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WO2010061675A1 - Catheter, method of inserting catheter into body, and method of extracting catheter - Google Patents

Catheter, method of inserting catheter into body, and method of extracting catheter Download PDF

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Publication number
WO2010061675A1
WO2010061675A1 PCT/JP2009/065364 JP2009065364W WO2010061675A1 WO 2010061675 A1 WO2010061675 A1 WO 2010061675A1 JP 2009065364 W JP2009065364 W JP 2009065364W WO 2010061675 A1 WO2010061675 A1 WO 2010061675A1
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WO
WIPO (PCT)
Prior art keywords
catheter
wire
anchoring portion
anchoring
proximal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2009/065364
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French (fr)
Japanese (ja)
Inventor
広明 小関
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Olympus Corp
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Olympus Corp
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Publication date
Application filed by Olympus Corp filed Critical Olympus Corp
Priority to JP2010540411A priority Critical patent/JPWO2010061675A1/en
Publication of WO2010061675A1 publication Critical patent/WO2010061675A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A63SPORTS; GAMES; AMUSEMENTS
    • A63FCARD, BOARD, OR ROULETTE GAMES; INDOOR GAMES USING SMALL MOVING PLAYING BODIES; VIDEO GAMES; GAMES NOT OTHERWISE PROVIDED FOR
    • A63F13/00Video games, i.e. games using an electronically generated display having two or more dimensions
    • A63F13/80Special adaptations for executing a specific game genre or game mode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/02Holding devices, e.g. on the body
    • A61M25/04Holding devices, e.g. on the body in the body, e.g. expansible
    • AHUMAN NECESSITIES
    • A63SPORTS; GAMES; AMUSEMENTS
    • A63FCARD, BOARD, OR ROULETTE GAMES; INDOOR GAMES USING SMALL MOVING PLAYING BODIES; VIDEO GAMES; GAMES NOT OTHERWISE PROVIDED FOR
    • A63F2300/00Features of games using an electronically generated display having two or more dimensions, e.g. on a television screen, showing representations related to the game
    • A63F2300/60Methods for processing data by generating or executing the game program
    • A63F2300/6027Methods for processing data by generating or executing the game program using adaptive systems learning from user actions, e.g. for skill level adjustment
    • AHUMAN NECESSITIES
    • A63SPORTS; GAMES; AMUSEMENTS
    • A63FCARD, BOARD, OR ROULETTE GAMES; INDOOR GAMES USING SMALL MOVING PLAYING BODIES; VIDEO GAMES; GAMES NOT OTHERWISE PROVIDED FOR
    • A63F2300/00Features of games using an electronically generated display having two or more dimensions, e.g. on a television screen, showing representations related to the game
    • A63F2300/60Methods for processing data by generating or executing the game program
    • A63F2300/61Score computation

Definitions

  • the present invention relates to a catheter which can be anchored in the body of a mammal including human and which guides a drug into the body, a method of inserting the catheter into the body, and a method of extracting the catheter from the body.
  • a catheter is used to introduce a drug into the body of a mammal including human.
  • a puncture needle having an internal passage is attached to the tip of a flexible tube (see Patent Document 1).
  • Patent Document 1 In order to fix such a catheter in place, it is common practice to bandage the catheter on the body surface.
  • a catheter in the body is similarly anchored to an organ in the body, if a member for anchoring is provided, the presence of the member for anchoring anchors the process of insertion and withdrawal of the catheter. And it takes time and effort.
  • the present invention has been made in view of the above, and it is a catheter that can be reliably anchored in the body without affecting the process of insertion and removal of the catheter, a method of inserting the catheter into the body, and a catheter
  • the purpose is to provide a method for the removal of
  • a catheter according to the present invention is a catheter for guiding a drug into the body of a mammal including human, which is provided on the side of the catheter and shaped by external operation. Are provided with anchoring portions for anchoring the catheter in the body.
  • a tube for guiding the drug into the body, and at least one drug discharge hole provided at the tip of the tube and discharging the drug led to the tube into the body A drug administration unit, and the anchor unit is provided in the drug administration unit.
  • the catheter according to the present invention comprises a wire having a tip attached to a predetermined portion of the catheter, a proximal end located outside the body, and disposed along the catheter; It is characterized in that the wire is advanced or retracted with respect to the catheter on the proximal side from the position to change the shape of the anchoring portion.
  • the catheter according to the present invention is characterized in that the wire is a metal wire.
  • the anchoring portion is provided on the catheter proximal to the attachment position of the wire and is a more flexible portion than the other portions of the catheter, By pulling the wire toward the proximal side with respect to the catheter on the proximal side from the attachment position of the wire to the catheter, the anchoring portion which is the flexible portion is compressed, and the anchoring portion is radially outward It is characterized by being raised.
  • the anchoring portion may be a protrusion projecting outward from the catheter, a core member provided inside the protrusion, and the wire relative to the wire. And a joint for pivotally attaching the core member, and pulling the wire rod toward the proximal end side with respect to the catheter on the proximal end side from the attachment position of the wire rod to the catheter relative to the wire rod.
  • the core material is pivoted, and an angle formed by the projecting direction of the projection with respect to the axial direction of the catheter is changed.
  • the catheter further includes a tip that can be separated at the tip, and a protrusion that is provided in the internal passage, and the wire is attached at the tip to the tip.
  • the proximal end is located outside the body through the internal passage of the catheter, and the anchor portion is provided on the catheter proximal to the protrusion and is a more flexible site than other parts of the catheter, By pulling the wire toward the proximal end with respect to the catheter, the distal end is locked at the projection when the distal end moves proximally through the internal passage in the catheter.
  • a compressive pressure is applied to the anchoring portion which is the flexible portion, and the anchoring portion bulges in a radially outward direction.
  • the distal end portion is a punctured portion having a sharpened distal end, and the punctured portion at the distal end portion in a state where the distal end portion is locked by the projection.
  • the punctured portion at the distal end portion in a state where the distal end portion is locked by the projection.
  • the catheter according to the present invention is provided with a coupled portion which is attached to a predetermined portion of the catheter and which can be coupled or engaged with the wire in the inner passage of the catheter.
  • a coupled portion which is attached to a predetermined portion of the catheter and which can be coupled or engaged with the wire in the inner passage of the catheter.
  • the catheter according to the present invention is a delivery unit which is located on the proximal end side of the catheter from the anchoring portion and which delivers a drug toward the distal direction of the catheter;
  • a distal end portion located on the distal end side is further included, and the shape of the anchoring portion is configured to be changed by relatively moving the delivery portion and the distal end portion.
  • the catheter is inserted into the body of a living tissue by inserting a catheter having a wire and an anchor portion projecting to the outer surface by pulling the wire.
  • a method of extracting the catheter according to the present invention from the body is a catheter having a wire and an anchoring portion whose protrusion is reduced from the outer surface by pushing or pulling the wire, which is anchored to a living tissue.
  • the anchoring portion provided on the side of the catheter for guiding the drug into the mammalian body, including human beings anchors the catheter in the body by changing its shape by operation from outside the body.
  • the catheter can be anchored in the body reliably without affecting the process of insertion and removal of the catheter.
  • FIG. 1 is a schematic view showing a state in which the catheter according to Embodiment 1 of the present invention is applied to a human body.
  • FIG. 2 is a perspective view showing a detailed configuration of a drug administration unit of the catheter shown in FIG.
  • FIG. 3 is a cross-sectional view showing the detailed configuration of the drug administration unit of the catheter shown in FIG.
  • FIG. 4 is a flowchart showing the procedure for inserting the catheter into the body.
  • FIG. 5 is a flow chart showing the procedure for extracting the catheter from the body.
  • FIG. 6 is a perspective view showing a detailed configuration of a drug administration unit of a catheter according to a second embodiment of the present invention.
  • FIG. 7 is a cross-sectional view showing the detailed configuration of the drug administration unit of the catheter shown in FIG. FIG.
  • FIG. 8 is a perspective view showing a detailed configuration of a drug administration unit of a catheter according to a third embodiment of the present invention.
  • FIG. 9 is a cross-sectional view showing the detailed configuration of the drug administration unit of the catheter shown in FIG.
  • FIG. 10 is a cross-sectional view showing the configuration of a modification of the catheter shown in FIG.
  • FIG. 11 is a cross-sectional view showing the detailed configuration of the medicine administration section of the catheter according to the fourth embodiment of the present invention.
  • FIG. 12 is a cross-sectional view showing the configuration of Modification 1 in which the position of the medicine discharge hole of the catheter shown in FIG. 3 is changed.
  • FIG. 13 is a cross-sectional view showing the configuration of Modification 2 in which the position of the medicine discharge hole of the catheter shown in FIG. 3 is changed.
  • FIG. 14 is a cross-sectional view showing the configuration of Modification 3 in which the configuration of the wire is removed from the catheter shown in FIG.
  • FIG. 1 is a schematic view showing a state in which a drug administration device having a catheter according to Embodiment 1 of the present invention is applied to a human body.
  • FIG. 2 is a perspective view showing a state in which the drug administration unit of the catheter shown in FIG. 1 is anchored to an internal organ.
  • FIG. 3 is a cross-sectional view showing the configuration of the drug administration unit including a change in the state of the anchoring unit.
  • a drug such as an anticancer drug is continuously and intensively discharged over a long period of about one week to an administration target which is a mammal including human, for example, an internal organ 4 such as the liver. It shows the case of planned administration.
  • drug as used herein includes liquid and gel drugs.
  • the drug administration device 100 has a catheter 1 and a drug administration device main body 3 for supplying a drug to the catheter 1.
  • the catheter 1 is provided with a tube 2 made of a biocompatible soft polyethylene and the like, and a distal end of the tube 2, and a drug administration made of hard titanium or molded polyethylene terephthalate (PET) resin, etc.
  • PET polyethylene terephthalate
  • the drug administration unit 8 punctures the internal organ 4.
  • a stopper 7 is provided between the tube 2 and the drug administration unit 8, and the stopper 7 rests on the surface of the internal organ 4 to define the relative position between the internal organ 4 and the drug administration unit 8. The stopper 7 can be moved and adjusted along the axial direction of the catheter 1.
  • the drug administration device main body 3 is fixed to the body surface 6 and supplies the drug to the catheter 1 side as described above.
  • the drug administration device main body 3 variably controls the pushing pressure of the drug.
  • the drug administration device main body 3 does not have to be attached to the body surface 6.
  • the drug administration device main body 3 may be implanted in the body or may be spaced apart from the body.
  • the drug discharge hole 9 is provided on the side surface, and the anchor portion 10 protruding in the radially outward direction is provided between the pointed tip 11 and the drug discharge hole 9. .
  • the anchoring portion 10 is raised from the surface of the catheter 1 at least while the catheter 1 is indwelled in the body, and anchors the catheter 1 in the internal organ 4.
  • the shape of this mooring part 10 is deformable by operation from the outside of the body, as will be described later.
  • the position of the anchoring portion 10 be in the vicinity of the medicine discharge hole 9 because the medicine discharge position is stabilized.
  • the position of the anchoring portion 10 is not limited to the vicinity of the drug discharge hole 9, and can be provided at an appropriate position in view of the arrangement of the target organ and surrounding tissue from among the sites where the catheter 1 is introduced into the body. .
  • FIG. 3 is a cross-sectional view for explaining the shape change of the mooring portion 10.
  • FIG. 3A shows the state of the catheter 1 before or during insertion into the body.
  • a wire 12 such as a metal wire passes through the inner passage 14 of the catheter 1, and the tip of the wire 12 is attached to the catheter 1 by an anchor 13.
  • the proximal end of the catheter 1 protrudes from the opening on the proximal end side of the inner passage 14 of the catheter 1 outside the body.
  • the anchoring portion 10 has a thin film portion 15 whose thickness is thinner than that of the other conduit portion of the catheter 1, and the thin film portion 15 is more flexible than the other conduit portion of the catheter 1.
  • the catheter 1 is inserted to a desired position of the affected area 5. That is, the operator pulls the distal end portion to bring the anchor portion 10 into the extended state shown in FIG. 3A, holds the affected area, and punctures the catheter (FIG. 4: step S101).
  • the distal end portion of the catheter 1 together with the anchor 13 Move to the proximal side of the catheter 1.
  • a compressive pressure is applied to the thin film portion 15, and the thin film portion 15 bulges radially outward.
  • the catheter 1 is anchored to the affected area 5 by the thin film portion 15 of the anchor portion 10 being raised. And an operator fixes so that the proximal end of the wire 12 may not move with respect to the proximal end of the catheter 1 (FIG. 4: step S102).
  • the projection by the thin film portion 15 of the anchoring portion 10 is a catheter It will be in the state inclined to the front end side of 1 (FIG. 5: step S201).
  • the anchoring portion 10 is less resistant to the direction of withdrawal of the catheter 1 from the body, and is easier to pull out. That is, the catheter 1 can be easily removed from the body by pulling out the entire catheter 1 (FIG. 5: step S202) while maintaining the state of FIG. 3 (c).
  • step S201 the wire 12 is pulled to the base end side, but the protrusion of the anchoring portion 10 may be reduced by pushing the wire 12 from the base end side. That is, when the wire 12 has a certain degree of rigidity, by pushing the wire 12 from the base end side from the anchored state shown in FIG. It moves and as shown to Fig.3 (a), the thin film part 15 of the anchoring part 10 becomes flat. In other words, pushing the wire 12 from the proximal end restores the anchored state of FIG. 3 (b) to the punctured state of FIG. 3 (a). In this restored state, the catheter 1 can be easily removed from the body by pulling out the entire catheter 1.
  • the anchoring portion 10 does not get in the way when inserting or removing the catheter 1, and the catheter 1 can be smoothly inserted / removed while the catheter 1 is reliably anchored in the body by the anchoring portion 10 during drug administration. Therefore, stable drug administration can be performed.
  • the state of FIG. 3B is restored to the state of FIG. 3A by releasing the fixation of the wire 12.
  • the fixation may be released.
  • yarn, a string, etc. can be used for the wire 12, it is not limited to this.
  • the use of a metal wire as the wire 12 can prevent the pressure in the insertion direction from causing a phenomenon in which the catheter 1, particularly the thin film portion 15 is folded like an accordion, when inserted into the internal passage 14 of the catheter 1 So preferred.
  • FIG. 7 is a cross-sectional view showing the configuration of a drug administration portion of a catheter according to a second embodiment of the present invention.
  • the wire 17 is inserted into the internal passage 14 of the catheter 1, and the wire 17 is inserted into the inside of the projecting portion 16 by the pivot joint 19 provided at the position corresponding to the projecting portion 16. It is pivotally connected to the proximal end of the embedded rod-shaped core 18.
  • the distal end stopper 21 is provided at the distal end of the wire rod 17, and the distal end stopper 21 abuts on the distal end surface of the internal passage 14 of the catheter 1 to inhibit the further advancement of the wire rod 17 in the distal direction.
  • the intermediate stopper 20 is provided in the vicinity of the proximal end side of the protruding portion 16 in the wire rod 17, and the intermediate stopper 20 is closer to the proximal end than the intermediate stopper 20 in the internal passage 14 near the proximal end side of the projecting portion 16. Abutment of the abutment projection 22 provided on the rear side prevents the wire rod 17 from retreating further.
  • the distal end stopper 21 is in contact with the distal end surface, and in this case, the core 18 is inclined toward the proximal end side of the catheter 1 with respect to the axis of the wire 17 Similarly, the protrusion direction of the protrusion 16 is inclined to the proximal end side of the catheter 1 to facilitate insertion of the catheter 1 into the body.
  • the wire 17 is further pulled toward the proximal end side of the catheter 1 until the intermediate stopper 20 abuts on the contact projection 22.
  • the projection direction of the projection 16 is also inclined to the distal end side of the catheter 1 and It becomes easy to pull out.
  • the shape of the projecting portion 16 is not limited to the spike shape, and may be, for example, a disk shape or a donut shape having an opening at the central portion similar to the shape of the anchoring portion 10 shown in FIG.
  • a plug 23 which is a separable tip is provided at the tip of the catheter 1, and the anchor 23 is formed on the tip side of the catheter 1 by using this plug 23. It is a thing.
  • FIG. 9 is a cross-sectional view showing a configuration of a drug administration unit of a catheter according to a third embodiment of the present invention.
  • the plug 23 is partially accommodated in the inner passage of the catheter 1 at the tip of the drug administration unit 8 of the catheter 1.
  • the wire 24 is attached to the plug 23 through the internal passage of the catheter 1.
  • the anchoring portion 25 is formed with a thin film portion 27 thinner than the other conduit portion 26 of the catheter 1 as in the first embodiment.
  • the abutment step 28 is provided at the tip of the internal passage of the catheter 1, and the proximal end of the plug 23 abuts on the abutment step 28, thereby restricting the movement of the catheter 1 to the proximal side. There is.
  • the wire 24 is further pulled to the proximal end side of the catheter 1 to cause a deformation in which the protuberances of the anchoring portion 25 incline to the distal end side.
  • the restriction on the movement of the plug 23 to the proximal side is released.
  • the plug 23 passes through the inner passage together with the wire 24 and is taken out from the proximal end opening of the catheter 1.
  • a cover 11c may be provided to cover the tip 11 of the plug 23.
  • the distal end portion 11 is accommodated in the internal passage 14 even when the catheter is in the indwelling state.
  • the wires 12 and 24 are integrally coupled to the anchor 13 and the plug 23, and the wire 17 and the core 18 are in the coupled state from the beginning through the pivot joint 19.
  • the wire corresponding to the wire 12, 24, 17 is separated and configured to produce the anchored state of the mooring portion 10, 25 or the protrusion 16
  • the wire is used as the anchor 13, 13,
  • the plug 23 or the core 18 and the pivot joint 19 are joined together.
  • a protrusion 36 stretched from the anchor 13 is provided so as to project from the distal end surface of the internal passage 14 of the catheter 1.
  • a forceps probe 32 having a forceps 35 at its tip is inserted into the internal passage 14 instead of the wire 12 and the forceps 35 make projections 36 as shown in FIG.
  • the forceps probe 32 and the anchor 13 are in a coupled state.
  • pulling the forceps probe 32 to the proximal end side of the catheter 1 forms a state in which the anchoring portion 10 is raised, whereby the catheter 1 is anchored in the body.
  • the raised state of the anchor portion 10 is obtained by pulling the forceps probe 32 further to the proximal end of the catheter 1. Inclined distally to facilitate withdrawal of the catheter 1 from the body.
  • the fourth embodiment can be applied to the second and third embodiments by using the wire rods 17 and 24 as the above-described forceps probes.
  • protrusion 36 and the forceps 35 was shown, it does not restrict to this, for example, wire rod 12,17,24, anchor 13, core 18, and rotation joint 19 , And the hooks in which the plug 23 engages with each other.
  • the medicine discharge hole 9 ⁇ the mooring portion 10 ⁇ the anchor 13 is disposed from the proximal end side, but this disposition is arbitrary, and for example, as shown in FIG. From the side, the mooring portion 10 ⁇ the drug discharge hole 9 ⁇ the anchor 13 may be sequentially arranged, or as shown in FIG. 13, from the base end side, the mooring portion 10 ⁇ anchor 13 ⁇ the drug discharge hole 9 is sequentially arranged May be
  • the anchor portion 10 is raised using the wire rods 12, 17, 24 or the insulator probe 32.
  • the wire rods 12, 17, 24, or insulators For example, as shown in FIG. 14, a wire or the like may not be provided in the inner passage 14 without using the probe 32.
  • the delivery portion 41 on the proximal side of the anchoring portion 10 and / or the puncture portion 42 on the distal end side are relatively extended or contracted by raising or lowering the anchoring portion 10 as shown by the arrows. Become.

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Abstract

A catheter for leading a medication into the body of a mammal including a human being.  The catheter is provided with an anchor section (10) provided to a side surface of the catheter and configured so that the shape of the anchor section is changed by operation from the outside of the body and that the catheter is anchored in the body, a wire member (12) mounted to an anchor (13) which is located at the front end of the catheter, having a base end located outside the body, and provided along an inner path (14) of the catheter.  The catheter is anchored in the body or released from the body by changing the shape of the anchor section (10) by advancing or retracting the wire member (12) relative to the base end side from the position of the anchor (13).

Description

カテーテル、カテーテルの体内への挿入方法およびカテーテルの体内からの抜出方法Catheter, method for inserting catheter into body and method for extracting catheter from body

 この発明は、人間を含む哺乳類の体内に係留でき、該体内に薬剤を導くカテーテル、カテーテルの体内への挿入方法およびカテーテルの体内からの抜出方法に関するものである。 The present invention relates to a catheter which can be anchored in the body of a mammal including human and which guides a drug into the body, a method of inserting the catheter into the body, and a method of extracting the catheter from the body.

 従来から、人間を含む哺乳類の体内に薬剤を導くためにカテーテルが用いられている。この従来のカテーテルは、柔軟なチューブの先端に内部通路を有する穿刺針が取り付けられている(特許文献1参照)。このようなカテーテルを所定の位置に固定するためには、体表においてカテーテルをバンデッジで留めることが一般的に行われている。 Conventionally, a catheter is used to introduce a drug into the body of a mammal including human. In this conventional catheter, a puncture needle having an internal passage is attached to the tip of a flexible tube (see Patent Document 1). In order to fix such a catheter in place, it is common practice to bandage the catheter on the body surface.

特開平3-57457号公報Japanese Patent Application Laid-Open No. 3-57457

 ところで、体内のカテーテルも同様にして体内臓器に係留されることが好ましいが、この係留のための部材を設けると、この係留のための部材の存在が、カテーテルの挿入や抜出の処理の邪魔となり、手間がかかるという問題点があった。 By the way, although it is preferable that a catheter in the body is similarly anchored to an organ in the body, if a member for anchoring is provided, the presence of the member for anchoring anchors the process of insertion and withdrawal of the catheter. And it takes time and effort.

 この発明は、上記に鑑みてなされたものであって、カテーテルの挿入や抜出の処理に影響を与えずに、確実に体内に係留することができるカテーテル、カテーテルの体内への挿入方法およびカテーテルの体内からの抜出方法を提供することを目的とする。 The present invention has been made in view of the above, and it is a catheter that can be reliably anchored in the body without affecting the process of insertion and removal of the catheter, a method of inserting the catheter into the body, and a catheter The purpose is to provide a method for the removal of

 上述した課題を解決し、目的を達成するために、この発明にかかるカテーテルは、人間を含む哺乳類の体内に薬剤を導くカテーテルであって、当該カテーテルの側面に設けられ、体外からの操作により形状が変化して当該カテーテルを体内に係留する係留部を備えたことを特徴とする。 In order to solve the problems described above and achieve the purpose, a catheter according to the present invention is a catheter for guiding a drug into the body of a mammal including human, which is provided on the side of the catheter and shaped by external operation. Are provided with anchoring portions for anchoring the catheter in the body.

 また、この発明にかかるカテーテルは、上述した発明において、前記薬剤を体内に導くチューブと、前記チューブの先端に設けられ、前記チューブに導かれた薬剤を体内に吐出する少なくとも1つの薬剤吐出穴を有する薬剤投与部と、を備え、前記係留部は、前記薬剤投与部に設けられていることを特徴とする。 In the catheter according to the present invention, in the above-described invention, a tube for guiding the drug into the body, and at least one drug discharge hole provided at the tip of the tube and discharging the drug led to the tube into the body A drug administration unit, and the anchor unit is provided in the drug administration unit.

 また、この発明にかかるカテーテルは、上述した発明において、先端が当該カテーテルの所定部位に取り付けられ、基端が体外に位置し、当該カテーテルに沿って配設された線材を備え、前記線材の取付位置から基端側の当該カテーテルに対して前記線材を前進あるいは後退させて前記係留部の形状を変化させることを特徴とする。 In the catheter according to the present invention, in the above-described invention, the catheter according to the present invention comprises a wire having a tip attached to a predetermined portion of the catheter, a proximal end located outside the body, and disposed along the catheter; It is characterized in that the wire is advanced or retracted with respect to the catheter on the proximal side from the position to change the shape of the anchoring portion.

 また、この発明にかかるカテーテルは、上述した発明において、前記線材は、金属ワイヤであることを特徴とする。 Further, in the above-mentioned invention, the catheter according to the present invention is characterized in that the wire is a metal wire.

 また、この発明にかかるカテーテルは、上述した発明において、前記係留部は、前記線材の取付位置より基端側の当該カテーテルに設けられ、当該カテーテルの他の部位よりも柔軟な部位であり、前記線材の当該カテーテルへの取付位置から基端側の当該カテーテルに対して前記線材を基端側に向けて引くことにより、前記柔軟な部位である係留部が圧縮され、前記係留部が径外方向に隆起することを特徴とする。 In the catheter according to the present invention, in the above-described invention, the anchoring portion is provided on the catheter proximal to the attachment position of the wire and is a more flexible portion than the other portions of the catheter, By pulling the wire toward the proximal side with respect to the catheter on the proximal side from the attachment position of the wire to the catheter, the anchoring portion which is the flexible portion is compressed, and the anchoring portion is radially outward It is characterized by being raised.

 また、この発明にかかるカテーテルは、上述した発明において、前記係留部は、当該カテーテルから外側に向けて突出した突出部と、前記突出部の内部に設けられた心材と、前記線材に対して前記心材を回動可能に取り付けるジョイントと、を備え、前記線材の当該カテーテルへの取付位置から基端側の当該カテーテルに対して前記線材を基端側に向けて引くことにより、前記線材に対して前記心材が回動し、当該カテーテルの軸方向に対する前記突出部の突出方向の成す角度が変化することを特徴とする。 In the catheter according to the present invention, in the above-described invention, the anchoring portion may be a protrusion projecting outward from the catheter, a core member provided inside the protrusion, and the wire relative to the wire. And a joint for pivotally attaching the core member, and pulling the wire rod toward the proximal end side with respect to the catheter on the proximal end side from the attachment position of the wire rod to the catheter relative to the wire rod The core material is pivoted, and an angle formed by the projecting direction of the projection with respect to the axial direction of the catheter is changed.

 また、この発明にかかるカテーテルは、上述した発明において、先端に分離可能な先端部と、内部通路に設けられた突起部と、をさらに備え、前記線材は、先端が前記先端部に取り付けられ、当該カテーテルの内部通路を通って、基端が体外に位置し、前記係留部は、前記突起部より基端側の当該カテーテルに設けられ、当該カテーテルの他の部位よりも柔軟な部位であり、当該カテーテルに対して前記線材を基端側に向けて引くことにより、前記先端部が当該カテーテル内の内部通路を通って基端側に移動する際に、前記突起部において前記先端部が係止されて前記柔軟な部位である係留部に圧縮圧力が印加され、前記係留部が径外方向に隆起することを特徴とする。 In the catheter according to the present invention, in the above-described invention, the catheter further includes a tip that can be separated at the tip, and a protrusion that is provided in the internal passage, and the wire is attached at the tip to the tip. The proximal end is located outside the body through the internal passage of the catheter, and the anchor portion is provided on the catheter proximal to the protrusion and is a more flexible site than other parts of the catheter, By pulling the wire toward the proximal end with respect to the catheter, the distal end is locked at the projection when the distal end moves proximally through the internal passage in the catheter. A compressive pressure is applied to the anchoring portion which is the flexible portion, and the anchoring portion bulges in a radially outward direction.

 また、この発明にかかるカテーテルは、上述した発明において、前記先端部は先端が尖った穿刺部となっており、前記突起部によって前記先端部が係止された状態で、前記先端部の穿刺部が全て前記カテーテルの内部通路内に収容されるように構成されていることを特徴とする。 In the catheter according to the present invention, in the above-described invention, the distal end portion is a punctured portion having a sharpened distal end, and the punctured portion at the distal end portion in a state where the distal end portion is locked by the projection. Are all configured to be housed within the internal passageway of the catheter.

 また、この発明にかかるカテーテルは、上述した発明において、当該カテーテルの所定部位に取り付けられ、当該カテーテルの内部通路内で線材と結合または係合が可能な被結合部を備え、前記被結合部に結合または係合した前記線材を基端側に向けて押すまたは引くことにより、該結合位置または係合位置を基端側の当該カテーテルに対して前進あるいは後退させて前記係留部の形状を変化させることを特徴とする。 Further, in the above-described invention, the catheter according to the present invention is provided with a coupled portion which is attached to a predetermined portion of the catheter and which can be coupled or engaged with the wire in the inner passage of the catheter. By pushing or pulling the coupled or engaged wire proximally, the coupled or engaged position is advanced or retracted relative to the proximal catheter to change the shape of the anchoring portion. It is characterized by

 また、この発明にかかるカテーテルは、上述した発明において、前記係留部より前記カテーテルの基端側にあり、前記カテーテルの先端方向に向けて薬剤を送達する送達部と、前記係留部より前記カテーテルの先端側に位置する先端部と、をさらに有し、前記送達部と前記先端部とを相対的に移動させることにより、前記係留部の形状が変化するように構成されたことを特徴とする。 Further, in the above-described invention, the catheter according to the present invention is a delivery unit which is located on the proximal end side of the catheter from the anchoring portion and which delivers a drug toward the distal direction of the catheter; A distal end portion located on the distal end side is further included, and the shape of the anchoring portion is configured to be changed by relatively moving the delivery portion and the distal end portion.

 また、この発明にかかるカテーテルの体内への挿入方法は、線材と、前記線材を引くことにより外側面に突出する係留部とをもつカテーテルを生体組織に挿入して留置するカテーテルの体内への挿入方法であって、前記係留部が突出していない状態で、前記カテーテルを生体組織に穿刺して前記係留部が生体組織内に位置させる穿刺ステップと、前記線材を引いて前記係留部を突出させ、前記係留部により前記カテーテルと前記生体組織との位置を固定する位置固定ステップと、を含むことを特徴とする。 Further, according to the method of inserting a catheter according to the present invention into the body, the catheter is inserted into the body of a living tissue by inserting a catheter having a wire and an anchor portion projecting to the outer surface by pulling the wire. A method of puncturing the catheter with the tissue so that the anchor portion is positioned in the body tissue, with the anchor portion not protruding, pulling the wire to project the anchor portion; And fixing the position of the catheter and the living tissue by the anchoring portion.

 また、この発明にかかるカテーテルの体内からの抜出方法は、線材と、前記線材を押すまたは引くことにより外側面から突出が減る係留部とを有するカテーテルであって、生体組織に係留されているカテーテルを前記生体組織から抜き出すカテーテルの体内からの抜出方法であって、前記カテーテルの基端を押さえて、前記線材を押すまたは引いて前記係留部の外側面からの突出を減らす係留減少ステップと、前記カテーテルを前記生体組織から引き抜く引抜ステップと、を含むことを特徴とする。 Further, a method of extracting the catheter according to the present invention from the body is a catheter having a wire and an anchoring portion whose protrusion is reduced from the outer surface by pushing or pulling the wire, which is anchored to a living tissue. A method for withdrawing the catheter from the body tissue, wherein the proximal end of the catheter is held and the wire is pushed or pulled to reduce the protrusion from the outer surface of the anchoring portion, and And withdrawing the catheter from the living tissue.

 この発明によれば、人間を含む哺乳類の体内に薬剤を導くカテーテルの側面に設けられた係留部は、体外からの操作により形状が変化することによって当該カテーテルを体内に係留するようにしているので、カテーテルの挿入や抜出の処理に影響を与えずに、確実に体内に係留することができる。 According to the present invention, the anchoring portion provided on the side of the catheter for guiding the drug into the mammalian body, including human beings, anchors the catheter in the body by changing its shape by operation from outside the body. The catheter can be anchored in the body reliably without affecting the process of insertion and removal of the catheter.

図1は、この発明の実施の形態1にかかるカテーテルが人体に適用された状態を示す模式図である。FIG. 1 is a schematic view showing a state in which the catheter according to Embodiment 1 of the present invention is applied to a human body. 図2は、図1に示したカテーテルの薬剤投与部の詳細構成を示す斜視図である。FIG. 2 is a perspective view showing a detailed configuration of a drug administration unit of the catheter shown in FIG. 図3は、図1に示したカテーテルの薬剤投与部の詳細構成を示す断面図である。FIG. 3 is a cross-sectional view showing the detailed configuration of the drug administration unit of the catheter shown in FIG. 図4は、カテーテルの体内への挿入処理手順を示すフローチャートである。FIG. 4 is a flowchart showing the procedure for inserting the catheter into the body. 図5は、カテーテルの体内からの抜出処理手順を示すフローチャートである。FIG. 5 is a flow chart showing the procedure for extracting the catheter from the body. 図6は、この発明の実施の形態2にかかるカテーテルの薬剤投与部の詳細構成を示す斜視図である。FIG. 6 is a perspective view showing a detailed configuration of a drug administration unit of a catheter according to a second embodiment of the present invention. 図7は、図6に示したカテーテルの薬剤投与部の詳細構成を示す断面図である。FIG. 7 is a cross-sectional view showing the detailed configuration of the drug administration unit of the catheter shown in FIG. 図8は、この発明の実施の形態3にかかるカテーテルの薬剤投与部の詳細構成を示す斜視図である。FIG. 8 is a perspective view showing a detailed configuration of a drug administration unit of a catheter according to a third embodiment of the present invention. 図9は、図8に示したカテーテルの薬剤投与部の詳細構成を示す断面図である。FIG. 9 is a cross-sectional view showing the detailed configuration of the drug administration unit of the catheter shown in FIG. 図10は、図9に示したカテーテルの変形例の構成を示す断面図である。FIG. 10 is a cross-sectional view showing the configuration of a modification of the catheter shown in FIG. 図11は、この発明の実施の形態4にかかるカテーテルの薬剤投与部の詳細構成を示す断面図である。FIG. 11 is a cross-sectional view showing the detailed configuration of the medicine administration section of the catheter according to the fourth embodiment of the present invention. 図12は、図3に示したカテーテルの薬剤吐出穴の位置を変えた変形例1の構成を示す断面図である。FIG. 12 is a cross-sectional view showing the configuration of Modification 1 in which the position of the medicine discharge hole of the catheter shown in FIG. 3 is changed. 図13は、図3に示したカテーテルの薬剤吐出穴の位置を変えた変形例2の構成を示す断面図である。FIG. 13 is a cross-sectional view showing the configuration of Modification 2 in which the position of the medicine discharge hole of the catheter shown in FIG. 3 is changed. 図14は、図3に示したカテーテルから線材の構成を削除した変形例3の構成を示す断面図である。FIG. 14 is a cross-sectional view showing the configuration of Modification 3 in which the configuration of the wire is removed from the catheter shown in FIG.

 以下、図面を参照して、この発明にかかるカテーテルの実施の形態を詳細に説明する。なお、この実施の形態によってこの発明が限定されるものではない。 Hereinafter, embodiments of a catheter according to the present invention will be described in detail with reference to the drawings. The present invention is not limited by the embodiment.

(実施の形態1)
 図1は、この発明の実施の形態1にかかるカテーテルを有した薬剤投与装置が人体に適用された状態を示す模式図である。また、図2は、図1に示したカテーテルの薬剤投与部が体内臓器に係留された状態を示す斜視図である。さらに、図3は、係留部の状態変化を含む薬剤投与部の構成を示す断面図である。図1では、人間を含む哺乳類である投与対象、たとえば肝臓などの体内臓器4に対して数十ml程度の抗癌剤などの薬剤を、1週間程度の長期間にわたり連続的かつ集中的に吐出して計画投与する場合を示している。なお、ここでいう薬剤には、液状およびゲル状の薬剤を含む。
Embodiment 1
FIG. 1 is a schematic view showing a state in which a drug administration device having a catheter according to Embodiment 1 of the present invention is applied to a human body. FIG. 2 is a perspective view showing a state in which the drug administration unit of the catheter shown in FIG. 1 is anchored to an internal organ. Furthermore, FIG. 3 is a cross-sectional view showing the configuration of the drug administration unit including a change in the state of the anchoring unit. In FIG. 1, several tens of ml of a drug such as an anticancer drug is continuously and intensively discharged over a long period of about one week to an administration target which is a mammal including human, for example, an internal organ 4 such as the liver. It shows the case of planned administration. The term "drug" as used herein includes liquid and gel drugs.

 図1~図3において、薬剤投与装置100は、カテーテル1と、このカテーテル1に薬剤を供給する薬剤投与装置本体3とを有する。カテーテル1は、生体適合性を有する柔軟なポリエチレンなどで形成されたチューブ2と、チューブ2の先端部に設けられ、硬質なチタンあるいは成型されたポリエチレンテレフタレート(PET)樹脂などで形成された薬剤投与部8とを有する。この薬剤投与部8は、体内臓器4に穿刺される。チューブ2と薬剤投与部8との間には、ストッパ7が設けられ、このストッパ7が体内臓器4表面に当て着くことによって、体内臓器4と薬剤投与部8との相対位置を規定する。なお、このストッパ7は、カテーテル1の軸方向に沿って移動調整が可能である。 In FIGS. 1 to 3, the drug administration device 100 has a catheter 1 and a drug administration device main body 3 for supplying a drug to the catheter 1. The catheter 1 is provided with a tube 2 made of a biocompatible soft polyethylene and the like, and a distal end of the tube 2, and a drug administration made of hard titanium or molded polyethylene terephthalate (PET) resin, etc. And 8. The drug administration unit 8 punctures the internal organ 4. A stopper 7 is provided between the tube 2 and the drug administration unit 8, and the stopper 7 rests on the surface of the internal organ 4 to define the relative position between the internal organ 4 and the drug administration unit 8. The stopper 7 can be moved and adjusted along the axial direction of the catheter 1.

 薬剤投与装置本体3は、体表6に固定され、上述したように、薬剤をカテーテル1側に供給する。薬剤投与装置本体3は、薬剤の押し出し圧力を可変に制御する。なお、薬剤投与装置本体3は、体表6に取り付けてある必要はなく、例えば、体内に埋め込む構成や、体外に離間して配置する構成が可能である。 The drug administration device main body 3 is fixed to the body surface 6 and supplies the drug to the catheter 1 side as described above. The drug administration device main body 3 variably controls the pushing pressure of the drug. The drug administration device main body 3 does not have to be attached to the body surface 6. For example, the drug administration device main body 3 may be implanted in the body or may be spaced apart from the body.

 薬剤投与部8は、図2に示すように、薬剤吐出穴9が側面に設けられ、尖った先端部11と薬剤吐出穴9との間に、径外方向に突出する係留部10が設けられる。この係留部10は、少なくともカテーテル1が体内に留置された状態で、カテーテル1の表面から隆起して、カテーテル1を体内臓器4内に係留する。なお、この係留部10の形状は、後述するように、体外からの操作で変形可能である。 As shown in FIG. 2, in the drug administration unit 8, the drug discharge hole 9 is provided on the side surface, and the anchor portion 10 protruding in the radially outward direction is provided between the pointed tip 11 and the drug discharge hole 9. . The anchoring portion 10 is raised from the surface of the catheter 1 at least while the catheter 1 is indwelled in the body, and anchors the catheter 1 in the internal organ 4. In addition, the shape of this mooring part 10 is deformable by operation from the outside of the body, as will be described later.

 なお、係留部10の位置は、薬剤吐出穴9の近傍であると、薬剤吐出位置が安定するため、好ましい。ただし、係留部10の位置は、薬剤吐出穴9の近傍に限らず、カテーテル1が体内に導入される部位のうちから、目的臓器や周辺組織の配置に鑑みて適切な位置に設けることができる。また、係留部10は、1箇所に限らず、複数箇所に設けてもよい。 It is preferable that the position of the anchoring portion 10 be in the vicinity of the medicine discharge hole 9 because the medicine discharge position is stabilized. However, the position of the anchoring portion 10 is not limited to the vicinity of the drug discharge hole 9, and can be provided at an appropriate position in view of the arrangement of the target organ and surrounding tissue from among the sites where the catheter 1 is introduced into the body. . Moreover, you may provide the mooring part 10 not only in one place but in multiple places.

 図3は、係留部10の形状変化を説明する断面図である。図3(a)は、体内に挿入前あるいは挿入中のカテーテル1の状態を示している。カテーテル1の内部通路14には、金属ワイヤなどの線材12が貫通し、線材12の先端は、アンカー13によってカテーテル1に取り付けられている。なお、カテーテル1の基端は、カテーテル1の内部通路14の基端側の開口から体外に突出した状態となっている。係留部10は、カテーテル1の他の管路部分よりも肉厚が薄い薄膜部15を有し、この薄膜部15によってカテーテル1の他の管路部分よりも柔軟になっている。 FIG. 3 is a cross-sectional view for explaining the shape change of the mooring portion 10. FIG. 3A shows the state of the catheter 1 before or during insertion into the body. A wire 12 such as a metal wire passes through the inner passage 14 of the catheter 1, and the tip of the wire 12 is attached to the catheter 1 by an anchor 13. The proximal end of the catheter 1 protrudes from the opening on the proximal end side of the inner passage 14 of the catheter 1 outside the body. The anchoring portion 10 has a thin film portion 15 whose thickness is thinner than that of the other conduit portion of the catheter 1, and the thin film portion 15 is more flexible than the other conduit portion of the catheter 1.

 この図3(a)の状態で、カテーテル1は、患部5の所望位置まで挿入される。すなわち、操作者が、先端部をもって引っ張って、係留部10が延びきった図3(a)の状態にし、患部を押さえてカテーテルを穿刺する(図4:ステップS101)。挿入後、図3(a)の矢印に示すように、操作者が、線材12を基端側に向けて引くと、図3(b)に示すように、アンカー13とともにカテーテル1の先端部がカテーテル1の基端側に移動する。この移動によって、薄膜部15に圧縮圧力が加わり、薄膜部15は、径外方向に隆起する。係留部10の薄膜部15が隆起することによって、カテーテル1は、患部5に係留される。そして、操作者は、線材12の基端がカテーテル1の基端に対して動かないように固定する(図4:ステップS102)。 In the state of FIG. 3A, the catheter 1 is inserted to a desired position of the affected area 5. That is, the operator pulls the distal end portion to bring the anchor portion 10 into the extended state shown in FIG. 3A, holds the affected area, and punctures the catheter (FIG. 4: step S101). After the insertion, as shown by the arrow in FIG. 3 (a), when the operator pulls the wire 12 toward the proximal end side, as shown in FIG. 3 (b), the distal end portion of the catheter 1 together with the anchor 13 Move to the proximal side of the catheter 1. By this movement, a compressive pressure is applied to the thin film portion 15, and the thin film portion 15 bulges radially outward. The catheter 1 is anchored to the affected area 5 by the thin film portion 15 of the anchor portion 10 being raised. And an operator fixes so that the proximal end of the wire 12 may not move with respect to the proximal end of the catheter 1 (FIG. 4: step S102).

 その後、カテーテル1による薬剤投与が終了すると、図3(c)に示すように、操作者は、線材12をカテーテル1の基端側にさらに引くと、係留部10の薄膜部15による突起がカテーテル1の先端側に傾いた状態となる(図5:ステップS201)。この場合、係留部10は、体内に対するカテーテル1の引き抜き方向に対して抵抗が小さくなり、抜きやすくなる。すなわち、図3(c)の状態を維持しつつ、カテーテル1全体を引き抜くことによって(図5:ステップS202)、カテーテル1は容易に体内から取り外すことができる。 Thereafter, when the administration of the drug by the catheter 1 is completed, as shown in FIG. 3C, when the operator further pulls the wire 12 to the proximal end side of the catheter 1, the projection by the thin film portion 15 of the anchoring portion 10 is a catheter It will be in the state inclined to the front end side of 1 (FIG. 5: step S201). In this case, the anchoring portion 10 is less resistant to the direction of withdrawal of the catheter 1 from the body, and is easier to pull out. That is, the catheter 1 can be easily removed from the body by pulling out the entire catheter 1 (FIG. 5: step S202) while maintaining the state of FIG. 3 (c).

 なお、ステップS201では、線材12を基端側に引くようにしていたが、線材12を基端側から押して係留部10の隆起を小さくするようにしてもよい。すなわち、線材12が、ある程度の剛性を有している場合、図3(b)に示した係留状態から、線材12を基端側から押すことによって、アンカー13を介して先端部が先端側に移動し、図3(a)に示すように、係留部10の薄膜部15は平坦となる。換言すれば、線材12を基端部から押すことによって、図3(b)の係留状態から図3(a)の穿刺状態に復元されることになる。この復元された状態で、カテーテル1全体を引き抜くことによって、カテーテル1は容易に体内から取り外すことができる。 In step S201, the wire 12 is pulled to the base end side, but the protrusion of the anchoring portion 10 may be reduced by pushing the wire 12 from the base end side. That is, when the wire 12 has a certain degree of rigidity, by pushing the wire 12 from the base end side from the anchored state shown in FIG. It moves and as shown to Fig.3 (a), the thin film part 15 of the anchoring part 10 becomes flat. In other words, pushing the wire 12 from the proximal end restores the anchored state of FIG. 3 (b) to the punctured state of FIG. 3 (a). In this restored state, the catheter 1 can be easily removed from the body by pulling out the entire catheter 1.

 この実施の形態1では、カテーテル1の挿脱時には係留部10が邪魔にならず、スムーズにカテーテル1を挿脱できるとともに、薬剤投与時には、カテーテル1が係留部10によって確実に体内に係留されるため、安定した薬剤投与を行うことができる。 In the first embodiment, the anchoring portion 10 does not get in the way when inserting or removing the catheter 1, and the catheter 1 can be smoothly inserted / removed while the catheter 1 is reliably anchored in the body by the anchoring portion 10 during drug administration. Therefore, stable drug administration can be performed.

 なお、薄膜部15の弾性が十分に大きければ、線材12の固定を解除することによって、図3(b)の状態から図3(a)の状態に復元するので、この場合に、線材12の固定を解除するようにしてもよい。 If the elasticity of the thin film portion 15 is sufficiently large, the state of FIG. 3B is restored to the state of FIG. 3A by releasing the fixation of the wire 12. The fixation may be released.

 また、線材12は、金属ワイヤ、糸、紐などを用いることができるが、これに限定されない。線材12として金属ワイヤを用いると、カテーテル1の内部通路14に挿入するときに、挿入方向の圧力によってカテーテル1、特に薄膜部15がアコーディオンのように折り畳まれる現象が生じるのを防止することができるので、好ましい。 Moreover, although the metal wire, thread | yarn, a string, etc. can be used for the wire 12, it is not limited to this. The use of a metal wire as the wire 12 can prevent the pressure in the insertion direction from causing a phenomenon in which the catheter 1, particularly the thin film portion 15 is folded like an accordion, when inserted into the internal passage 14 of the catheter 1 So preferred.

(実施の形態2)
 つぎに、この発明の実施の形態2について説明する。この実施の形態2では、図6に示すように、係留部としてスパイク状の突出部16を設けている。図7は、この発明の実施の形態2であるカテーテルの薬剤投与部の構成を示す断面図である。図7(a)に示すように、カテーテル1の内部通路14に線材17が挿入され、線材17は、突出部16に対応する位置に設けられた回動ジョイント19によって、突出部16の内部に埋め込まれた棒状の心材18の基端部と回動可能に結合される。線材17の先端には、先端ストッパ21が設けられ、先端ストッパ21がカテーテル1の内部通路14の先端面に当接することによって、これ以上の線材17の先端方向への前進が阻害される。また、線材17には、突出部16の基端側近傍に中間ストッパ20が設けられ、中間ストッパ20は、突出部16の基端側近傍の内部通路14内で中間ストッパ20よりも基端側に設けられた当接突起22に当接することによって、これ以上の線材17の後退が阻害される。
Second Embodiment
Next, a second embodiment of the present invention will be described. In the second embodiment, as shown in FIG. 6, a spike-like protruding portion 16 is provided as a mooring portion. FIG. 7 is a cross-sectional view showing the configuration of a drug administration portion of a catheter according to a second embodiment of the present invention. As shown in FIG. 7A, the wire 17 is inserted into the internal passage 14 of the catheter 1, and the wire 17 is inserted into the inside of the projecting portion 16 by the pivot joint 19 provided at the position corresponding to the projecting portion 16. It is pivotally connected to the proximal end of the embedded rod-shaped core 18. The distal end stopper 21 is provided at the distal end of the wire rod 17, and the distal end stopper 21 abuts on the distal end surface of the internal passage 14 of the catheter 1 to inhibit the further advancement of the wire rod 17 in the distal direction. Further, the intermediate stopper 20 is provided in the vicinity of the proximal end side of the protruding portion 16 in the wire rod 17, and the intermediate stopper 20 is closer to the proximal end than the intermediate stopper 20 in the internal passage 14 near the proximal end side of the projecting portion 16. Abutment of the abutment projection 22 provided on the rear side prevents the wire rod 17 from retreating further.

 図7(a)の状態では、先端ストッパ21が先端面に当接した状態であり、この場合、心材18は、線材17の軸に対してカテーテル1の基端側に傾斜しているため、突出部16の突起方向も同様にカテーテル1の基端側に傾斜し、カテーテル1の体内への挿入がし易くなる。 In the state of FIG. 7A, the distal end stopper 21 is in contact with the distal end surface, and in this case, the core 18 is inclined toward the proximal end side of the catheter 1 with respect to the axis of the wire 17 Similarly, the protrusion direction of the protrusion 16 is inclined to the proximal end side of the catheter 1 to facilitate insertion of the catheter 1 into the body.

 ここで、図7(a)に示すように、線材17をカテーテル1の基端側に引くと、図7(b)に示すように、心材18は、線材17の軸に対して直交した状態となり、突出部16は、カテーテル1の軸に対して径外方向に突出することになる。この結果、カテーテル1は、体内で係留されることになる。 Here, as shown in FIG. 7 (a), when the wire 17 is pulled to the proximal end side of the catheter 1, as shown in FIG. 7 (b), the core 18 is orthogonal to the axis of the wire 17. Thus, the protrusion 16 protrudes radially outward with respect to the axis of the catheter 1. As a result, the catheter 1 is anchored in the body.

 その後、薬剤の投与が終了した場合、図7(b)に示すように、中間ストッパ20が当接突起22に当接するまで、線材17をカテーテル1の基端側にさらに引くと、図7(c)に示すように、心材18は、線材17の軸に対して、先端側に傾斜するため、突出部16の突起方向も同様にカテーテル1の先端側に傾斜し、カテーテル1の体内からの引き抜きが容易になる。 Thereafter, when the administration of the drug is completed, as shown in FIG. 7 (b), the wire 17 is further pulled toward the proximal end side of the catheter 1 until the intermediate stopper 20 abuts on the contact projection 22. As shown in c), since the core material 18 is inclined to the distal end side with respect to the axis of the wire rod 17, the projection direction of the projection 16 is also inclined to the distal end side of the catheter 1 and It becomes easy to pull out.

 なお、突出部16の形状は、スパイク状に限らず、たとえば、図2に示した係留部10の形状と同様な、中心部に開口をもった円盤状あるいはドーナツ状であってもよい。 The shape of the projecting portion 16 is not limited to the spike shape, and may be, for example, a disk shape or a donut shape having an opening at the central portion similar to the shape of the anchoring portion 10 shown in FIG.

(実施の形態3)
 つぎに、この発明の実施の形態3について説明する。この実施の形態3では、図8に示すように、カテーテル1の先端に分離可能な先端部であるプラグ23を設け、このプラグ23を用いて、カテーテル1の先端側面に係留部25を形成するものである。
Third Embodiment
Next, a third embodiment of the present invention will be described. In this third embodiment, as shown in FIG. 8, a plug 23 which is a separable tip is provided at the tip of the catheter 1, and the anchor 23 is formed on the tip side of the catheter 1 by using this plug 23. It is a thing.

 図9は、この発明の実施の形態3であるカテーテルの薬剤投与部の構成を示す断面図である。図9(a)に示すように、プラグ23は、カテーテル1の薬剤投与部8の先端で、カテーテル1の内部通路内にその一部が収容される。線材24は、カテーテル1の内部通路を通って、プラグ23に取り付けられている。係留部25は、実施の形態1と同様に、カテーテル1の他の管路部分26よりも肉薄な薄膜部27が形成されている。また、カテーテル1の内部通路の先端に当接段差28が設けられ、プラグ23は、当接段差28にその基端部が当接することによって、カテーテル1の基端側への移動が規制されている。 FIG. 9 is a cross-sectional view showing a configuration of a drug administration unit of a catheter according to a third embodiment of the present invention. As shown in FIG. 9A, the plug 23 is partially accommodated in the inner passage of the catheter 1 at the tip of the drug administration unit 8 of the catheter 1. The wire 24 is attached to the plug 23 through the internal passage of the catheter 1. The anchoring portion 25 is formed with a thin film portion 27 thinner than the other conduit portion 26 of the catheter 1 as in the first embodiment. Further, the abutment step 28 is provided at the tip of the internal passage of the catheter 1, and the proximal end of the plug 23 abuts on the abutment step 28, thereby restricting the movement of the catheter 1 to the proximal side. There is.

 この図9(a)の状態で、線材24をカテーテル1の基端側に引くと、図9(b)に示すように、係留部25の薄膜部27が径外方向に隆起し、この隆起した係留部25によってカテーテル1が体内に係留される。 When the wire 24 is pulled to the proximal end side of the catheter 1 in the state of FIG. 9A, as shown in FIG. 9B, the thin film portion 27 of the anchoring portion 25 bulges radially outward, The catheter 1 is anchored in the body by the anchor portion 25.

 その後、カテーテル1による薬剤の投与が終了すると、さらに線材24をカテーテル1の基端側に引くと、係留部25の隆起が先端側に傾斜する変形が生じ、この変形に伴って当接段差28によるプラグ23の基端側への移動規制が解除される。この結果、プラグ23は、線材24とともに内部通路を通り、カテーテル1の基端側開口から取り出される。 Thereafter, when the administration of the drug by the catheter 1 is completed, the wire 24 is further pulled to the proximal end side of the catheter 1 to cause a deformation in which the protuberances of the anchoring portion 25 incline to the distal end side. The restriction on the movement of the plug 23 to the proximal side is released. As a result, the plug 23 passes through the inner passage together with the wire 24 and is taken out from the proximal end opening of the catheter 1.

 プラグ23および線材24がカテーテル1から取り出されると、図9(c)に示すように、体内のカテーテル1の係留部25は弾性復元し、径外方向への隆起がなくなり、カテーテル1の体内への係留が解除される。この結果、カテーテル1は、体内から体外に容易に引き抜くことができる。 When the plug 23 and the wire 24 are removed from the catheter 1, as shown in FIG. 9 (c), the anchoring portion 25 of the catheter 1 in the body elastically recovers, and the protrusion in the radial direction disappears. Mooring is released. As a result, the catheter 1 can be easily withdrawn from the body outside.

 なお、図10に示すように、プラグ23の先端部11を覆うカバー部11cを設けるようにしてもよい。このカバー部11cを設けることによって、カテーテルが留置状態のときでも、先端部11が内部通路14内に収容されることになる。 As shown in FIG. 10, a cover 11c may be provided to cover the tip 11 of the plug 23. By providing the cover portion 11c, the distal end portion 11 is accommodated in the internal passage 14 even when the catheter is in the indwelling state.

(実施の形態4)
 つぎに、この発明の実施の形態4について説明する。上述した実施の形態1~3では、線材12,24がアンカー13やプラグ23と一体的に結合され、また、線材17と心材18とが回動ジョイント19を介して最初から結合状態であったが、この実施の形態4では、線材12,24,17に対応する線材が分離して構成され、係留部10,25あるいは突出部16の係留状態を生成するときに、線材を、アンカー13、プラグ23、あるいは心材18と回動ジョイント19との部分を結合するようにしている。
Embodiment 4
Next, the fourth embodiment of the present invention will be described. In the first to third embodiments described above, the wires 12 and 24 are integrally coupled to the anchor 13 and the plug 23, and the wire 17 and the core 18 are in the coupled state from the beginning through the pivot joint 19. However, in the fourth embodiment, when the wire corresponding to the wire 12, 24, 17 is separated and configured to produce the anchored state of the mooring portion 10, 25 or the protrusion 16, the wire is used as the anchor 13, 13, The plug 23 or the core 18 and the pivot joint 19 are joined together.

 たとえば、実施の形態1に対応させた場合、図11(a)に示すように、アンカー13から引き伸ばされた突起36が、カテーテル1の内部通路14の先端面から突出して設けられる。 For example, in the case of corresponding to the first embodiment, as shown in FIG. 11A, a protrusion 36 stretched from the anchor 13 is provided so as to project from the distal end surface of the internal passage 14 of the catheter 1.

 その後、カテーテル1を体内に係留する場合、線材12に替えて、先端に鉗子35を有する鉗子プローブ32が内部通路14に挿入され、図11(b)に示すように、鉗子35が突起36を把持することによって、鉗子プローブ32とアンカー13とが結合された状態となる。 After that, when the catheter 1 is anchored in the body, a forceps probe 32 having a forceps 35 at its tip is inserted into the internal passage 14 instead of the wire 12 and the forceps 35 make projections 36 as shown in FIG. By holding, the forceps probe 32 and the anchor 13 are in a coupled state.

 その後は、実施の形態1と同様であり、鉗子プローブ32を、カテーテル1の基端側に引くことによって、係留部10が隆起した状態を形成し、これによってカテーテル1が体内に係留される。その後、カテーテル1による薬剤の投与が終了した場合、図11(d)に示すように、鉗子プローブ32をさらにカテーテル1の基端側に引くことによって、係留部10の隆起状態は、カテーテル1の先端側に傾斜し、カテーテル1の体内からの引き抜きを容易にする。 Thereafter, as in the first embodiment, pulling the forceps probe 32 to the proximal end side of the catheter 1 forms a state in which the anchoring portion 10 is raised, whereby the catheter 1 is anchored in the body. After that, when the administration of the drug by the catheter 1 is finished, as shown in FIG. 11 (d), the raised state of the anchor portion 10 is obtained by pulling the forceps probe 32 further to the proximal end of the catheter 1. Inclined distally to facilitate withdrawal of the catheter 1 from the body.

 なお、上述したように、線材17,24を上述した鉗子プローブとすることによって実施の形態2,3にも、実施の形態4を適用することができる。また、上述した実施の形態4では、突起36と鉗子35とによる結合の一例を示したが、これに限らず、たとえば、線材12,17,24と、アンカー13、心材18と回動ジョイント19との部分、プラグ23とが互いに係合するフックなどによっても実現することができる。 As described above, the fourth embodiment can be applied to the second and third embodiments by using the wire rods 17 and 24 as the above-described forceps probes. Moreover, in Embodiment 4 mentioned above, although an example of the coupling | bonding by the processus | protrusion 36 and the forceps 35 was shown, it does not restrict to this, for example, wire rod 12,17,24, anchor 13, core 18, and rotation joint 19 , And the hooks in which the plug 23 engages with each other.

 また、図3(b)では、基端側から、薬剤吐出穴9→係留部10→アンカー13を配置していたが、この配置は任意であり、たとえば、図12に示すように、基端側から、係留部10→薬剤吐出穴9→アンカー13を順次配置してもよいし、図13に示すように、基端側から、係留部10→アンカー13→薬剤吐出穴9を順次配置してもよい。 Further, in FIG. 3B, the medicine discharge hole 9 → the mooring portion 10 → the anchor 13 is disposed from the proximal end side, but this disposition is arbitrary, and for example, as shown in FIG. From the side, the mooring portion 10 → the drug discharge hole 9 → the anchor 13 may be sequentially arranged, or as shown in FIG. 13, from the base end side, the mooring portion 10 → anchor 13 → the drug discharge hole 9 is sequentially arranged May be

 ところで、上述した実施の形態1~4では、いずれも線材12,17,24あるいは鉗子プローブ32を用いて係留部10を隆起させていたが、これに限らず、線材12,17,24あるいは鉗子プローブ32を用いず、たとえば、図14に示すように、内部通路14内に線材などを設けない構成としてもよい。この場合、係留部10の基端側の送達部41および/または先端側の穿刺部42が、矢印に示したように、相対的に伸縮されることによって係留部10が隆起し、あるいは平坦になる。 By the way, in the first to fourth embodiments described above, the anchor portion 10 is raised using the wire rods 12, 17, 24 or the insulator probe 32. However, the present invention is not limited to this, the wire rods 12, 17, 24, or insulators For example, as shown in FIG. 14, a wire or the like may not be provided in the inner passage 14 without using the probe 32. In this case, the delivery portion 41 on the proximal side of the anchoring portion 10 and / or the puncture portion 42 on the distal end side are relatively extended or contracted by raising or lowering the anchoring portion 10 as shown by the arrows. Become.

 なお、上述した実施の形態1~4および変形例は、適宜組合せが可能である。 The first to fourth embodiments and the modifications described above can be combined as appropriate.

  1 カテーテル
  2 チューブ
  3 薬剤投与装置本体
  4 体内臓器
  5 患部
  6 体表
  7 ストッパ
  8 薬剤投与部
  9 薬剤吐出穴
 10,25 係留部
 11 先端部
 11c カバー部
 12,17,24 線材
 13 アンカー
 14 内部通路
 15,27 薄膜部
 16 突出部
 18 心材
 19 回動ジョイント
 20 中間ストッパ
 21 先端ストッパ
 22 当接突起
 23 プラグ
 28 当接段差
 32 鉗子プローブ
 35 鉗子
 36 突起
 41 送達部
 42 穿刺部
Reference Signs List 1 catheter 2 tube 3 drug administration device main body 4 internal organ 5 affected area 6 body surface 7 stopper 8 drug administration portion 9 drug ejection hole 10, 25 anchored portion 11 tip portion 11 c cover portion 12, 17, 24 wire rod 13 anchor 14 internal passage 15 , 27 thin film portion 16 protrusion portion 18 core 19 rotation joint 20 intermediate stopper 21 tip stopper 22 contact projection 23 plug 28 contact step 32 forceps probe 35 forceps 36 projection 41 delivery portion 42 puncture portion

Claims (12)

 人間を含む哺乳類の体内に薬剤を導くカテーテルであって、
 当該カテーテルの側面に設けられ、体外からの操作により形状が変化して当該カテーテルを体内に係留する係留部を備えたことを特徴とするカテーテル。
A catheter for guiding drugs into the body of mammals including humans,
What is claimed is: 1. A catheter comprising a anchoring portion provided on the side of the catheter and having a shape changed by manipulation from outside the body to anchor the catheter in the body.
 前記薬剤を体内に導くチューブと、
 前記チューブの先端に設けられ、前記チューブに導かれた薬剤を体内に吐出する少なくとも1つの薬剤吐出穴を有する薬剤投与部と、
 を備え、
 前記係留部は、前記薬剤投与部に設けられていることを特徴とする請求項1に記載のカテーテル。
A tube for introducing the drug into the body,
A drug administration unit provided at the tip of the tube and having at least one drug discharge hole for discharging the drug introduced into the tube into the body;
Equipped with
The catheter according to claim 1, wherein the anchoring portion is provided in the drug administration portion.
 先端が当該カテーテルの所定部位に取り付けられ、基端が体外に位置し、当該カテーテルに沿って配設された線材を備え、
 前記線材の取付位置から基端側の当該カテーテルに対して前記線材を前進あるいは後退させて前記係留部の形状を変化させることを特徴とする請求項1に記載のカテーテル。
The distal end is attached to a predetermined site of the catheter, the proximal end is outside the body, and comprises a wire disposed along the catheter;
The catheter according to claim 1, wherein the shape of the anchor portion is changed by advancing or retracting the wire from the attachment position of the wire with respect to the catheter on the proximal side.
 前記線材は、金属ワイヤであることを特徴とする請求項3に記載のカテーテル。 The catheter according to claim 3, wherein the wire is a metal wire.  前記係留部は、前記線材の取付位置より基端側の当該カテーテルに設けられ、当該カテーテルの他の部位よりも柔軟な部位であり、
 前記線材の当該カテーテルへの取付位置から基端側の当該カテーテルに対して前記線材を基端側に向けて引くことにより、前記柔軟な部位である係留部が圧縮され、前記係留部が径外方向に隆起することを特徴とする請求項3に記載のカテーテル。
The anchoring portion is provided on the catheter proximal to the attachment position of the wire, and is a portion that is more flexible than other portions of the catheter,
By pulling the wire toward the proximal end with respect to the catheter on the proximal side from the attachment position of the wire to the catheter, the anchoring portion which is the flexible portion is compressed, and the anchoring portion is outside the diameter The catheter according to claim 3, characterized in that it bulges in a direction.
 前記係留部は、
 当該カテーテルから外側に向けて突出した突出部と、
 前記突出部の内部に設けられた心材と、
 前記線材に対して前記心材を回動可能に取り付けるジョイントと、
 を備え、
 前記線材の当該カテーテルへの取付位置から基端側の当該カテーテルに対して前記線材を基端側に向けて引くことにより、前記線材に対して前記心材が回動し、当該カテーテルの軸方向に対する前記突出部の突出方向の成す角度が変化することを特徴とする請求項3に記載のカテーテル。
The mooring section is
A projection projecting outward from the catheter;
A core material provided inside the protrusion;
A joint pivotally attaching the core to the wire;
Equipped with
The core is rotated relative to the wire by pulling the wire toward the proximal side with respect to the catheter on the proximal side from the attachment position of the wire to the catheter, and the core relative to the axial direction of the catheter The catheter according to claim 3, wherein an angle formed by the projecting direction of the projecting portion changes.
 先端に分離可能な先端部と、
 内部通路に設けられた突起部と、
 をさらに備え、
 前記線材は、先端が前記先端部に取り付けられ、当該カテーテルの内部通路を通って、基端が体外に位置し、
 前記係留部は、前記突起部より基端側の当該カテーテルに設けられ、当該カテーテルの他の部位よりも柔軟な部位であり、
 当該カテーテルに対して前記線材を基端側に向けて引くことにより、前記先端部が当該カテーテル内の内部通路を通って基端側に移動する際に、前記突起部において前記先端部が係止されて前記柔軟な部位である係留部に圧縮圧力が印加され、前記係留部が径外方向に隆起することを特徴とする請求項3に記載のカテーテル。
A separable tip at the tip,
A projection provided in the inner passage,
And further
The wire is attached at its distal end to the distal end, the proximal end is located outside the body through the internal passage of the catheter,
The anchoring portion is provided on the catheter proximal to the protrusion, and is a portion that is more flexible than other portions of the catheter,
By pulling the wire toward the proximal end with respect to the catheter, the distal end is locked at the projection when the distal end moves proximally through the internal passage in the catheter. The catheter according to claim 3, characterized in that compressed pressure is applied to the anchoring portion which is the flexible portion, and the anchoring portion bulges in the radially outward direction.
 前記先端部は先端が尖った穿刺部となっており、
 前記突起部によって前記先端部が係止された状態で、前記先端部の穿刺部が全て前記カテーテルの内部通路内に収容されるように構成されていることを特徴とする請求項7に記載のカテーテル。
The tip end is a puncturing portion with a pointed tip,
8. The apparatus according to claim 7, wherein all the puncturing portions of the tip end portion are accommodated in the inner passage of the catheter in a state where the tip end portion is locked by the projection portion. catheter.
 当該カテーテルの所定部位に取り付けられ、当該カテーテルの内部通路内で線材と結合または係合が可能な被結合部を備え、
 前記被結合部に結合または係合した前記線材を基端側に向けて押すまたは引くことにより、該結合位置または係合位置を基端側の当該カテーテルに対して前進あるいは後退させて前記係留部の形状を変化させることを特徴とする請求項1に記載のカテーテル。
And a coupled portion attached to a predetermined portion of the catheter and capable of being coupled or engaged with the wire in an inner passage of the catheter;
By pushing or pulling the wire coupled or engaged with the coupled portion toward the proximal side, the coupled position or engaged position is advanced or retracted relative to the catheter on the proximal side to thereby hold the anchoring portion. The catheter according to claim 1, wherein the shape of is changed.
 前記係留部より前記カテーテルの基端側にあり、前記カテーテルの先端方向に向けて薬剤を送達する送達部と、
 前記係留部より前記カテーテルの先端側に位置する先端部と、
 をさらに有し、
 前記送達部と前記先端部とを相対的に移動させることにより、前記係留部の形状が変化するように構成されたことを特徴とする請求項1に記載のカテーテル。
A delivery portion which is proximal to the catheter from the anchoring portion and which delivers a drug toward the distal direction of the catheter;
A distal end portion located closer to the distal end side of the catheter than the anchoring portion;
And have
The catheter according to claim 1, characterized in that the shape of the anchoring portion is changed by relatively moving the delivery portion and the tip portion.
 線材と、前記線材を引くことにより外側面に突出する係留部とをもつカテーテルを生体組織に挿入して留置するカテーテルの体内への挿入方法であって、
 前記係留部が突出していない状態で、前記カテーテルを生体組織に穿刺して前記係留部が生体組織内に位置させる穿刺ステップと、
 前記線材を引いて前記係留部を突出させ、前記係留部により前記カテーテルと前記生体組織との位置を固定する位置固定ステップと、
 を含むことを特徴とするカテーテルの体内への挿入方法。
A method of inserting a catheter having a wire and a catheter having an anchor portion projecting on the outer surface by pulling the wire into a living tissue, into the body of the catheter,
A puncturing step of puncturing the catheter with a living tissue to position the anchoring portion in the living tissue in a state where the anchoring portion is not protruded;
Fixing the position of the catheter and the living tissue with the anchoring portion by pulling the wire to cause the anchoring portion to protrude;
A method of inserting a catheter into the body, comprising:
 線材と、前記線材を押すまたは引くことにより外側面から突出が減る係留部とを有するカテーテルであって、生体組織に係留されているカテーテルを前記生体組織から抜き出すカテーテルの体内からの抜出方法であって、
 前記カテーテルの基端を押さえて、前記線材を押すまたは引いて前記係留部の外側面からの突出を減らす係留減少ステップと、
 前記カテーテルを前記生体組織から引き抜く引抜ステップと、
 を含むことを特徴とするカテーテルの体内からの抜出方法。
What is claimed is: 1. A catheter having a wire and an anchor portion in which the protrusion is reduced from the outer surface by pushing or pulling the wire, the catheter anchored to the living tissue being extracted from the living tissue. There,
An anchorage reduction step to hold the proximal end of the catheter and to push or pull the wire to reduce protrusion of the anchor from the outer surface;
Extracting the catheter from the living tissue;
A method of extracting a catheter from the body, comprising:
PCT/JP2009/065364 2008-11-27 2009-09-02 Catheter, method of inserting catheter into body, and method of extracting catheter Ceased WO2010061675A1 (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0634646U (en) * 1992-02-07 1994-05-10 富士システムズ株式会社 Medical catheter
JPH10118013A (en) * 1996-10-23 1998-05-12 Asahi Optical Co Ltd Multipurpose tube for endoscope

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0634646U (en) * 1992-02-07 1994-05-10 富士システムズ株式会社 Medical catheter
JPH10118013A (en) * 1996-10-23 1998-05-12 Asahi Optical Co Ltd Multipurpose tube for endoscope

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