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WO2010064134A3 - Process of synthesis of paliperidone - Google Patents

Process of synthesis of paliperidone Download PDF

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Publication number
WO2010064134A3
WO2010064134A3 PCT/IB2009/007652 IB2009007652W WO2010064134A3 WO 2010064134 A3 WO2010064134 A3 WO 2010064134A3 IB 2009007652 W IB2009007652 W IB 2009007652W WO 2010064134 A3 WO2010064134 A3 WO 2010064134A3
Authority
WO
WIPO (PCT)
Prior art keywords
paliperidone
synthesis
pyrido
chloroethyl
pyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2009/007652
Other languages
French (fr)
Other versions
WO2010064134A2 (en
Inventor
Indravadan Ambalal Modi
Keval Rameshchandra Sodagar
Malik Vineet
Sudhir Hukamchand Jain
Sanjay Natvarlal Parikh
Arun Omprakash Sharma
Uday Rajaram Bapat
Bakulesh Mafatlal Khamar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cadila Pharmaceuticals Ltd
Original Assignee
Cadila Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Pharmaceuticals Ltd filed Critical Cadila Pharmaceuticals Ltd
Publication of WO2010064134A2 publication Critical patent/WO2010064134A2/en
Publication of WO2010064134A3 publication Critical patent/WO2010064134A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to an improved process for preparation of 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one, an intermediate used in the synthesis of paliperidone and process for converting the same to Paliperidone.
PCT/IB2009/007652 2008-12-05 2009-12-04 Process of synthesis of paliperidone Ceased WO2010064134A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2544MU2008 2008-12-05
IN2544/MUM/2008 2008-12-05

Publications (2)

Publication Number Publication Date
WO2010064134A2 WO2010064134A2 (en) 2010-06-10
WO2010064134A3 true WO2010064134A3 (en) 2010-08-12

Family

ID=42233673

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/007652 Ceased WO2010064134A2 (en) 2008-12-05 2009-12-04 Process of synthesis of paliperidone

Country Status (1)

Country Link
WO (1) WO2010064134A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011073997A2 (en) * 2009-12-14 2011-06-23 Cadila Healthcare Limited Process for preparing paliperidone and pharmaceutically acceptable salts thereof
WO2012042368A1 (en) * 2010-09-30 2012-04-05 Aurobindo Pharma Limited Process for preparation of paliperidone

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688799A (en) * 1993-11-23 1997-11-18 Janssen Pharmaceutica N.V. 9-Hydroxy-pyrido 1,2-a!pyrimidin-4-one ether derivatives
US6320048B1 (en) * 1988-11-07 2001-11-20 Janssen Pharmaceutica, N.V. 3-piperidinyl-1,2-benzisoxazoles
US20050222228A1 (en) * 2004-04-02 2005-10-06 Birgit Bossenmaier Novel diazine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6320048B1 (en) * 1988-11-07 2001-11-20 Janssen Pharmaceutica, N.V. 3-piperidinyl-1,2-benzisoxazoles
US5688799A (en) * 1993-11-23 1997-11-18 Janssen Pharmaceutica N.V. 9-Hydroxy-pyrido 1,2-a!pyrimidin-4-one ether derivatives
US20050222228A1 (en) * 2004-04-02 2005-10-06 Birgit Bossenmaier Novel diazine derivatives

Also Published As

Publication number Publication date
WO2010064134A2 (en) 2010-06-10

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