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WO2010058427A3 - Process for production and purification of polymyxin b sulfate - Google Patents

Process for production and purification of polymyxin b sulfate Download PDF

Info

Publication number
WO2010058427A3
WO2010058427A3 PCT/IN2009/000672 IN2009000672W WO2010058427A3 WO 2010058427 A3 WO2010058427 A3 WO 2010058427A3 IN 2009000672 W IN2009000672 W IN 2009000672W WO 2010058427 A3 WO2010058427 A3 WO 2010058427A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymyxin
purification
sulfate
production
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2009/000672
Other languages
French (fr)
Other versions
WO2010058427A2 (en
Inventor
Rangaswamy Vidhya
Baiu Guduri
Hiremath Anand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reliance Life Sciences Pvt Ltd
Original Assignee
Reliance Life Sciences Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reliance Life Sciences Pvt Ltd filed Critical Reliance Life Sciences Pvt Ltd
Publication of WO2010058427A2 publication Critical patent/WO2010058427A2/en
Publication of WO2010058427A3 publication Critical patent/WO2010058427A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to improved process of producing high yield of polymyxin B by fermentation. The present invention in particular provides an optimized fermentation conditions and an efficient process for the purification of polymyxin B.
PCT/IN2009/000672 2008-11-24 2009-11-20 Process for production and purification of polymyxin b sulfate Ceased WO2010058427A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2474/MUM/2008 2008-11-24
IN2474MU2008 2008-11-24

Publications (2)

Publication Number Publication Date
WO2010058427A2 WO2010058427A2 (en) 2010-05-27
WO2010058427A3 true WO2010058427A3 (en) 2010-09-10

Family

ID=42082777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000672 Ceased WO2010058427A2 (en) 2008-11-24 2009-11-20 Process for production and purification of polymyxin b sulfate

Country Status (1)

Country Link
WO (1) WO2010058427A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103130876A (en) * 2011-11-30 2013-06-05 天津市海德安科医药科技发展有限公司 Preparing method of high-purity polymyxin B

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103509839B (en) * 2013-10-12 2015-02-25 河北圣雪大成制药有限责任公司 Method for reducing ammonia nitrogen content in polymyxin E fermentation liquor
CN103540633B (en) * 2013-10-24 2016-01-20 河北圣雪大成制药有限责任公司 A kind of method of fermentative Production PXB
CN108977482B (en) * 2018-08-21 2020-11-24 浙江孚诺医药股份有限公司 Preparation method of polymyxin B sulfate
CN109206486B (en) * 2018-09-03 2020-11-10 杭州中美华东制药有限公司 Polymyxin B sulfate impurity and preparation method thereof
CN112553277B (en) * 2019-09-10 2023-06-13 华北制药集团新药研究开发有限责任公司 Method for improving fermentation level of polymyxin B sulfate
CN112940083A (en) * 2019-11-26 2021-06-11 重庆乾泰生物医药有限公司 High-purity polymyxin sulfate B1 crystal form and preparation method thereof
CN113755548A (en) * 2021-09-02 2021-12-07 河北圣雪大成制药有限责任公司 Method for improving fermentation level of polymyxin B

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2565057A (en) * 1946-12-21 1951-08-21 Burroughs Wellcome Co Polymyxin antibiotic
US2595605A (en) * 1948-08-07 1952-05-06 American Cyanamid Co Method of producing polymyxin
US2599950A (en) * 1947-04-30 1952-06-10 American Cyanamid Co Method of preparing polymyxin
JPS54138194A (en) * 1978-04-19 1979-10-26 Kyowa Hakko Kogyo Co Ltd Preparation of antibiotic substance

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB315263A (en) 1928-07-10 1930-08-28 Thomas Hermanus Verhave Senior Process for the preparation of 2:3-butylene-glycol from carbohydrates
US1899156A (en) 1928-07-10 1933-02-28 Thomas Hermanus Verhave Senior Process for the preparation of 2.3-butylene-glycol from carbohydrates
US2695261A (en) 1946-12-21 1954-11-23 Burroughs Wellcome Co Production of polymyxins a, b, and e
US2602041A (en) 1947-04-21 1952-07-01 Burroughs Wellcome Co Method for the manufacture of polymyxin
GB656897A (en) 1947-04-30 1951-09-05 American Cyanamid Co Improvements in or relating to antibacterial substances
US2511104A (en) 1947-06-26 1950-06-13 Carnegie Illinois Steel Corp Apparatus for indicating differential speeds of rotating elements
US2571104A (en) 1948-05-07 1951-10-16 Robert G Benedict Polymyxin production
GB647925A (en) 1948-05-19 1950-12-28 Wellcome Found Improvements relating to the extraction and purification of an antibiotic
US2759868A (en) 1948-08-05 1956-08-21 Burroughs Wellcome Co Manufacture of polymyxins b and e
GB658766A (en) 1948-09-07 1951-10-10 Wellcome Found Improvements in and relating to the purification of antibiotics
US2556376A (en) 1948-09-09 1951-06-12 Chas Pflzer & Co Inc Recovery of polymyxin from fermentation broths
GB645750A (en) 1948-11-30 1950-11-08 Wellcome Found Improvements in and relating to the purification of polymyxin
GB742589A (en) 1953-01-03 1955-12-30 Distillers Co Yeast Ltd Recovery of polymyxin
US3132994A (en) 1961-03-10 1964-05-12 Burroughs Wellcome Co Polymyxin purification
GB991602A (en) 1961-03-10 1965-05-12 Wellcome Found Antibiotics and their purification
GB924652A (en) 1961-08-15 1963-04-24 Upjohn Co Pharmaceutical compositions comprising progesterone derivatives
GB1089765A (en) 1963-08-30 1967-11-08 Wellcome Found Purification of polymyxin
RU2115721C1 (en) 1994-01-05 1998-07-20 Закрытое акционерное общество "Гекта" Strain bacillus polymyxa - a producer of antibiotic polymyxin
JP4151802B2 (en) 1997-11-07 2008-09-17 東レ株式会社 Production method of polysulfone polymer
CN100347188C (en) 2005-12-06 2007-11-07 河北工业大学 Polymyxin E separation preparation method
SK287315B6 (en) 2006-06-02 2010-06-07 Biotika, A. S. A method for polymyxin B isolation from fermented soil
SK287293B6 (en) 2006-06-15 2010-05-07 Biotika, A. S. A method for fermentation of polymyxin B by means of productive microorganism Bacillus polymyxa

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2565057A (en) * 1946-12-21 1951-08-21 Burroughs Wellcome Co Polymyxin antibiotic
US2599950A (en) * 1947-04-30 1952-06-10 American Cyanamid Co Method of preparing polymyxin
US2595605A (en) * 1948-08-07 1952-05-06 American Cyanamid Co Method of producing polymyxin
JPS54138194A (en) * 1978-04-19 1979-10-26 Kyowa Hakko Kogyo Co Ltd Preparation of antibiotic substance

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103130876A (en) * 2011-11-30 2013-06-05 天津市海德安科医药科技发展有限公司 Preparing method of high-purity polymyxin B
CN103130876B (en) * 2011-11-30 2014-07-23 广东双柏药业有限公司 Preparing method of high-purity polymyxin B

Also Published As

Publication number Publication date
WO2010058427A2 (en) 2010-05-27

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