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WO2010052727A1 - Compositions de revêtement fdlm à hautes performances - Google Patents

Compositions de revêtement fdlm à hautes performances Download PDF

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Publication number
WO2010052727A1
WO2010052727A1 PCT/IN2009/000018 IN2009000018W WO2010052727A1 WO 2010052727 A1 WO2010052727 A1 WO 2010052727A1 IN 2009000018 W IN2009000018 W IN 2009000018W WO 2010052727 A1 WO2010052727 A1 WO 2010052727A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
coating composition
coating
range
dry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2009/000018
Other languages
English (en)
Inventor
Suresh Rukmanand Pareek
Chetan Rajsharad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ideal Cures Pvt Ltd
Original Assignee
Ideal Cures Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ideal Cures Pvt Ltd filed Critical Ideal Cures Pvt Ltd
Publication of WO2010052727A1 publication Critical patent/WO2010052727A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/262—Cellulose; Derivatives thereof, e.g. ethers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/105—Coating with compositions containing vegetable or microbial fermentation gums, e.g. cellulose or derivatives; Coating with edible polymers, e.g. polyvinyalcohol
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/12—Apparatus or processes for applying powders or particles to foodstuffs, e.g. for breading; Such apparatus combined with means for pre-moistening or battering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin

Definitions

  • This invention relates to the field of film coating compositions for substrates like pharmaceutical tablets, nutritional supplements, food products, confectionery, agricultural seeds for providing protection to the substrate from environmental conditions like light, humidity, atmospheric gases etc. wherein the solids content in the coating suspension can be raised upto 30% w/w so as to complete the coating very quickly.
  • polyvinyl alcohol which is now increasingly being used for film coating due to its adhesive properties and high water solubility, however, this polymer is not very suitable for non-aqueous coating applications as it is not soluble in organic solvents (though the science is moving toward total aqueous coating, still lots of products all over the world are coated with solvent based or hydro-alcoholic based coating due to moisture sensitivity of some of the active ingredients). Most of the other polymers are not so popular among the formulation scientist unless otherwise for any specific application.
  • US patent 5,630,871 describes a film coating composition wherein HPMC has been combined with lactose thereby increasing the solids content in the water based coating suspension to about 17% w/w. Increasing the solids content beyond this level, increases the suspension viscosity so high that it becomes unsuitable for coating application,. Further drawback of this composition is as it is applicable only with water as the solvent and the same is not been able to use with any organic solvent or hydro-alcoholic solvent system.
  • US patent 5,885,671 describe film coating compositions based on polyvinyl alcohol as the polymer wherein the solid content in the film coating composition can be as high as 20% w/w, however, due to the sticky nature of PVA, the coating process using these compositions is comparatively slow and require fairly high tablet temperature to prevent tablet to tablet sticking (desired tablet temperature for these compositions is 42 - 45 deg.C as compared to 38 - 40 deg.C for HPMC based coating compositions), thus, requiring high energy consumption for the operation. It has been observed that though the solid content of composition described in US patent 5,630,871 is only 15 - 17% (as compared to 20% for PVA based compositions), the coating process is much easier and faster with the composition of 5,630,871.
  • the objective of this invention is to develop a film coating formulation wherein the solid content in the coating composition can be raised to much higher levels as compared to currently available coating compositions so as to reduce the coating time and overall energy consumption.
  • Another objective of the invention is to provide a composition with reasonable viscosity, and good film adhesion properties so as to have excellent logo definition on the finish product and also easy to work with all kind of available coating machines.
  • objective of the invention is to provide a method for coating the substrate using the compositions of the invention.
  • the present invention provides cost - effective dry film coating compositions comprising of HPMC and Modified Starch as the essential ingredients along with other commonly used polymers, plasticizers, excipients like suspending agents, pigments, diluents, lubricants, glidents, opacifiers, flavours, sweeteners etc. for use in coating of pharmaceutical tablets, nutritional supplements, food products, confectionery, agricultural seeds and the like.
  • the invention provides a method of coating a substrate using the invented coating compositions.
  • HPMC is a very versatile polymer which is soluble in aqueous as well as non-aqueous solvents and hence more popular among the scientific community.
  • the two most important grades (based on viscosity) of HPMC which are commonly used in film coating compositions are 5 cps (Methocel E-5, Pharmacoat 606 and other brands) and 15 cps (Methocel E- 15, Pharmacoat 616 and other brands).
  • 15 cps grade is generally used for non-aqueous coating (solid content in coating suspension being 3 - 6% w/w) whereas 5 cps grade is used for aqueous coating (solid content in coating suspension being 8 - 11% w/w).
  • any reduction in the coating process time will be the most desired development and this can be achieved by increasing the solid content in the coating suspension so that one has to spray less amount of suspension thereby reducing the coating time and energy consumption.
  • a dry film coating composition for use in pharmaceutical tablets, nutritional supplements, food products, confectionery or agricultural seed comprising : a) a low viscosity cellulosic polymer; b) modified starch; and c) optionally in combination with other water soluble polymer, diluents, glidents, plasticizer and pigments.
  • the cellulosic polymer is selected from low viscosity grade of hydroxyl propyl methyl cellulose selected among 3cps, 5cps, 15cps or 50cps, hydroxyl propyl cellulose or methyl cellulose used either alone or in combination thereof.
  • the cellulosic polymer is advantageously present in a range of about 5% to about 50%; more preferably in a range of about 10% to about 45% by weight of the dry composition.
  • the modified starch is present in a range of about 3% to about 25%; more preferably in a range of about 5% to about 20% by weight of the dry composition.
  • the coating composition optionally comprise water soluble polymer such as polyvinyl alcohol, sodium CMC, alginic acid, sodium alginate, guar gum, gum acacia, gellan gum, xanthan gum either alone or in combination thereof.
  • water soluble polymer such as polyvinyl alcohol, sodium CMC, alginic acid, sodium alginate, guar gum, gum acacia, gellan gum, xanthan gum either alone or in combination thereof.
  • the water soluble polymer is polyvinyl alcohol used in an amount of about 0% to about 25%; more preferably in a range of about 0% to about 18% by weight of dry composition.
  • the coating composition of the present invention further comprises a diluent such as lactose, mannitol, sucrose, dextrose, maltodextrin, microcrystalline cellulose either alone or in combination thereof, present in a range of about 0% to about 15%; more preferably in a range of about 0% to about 10% by weight of the dry composition.
  • a diluent such as lactose, mannitol, sucrose, dextrose, maltodextrin, microcrystalline cellulose either alone or in combination thereof, present in a range of about 0% to about 15%; more preferably in a range of about 0% to about 10% by weight of the dry composition.
  • Glidant used in the coating composition is selected among talc, fumed silica, magnesium stearate, stearic acid, kaolin, magnesium trisilicate either alone or in combination thereof.
  • One preferred glidant is talc being present in a range of about 0% to about 25%, more preferably in a range of about 0% to about 15% by weight of the dry composition.
  • Polyethylene glycol, propylene glycol, triacetin, liquid paraffin, diethyl phthalate, dibutyl phthalate, glycerin, lecithin, triethyl citrate, fractionated coconut oil, castor oil or polysorbate-80 were used as plasticizers either alone or in combination thereof.
  • the coating composition of the invention comprise polyethylene glycol as plasticizer in an amount ranges about 0% to about 25%; preferably in a range of about 0% to about 20% by weight of the dry composition.
  • the coating composition further includes pigment / opacifier / colouring agent selected from titanium dioxide, calcium carbonate, calcium phosphate, iron oxide colours, lake colours, soluble colours, mica based pearlescent pigments, natural colours used either alone or in combination thereof.
  • pigment / opacifier / colouring agent selected from titanium dioxide, calcium carbonate, calcium phosphate, iron oxide colours, lake colours, soluble colours, mica based pearlescent pigments, natural colours used either alone or in combination thereof.
  • the pigment / opacifier / colouring agent is present in a range of about 0% to about 35% by weight of the composition.
  • the coating composition further includes a sweetener selected from sodium saccharin, aspartame, neutrame either alone or in combination thereof being present in a range of about 0% to about 7%; more preferably in a range of about 0% to about 3% by weight of the composition.
  • the coating composition further includes a flavouring agent in a range of about 0% to about 10% by weight of the dry composition.
  • the invention provides a method for manufacturing the coating composition which method comprises dry blending the ingredients of the composition in a suitable mixer and then sieving through a suitable screen to ensure homogenous mixing.
  • the method comprises dry blending the ingredients of composition in a mixer; granulating the blend with water or other suitable binder solution; drying the granules, and sieving through suitable screen.
  • Another alternative method comprises dry blending the ingredients of composition in a mixer; converting the blend to paste form or liquid form by mixing enough solvent, and sieving the paste / liquid through suitable screen to ensure homogeneity.
  • compositions with 20% solid content are Compositions with 20% solid content:
  • Modified Starch (USP grade) is a very useful excipient in the film coating compositions.
  • the film strength of this combination was quite reasonable, it was found that the film strength can further be increased by replacing a small part of HPMC 3 cps with HPMC 15 cps without compromising much on the suspension viscosity so that the solid content of the suspension can easily be raised upto 20% w/w or more.
  • HPMC based film coating composition could be made possible with 20% or more solid content with easily workable suspension viscosity (200 - 300 cps) and fairly good film strength.
  • the inventors further found that addition of small amount of an excipient like lactose further enhances the film properties in terms of film smoothness and sheen.
  • a combination of HPMC 3 cps, HPMC 15 cps, modified starch and lactose provides a film coating composition which provides very fast coating process (laboratory scale operation upto 500gm tablets lot in a conventional coating pan set-up could be easily completed in about 20 minutes time with 2.5% coating weight gain) with excellent logo definition, surface smoothness, surface coverage, colour uniformity and ease of operation. Coating trials in more efficient coating machines like perforated pan set-up, also produced excellent results as compared to earlier known compositions.
  • composition of US patent 5,630,871 HPMC and lactose based with 15 - 17% solid content
  • the uniformity of dark colours using high concentration of pigments
  • frost effect giving small white specs against very dark colour shade. Any such disadvantage was not observed in the newly invented composition.
  • the invented composition works well with aqueous or hydro-alcoholic or organic solvent systems, the solids content in the coating suspension can be around 20% w/w whereas for organic solvent system the solid content has to be reduced according to the volatility of the solvents used.
  • compositions with 30% solid content are Compositions with 30% solid content:
  • dry film coating composition of the present invention suitable for use in coating pharmaceutical tablets, nutritional supplements, foods, confectionary and agricultural seeds were prepared which comprises HPMC and Modified Starch, optionally in combination with PVA, Lactose, a plasticizer system, opacifier and pigments.
  • HPMC HPMC
  • Modified Starch optionally in combination with PVA, Lactose, a plasticizer system, opacifier and pigments.
  • the invented composition has excellent film forming ability and film adhesion to the substrate and provides excellent protection to the substrate against environmental conditions.
  • the invented composition can easily be used with water or combination of water and alcohol (for moisture sensitive actives) as the solvent system.
  • the invention also provides ample opportunity to make variations in preparing compositions suitable for any specific application by varying the concentration of different ingredients, solvent system and the solid content of the coating suspension.
  • the dry film coating composition of the present invention may comprise of HPMC 3cps 15-50% w/w and Modified Starch 3-25%, in addition to these it may also contain HPMC 15cps 2-15% w/w or PVA 3-25%.
  • the other excipients which may be added to the composition comprises 2- 15% w/w of a diluent chosen from lactose, mannitol, sucrose, dextrose, maltodextrin, a plasticizer system 5-25% w/w, pigments / opacifiers 0-30% w/w, Talc 0-25% w/w.
  • excipients which may optionally be added to the composition to achieve certain specific applications like flavours and sweeteners.
  • Some of the additives like HPMC 5cps, HPMC 6cps, HPMC 50cps, HPC, HEC, methyl cellulose, sodium CMC, aqueous dispersion of ethyl cellulose, gellan gum, xanthan gum, sodium alginate, alginic acid, calcium phosphate, calcium carbonate, microcrystalline cellulose, fumed silica, kaolin, magnesium stearate, stearic acid, magnesium trisilicate, either alone or in combination of more than one ingredient may be added to the invented composition to make alternate compositions.
  • the invented composition can very easily be manufactured by dry mixing of various ingredients (mixing may need specific order of addition depending on the ingredients used), carrying out the colour matching exercise using spectrophotometric colour scan method.
  • the invented composition can also be easily granulated before marketing in order to avoid the dust generation while handling the product at the user site.
  • the granulation can be carried out either for the whole composition or a part of the composition and then mixing with other ingredients.
  • the invented composition may also be converted to either to the paste form or to the liquid form by mixing with suitable solvent system before marketing and then diluting the same further at the user site, thereby eliminating any possibility of powder dust.
  • the invention describes a method for coating substrates. Accordingly, a method for coating substrates such as pharmaceutical tablets, nutritional supplements, food, confectionery, agricultural seeds, and the like, with a film coating composition comprising of the steps of:
  • the coating composition a) mixing the coating composition with water to form a smooth dispersion (the solid content in the dispersion can be varied 20-30% w/w according to ingredients used); b) applying an effective amount of said coating dispersion onto said substrate to form a film on the said substrate (the coating weight gain can be varied from 2 - 2.5% w/w for normal film coating to 4 - 6% w/w for protective coating against environmental conditions), and c) drying the film coating on said substrate.
  • the dry mix composition can easily be converted into coating suspension by suspending in suitable solvent system (aqueous, non-aqueous or hydro-alcoholic).
  • suitable solvent system aqueous, non-aqueous or hydro-alcoholic.
  • Example 1 The ranges of each component of the dry coating compositions of the invention are as follows, by weight : Example 1
  • the dry film coating composition of the invention may be granulated using a planetary mixer. After the dry film coating composition was loaded into the mixer, sufficient water was slowly added during the mixing process until the composition forms slightly adherent granules. These granules were then passed through 2 mm screen and then dried in an oven at 30 0 C until the moisture content below 4% is achieved. The composition was then sieved again to convert the whole mass to 20 mesh size to make it ready for use in a non-dusting granular form. Other methods of granulation, which may be used, are spray granulation and roller compaction.
  • 30gm of the resulting film coating composition was dispersed into 70 gm of purified water to form an inventive coating dispersion (30% solids), and the dispersion was sprayed onto 500gm of tablets using a conventional coating pan set-up to form the inventive coating on the tablets.
  • the tablets were rotated in the coater at a rotation speed of 30 rpm.
  • the coating of around 2.2% weight build up was completed in 15 minutes.
  • the tablets Upon completion of the coating process, the tablets showed a smooth surface with excellent logo definition and colour uniformity.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des compositions de revêtement de film sec constituées par un mélange d’hydroxy propyl méthyl cellulose à faible viscosité et d’amidon modifié en tant que le composant essentiel conjointement à d’autres polymères solubles dans l’eau, des diluants, des plastifiants, des excipients comme des agents de mise en suspension, des pigments, des lubrifiants, des agents de glissement, des opacifiants, des couleurs, des agents aromatisants, des agents édulcorants, etc. destinées à être utilisées pour l’enrobage de comprimés pharmaceutiques, de suppléments nutritionnels, de produits alimentaires, de confiserie, de graines agricoles et équivalents. L’invention concerne en outre un procédé de fabrication de ces compositions et un procédé de revêtement d’un substrat utilisant les compositions de revêtement de l’invention.
PCT/IN2009/000018 2008-11-04 2009-01-06 Compositions de revêtement fdlm à hautes performances Ceased WO2010052727A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2352/MUM/2008 2008-11-04
IN2352MU2008 2008-11-04

Publications (1)

Publication Number Publication Date
WO2010052727A1 true WO2010052727A1 (fr) 2010-05-14

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013032673A1 (fr) 2011-08-30 2013-03-07 Dow Global Technologies Llc Composition d'enrobage comprenant un éther de cellulose et de l'amidon
WO2013098842A3 (fr) * 2011-11-03 2013-10-03 Wincoat Colours And Coatings Private Limited Nouvelle composition d'enrobage par film
US20130266646A1 (en) * 2012-04-04 2013-10-10 Boehringer Ingelheim International Gmbh Pharmaceutical formulations comprising ccr3 antagonists
WO2016108250A1 (fr) 2015-01-01 2016-07-07 Ideal Cures Pvt. Ltd. Nouvelle composition de revêtement de type film
EP3474824A4 (fr) * 2016-08-04 2019-07-31 BPSI Holdings, LLC. Enrobage faciles à avaler et substrats revêtus de ceux-ci
USRE48059E1 (en) 2005-04-14 2020-06-23 Otsuka Pharmaceutical Co., Ltd. Piperazine-substituted benzothiophenes for treatment of mental disorders
WO2021010814A2 (fr) 2019-07-15 2021-01-21 Dva Farma Mexicana S.A. De C.V. Compositions d'enrobages sous forme de pellicule pour comprimés à brillance augmentée, leur procédé de préparation et leur utilisation
US11254833B2 (en) * 2013-03-13 2022-02-22 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Coating composition based on coloring foodstuffs
WO2022168878A1 (fr) * 2021-02-04 2022-08-11 株式会社ミライ化成 Modificateur alimentaire et procédé de fabrication d'aliment modifié

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US4252786A (en) * 1979-11-16 1981-02-24 E. R. Squibb & Sons, Inc. Controlled release tablet
US20020034549A1 (en) * 1998-04-02 2002-03-21 Nathaniel T. Becker Modified starch coating
US6660302B1 (en) * 2000-09-06 2003-12-09 Chr. Hansen, Inc. Dry-powder film coating composition and method of preparation
US20050048164A1 (en) * 1998-03-04 2005-03-03 Bronislaw-Jan Stahl Coated chewing gum comprising an active substance having systemic activity
US20070003621A1 (en) * 2005-06-23 2007-01-04 Spherics, Inc. Dosage forms for movement disorder treatment
US20070196482A1 (en) * 2005-12-16 2007-08-23 Penwest Pharmaceuticals Co. Sustained release torsemide dosage forms

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252786A (en) * 1979-11-16 1981-02-24 E. R. Squibb & Sons, Inc. Controlled release tablet
US20050048164A1 (en) * 1998-03-04 2005-03-03 Bronislaw-Jan Stahl Coated chewing gum comprising an active substance having systemic activity
US20020034549A1 (en) * 1998-04-02 2002-03-21 Nathaniel T. Becker Modified starch coating
US6660302B1 (en) * 2000-09-06 2003-12-09 Chr. Hansen, Inc. Dry-powder film coating composition and method of preparation
US20070003621A1 (en) * 2005-06-23 2007-01-04 Spherics, Inc. Dosage forms for movement disorder treatment
US20070196482A1 (en) * 2005-12-16 2007-08-23 Penwest Pharmaceuticals Co. Sustained release torsemide dosage forms

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE48059E1 (en) 2005-04-14 2020-06-23 Otsuka Pharmaceutical Co., Ltd. Piperazine-substituted benzothiophenes for treatment of mental disorders
CN103764124A (zh) * 2011-08-30 2014-04-30 陶氏环球技术有限责任公司 包含纤维素醚和淀粉的涂层组合物
WO2013032673A1 (fr) 2011-08-30 2013-03-07 Dow Global Technologies Llc Composition d'enrobage comprenant un éther de cellulose et de l'amidon
WO2013098842A3 (fr) * 2011-11-03 2013-10-03 Wincoat Colours And Coatings Private Limited Nouvelle composition d'enrobage par film
US20140251181A1 (en) * 2011-11-03 2014-09-11 Wincoat Colours And Coatings Private Limited Novel Film Composition
US20130266646A1 (en) * 2012-04-04 2013-10-10 Boehringer Ingelheim International Gmbh Pharmaceutical formulations comprising ccr3 antagonists
US10213421B2 (en) * 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
US11612596B2 (en) 2012-04-04 2023-03-28 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
US11254833B2 (en) * 2013-03-13 2022-02-22 Societe D'exploitation De Produits Pour Les Industries Chimiques Seppic Coating composition based on coloring foodstuffs
WO2016108250A1 (fr) 2015-01-01 2016-07-07 Ideal Cures Pvt. Ltd. Nouvelle composition de revêtement de type film
EP3240842A4 (fr) * 2015-01-01 2018-08-08 Ideal Cures Pvt. Ltd. Nouvelle composition de revêtement de type film
EP3474824A4 (fr) * 2016-08-04 2019-07-31 BPSI Holdings, LLC. Enrobage faciles à avaler et substrats revêtus de ceux-ci
AU2017307194B2 (en) * 2016-08-04 2022-06-23 Bpsi Holdings, Llc Easy to swallow coatings and substrates coated therewith
WO2021010814A2 (fr) 2019-07-15 2021-01-21 Dva Farma Mexicana S.A. De C.V. Compositions d'enrobages sous forme de pellicule pour comprimés à brillance augmentée, leur procédé de préparation et leur utilisation
WO2022168878A1 (fr) * 2021-02-04 2022-08-11 株式会社ミライ化成 Modificateur alimentaire et procédé de fabrication d'aliment modifié
JPWO2022168878A1 (fr) * 2021-02-04 2022-08-11
JP7480949B2 (ja) 2021-02-04 2024-05-10 株式会社ミライ化成 食品改質剤及び改質食品の製造方法

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