to 40 slices capture an image of the prostate organ, and contours must be identified for each slice.
  • the clinician can at this time assign alpha/beta ratios to each of the outlined structures, with the alpha/ beta ratio being used by the physical dose computation algorithm to determine the physical dose array.
  • the next significant operation of the TS software is to compute the physical dose distribution array ("dose array") across each particular CT slice.
  • dose array physical dose distribution array
  • the particular model used can be optimized to consider issues associated with beam radiation techniques, such as beam angle, range dilution effects, scattering and so forth.
  • the treatment planning calculations are sometimes calculated using or gauged against Monte Carlo dose distribution calculations, and other algorithms such as based on point-source or line-source radiators.
  • TP software packages can render the computed physical dose array on the CT image, for example, as iso-dose contour lines at prescribed or definable gradation (spacing).
  • Fig. 4A a prior art display of a physical dose by the VariseedTM TP software package is shown.
  • the physical dose is displayed as iso-dose contour lines superimposed in relation to several organs shown in a CT scan, in this illustration, the rectum, prostate and bladder shown between the femoral heads and pubic bones.
  • the present invention is configured to process dual-modality therapies to provide iso-dose information to the clinician, preferably in terms of its biological equivalent dose. In this regard, it extends the capabilities of conventional TP software packages, and, in part, must transform the dose array into BED values to permit the combinatory assessment of dose delivery to tissue. If a conventional TP software package is used, then at block 240 the dose array is exported to a planning system 100 configured to process and output data suitable for planning dual-modality radiotherapy treatment planning, such as, without limitation, brachytherapy and EBRT or brachytherapy and IMRT.
  • the TP software includes an option to export data, such as a pull down menu having a tab that invokes a data file export process.
  • the data is exported in the DICOM format, a standard set by the Medical Imaging and Technology Alliance (MITA) , a division of National Electrical Manufacturers Association (NEMA). DICOM ("Digital Imaging and Communications In Medicine").
  • the exported data can include the initial dose rate of implant Ro, any brachytherapy parameters (e.g., the physical dose in Gray, the isotope decay constant ⁇ , and a repair rate constant ⁇ ), any EBRT parameters (e.g., the prescription dose in Gray), any contour lines that had been identified with regard to internal structures such as organs, ⁇ / ⁇ values for any identified structures, and an array of physical dose data calculated by the conventional TP software package across each CT slice.
  • any brachytherapy parameters e.g., the physical dose in Gray, the isotope decay constant ⁇ , and a repair rate constant ⁇
  • any EBRT parameters e.g., the prescription dose in Gray
  • any contour lines that had been identified with regard to internal structures such as organs
  • ⁇ / ⁇ values for any identified structures e
  • the DICOM format provides a standard reference that permits multiple image slices to be superimposed and managed by the system 100.
  • Variseed and Eclipse treatment planning programs made available by Varian Medical Systems, Inc. for brachy therapy and EBRT, respectively, both permit export of data, as called for at block 240, in the form of a DICOM file.
  • Other output formats can be integrated into the system 100.
  • the treatment planning program from Brainlab has the data output relative to a treatment isocenter, and so an alignment module can be invoked (e.g., using controls 650; Fig.
  • the alignment module provides controls through the user interface 105 that enables the user to identify the isocenter.
  • the alignment module then operates to map the dose distribution array in each slice so as to be in alignment with a common feature of each other slice (e.g., the isocenter of each other slice), or, equivalently, maps the imported data to the DICOM format.
  • Fig. 5 illustrates a portion of a data file 500A in the DICOM format, comprising, among other things, an array of data for each CT slice, in which hexadecimal data is arranged in 16-byte rows 510, with a pattern of leading bytes 520 followed by data 530 that represents the physical dose computation at a given zoom and orientation (e.g., plan view) of the CT scan.
  • the hexadecimal data encodes the physical dose calculations.
  • such files include a few bytes per row of ASCII characters 540 that can be used to provide human-readable information relating to the data file.
  • This data file can be output from a bradytherapy TP package, for example, and a digital file 500B (not shown) of the same or different format can be output from an EBRT TP package.
  • a process 300 includes functional blocks that are preferably implemented as one or more software modules comprising the program 120.
  • a clinician can cause a physical dose array to be imported from discrete TP software packages, such as a brachytherapy TP software package on the one hand, as indicated at block 310A, and an EBRT software package, as indicated at block 310B.
  • Blocks 310A, 310B are functionally the same, except they are preferably adapted to receive data files of a defined format type. Additional blocks (not shown) can be provided as part of an API of the program 120 to accommodate additional data formats.
  • the import module 310 can be configured to present a variety of data file formats to the system 100 in a format that is suitable for the being operated upon at the remaining blocks of Fig. 3.
  • a verification phase is performed in which organ contours are shown rendered in superimposed relation to an underlying CT image, as a result of the operation of blocks 320A, 320B.
  • These blocks operate on the imported brachytherapy and EBRT data files.
  • blocks 320 are configured to generate contour lines and/ or physical dose isodose contour lines based on the raw dose array data.
  • the output of blocks 320 is preferably provided through the user interface 105, and more preferably in a dedicated window 400 provided by the system 100.
  • the window 400 includes interactive controls such as check boxes that permit the selection and selective display of the brachytherapy physical dose (such as may have been imported from a conventional TP package or computed internally), the EBRT physical dose (such as may have been imported from a conventional TP package or computed internally), or a combined BED presentation of the proposed treatment plan, as will be described in connection with block 350.
  • the contours from blocks 320A and 320B can be displayed in the same window 400.
  • discrete windows are provided to display each of the renderings.
  • the verification phase includes a confirmation from the clinician that the rendering comports with the clinician's expectations.
  • the confirmation can comprise an input provided through the user interface, such as a mouse click as one non-limiting example.
  • the input is captured and the event is tested at block 330A, 330B to see if this threshold has been met.
  • the clinician is satisfied that the renderings match the contours of a conventional physical-dose TP package, he or she can provide the required input indicating this fact. If, on the other hand, the clinician is not satisfied that the threshold match has been met -such as when the data did not import correctly, the process flow diverts to block 332 which invokes a process that seeks to import the data file having dubious rendering results.
  • the clinician may have to return to block 240 to export the physical dose array again, or if there is a linkage between program 120 and the physical-dose TP package, then the program 120 can invoke a data export process that results in a data file importation at one of blocks 310.
  • the physical dose that is delivered or proposed to be delivered to the patient is rendered with isodose lines in relation to surrounding tissue structures such as any of the organs noted above, as shown in Fig. 4A.
  • mathematical transformations are applied across the various CT slices in order to derive a biological equivalent dose (BED) value of the physical dose.
  • BED biological equivalent dose
  • this is to present to the clinician an assessment of the total radiation therapy that has been delivered to the patient for a given mode of treatment.
  • the transformation into a BED value enables a mathematical combination of BED values from multiple treatments and treatment modes in a meaningful way.
  • the system 100 is configured to permit dramatically different radiation treatment plans to be considered in a pre-treatment setting so that treatment doses can be more effectively tailored to deliver doses to targeted areas with controlled or informed impact on surrounding organs and other tissue structures.
  • the system 100 enables a clinician to define an EBRT or IMRT procedure subsequent to brachytherapy.
  • the clinician had to rely on experience and an educated guess as to how to mix two treatment modalities without over-radiating an organ nearby a target site. This determination is complicated by the various treatment regimes available, including temporary implant seeds, permanent implant seeds, and the impact of beam therapy in terms of position, intensity and fractionation.
  • the cumulative biological dose delivered should not exceed a given organ's tolerance, and so care must be'taken to adjust a dual-modality plan in view of this constraint.
  • implanted seeds can, remain for intervals of, say, two to eight months, having a different total radiation delivery on the target and surrounding structures than a short (seventeen day) delivery time seed such as palladium.
  • a short (seventeen day) delivery time seed such as palladium.
  • one treatment has already been completed by the time the second modality begins.
  • the clinician would have to take into account the total radiation delivered to the structures surrounding the target site so as to not overwhelm and harm surrounding structures in the patient.
  • the clinician can pre-plan a dual-therapy treatment program including the type of seed (its strength and implant time) and the beam orientation and intensity.
  • the clinician can test different seed counts and beam strengths to tailor the treatment in view of a BED goal and any prior radiation treatment.
  • the imported data files 500 are further processed in order to convert the physical dose distribution into an array of corresponding BED values. This data processing is performed for each treatment modality.
  • the processing and conversion performed by block 340A uses a known BED equation such as equation (1) from above, applied to each of the CT slices in the file 500A.
  • equation (1) applies a known BED equation to each of the CT slices in the file 500A.
  • the contents of the data file are applied to equation (1) with respect to each coordinate location, as follows: a
  • d is the physician's prescribed dose per fractionation and n is the number of fractionations.
  • the system 100 converts this data file of hex values into an (x,y,z) table of BED values using the output of equation (3) . Thereafter, the BED data can be displayed using a color coded scheme such as described above.
  • the clinician can cause the system 100 to output the combined modality data, such as by selecting box 420 (Fig. 4B) .
  • the physical dose array data for each modality is first converted to a biological equivalent dose for each point in the array using a physical-dose conversion module adapted to the particular physical dose " being acted upon (e.g., configured to apply one of equations (2) or (3)) .
  • the BED data is combined by addition of the BED at each corresponding point using a BED summation module.
  • the resultant array is the combined BED array.
  • the combined BED array provides an additional quality index to evaluate treatment plans.
  • a rendering module operates upon the combined BED array by applying the color-scheme so as to compute iso-potential lines that can be mapped on the output device, alone or in relation to a CT image.
  • An example of combined BED array is shown in Fig. 4C in which the data in the BED array is plotted as iso-potential lines.
  • the interface affords the clinician with control over the image presentation using an input device such as a mouse, and the display in the window 400 is a function of commands input by the clinician, as tested at block 350. For instance, the image can be rotated and tilted to change the view angle presented in the window 400 by pressing the left mouse button and dragging the mouse.
  • the right mouse button can be pressed and then the mouse dragged forward or backward to zoom in and out, respectively so as to change how close-up the isodose contours, outlines of the organs, or any other structures appear.
  • the right mouse button can be held and the mouse dragged laterally for a panning function.
  • Other controls can be provided, so as to fade or enhance the CT level within the window 400. In this manner, the CT image can be made to fade away entirely, leaving behind the contour lines (or map in the case of a 3D rendering formed by interpolation between the contour lines of adjacent slices).
  • Another control such as the page up/ down keys can be used to move through slices that have been imported to the system 100.
  • the command provided by the clinician through the interface is tested at block 350 and if the command is to display one or more of the slices, then at block 360 one of several renderings can be displayed.
  • the clinician can choose to display the brachytherapy physical dose, the EBRT physical dose, and the combined BED dose.
  • the system 100 captures a command from the clinician that has been received through the user interface, and that command is processed at block 364. For instance, the processing can cause a rotation, zoom, pan, or fade operation as described above.
  • the system then awaits a further command, as indicated conceptually by the return arrow to block 350.
  • the command provided by the clinician through the interface tested at block 350 is not to display one or more of the slices, then it may indicate a desire to display a dose volume histogram (DVH).
  • DVDH dose volume histogram
  • commands can be received and operated upon through the user interface 105, such as print, save, export, annotate, and other functions that are not detailed herein as they can be included using conventional modules as understood by persons of ordinary skill in the art.
  • a control panel of an exemplary embodiment is shown in Fig. 6.
  • the control panel can provide the interface for the decision made at block 350 (and elsewhere) in the functional operation of the program 120.
  • the BED values 610 described above can be input through this control panel.
  • the ⁇ / ⁇ for various organs can be input through panel 620 which includes a pull-down list 622 of body structures, an ⁇ / ⁇ value text-box 624, and a set button 626 for instantiating the selected value.
  • the ⁇ / ⁇ takes into account the weight of the tissue, e.g., the ⁇ / ⁇ for bladder tissue is 2.0 Gy and the ⁇ / ⁇ for prostate tissue is 1.0 Gy.
  • the control panel further has panels 630, 640 for inputting brachytherapy and EBRT parameters, as described above.
  • panel 660 provides controls for identifying the structures of interest (e.g., the prostate) and for identifying whether to present the DVH for a single slice or for all slices (e.g., using radio buttons 662). Once these parameters have been input, the DVH function can be invoked, such as by pressing a button 664. This is identified at block 350, and causes the process 300 to branch to blocks 380, 382, and 384 in which parameters are set, the structures of interest are stored and the histograms are rendered. The histogram plot is calculated for the same volume as the physics dose (i.e., the physical " dose array 310).
  • the physics dose i.e., the physical " dose array 310.
  • a dose volume histogram obtained such as at blocks 310 contains a physics dose increment, typically in Gy, for the volume of tissue that has been or is proposed to be irradiated in the treatment plan.
  • the physical dose array is converted into a BED over the same volume, such as by application of equations (2) and (3), for example.
  • the BED for each of the physical dose arrays 310A, 310B are then summed together for each corresponding point in the volume. Then, the combined BED is plotted, at block 384, to the output device.
  • the DVH is of interest because it calculates how much radiation an organ receives for the proposed treatment plan. Radiation to organs in the vicinity of an intended treatment location should be investigated through DVH review because the response of organ tissue to radiation therapy differs from the response of surrounding tissue.
  • Figs. 7 A and 7B illustrate DVH curves for bradytherapy and EBRT of the imported physical dose data.
  • Fig. 7C the combined BEB DVH is illustrated.
  • the impact on bystander organs can be more readily assessed by a review of these DVHs.
  • the clinician can specify the alpha/ beta ratio for each structure of interest.
  • the DVHs can each be presented in a pop-up window and positioned on a display screen as desired.
  • contours from slice-to- slice can be rendered as a 3D model.
  • a distribution cloud in 3D can span discrete slices by interpolating the BED data from slice to adjacent slice.
  • the system 100 can provide an inverse planning tool for a clinician interested in delivering a particular amount of radiation therapy at a specific location after data from a prior radiotherapy treatment has been input.

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Abstract

L'invention concerne un système implémenté par ordinateur comprenant une pluralité de modules logiciels fonctionnels pour générer et présenter des données de dose biologique efficace (DBE) hybride en provenance d'au moins deux modalités de traitement (par exemple, brachythérapie et radiothérapie par faisceau d'électrons). Une pluralité de modules de conversion de dose physique convertit des distributions de doses physiques (PDA) en des première et seconde distributions correspondantes de valeurs DBE. Un module d'addition de DBE totalise les points respectifs dans chacune des première et seconde distributions de valeur DBE et génère une distribution DBE combinée. Un module de rendu fonctionne d'après la distribution DBE combinée et délivre la présentation des données DBE hybrides en association avec au moins une structure biologique. Un procédé pour générer une présentation de données DBE hybrides en association avec au moins une structure biologique est également décrit.
PCT/US2009/067483 2008-12-11 2009-12-10 Système et procédé de génération de cartes de contour de dbe hybride Ceased WO2010068744A2 (fr)

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CN104107062A (zh) * 2013-04-17 2014-10-22 深圳市医诺智能科技发展有限公司 一种评估放射治疗效果方法及系统
CN109499013A (zh) * 2018-12-28 2019-03-22 济南大学 一种肿瘤放射治疗中生物效应剂量确定方法及系统
CN119763781A (zh) * 2023-09-27 2025-04-04 西安大医集团股份有限公司 放疗计划的生成方法及电子设备

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US7046762B2 (en) * 1999-11-05 2006-05-16 Georgia Tech Research Corporation Systems and methods for global optimization of treatment planning for external beam radiation therapy
US9387344B2 (en) * 2006-11-21 2016-07-12 The Johns Hopkins University Methods for determining absorbed dose information

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CN104107062A (zh) * 2013-04-17 2014-10-22 深圳市医诺智能科技发展有限公司 一种评估放射治疗效果方法及系统
CN104107062B (zh) * 2013-04-17 2016-08-10 深圳市医诺智能科技发展有限公司 一种评估放射治疗效果方法及系统
CN109499013A (zh) * 2018-12-28 2019-03-22 济南大学 一种肿瘤放射治疗中生物效应剂量确定方法及系统
CN109499013B (zh) * 2018-12-28 2020-04-28 济南大学 一种肿瘤放射治疗中生物效应剂量确定方法及系统
CN119763781A (zh) * 2023-09-27 2025-04-04 西安大医集团股份有限公司 放疗计划的生成方法及电子设备

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