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WO2010067813A1 - Appareil optique d’imagerie à structure stéréographique et procédé de traitement de signal optique pour celui-ci - Google Patents

Appareil optique d’imagerie à structure stéréographique et procédé de traitement de signal optique pour celui-ci Download PDF

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Publication number
WO2010067813A1
WO2010067813A1 PCT/JP2009/070583 JP2009070583W WO2010067813A1 WO 2010067813 A1 WO2010067813 A1 WO 2010067813A1 JP 2009070583 W JP2009070583 W JP 2009070583W WO 2010067813 A1 WO2010067813 A1 WO 2010067813A1
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Prior art keywords
light
optical
information
dimensional structure
wavelength band
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English (en)
Japanese (ja)
Inventor
寺村　友一
和弘 広田
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Fujifilm Corp
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Fujifilm Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852—Catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G01B11/24—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
    • G01B11/2441—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures using interferometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/02001—Interferometers characterised by controlling or generating intrinsic radiation properties
    • G01B9/02007—Two or more frequencies or sources used for interferometric measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B9/00—Measuring instruments characterised by the use of optical techniques
    • G01B9/02—Interferometers
    • G01B9/0209—Low-coherence interferometers
    • G01B9/02091—Tomographic interferometers, e.g. based on optical coherence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Definitions

  • the present invention relates to an optical three-dimensional structure image device and an optical signal processing method thereof, and more particularly to an optical three-dimensional structure image device characterized by generation of an optical three-dimensional structure image and an optical signal processing method thereof.
  • an optical tomographic image acquisition device using OCT Optical Coherence Tomography
  • This optical tomographic image acquisition apparatus divides low-coherent light emitted from a light source into measurement light and reference light, and then reflects or backscatters light from the measurement object when the measurement light is applied to the measurement object.
  • the light and the reference light are combined, and an optical tomographic image is acquired based on the intensity of the interference light between the reflected light and the reference light (Patent Document 1).
  • the reflected light and the backscattered light from the measurement object are collectively referred to as reflected light.
  • the above-mentioned OCT measurement is roughly divided into two types: TD-OCT (Time domain) OCT measurement and FD-OCT (Fourier domain OCT) measurement.
  • TD-OCT Time domain OCT measurement
  • FD-OCT Fullier domain OCT
  • the reflected light intensity distribution corresponding to the position in the depth direction of the measurement target (hereinafter referred to as the depth position) is obtained by measuring the interference light intensity while changing the optical path length of the reference light. Is the method.
  • the interference light intensity is measured for each spectral component of the light without changing the optical path lengths of the reference light and the signal light, and the obtained spectral interference intensity signal is Fourier transformed by a computer.
  • This is a method of obtaining a reflected light intensity distribution corresponding to a depth position by performing a representative frequency analysis.
  • it has been attracting attention as a technique that enables high-speed measurement by eliminating the need for mechanical scanning existing in TD-OCT.
  • SD-OCT Spectral Domain OCT
  • SS-OCT Session Source OCT
  • the SD-OCT apparatus uses broadband low-coherent light such as SLD (Super Luminescence Diode) or ASE (Amplified Spontaneous Emission) light source or white light as a light source, and uses a Michelson interferometer or the like to generate broadband low-coherent light. After splitting into measurement light and reference light, irradiate the measurement light on the object to be measured, cause the reflected light and reference light that have returned at that time to interfere with each other, and decompose this interference light into frequency components using a spectrometer.
  • SLD Super Luminescence Diode
  • ASE Amontaneous Emission
  • the interference light intensity for each frequency component is measured using a detector array in which elements such as photodiodes are arranged in an array, and the spectrum interference intensity signal obtained thereby is Fourier transformed by a computer to obtain an optical signal.
  • a tomographic image is constructed.
  • the SS-OCT apparatus uses a laser that temporally sweeps the optical frequency as a light source, causes reflected light and reference light to interfere with each other at each wavelength, and measures the time waveform of the signal corresponding to the temporal change of the optical frequency.
  • An optical tomographic image is constructed by Fourier-transforming the spectral interference intensity signal thus obtained with a computer.
  • OCT measurement is a method for acquiring an optical tomographic image of a specific region as described above.
  • an endoscope for example, a cancer lesion is observed by observation with a normal illumination endoscope or a special optical endoscope.
  • OCT measurement of the region it is possible to determine how far the cancerous lesion has infiltrated.
  • scanning the optical axis of the measurement light two-dimensionally three-dimensional information can be acquired together with depth information obtained by OCT measurement.
  • the fusion of OCT measurement and 3D computer graphic technology makes it possible to display a 3D structure model consisting of structural information of a measurement object having a resolution of micrometer order.
  • the model is called an optical three-dimensional structure image.
  • the optical three-dimensional structure image is usually acquired by infrared light that is less absorbed by the living tissue, it is different from a color image obtained by a normal illumination light endoscope. From the color image of the surface of the biological tissue that is usually measured by the illumination optical endoscope, information such as the distribution of blood vessels and inflammation near the surface layer and the difference in color between normal and lesions can be obtained from the change in color. There is no such information in images obtained by OCT measurement. In addition, it is difficult to accurately apply the optical axis of the measurement light of the OCT measurement to a place that the user wishes to see when observing with a normal illumination light endoscope.
  • the conventional technique for observing a normal illumination light endoscope image and an OCT image at the same time is a combination of a normal illumination light endoscope and an OCT measurement integrated.
  • a mirror Patent Document 2
  • a probe Patent Document 3
  • an endoscope that combines a fiber bundle and OCT measurement
  • the endoscope disclosed in Patent Document 2 has a problem that it is difficult to match the images of the two because the viewpoint angle of the OCT measurement is different from that of the normal illumination light endoscope.
  • the probe disclosed in Patent Document 3 has the same viewpoint direction for the CCD camera and OCT measurement, which is convenient for synthesizing both images, but it is necessary to incorporate the CCD camera into the probe tip. There is a drawback that the probe is enlarged. In addition, in order to reduce the diameter of the probe, the probe is limited to one having a small number of CCD pixels, and there is a drawback that a normal illumination light image becomes rough.
  • the CCD camera can be arranged on the base end side of the main body and the probe can be reduced in diameter, but can be bundled.
  • the number of fibers is small and the resolution is remarkably inferior.
  • the probe becomes relatively thick.
  • the present invention has been made in view of such circumstances, and has a wavelength different from that of the measurement light without increasing the size of the optical system that scans the measurement light, irradiates the measurement object, and enters the light from the measurement object.
  • An optical three-dimensional structure image apparatus capable of acquiring image information by light in a band with high resolution and corresponding the image information to surface information of an optical three-dimensional structure image to be measured with high accuracy and an optical signal processing method thereof The purpose is to provide.
  • an optical three-dimensional structure imaging device includes a first wavelength band light source that emits light in a first wavelength band, measurement light and reference light for light in the first wavelength band.
  • a light separating unit that separates the measurement light, a first waveguide unit that guides the measurement light, an irradiation unit that irradiates the measurement target with the measurement light guided through the first waveguide unit, and the measurement target From the point on the measuring object guided by the first waveguide means, the first light collecting means for condensing the light based on the measurement light from the upper point on the first waveguide means
  • Interference information detecting means for detecting interference information between the light based on the measurement light and the reference light, and light in a second wavelength band different from the first wavelength band from the point on the measurement object
  • the first waveguide unit guides the measurement light
  • the interference information detection unit includes light based on the measurement light from the point on the measurement target. Detecting interference information with the reference light, and the second waveguide means guides light in a second wavelength band different from the first wavelength band from the point on the measurement object;
  • the light receiving means receives the light in the second wavelength band and obtains the light reception signal, without increasing the size of the optical system that scans the measurement light, irradiates the measurement target, and enters the light from the measurement target.
  • Image information using light in a wavelength band different from that of the measurement light can be acquired with high resolution, and the image information can be made to correspond to the surface information of the optical three-dimensional structure image to be measured with high accuracy.
  • the optical three-dimensional structure image device of the second aspect is the optical three-dimensional structure image device of the first aspect, and the first condensing means and the second condensing means are integrally configured.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to claim 1, wherein the first waveguide means is a single mode with respect to the first wavelength band. It is a waveguide.
  • the optical three-dimensional structure image device is the optical three-dimensional structure image device according to any one of claims 1 to 3, wherein the second waveguide means is in the second wavelength band. On the other hand, it is a multimode waveguide.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to claim 1, wherein the first waveguide means is a core of a double clad single mode fiber, and the second The waveguide means is a clad of the double clad single mode fiber.
  • the optical three-dimensional structure image device is the optical three-dimensional structure image device according to any one of the first to fifth aspects, wherein the interference information detected by the interference information detection means is the depth of the measurement object. It is direction information, and the scanning unit performs two-dimensional scanning on a surface substantially orthogonal to the depth direction.
  • the optical three-dimensional structure image device is the optical three-dimensional structure image device according to any one of the first to sixth aspects, wherein the second wavelength band is a visible light range, and the light receiving means is Light is received for each of the R component, G component, and B component in the visible light region.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to the seventh aspect, wherein the first wavelength band is between 700 nm and 1600 nm, and the second wavelength band is from 350 nm. Between 1000 nm.
  • the optical three-dimensional structure image device is the optical three-dimensional structure image device according to the eighth aspect, wherein the interference information detecting means includes an InGaAs photodetector, and the light receiving means includes an Si photo detector.
  • the optical three-dimensional structure image device is the optical three-dimensional structure image device according to any one of the first to ninth aspects, and further includes a second wavelength band light source that emits light in the second wavelength band.
  • the scanning unit combines the measurement light and the second wavelength band light from the second wavelength band light source, and scans the combined measurement light and second wavelength band light. To do.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to the tenth aspect, wherein the second waveguide means has the second wavelength band emitted from the second wavelength band light source.
  • a light source waveguide for guiding light to the second light collecting means, and the light receiving means for receiving light of the second wavelength band from the point on the measurement object condensed by the second light collecting means.
  • a light receiving waveguide which is guided to the surface.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to the eleventh aspect, wherein the second wavelength band light source is provided at an ultraviolet light source unit that emits ultraviolet light and a tip of the light source waveguide. And a white fluorescent part that emits white fluorescence by the ultraviolet rays.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to any one of the first to sixth aspects, wherein the light in the second wavelength band is autofluorescence or medicine from the measurement object.
  • An excitation light source that emits excitation light for exciting the autofluorescence or the drug fluorescence is provided, and the scanning unit scans the measurement light and the excitation light.
  • a four-dimensional structure image device is the light three-dimensional structure image device according to any one of the first to thirteenth aspects, wherein the interference information detection means detects the interference information and the light receiving means. It is possible to further comprise synchronization means for synchronizing the received light information acquisition timing.
  • the optical three-dimensional structure image device is the optical three-dimensional structure image device according to the fourteenth aspect, comprising optical path length varying means for sweeping and varying the predetermined optical path length of the reference light based on a trigger signal. Further, the synchronization means synchronizes the detection timing of the interference information by the interference information detection means and the acquisition timing of the light reception information by the light receiving means based on the trigger signal.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to the fourteenth aspect, wherein the first wavelength range light source uses a broadband low-coherent light as the light in the first wavelength band.
  • the interference information detecting means is a detector array for detecting the intensity of each frequency component of the interference light between the reflected light of the measurement light from the measurement object and the reflected light of the reference light from the reference light reflecting means. The interference information is detected from the detector array based on a predetermined trigger signal, and the synchronization means detects the interference information at the interference information detection means based on the trigger signal and the light reception at the light receiving means. Synchronize with information acquisition timing.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to the fourteenth aspect, wherein the first wavelength band light source calculates the frequency of light in the first wavelength band on the basis of a trigger signal.
  • the synchronization unit synchronizes the detection timing of the interference information by the interference information detection unit and the acquisition timing of the light reception information by the light receiving unit based on the trigger signal.
  • the optical three-dimensional structure image device is the optical three-dimensional structure image device according to any one of the first to seventeenth aspects, and stores the interference information detected by the interference information detection means. And a second storage means for storing the received light information acquired by the light receiving means, and the measurement at an arbitrary point on the measurement object based on the interference information stored in the first storage means.
  • An optical structure information generating unit configured to generate optical structure information depending on an optical path length of the light, and based on the scanning information of the scanning unit, the optical structure information, and the received light information stored in the second storage unit; And an optical structure image generation means for generating a structure image.
  • the optical three-dimensional structure image device of the nineteenth aspect is the optical three-dimensional structure image device of the eighteenth aspect, wherein the structure information is three-dimensional structure information, and the optical structure image generation means is the measurement object.
  • a surface position calculating means for calculating the surface position of the image
  • an image information generating means for generating image information of the measurement object based on the light reception information stored in the second storage means, and the image information as the surface information.
  • Rendering means for rendering at the position of the three-dimensional structure information corresponding to the position.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to the nineteenth aspect, wherein the image information generating means receives a plurality of narrowband light components in the light reception information of the light receiving means. The image information is generated based on the information.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to the nineteenth aspect, wherein the light receiving means receives a plurality of narrowband lights, and the image information generating means is the narrowband light. The image information is generated based on the received light information.
  • the optical three-dimensional structure image device is the optical three-dimensional structure image device according to any one of the eighteenth to twenty-first aspects, further comprising image display means for displaying the optical structure image. it can.
  • An optical three-dimensional structure image device is the optical three-dimensional structure image device according to any one of the first to sixth aspects, wherein the first wavelength band light source emits light in the first wavelength band in a pulsed manner. And a second wavelength band light source that emits light of the second wavelength band when the first wavelength band light source is not emitting light.
  • light in the first wavelength band is separated into measurement light and reference light, the measurement light is irradiated onto the measurement target, and the measurement target is irradiated
  • the light from the point is condensed and guided to the first waveguide, and the point on the measurement object is scanned, and the light from the point on the measurement object is interfered with the reference light.
  • An interference information detecting step for detecting information; and condensing light from the measurement object to guide the light to a second waveguide, and emitting light in a second wavelength band different from the first wavelength band
  • a light receiving step for selecting and receiving light to obtain a light reception signal.
  • light in the first wavelength band is separated into measurement light and reference light in the interference information detection step, and the measurement light is placed on the measurement object. And condensing the light from the point on the measurement object to guide the light to the first waveguide and scanning the point on the measurement object, from the point on the measurement object And detecting the interference information between the first light and the reference light, condensing the light from the measurement object in the light receiving step, and guiding the light to the second waveguide, Without selecting an optical system that scans the measurement light, irradiates the measurement target, and enters the light from the measurement target by selecting and receiving the light of different second wavelength bands and receiving the received light signal. , Acquiring image information with light of a wavelength band different from that of the measurement light with high resolution, and the image information It makes it possible to cope with high precision on the surface information of the optical stereoscopic structure image of the measurement target.
  • the optical signal processing method for the optical three-dimensional structure image device of the twenty-fifth aspect is the optical signal processing method for the optical three-dimensional structure image device of the twenty-fourth aspect, and stores the interference information detected in the interference information detecting step.
  • the second storage step for storing the light reception information acquired in the light reception step, and the interference information stored in the first storage step.
  • An optical structure information generation step for generating structure information depending on the optical path length of the measurement light at the point; scanning information of the scanning means; the optical structure information; and the light reception information stored in the second storage means And an optical structure image generation step for generating an optical structure image.
  • the optical signal processing method of the optical three-dimensional structure image device of the twenty-sixth aspect is the optical signal processing method of the optical three-dimensional structure image device of the twenty-fifth aspect, wherein the structure information is three-dimensional structure information
  • the optical structure image generation step generates image information of the measurement target based on the surface position calculation step of calculating the surface position of the measurement target and the light reception information stored in the second storage step.
  • a rendering step for rendering the image information at the position of the three-dimensional structure information corresponding to the surface position.
  • the present invention it is possible to use light of a wavelength band different from that of the measurement light without increasing the size of the optical system that scans the measurement light, irradiates the measurement object, and enters the light from the measurement object.
  • the image information can be acquired with high resolution, and the image information can correspond to the surface information of the optical three-dimensional structure image to be measured with high accuracy.
  • FIG. 1 is a block diagram showing a configuration of the optical three-dimensional structure imaging apparatus according to the first embodiment.
  • FIG. 2 is a cross-sectional view showing a detailed configuration of the probe of FIG.
  • FIG. 3 is a block diagram showing a configuration of the signal processing unit of FIG.
  • FIG. 4 is a flowchart showing the flow of the three-dimensional CG image generation process of the optical three-dimensional structure imaging apparatus of FIG.
  • FIG. 5 is a diagram showing a three-dimensional CG image generated by the process of FIG.
  • FIG. 6 is a diagram showing an example of an endoscopic image compared with the three-dimensional CG image of FIG.
  • FIG. 7 is a diagram showing a configuration of Modification 1 of the probe of FIG. FIG.
  • FIG. 8 is a diagram showing a configuration of Modification 2 of the probe of FIG.
  • FIG. 9 is a cross-sectional view taken along line AA in FIG.
  • FIG. 10 is a diagram showing a configuration of an optical three-dimensional structure imaging apparatus applied to the probe of FIG.
  • FIG. 11 is a diagram showing a configuration of Modification 3 of the probe of FIG.
  • FIG. 12 is a diagram showing a configuration of Modification 4 of the probe of FIG.
  • FIG. 13 is a diagram showing a configuration of Modification 5 of the probe of FIG.
  • FIG. 14 is a diagram illustrating a first modification of the visible light information detection unit in FIG. 1.
  • FIG. 15 is a diagram illustrating a second modification of the visible light information detection unit in FIG. 1.
  • FIG. 16 is a diagram illustrating a third modification of the visible light information detection unit in FIG. 1.
  • FIG. 17 is a diagram illustrating a fourth modification of the visible light information detection unit in FIG. 1.
  • 18 is a block diagram showing a configuration of a modification of the optical three-dimensional structure imaging apparatus of FIG.
  • FIG. 1 is a block diagram showing the configuration of the optical three-dimensional structure imaging apparatus according to the first embodiment.
  • an optical three-dimensional structure imaging apparatus 1 acquires, for example, a tomographic image of a measurement target such as a living tissue or a cell in a body cavity by, for example, SS-OCT measurement centered on a wavelength of 1.3 ⁇ m.
  • visible light as the first wavelength band light source for example, OCT light source 10 that emits light having a band of 700 nm to 1600 nm
  • visible light as the second wavelength band light source for example, that emits white light having a band of 350 nm to 1000 nm
  • three-dimensional as a light source 20 an OCT interferometer 30 having an interference information detection unit 70 as an interference information detection unit, a probe 40, a visible light information detection unit 60 as a light receiving unit, an optical structure information generation unit, and an optical structure image generation unit
  • a CG image generation unit 90 and a monitor 100 are provided.
  • the OCT light source 10 is a light source that emits laser light L centered at a wavelength of 1.3 ⁇ m, for example, in the infrared region while sweeping the frequency at a constant period, and the visible light source 20 is an illumination light composed of white light. Is a light source that emits visible light La.
  • the synchronizing means is composed of the OCT light source 10, and the sweep trigger signal S for frequency sweeping of the laser light L in the infrared region is the synchronizing signal of the synchronizing means.
  • the laser light L emitted from the OCT light source 10 is demultiplexed into the measurement light L1 and the reference light L2 by the optical demultiplexing unit 3 in the OCT interferometer 30.
  • the reference light L2 demultiplexed by the optical demultiplexing unit 3 is reflected by the optical path length adjusting unit 80 serving as reference light adjusting means via the circulator 5a.
  • the optical path length adjusting unit 80 changes the optical path length of the reference light L2 in order to adjust the position where the acquisition of tomographic images is started, and includes collimator lenses 81 and 82 and a reflection mirror 83.
  • the reference light L2 from the circulator 5a passes through the collimator lenses 81 and 82 and then is reflected by the reflection mirror 83.
  • the return light L2a of the reference light L2 is incident on the circulator 5a again through the collimator lenses 81 and 82.
  • the reflection mirror 83 is disposed on the movable stage 84, and the movable stage 84 is provided so as to be movable in the arrow A direction by the mirror moving unit 85.
  • the movable stage 84 moves in the direction of arrow A, the optical path length of the reference light L2 is changed.
  • the return light L2a of the reference light L2 from the optical path length adjustment unit 80 is guided to the optical multiplexing / demultiplexing unit 4 via the circulator 5a.
  • the measurement light L1 demultiplexed by the optical demultiplexing unit 3 is incident on the fiber FB1 inserted through the probe 40 via the circulator 5b.
  • the visible light La emitted from the visible light source 20 is condensed by the condenser lens 20b via the collimator lens 20a and the half mirror 21, and is incident on the fiber FB2 inserted through the probe 40.
  • the fiber FB1 constituting the probe 40 is a 1.3 ⁇ m band single mode fiber
  • the fiber FB2 constituting the probe 40 is a multimode fiber. The detailed configuration of the probe 40 will be described later.
  • the fiber FB1 for OCT measurement needs to be in a single mode with respect to the wavelength band of the OCT light source 10.
  • the visible light measuring fiber FB2 may be either a single mode or a multimode. However, when the reflected light intensity is low, the multimode is more preferable in order to collect more light.
  • the visible light La and the measurement light L1 are emitted from the emission end of the probe 40 and irradiated onto the measurement target T, the return light L3 is incident on the probe 40 again, and the visible light component light L3 of the return light is the fiber FB2.
  • the reflected light (or backscattered light) L4 of the measurement light L1 which is the infrared light component of the return light, is guided to the fiber FB1.
  • the visible light component light guided to the fiber FB2 is reflected by the half mirror 21 and guided to the visible light information detection unit 60.
  • the visible light component light is red
  • the green and blue filters 110r, 110g, and 110b are incident on the three Si photodetectors 111r, 111g, and 111b attached to the front surface, and the visible light detection unit 112 synchronizes with the sweep trigger signal S of the OCT light source 10. Instantaneous red, green, and blue light intensities are detected.
  • the reflected light (or backscattered light) L4 guided to the fiber FB1 is guided to the OCT interferometer 30 and guided to the optical multiplexing / demultiplexing unit 4 by the OCT interferometer 30 via the circulator 5b. .
  • the reflected light (or backscattered light) L4 of the measurement light L1 and the return light L2a of the reference light L2 are combined and emitted to the interference information detecting unit 70 side.
  • the interference information detection unit 70 generates the interference light L5 between the reflected light (or backscattered light) L4 of the measurement light L1 combined by the optical multiplexing / demultiplexing unit 4 and the return light L2a of the reference light L2 at a predetermined sampling frequency.
  • InGaAs photodetectors 71a and 71b that measure the light intensity of the interference light L5, and an interference light detector 72 that performs balance detection of the detection value of the InGaAs photodetector 71a and the detection value of the InGaAs photodetector 71b. .
  • the interference light L5 is divided into two by the optical multiplexing / demultiplexing unit 4, detected by the InGaAs photodetectors 71a and 71b, and output to the interference light detection unit 72.
  • the interference light detection unit 72 performs Fourier transform on the interference light L5 in synchronization with the sweep trigger signal S of the OCT light source 10, thereby the intensity of the reflected light (or backscattered light) L4 at each depth position of the measurement target T. Is detected.
  • the three-dimensional CG image generation unit 90 stores the intensity of the reflected light (or backscattered light) L4 at each depth position of the measurement target T detected by the interference light detection unit 72 in the first memory 91 as interference information. Further, the three-dimensional CG image generation unit 90 uses the red, green, and blue light intensity signals of the visible light components from the measurement target T detected by the visible light detection unit 112 as image information in the second memory 92. To store.
  • the three-dimensional CG image generation unit 90 includes a signal processing unit 93 and a control unit 94 in addition to the first memory 91 as the first storage unit and the second memory 92 as the second storage unit.
  • the signal processing unit 93 generates an optical three-dimensional structure image composed of the structure information of the measurement target T based on the interference information stored in the first memory 91 and measures based on the image information stored in the second memory 92. A visible light image is rendered on the surface of the target T. A detailed configuration will be described later.
  • control unit 94 controls the signal processing unit 93, performs light emission control of the OCT light source 10 and the visible light source 20, and controls the mirror moving unit 85.
  • FIG. 2 is a cross-sectional view showing a detailed configuration of the probe of FIG. As shown in FIG. 2, which is an enlarged view of reference numeral 40A in FIG. 1, in the probe 40, collimating lenses 451 and 452 for collimating light are fused to the emission ends of the fibers FB1 and FB2.
  • the measurement light L1 emitted from the fiber FB1 becomes a collimated beam by the collimating lens 451.
  • the visible light La emitted from the fiber FB2 also becomes a collimated beam by the collimating lens 452.
  • the exit ends of the two fibers FB1 and FB2 are arranged so that the collimated beams are substantially parallel to each other.
  • the two parallel collimated beams are incident on one condenser lens 460, then reflected by the deflection rotating mirror 470, and irradiated onto the measurement target T.
  • the two beams are condensed and irradiated at substantially the same point by the condenser lens 460.
  • the deflection rotation mirror 470 is rotated by a motor 480, and thereby the condensing point of the measurement light L1 and the visible light La is scanned.
  • the deflection rotation mirror 470 is rotated by the motor 480, and the circle on the measurement target T
  • the visible light La and the measurement light L1 are scanned in a circumferential shape, and a two-dimensional tomographic image on the ZY plane can be measured.
  • the motor 480 is driven by the optical scanning unit 42 based on the control of the control unit 94 (see FIG. 1).
  • the tip of the probe 40 is advanced and retracted in a direction X perpendicular to the plane formed by the scanning circle of the visible light La and the measuring light L1 by a motor (not shown) in the optical scanning unit 42 (see FIG. 1). Measurement of an XYZ three-dimensional tomographic image is possible.
  • the measurement light L1 emitted from the fiber FB1 and applied to the measurement target is reflected and backscattered in the measurement target T, and a part of the measurement light L1 is collected by the condenser lens 460 and the collimator lens 451 and enters the fiber FB1. .
  • the visible light La emitted from the fiber FB2 and applied to the measurement target T is reflected and backscattered in the measurement target T, and a part of the visible light La is collected by the condenser lens 460 and the collimator lens 452, and the fiber FB2 is collected. Is incident on.
  • the fibers FB1 and FB2 of the probe 40 guide the incident visible light La and measurement light L1 to the measurement target T and irradiate the measurement target T.
  • the fibers FB1 and FB2 of the probe 40 guide the return lights L4 and L3 from the measurement target T when the visible light La and the measurement light L1 are irradiated on the measurement target T, respectively.
  • the probe tip shape and scanning direction are not limited to this, and as shown in FIG. 18, for example, a high-speed scanning mirror 990 such as a condenser lens 460 and a galvanometer mirror on the fiber tip side provided with collimating lenses 451 and 452.
  • the light transmission / reception unit 991 may be provided, and two-dimensional scanning may be performed by the high-speed scanning mirror 990, or the condensing unit and the scanning unit may be configured to advance and retreat by the stage 992.
  • the measurement target T may be scanned two-dimensionally by the stage 992.
  • these optical axis scanning mechanisms and measurement sample moving mechanisms may be combined.
  • FIG. 3 is a block diagram showing the configuration of the signal processing unit of FIG.
  • the signal processing unit 93 is a three-dimensional optical structure information generating unit that constructs an optical three-dimensional structure image composed of the structural information of the measurement target T based on the interference information stored in the first memory 91.
  • a surface position calculation unit 121 as a surface position calculation unit that calculates the surface position of the measurement target T, which is position information of the surface of the optical three-dimensional structure image constructed by the three-dimensionalization unit 120
  • a second memory The visible light image generation unit 122 as an image information generation unit that generates a visible light image of the measurement target T based on the image information stored in 92, and the light three-dimensional structure image and surface position calculation unit from the three-dimensionalization unit 120 Based on the position information of the surface from 121 and the color image from the visible light image generation unit 122, a label for generating a three-dimensional CG image that is a light structure image obtained by rendering the visible light image on the surface of the light three-dimensional structure image. Is constructed and a rendering unit 123 as Daringu means, these units are controlled by the control unit 94, the rendering unit 123 is arranged to output a 3-dimensional CG image generated on the monitor 100.
  • the optical structure information is the structure information in the depth direction of the measurement target T based on the interference information
  • the optical three-dimensional structure image is an optical three-dimensional structure model composed of the optical structure information of the measurement target T
  • the optical structure image is a light It is the three-dimensional CG image which rendered the visible light image on the surface of the three-dimensional structure image.
  • the light structure image generation means includes a surface position calculation unit 121 as a surface position calculation unit, a visible light image generation unit 122 as an image information generation unit, and a rendering unit 123 as a rendering unit.
  • the surface position calculation unit 121 calculates the surface position of the measurement target T from, for example, a change in OCT signal intensity that moves from space to the object.
  • FIG. 4 is a flowchart showing the flow of the three-dimensional CG image generation process of the optical three-dimensional structure imaging apparatus of FIG.
  • the control unit 94 controls the OCT light source 10 and the visible light source 20 to start emission control of infrared light and visible light (step S1).
  • the OCT light source 10 emits laser light L in the infrared region while sweeping the frequency at a constant period in synchronization with the sweep trigger signal S.
  • control unit 94 stores the intensity of the reflected light (or backscattered light) L4 at each depth direction Z position of the measurement target T detected by the interference light detection unit 72 in the first memory 91 as interference information.
  • the red, green, and blue light intensity signals of the visible light components from the measurement target T detected by the visible light detector 112 are stored in the second memory 92 as image information (step S2).
  • control unit 94 controls the light scanning unit 42 to scan the visible light La and the measurement light L1 on the measurement target T in the Y direction (step S3), and performs step S2 to step until the Y direction scanning is completed.
  • step S3 is repeated (step S4).
  • control unit 94 controls the optical scanning unit 42 to scan the visible light La and the measuring light L1 on the measurement target T in the X direction (step S5), and the X-direction scanning is completed. Steps S2 to S5 are repeated until (Step S6).
  • control unit 94 controls the three-dimensional unit 120 to construct an optical three-dimensional structure image of the measurement target T based on the interference information stored in the first memory 91 (step S7). .
  • control unit 94 controls the surface position calculation unit 121 to calculate the position information of the surface of the optical three-dimensional structure image constructed by the three-dimensionalization unit 120 (step S8).
  • control unit 94 controls the visible light image generation unit 122 to generate a visible light image of the measurement target T based on the image information stored in the second memory 92 (step S9).
  • control unit 94 controls the rendering unit 123 to display the three-dimensional three-dimensional structure image from the three-dimensionalization unit 120, the surface position information from the surface position calculation unit 121, and the visible light image from the visible light image generation unit 122.
  • a three-dimensional CG image in which a visible light image is rendered on the surface of the optical three-dimensional structure image is generated (step S10), the three-dimensional CG image is displayed on the monitor 100 (step S11), and the process ends.
  • the optical stereoscopic structure is rendered.
  • a normal visible light image 200 is displayed in full color from the upper surface, and an optical three-dimensional structure image 201 obtained by OCT is displayed below the visible light surface information on the surface of the image.
  • a three-dimensional CG image 203 which is the optical structure image thus completed is completed. Since the visible light image 200 is pasted as a surface image based on the OCT information, the three-dimensional CG image 203 displayed on the monitor 100 is an image having a three-dimensional surface image.
  • the optical three-dimensional structure imaging apparatus 1 of the present embodiment is used with, for example, a normal electronic endoscope apparatus that uses visible light as illumination light
  • the probe 40 is inserted through a treatment instrument channel or the like of the electronic endoscope.
  • the electronic endoscope images the affected part in the body cavity as the measurement target T, an endoscopic image 300 as shown in FIG. 6 is displayed on a monitor or the like.
  • OCT measurement is performed on the affected area 301 with the probe 40, and an optical stereoscopic structure image of the affected area 301 is obtained.
  • FIG. 5 is a diagram showing a three-dimensional CG image generated by the processing of FIG. 4, and FIG. 6 is a diagram showing an example of an endoscopic image compared with the three-dimensional CG image of FIG.
  • Visible light surface information (hue, contrast, brightness, etc.) of the affected area 301 (see FIG. 5) on the visible light image 200 on the surface of the three-dimensional CG image 203 and the affected area 301 (see FIG. 6) on the endoscopic image.
  • Visible light image information (hue, contrast, brightness, etc.) can be identified in correspondence, so it can be easily determined whether the affected area 301 has been reliably subjected to OCT measurement.
  • this three-dimensional CG image it is possible to extract a lesion part using a feature of a lesion that can be visually recognized in a normal endoscopic image and a feature of an optical three-dimensional structure image, and the resolution is high. Can be determined with higher accuracy.
  • the probe 40 includes the fibers FB1 and FB2 in which the collimating lenses 451 and 452 are fused, the condensing lens 460, the deflection rotating mirror 470, and the motor 480. Examples 1> to ⁇ Modification 5> may be used.
  • FIG. 7 is a diagram showing a configuration of Modification 1 of the probe shown in FIG.
  • the condensing lens 460 is two condensing lenses 460a and 460b.
  • the measurement light L1 emitted from the fiber FB1 becomes a collimated beam by the collimating lens 451.
  • the visible light La emitted from the fiber FB2 also becomes a collimated beam by the collimating lens 452.
  • the two parallel collimated beams are incident on the two condenser lenses 460a and 460b, respectively, reflected by the deflection rotating mirror 470, and irradiated onto the measurement target T.
  • FIG. 8 is a diagram showing a configuration of Modification 2 of the probe of FIG. 2
  • FIG. 9 is a diagram showing a cross section taken along line AA of FIG. 8, and
  • FIG. 10 is applied to the probe of FIG. It is a figure which shows the structure of the optical three-dimensional structure imaging device performed.
  • Modification 2 of the probe is an example in which three fibers are used for the probe 40. That is, in the probe modification 2, the visible light fiber FB2 is divided into an illumination fiber FB21 and a reflected light receiving fiber FB22. As shown in FIG. 9, collimating lenses 452a and 452b are provided at the tips of the FBs 21 and 22, respectively. As described above, when the visible light fiber FB2 is divided into the illumination fiber FB21 and the reflected light receiving fiber FB22, the half-mirror 21 is not necessary in the optical three-dimensional structure imaging apparatus 1, as shown in FIG. The light utilization efficiency increases.
  • the number of fibers used for the probe 40 is not limited to two, and any number of fibers may be stacked depending on the application.
  • two fibers may be used for irradiation and reflection for the fiber FB1 for OCT measurement light.
  • two polarization-maintaining fibers may be used to irradiate or receive polarized light perpendicular to each other.
  • Modification 2 a specific example of Modification 2 will be described as Examples 1 to 3.
  • visible light La which is white light
  • the illumination light is not limited to white light.
  • the blue excitation light used in the fluorescence endoscope is used as illumination light, the blue excitation light is guided by the fiber FB21, and the autofluorescence of the cell is guided by the fiber FB22.
  • a filter that transmits green fluorescence to the detector that receives the autofluorescence of the cells it is possible to display a combination of the same image and OCT as a fluorescence endoscope, and to improve the visibility of the cancer area. it can.
  • an agent that selectively accumulates in cancer and injects specific fluorescence is injected, the excitation light is used as illumination light, a fiber matched to the excitation light is used as fiber FB21, and the fluorescence wavelength is selectively selected.
  • the visibility of the cancer area can be further improved by combining the detector for receiving light and the fiber FB22 matched to the wavelength.
  • excitation light and fluorescence are not always in the visible range.
  • a known fluorescent material called indocyanine green has an absorption wavelength in the invisible region of 800 nm to 810 nm, and emits fluorescence with a wavelength of 830 nm in the invisible region when excited with a laser beam of 806 nm. Therefore, by using a filter that removes the light near 806 nm and extracts the light near 830 nm as the illumination light for the 806 nm laser and the detector, the region on the XY plane where the indocyanine green is accumulated is shown as an optical three-dimensional structure image. Can be specified.
  • Example 2 An ultrashort pulse laser is guided using a dispersion shifted fiber as the fiber FB21, and two-photon excitation fluorescence and second harmonics generated when the measurement object is irradiated with the ultrashort pulse laser are guided. It is good also as a structure which combines a multimode fiber as fiber FB22. Alternatively, the measurement object may be irradiated with ultraviolet light using a hollow fiber to receive fluorescence.
  • Example 3 It may be configured in combination with Raman spectroscopy or coherent anti-Stokes Raman spectroscopy (CARS).
  • CARS coherent anti-Stokes Raman spectroscopy
  • excitation light having a wavelength of 568 nm and 600 nm is used, two fibers FB21 made of separate single mode fibers are used as irradiation fibers, and a multimode fiber for light reception is bundled as a fiber FB22.
  • the position of the tip of each fiber and the optical system are adjusted so that the beam is irradiated and condensed at an angle suitable for CARS measurement at the tip of the probe 40.
  • a light receiving end of the fiber FB22 which is a multimode fiber for light reception, is provided with a spectroscope composed of a spectroscopic element and a one-dimensional photo detector to acquire spectroscopic information.
  • a spectroscope composed of a spectroscopic element and a one-dimensional photo detector to acquire spectroscopic information.
  • FIG. 11 is a diagram showing a configuration of Modification 3 of the probe shown in FIG.
  • the third modification of the probe is almost the same as the second modification, and an ultraviolet laser light source (not shown) that emits ultraviolet laser light and a fluorescent paint 455 applied to the tip of the fiber FB21. It is the example which comprised the visible light source 20 from these.
  • the fiber FB21 guides the ultraviolet laser light, and the ultraviolet laser light is absorbed by the fluorescent paint at the tip of the fiber FB2.
  • the fluorescent paint emits white fluorescence and becomes illumination light.
  • the light is condensed and irradiated, and the reflected light is guided by a light receiving fiber FB22 made of a light receiving multimode fiber and received by a visible light information detection unit 60 provided in the optical three-dimensional structure imaging apparatus 1. To do.
  • FIG. 12 is a diagram showing a configuration of Modification 4 of the probe shown in FIG.
  • the probe modification 4 uses a single mode double clad fiber 490 as a fiber instead of the fibers FB1 and FB2, a collimating lens 491 is provided separately, and a galvanometer instead of the deflection rotation mirror 470.
  • This is a configuration example in which a mirror 492 is provided.
  • the core 490a of the single mode double clad fiber 490 is a single mode waveguide that replaces the fiber FB1
  • the clad 490b of the single mode double clad fiber 490 is a multimode waveguide that propagates visible light instead of the fiber FB2. . If this single mode double clad fiber 490 is used, it is not necessary to bundle a plurality of fibers, and the probe can be made thinner.
  • FIG. 13 is a diagram showing a configuration of Modification 5 of the probe shown in FIG.
  • the collimating lens and the condensing lens provided at the ends of the fibers FB1 and FB2 may be combined into one optical lens 495a and 495b, respectively.
  • This configuration makes the probe 40 more compact.
  • a plurality of lenses may be combined to increase the resolution. It is more desirable to eliminate chromatic aberration using a combination lens.
  • the visible light information detection unit 60 uses the three Si photodetectors 111r, 111g, and 111b with red, green, and blue filters 110r, 110g, and 110b attached to the front surface as the sweep trigger signal S of the OCT light source 10, respectively. Synchronously, the visible light detection unit 112 detects the red, green, and blue light intensities at that moment as image information with respect to the light of the visible light component, but the present invention is not limited to this. You may comprise as the following (1) to (4).
  • FIG. 14 is a diagram showing a first modification of the visible light information detection unit of FIG.
  • red, green, and blue light components are separated by two dichroic mirrors 400 and 401, and the sweep trigger of the OCT light source 10 is detected by three Si photodetectors 111r, 111g, and 111b without filters.
  • the visible light information detection unit 60 is configured so that the visible light detection unit 112 detects the red, green, and blue light intensities at that moment as image information in synchronization with the signal S. May be.
  • FIG. 15 is a diagram showing a second modification of the visible light information detection unit of FIG.
  • red, green, and blue are divided into visible light components by the diffraction grating 410, and the sweep trigger signal S of the OCT light source 10 is output by three Si photodetectors 111r, 111g, and 111b without filters.
  • the visible light information detection unit 60 may be configured so that the visible light detection unit 112 detects each light intensity of red, green, and blue as image information in synchronization with visible light component light. .
  • FIG. 16 is a diagram showing a third modification of the visible light information detection unit of FIG.
  • the visible light component light is separated into red, green, and blue using an all-fiber optical system 420 such as a WDM (Wavelength Division Multiplexing) coupler or AWG (Arrayed Waveguide Grating).
  • an all-fiber optical system 420 such as a WDM (Wavelength Division Multiplexing) coupler or AWG (Arrayed Waveguide Grating).
  • Each of the Si photodetectors 111r, 111g, and 111b is synchronized with the sweep trigger signal S of the OCT light source 10, and the visible light detection unit 112 detects the light intensity of each of red, green, and blue at that moment.
  • the visible light information detection unit 60 may be configured to detect the image information as image information.
  • FIG. 17 is a diagram showing a fourth modification of the visible light information detection unit in FIG.
  • the color of the illumination light from the visible light source 20 may be irradiated in a time division manner. That is, by forming the visible light source 20 using red, green, and blue lasers as illumination light, irradiation is performed in a pulsed manner so that the emission time zones of the red, green, and blue lasers do not overlap with each other.
  • the information detector 60 receives light by one Si photodetector 111.
  • the laser light emission timing of the visible light source 20 and the detection timing of the visible light information detector 60 are synchronized with the sweep trigger signal S, and are input to the computer as information on the color of light emitted according to the time zone to generate a full color image.
  • a white light source through a color filter may be used and the color filter may be switched over time.
  • the trigger signal corresponding to the sweep trigger signal S is the period of the optical path length delay circuit in the case of TD-OCT measurement, and the signal acquisition period of the detector array for OCT in the case of SD-OCT measurement.
  • any wavelength range is not limited to red, green, and blue.
  • NBI Near Band Imaging
  • FICE Fluorescent Spectral Imaging Color Enhancement
  • NBI Narrow Band Imaging
  • FICE Fluorescent Spectral Imaging Color Enhancement
  • the number of detectors is not limited to three, and a detector corresponding to special light observation such as NBI or fluorescent endoscope may be arranged in addition to the same red, green, and blue as the normal endoscope.
  • the optical axis scanning of the OCT apparatus may be performed using a probe, a galvano mirror, or a type that scans using a stage.
  • a probe only the deflecting mirror may be rotated by a motor, or it may be fixed to a fiber and rotated for each fiber.
  • linear scanning may be performed using a MEMS (Micro Electro Mechanical Systems) mirror.
  • MEMS Micro Electro Mechanical Systems
  • the visible light La as illumination light also has an effect as aiming light (marking light that clearly indicates the measurement position).
  • aiming light marking light that clearly indicates the measurement position.
  • optical three-dimensional structure imaging device as the optical three-dimensional structure image device of the present invention has been described in detail, the present invention is not limited to the above examples, and various types can be made without departing from the gist of the present invention. Of course, improvements and modifications may be made.
  • SYMBOLS 10 OCT light source, 20 ... Visible light source, 30 ... OCT interferometer, 40 ... Probe, 60 ... Visible light information detection part, 70 ... Interference information detection part, 90 ... Tomographic image generation part, 91 ... First memory, 92 2nd memory, 93 ... Signal processing unit, 94 ... Control unit, 100 ... Monitor, 120 ... 3D conversion unit, 121 ... Surface position calculation unit, 122 ... Visible light image generation unit, 123 ... Rendering unit, 451, 452 ... collimating lens, 460 ... condensing lens, 470 ... deflection rotating mirror, 480 ... motor, FB1, FB2 ... fiber

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Abstract

L'invention concerne un appareil optique d’imagerie à structure stéréographique, comportant une source lumineuse (10) d’une première longueur d’onde, un séparateur optique (3) qui sépare la lumière de la première longueur d’onde en une lumière de mesure et une lumière de référence, un premier guide d’ondes qui guide la lumière de mesure, une partie (470, 492, 990) de rayonnement lumineux qui rayonne la lumière de mesure guidée par le premier guide d’ondes sur un objet à mesurer, une première partie collectrice (460, 451, 460a, 491, 495a) de lumière qui collecte sur le premier guide d’ondes de la lumière sur la base de la lumière de mesure issue de points situés sur l’objet à mesurer, une unité (70) de détection d’informations d’interférence qui détecte des informations d’interférence de la lumière sur la base de la lumière de mesure issue des points situés sur l’objet à mesurer et guidée par le premier guide d’ondes, avec la lumière de mesure, une deuxième partie collectrice (460, 452, 460b, 452a, 491, 495b) de lumière qui collecte une lumière dont la longueur d’onde est différente de celle de la lumière émanant de la source lumineuse de la première longueur d’onde, issue des points situés sur l’objet à mesurer, un deuxième guide d’ondes qui guide la lumière collectée par la deuxième partie collectrice de lumière et une partie réceptrice (60) de lumière qui reçoit la lumière guidée par le deuxième guide d’ondes pour obtenir un signal de lumière reçue.
PCT/JP2009/070583 2008-12-10 2009-12-09 Appareil optique d’imagerie à structure stéréographique et procédé de traitement de signal optique pour celui-ci Ceased WO2010067813A1 (fr)

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